Congres The Art of Self-Healing, 7th of October 2016, Antropia Driebergen

1. Jan van der Greef
“Transformation to a
Health-ecosysteem”

2. Connectivity

4. A systems view looks at the world in terms of
dynamic patterns of (non-linear) relationships
and organization
.
Van der Greef, Jan, 2011. All systems go. Article in Nature,
Perspective, Volume 480, p. 87.

5. Lao Tzu (604 BC - 531 BC)
If you do not change direction,
you may end up where you are heading.
Future of Health Care ???

6. Future driven by Health EconomicsFuture driven by Disease Economics
Time for a different
(Systems) View?

7. The Challenge in current Health Care: Medicine-related
> “One-size fits all” to Personalized Medicine

8. An Early Lesson
What a Genome Cannot Tell Us

9. What Cannot Be Learnt from a Genome
One Animal
One Genome
Two States
There is more to life
than DNA
Understanding
from
a Systems Perspective?

10. Biomarkers
Pathways
System
Knowledge
Informatics
Transcripts
Proteins
Metabolites
Proteins
Metabolites
Systems Biology, towards personalized fingerprints
Systems
Analysis
Tissue
Cell Organism Measurement Interpretation
Systems cannot be understood by studying fundamental constituents,
the properties of the parts are not intrinsic but can be understood within the
context of the whole

11. Entire Correlation Network : Organized complexity
~3400 nodes
~17000 edges
abs R > 0.8
Patterns of self-organization are the key

12. Treatment a Treatment b Treatment c
Empirical Medicine
Biomarker-guided
therapy
Treatment a
Treatment b
Treatment c
Biomarker-Guided Medicine
Personalized Health strategies based on drugs developed
via a reductionistic focus and the “golden-standard”
clinical trial design are limited !!
Van der Greef Jan; Hankemeier Thomas; McBurney Robert N, Metabolomics-based systems biology and personalized
medicine: moving towards n = 1 clinical trials?
Pharmacogenomics 2006;7(7):1087-94.
Towards biomarkers & Biomarker fingerprints

13. Nature Vol 520, p 609–611, 2015

14. What is Health ??
WHO 1948 :
“A state of complete physical, mental, and social well-
being and not merely the absence of disease, or infirmity.”

15. …………..Towards a new definition of health
Lancet 2009; vol.373, march 7: p.781

16. ….ability to adapt and self-manage in
the face of social, physical and emotional challenges
…… towards a new definition of health

17. Homeostasis
AllostasisAdapted state
of the system
Disease
“Disease management”
Focus on single symptom
“Health promotion”
Focus on salutogenesis
Resilience
to different stimuli
physical, psychological, social, spiritual
Challenge

18. “Systems Thinking, natural products
and the future of Health Care”
• Smallest bird and animal with a backbone
• Has the largest brain of all birds (4.2% bw)
• Only bird that can fly backwards
• Heart rate up to 1260 beats/min
• Wing beat up to 200/sec
• Can lower metabolic rate to 1/15th and body
temperature by 20-50 degrees during torgor
• Can switch from nectar to insect diet
Resilience ??

19. In these “Blue Zones” they found that people reach age 100
at rates 10 times greater than in the United States.
Health Promotion By Reverse Engineering Longevity
Dan Buettner

20.  “The dominant model of disease today is biomedical, and it
leaves no room within its framework for the social, psychological
and behavioral dimensions of illness.”
 “How much longer must medicine’s science be bound by a 17th
century world view?”
>>> biopsychosocial model
George L Engel (1913-1999)
The need for a new medical model:
a challenge for biomedicine,
Science, 1977,196:129-132
New insights
Slide adapted after Ton Nicolai

21. Correlation Network : Organized complexity
How to find Phenotypic differences
In the Health – Disease space ?

22. SYSTEM BIOLOGY : New insights, new options ?

23. Bioinformatics
“OMICS
”
Oltvai et al Science 298 (2002) 763
Life’s Complexity
Pyramid
Phenomenological
Systems perspective
Chinese Medicine

24. “ East is East and West is West and
never the Twain shall meet? ”
Science 19 December 2014:
Vol. 346 p. 1569
Symptom relations
as bridge between
Chinese and Western medicine,
a step towards
Personalized Health/Medicine
DIAGNOSIS
is
KEY !!

26. Subtype B
Subtype A
Targeted care – disease phenotype focus
theranostics related to efficacy and adverse effects
Stratified/Individualized Care
Symptom/Signs
Molecular pathology
@
@
Disease - symptom management
1 disease -1 target – 1 (block buster) drug
Patient Wellness focus
Integrated systems approach
Life style
Psychology/Consciousness
Environment, Nutrition
Medicine
One-size-fits-all
Personalized
Health Care Ecosystem
Symptom/Signs
Molecular pathology fingerprint
Diagnosis is key !!

27. Subtype B
Subtype A
disease phenotyping
Stratified/Individualized Care
Symptom/Signs
Molecular pathology
One-size-fits-all
Heng Wei
Sub-typing :
early Diabetes type 2
Herman van Wietmarschen
Sub-typing :
Rheumatoid Arthritis
J. Clinical Reumatology, 2009, 15 ,330-337
Mol. BioSyst., 2012, 8, 1482–1491
Diagnosis is key !!

28. New diagnostic tools available for System Diagnosis?
How to measure
coherence in
organization?
Life Complexity Pyramid
How to measure
interrelation with the
outside world?

30. Bioluminescence is directly related to
Dynamic Systems Organisation (Chronobiology)
Every organism (every cell) emits light ( bioluminescence) , which is unique
in wavelength, duration, timing and rhythms (information & communication)
1923 Alexander Gavrilovich Gurwitsch
Алекса́ндр Гаври́лович Гу́рвич
Roel en Eduard
Van Wijk

31. “The human body
literally glimmers”
The light intensity emitted by
the body is 1000 times lower
than the sensitivity of our
naked eyes.
Human biophoton emission is invisible to the naked eye but can be
detected by Ultra-weak Photon Emission (UPE)-TECHNOLOGY

32. UPE-technology measures light emission dynamics
L:palm R:dorsum
R:palm L:dorsum
Reactive Oxygen Species (ROS), free radical reactions and
excited chemiluminescence species >> sources of photon emission

33. Healthy (N=50)
pre-diabetes (N=50)
patient (N=50)
-0,05 0,00 0,05 0,10 0,15 0,20 0,25 0,30
0
5
10
15
20
25
30
35
Noofobs
The squeezing parameter r show
differences between groups of healthy, pre-
patient and patient subjects
(M. Orszag, Quantum optics 2000)
Quantum photon signal analysis in health and disease
4 parameters to describe the properties of
the signal, i.e., the magnitudes and phases of
the two complex parameters:
α = |α| exp (iΦ)
ξ = r exp (iθ)
Roel en Eduard van Wijk et al. – Sino-Dutch center for Preventive and Personalized Medicine

34. Paramecia are widespread in freshwater, brackish and marine environments
Observed mutual influence on population growth
is stopped with Visible Light filter
Fels D (2009) Cellular Communication through Light. PLoS ONE 4(4): e5086. doi:10.1371
Communication
by Light
Paramecia
in closed
container
Paramecia
in closed
container
Filter

35. Human – Human intentional healing influences Algae bioluminescence
Biofield
Communication
Roel en Eduard van Wijk et al.

36. The music of Life :
System coherence :
biophoton dynamics of left and right hands

38. The Rhythm of Life is a collaboration between designers / artists Mike Thompson, Susana Cámara Leret and
Dave Young and the SD PPM / Netherlands Metabolomics Centre.
The artists investigate the potential of sensory data experiences, through an ambiguous data collection process

39. Psychology Words (psychotherapy)
Body language
Nutrition
Medicine
Life Style advice
Health care provider
World view
Spirituality
Patient
Physiology
Family
Culture
Socialnetwork
Self-identity
Diagnosis & Treatment in a Personalized Health Care Ecosystem
Relationship between patient and Health Care provider is key
(compassion)

40. Patient-Physician relationships
Otto Scharmer, U-Theory

41. Mensgerichte
Zorg
……. towards a Human-oriented
Health Care Ecosystem
Production
oriented Care
Outcome
oriented Care
Human
(Compassion)
oriented Care
4P Health
 Personalized
 Preventive
 Participatory
 Predictive
2012 20202007
Participation
society
Integrated Medicine
Information
society

42. From reductionism
to systems biology
From disease
to personalized system wellness
Perspectives
“I”-llness <> “We”-llness