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Therapy of human rabies: lessons from experimental studies in a mouse model Alan C. Jackson, MD Courtney A. Scott, BSc James Owen, BSc Simon C. Weli, PhD John P. Rossiter, MB, PhD Departments of Medicine (Neurology) Microbiology and Immunology Centre for Neuroscience Studies Queen’s University, Kingston, ON, Canada
Medical complications of rabies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Recovery from rabies ,[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Infectious Diseases 36:60-63, 2003
Specific therapies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Jackson et al.: Clinical Infectious Diseases 36:60-63, 2003
N Engl J Med 352:2508-14, 2005
Survival Case ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],N Engl J Med 352:2508-14, 2005
Survival Case ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ketamine ,[object Object],[object Object],[object Object],Lockhart et al. – Antiviral Chem Chemother 1991 and 1992 Antimicro Agents Chemother 1991
Journal of Virology 80:10270, 2006
Toluidine blue-stained plastic sections cerebral cortex – 48 hrs ,[object Object],J Virol 80:10270, 2006
Trypan blue exclusion cerebral cortex – 72 hrs ,[object Object],J Virol 80:10270, 2006
Trypan Blue Staining Cerebral Cortex Hippocampus J Virol 80:10270, 2006
Effects of 125 μ M ketamine on viability of cortical neurons in CVS infection J Virol 80:10270, 2006
 
Cumulative mortality ketamine 60 mg IP q12h or vehicle ,[object Object],[object Object],J Virol 80:10270, 2006
Therapy with Ketamine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Lancet Neurology 3:744, 2004 multiple sclerosis spinal cord injury Parkinson’s disease Huntington’s disease amyotrophic lateral sclerosis viral diseases of CNS – reovirus, SIV, Sindbis v.
Journal of Virology 81:6248, 2007
log rank test p=0.003 J Virol 81:6248, 2007
Summary ,[object Object],[object Object],[object Object],[object Object],J Virol 81:6248, 2007
Conclusions ,[object Object],[object Object]
Therapeutic approach similar to the Willoughby protocol has been unsuccessful in at least 8 cases: ,[object Object],[object Object],[object Object],[object Object],[object Object]
Conclusions: Ketamine ,[object Object],[object Object],[object Object]
Therapeutic coma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Willoughby protocol ,[object Object],[object Object],[object Object],[object Object],[object Object]
Acknowledgments Queen’s University Violet E. Powell Fund
 

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2 Jackson Humans

  • 1. Therapy of human rabies: lessons from experimental studies in a mouse model Alan C. Jackson, MD Courtney A. Scott, BSc James Owen, BSc Simon C. Weli, PhD John P. Rossiter, MB, PhD Departments of Medicine (Neurology) Microbiology and Immunology Centre for Neuroscience Studies Queen’s University, Kingston, ON, Canada
  • 2.
  • 3.
  • 5.
  • 6. N Engl J Med 352:2508-14, 2005
  • 7.
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  • 10. Journal of Virology 80:10270, 2006
  • 11.
  • 12.
  • 13. Trypan Blue Staining Cerebral Cortex Hippocampus J Virol 80:10270, 2006
  • 14. Effects of 125 μ M ketamine on viability of cortical neurons in CVS infection J Virol 80:10270, 2006
  • 15.  
  • 16.
  • 17.
  • 18. Lancet Neurology 3:744, 2004 multiple sclerosis spinal cord injury Parkinson’s disease Huntington’s disease amyotrophic lateral sclerosis viral diseases of CNS – reovirus, SIV, Sindbis v.
  • 19. Journal of Virology 81:6248, 2007
  • 20. log rank test p=0.003 J Virol 81:6248, 2007
  • 21.
  • 22.
  • 23.
  • 24.
  • 25.
  • 26.
  • 27. Acknowledgments Queen’s University Violet E. Powell Fund
  • 28.