SlideShare uma empresa Scribd logo
1 de 8
Presentation on Penetration
                           enhancers




Dr. Sanjula Baboota                 Abdul Muheem
Deptt of pharmaceutics              M.Pharma(pharmaceutics)
JAMIA HAMDARD                       F/O PHARMACY
                                    JAMIA HAMDARD
Introduction
• Permeation of drugs throughout epithelial
  barriers could be promoted by ‘penetration
  enhencers’capable     of    decreasing   barrier
  properties of the mucosa by different
  mechanisms.
• Enhancement is founded on different techniques
  that are usually divided in chemical or physical
  methods.
Chemical methods-
chemical enhancers are through to improve
absorption without irritation or damage the
mucosa by-
• Alteration the rheology of the mucus layer.
• Transiently altering the lipid bilayer membrane.
• Increasing cell membrane fluidity.
• Extracting structural lipids.
• Altering cellular proteins.
• Increasing the thermodynamics activity of          the
  permeate.
• Overcoming the enzymatic barrier.

-chemical enhancers could be added to a formulation,
alone or in combination ;their efficacy depends on the
physiochemical properties of both the drug & vehicle.
-various chelators ,surfactants, bile salts &fatty acids,
have been used as permeation enhancers ;chitosan & its
derivatives have been used as enhancers of small polar
moiety & hydrophobic large molecules.
 recently lysalbinic acid ,a product of egg albumin
,hydrolysis ,has been successfully used as enhancers for
protein & peptides.
Enzymatic drug inactivation is neither rapid nor extensive
as the enzymatic activity of buccal mucosa is relatively
low .
Nevertheless ,enzymes of the oral cavity could degrades
some peptide & protein drugs
Co- administration of enzyme inhibitors such as aprotinin
,could be effective as they reduce the activity of
proteolytic enzymes.
S.No   Penetration Enhancers     S.No   Penetration Enhancers

1      Aprotinin                 8      Phosphotidyl choline

2      Azone                     9      Polyoxyethylene

3      Lauric acids              10     Sod. Glycocholate

4      Glycol                    11     Sod. Taurocholate

5      Cyclodextrin              12     Sod.glycodeoxycholate

6      Cetyltrimethyl ammonium   13     Sod.EDTA
       bromide
7      Polysrbate 80             14     Sod.taurodeoxycholine
S.N. Drug         Enhancers                 results                  Methods


1    Insulin      Sod.glycocholate          F=0.5%                   Dog in-vivo


2    Glucose      SLS, polysorbate 80       SLS increased the        Rat in-vivo
                                            permeability,
                                            polysorbate 80 less
                                            effective
3    Insulin      5% sod. Glycocholate      Increased F buccal       Rat in vivo
                                            from 0.7% -26%

4    insulin      5% laureth-9,aprotinin,   Increased F from 0.7-    Rat in vivo
                  sod.salicylate            3.6% ,laureth-9 ,other
                                            had no effect
5    Calcitonin   Various bile salts        Increased                Rat in vivo
                                            pharmacologic effect,
                                            increased stability
6    Interferon   1-4% sod.taurocholate     Increased F from         Rat in vivo
                  ,5% cyclodextrin          0.014% to 0.25% with
                                            sod.taurocholate,
                                            other have less effect
Penetration enhencers

Mais conteúdo relacionado

Mais procurados

PRODUCT LIST OF ALIVE PHARMACEUTICAL
PRODUCT LIST OF ALIVE PHARMACEUTICAL PRODUCT LIST OF ALIVE PHARMACEUTICAL
PRODUCT LIST OF ALIVE PHARMACEUTICAL Santosh Adhikari
 
LIST OF AVAILABLE MEDICINE FROM DJPL
LIST OF AVAILABLE MEDICINE FROM DJPLLIST OF AVAILABLE MEDICINE FROM DJPL
LIST OF AVAILABLE MEDICINE FROM DJPLNiraj Bartaula
 
Analytical characterization of fatty acids composition of datura alba
Analytical characterization of fatty acids composition of datura albaAnalytical characterization of fatty acids composition of datura alba
Analytical characterization of fatty acids composition of datura albaPCSIR
 
Bayberry Pharmaceuticals Pvt. Ltd., Pune, Antibiotics Tablets & Capsules
 Bayberry Pharmaceuticals Pvt. Ltd., Pune, Antibiotics Tablets & Capsules Bayberry Pharmaceuticals Pvt. Ltd., Pune, Antibiotics Tablets & Capsules
Bayberry Pharmaceuticals Pvt. Ltd., Pune, Antibiotics Tablets & CapsulesIndiaMART InterMESH Limited
 
Ayo Adesokan final
Ayo Adesokan finalAyo Adesokan final
Ayo Adesokan finalAyo Adesokan
 
Product List 2017-Nick
Product List  2017-NickProduct List  2017-Nick
Product List 2017-NickNick Duan
 
Vitamin d3-cholecalciferol-resin-oil-product-information
Vitamin d3-cholecalciferol-resin-oil-product-informationVitamin d3-cholecalciferol-resin-oil-product-information
Vitamin d3-cholecalciferol-resin-oil-product-informationFermenta Biotech Ltd
 
FAME (Fatty Acid Methyle ester) analysis
FAME (Fatty Acid Methyle ester) analysis FAME (Fatty Acid Methyle ester) analysis
FAME (Fatty Acid Methyle ester) analysis Athar Mutahari
 
Fame analysis techniques
Fame analysis techniquesFame analysis techniques
Fame analysis techniquesSarfaraz Nasri
 
USA RESEARCH PEPTIDES & CHEMICALS
USA RESEARCH PEPTIDES & CHEMICALSUSA RESEARCH PEPTIDES & CHEMICALS
USA RESEARCH PEPTIDES & CHEMICALSPeptides
 

Mais procurados (17)

PRODUCT LIST OF ALIVE PHARMACEUTICAL
PRODUCT LIST OF ALIVE PHARMACEUTICAL PRODUCT LIST OF ALIVE PHARMACEUTICAL
PRODUCT LIST OF ALIVE PHARMACEUTICAL
 
LIST OF AVAILABLE MEDICINE FROM DJPL
LIST OF AVAILABLE MEDICINE FROM DJPLLIST OF AVAILABLE MEDICINE FROM DJPL
LIST OF AVAILABLE MEDICINE FROM DJPL
 
Haematology
HaematologyHaematology
Haematology
 
Agar
AgarAgar
Agar
 
Food test
Food test Food test
Food test
 
Acacia
AcaciaAcacia
Acacia
 
Tragacanth
TragacanthTragacanth
Tragacanth
 
Analytical characterization of fatty acids composition of datura alba
Analytical characterization of fatty acids composition of datura albaAnalytical characterization of fatty acids composition of datura alba
Analytical characterization of fatty acids composition of datura alba
 
Bayberry Pharmaceuticals Pvt. Ltd., Pune, Antibiotics Tablets & Capsules
 Bayberry Pharmaceuticals Pvt. Ltd., Pune, Antibiotics Tablets & Capsules Bayberry Pharmaceuticals Pvt. Ltd., Pune, Antibiotics Tablets & Capsules
Bayberry Pharmaceuticals Pvt. Ltd., Pune, Antibiotics Tablets & Capsules
 
Ayo Adesokan final
Ayo Adesokan finalAyo Adesokan final
Ayo Adesokan final
 
Product List 2017-Nick
Product List  2017-NickProduct List  2017-Nick
Product List 2017-Nick
 
Vitamin d3-cholecalciferol-resin-oil-product-information
Vitamin d3-cholecalciferol-resin-oil-product-informationVitamin d3-cholecalciferol-resin-oil-product-information
Vitamin d3-cholecalciferol-resin-oil-product-information
 
Macrolides
MacrolidesMacrolides
Macrolides
 
FAME (Fatty Acid Methyle ester) analysis
FAME (Fatty Acid Methyle ester) analysis FAME (Fatty Acid Methyle ester) analysis
FAME (Fatty Acid Methyle ester) analysis
 
Fame analysis techniques
Fame analysis techniquesFame analysis techniques
Fame analysis techniques
 
USA RESEARCH PEPTIDES & CHEMICALS
USA RESEARCH PEPTIDES & CHEMICALSUSA RESEARCH PEPTIDES & CHEMICALS
USA RESEARCH PEPTIDES & CHEMICALS
 
Purine
PurinePurine
Purine
 

Destaque (20)

Permeation enhancement through skin
Permeation enhancement through skinPermeation enhancement through skin
Permeation enhancement through skin
 
Penetration enhancers Used in transdermal drug delivry
Penetration enhancers Used in transdermal drug delivryPenetration enhancers Used in transdermal drug delivry
Penetration enhancers Used in transdermal drug delivry
 
Packaging designs and specifications
Packaging designs and specificationsPackaging designs and specifications
Packaging designs and specifications
 
Drug design intro
Drug design introDrug design intro
Drug design intro
 
Optimization in pharmaceutics & processing
Optimization in pharmaceutics & processingOptimization in pharmaceutics & processing
Optimization in pharmaceutics & processing
 
Who
WhoWho
Who
 
2 genomes
2 genomes2 genomes
2 genomes
 
Validation03
Validation03Validation03
Validation03
 
Optimization in pharmaceutics & processing
Optimization in pharmaceutics & processingOptimization in pharmaceutics & processing
Optimization in pharmaceutics & processing
 
Bio info statistical-methods[1]
Bio info statistical-methods[1]Bio info statistical-methods[1]
Bio info statistical-methods[1]
 
Who
WhoWho
Who
 
1 amino acids
1 amino acids1 amino acids
1 amino acids
 
What is glp
What is glpWhat is glp
What is glp
 
Wto scope introd
Wto scope introdWto scope introd
Wto scope introd
 
Validation of water supply system
Validation of water supply systemValidation of water supply system
Validation of water supply system
 
Laminar Air Flow Clean Beach Daihan
Laminar Air Flow Clean Beach DaihanLaminar Air Flow Clean Beach Daihan
Laminar Air Flow Clean Beach Daihan
 
Federal food, drug & cosmetics act
Federal food, drug & cosmetics actFederal food, drug & cosmetics act
Federal food, drug & cosmetics act
 
Process validation of tablets
Process validation of tabletsProcess validation of tablets
Process validation of tablets
 
Validation
ValidationValidation
Validation
 
Muheem on mg
Muheem on mgMuheem on mg
Muheem on mg
 

Semelhante a Penetration enhencers

Patulin-secondary metabolite
Patulin-secondary metabolitePatulin-secondary metabolite
Patulin-secondary metaboliteSudhaRameshwari2
 
Pradip digge
Pradip diggePradip digge
Pradip diggeswapy123
 
Protein and-peptide-drug-delivery-systems
Protein and-peptide-drug-delivery-systemsProtein and-peptide-drug-delivery-systems
Protein and-peptide-drug-delivery-systemsGaurav Kr
 
Formulation and Evaluation of Floating in Situ Gel of Lafutidine
Formulation and Evaluation of Floating in Situ Gel of LafutidineFormulation and Evaluation of Floating in Situ Gel of Lafutidine
Formulation and Evaluation of Floating in Situ Gel of LafutidineAI Publications
 
Over the-counter medications for pets
Over the-counter medications for petsOver the-counter medications for pets
Over the-counter medications for petsUtai Sukviwatsirikul
 
PRODRUG 1[988].pptx [Read-Only].pptx
PRODRUG 1[988].pptx [Read-Only].pptxPRODRUG 1[988].pptx [Read-Only].pptx
PRODRUG 1[988].pptx [Read-Only].pptxSourinDe2
 
Intra vaginal drug delivery system
Intra vaginal drug delivery systemIntra vaginal drug delivery system
Intra vaginal drug delivery systemSaloniDalwadi
 
Class antifungal agents
Class antifungal agentsClass antifungal agents
Class antifungal agentsRaghu Prasada
 
Class antifungal agents
Class antifungal agentsClass antifungal agents
Class antifungal agentsRaghu Prasada
 
Anti hyperlipidemic agents ppt
Anti hyperlipidemic agents ppt Anti hyperlipidemic agents ppt
Anti hyperlipidemic agents ppt Indraj Saini
 
Effcet of Vernonia Amygdalina.Del Ethanolic Extract Fraction on Serum Prolact...
Effcet of Vernonia Amygdalina.Del Ethanolic Extract Fraction on Serum Prolact...Effcet of Vernonia Amygdalina.Del Ethanolic Extract Fraction on Serum Prolact...
Effcet of Vernonia Amygdalina.Del Ethanolic Extract Fraction on Serum Prolact...iosrjce
 
floating tablets enalapril maleate
floating tablets enalapril maleatefloating tablets enalapril maleate
floating tablets enalapril maleatePushplata Puskar
 
Protease for use in poultry
Protease for use in poultryProtease for use in poultry
Protease for use in poultryDVS BioLife Ltd
 
Overview of Oral Delivery Strategies for Peptides.pdf
Overview of Oral Delivery Strategies for Peptides.pdfOverview of Oral Delivery Strategies for Peptides.pdf
Overview of Oral Delivery Strategies for Peptides.pdfDoriaFang
 
FORMULATION AND INVITRO EVALUATION OF COLON SPECIFIC DRUG DELIVERY SYSTEM BY ...
FORMULATION AND INVITRO EVALUATION OF COLON SPECIFIC DRUG DELIVERY SYSTEM BY ...FORMULATION AND INVITRO EVALUATION OF COLON SPECIFIC DRUG DELIVERY SYSTEM BY ...
FORMULATION AND INVITRO EVALUATION OF COLON SPECIFIC DRUG DELIVERY SYSTEM BY ...alok prakash kar
 
Prodrug basic concepts and application of Prodrug Design.pptx
Prodrug basic concepts and application of Prodrug Design.pptxProdrug basic concepts and application of Prodrug Design.pptx
Prodrug basic concepts and application of Prodrug Design.pptxpankajnepal764
 
Powerpoints Hypolipidemics
Powerpoints HypolipidemicsPowerpoints Hypolipidemics
Powerpoints HypolipidemicsMD Specialclass
 

Semelhante a Penetration enhencers (20)

Patulin-secondary metabolite
Patulin-secondary metabolitePatulin-secondary metabolite
Patulin-secondary metabolite
 
Pradip digge
Pradip diggePradip digge
Pradip digge
 
Protein and-peptide-drug-delivery-systems
Protein and-peptide-drug-delivery-systemsProtein and-peptide-drug-delivery-systems
Protein and-peptide-drug-delivery-systems
 
Formulation and Evaluation of Floating in Situ Gel of Lafutidine
Formulation and Evaluation of Floating in Situ Gel of LafutidineFormulation and Evaluation of Floating in Situ Gel of Lafutidine
Formulation and Evaluation of Floating in Situ Gel of Lafutidine
 
Over the-counter medications for pets
Over the-counter medications for petsOver the-counter medications for pets
Over the-counter medications for pets
 
Prodrug
ProdrugProdrug
Prodrug
 
PRODRUG 1[988].pptx [Read-Only].pptx
PRODRUG 1[988].pptx [Read-Only].pptxPRODRUG 1[988].pptx [Read-Only].pptx
PRODRUG 1[988].pptx [Read-Only].pptx
 
Intra vaginal drug delivery system
Intra vaginal drug delivery systemIntra vaginal drug delivery system
Intra vaginal drug delivery system
 
Class antifungal agents
Class antifungal agentsClass antifungal agents
Class antifungal agents
 
Class antifungal agents
Class antifungal agentsClass antifungal agents
Class antifungal agents
 
Anti hyperlipidemic agents ppt
Anti hyperlipidemic agents ppt Anti hyperlipidemic agents ppt
Anti hyperlipidemic agents ppt
 
Effcet of Vernonia Amygdalina.Del Ethanolic Extract Fraction on Serum Prolact...
Effcet of Vernonia Amygdalina.Del Ethanolic Extract Fraction on Serum Prolact...Effcet of Vernonia Amygdalina.Del Ethanolic Extract Fraction on Serum Prolact...
Effcet of Vernonia Amygdalina.Del Ethanolic Extract Fraction on Serum Prolact...
 
floating tablets enalapril maleate
floating tablets enalapril maleatefloating tablets enalapril maleate
floating tablets enalapril maleate
 
Protease for use in poultry
Protease for use in poultryProtease for use in poultry
Protease for use in poultry
 
Overview of Oral Delivery Strategies for Peptides.pdf
Overview of Oral Delivery Strategies for Peptides.pdfOverview of Oral Delivery Strategies for Peptides.pdf
Overview of Oral Delivery Strategies for Peptides.pdf
 
FORMULATION AND INVITRO EVALUATION OF COLON SPECIFIC DRUG DELIVERY SYSTEM BY ...
FORMULATION AND INVITRO EVALUATION OF COLON SPECIFIC DRUG DELIVERY SYSTEM BY ...FORMULATION AND INVITRO EVALUATION OF COLON SPECIFIC DRUG DELIVERY SYSTEM BY ...
FORMULATION AND INVITRO EVALUATION OF COLON SPECIFIC DRUG DELIVERY SYSTEM BY ...
 
Plant_Sweeteners
Plant_SweetenersPlant_Sweeteners
Plant_Sweeteners
 
Prodrug basic concepts and application of Prodrug Design.pptx
Prodrug basic concepts and application of Prodrug Design.pptxProdrug basic concepts and application of Prodrug Design.pptx
Prodrug basic concepts and application of Prodrug Design.pptx
 
Shopan
ShopanShopan
Shopan
 
Powerpoints Hypolipidemics
Powerpoints HypolipidemicsPowerpoints Hypolipidemics
Powerpoints Hypolipidemics
 

Mais de Jamia Hamdard

Research report on small molecules in multiple myeloma treatment
Research report on small molecules in multiple myeloma treatmentResearch report on small molecules in multiple myeloma treatment
Research report on small molecules in multiple myeloma treatmentJamia Hamdard
 
Control of component, containers and closures
Control of component, containers and closuresControl of component, containers and closures
Control of component, containers and closuresJamia Hamdard
 
Resealed erytrocytes
Resealed erytrocytesResealed erytrocytes
Resealed erytrocytesJamia Hamdard
 
Antibodies drug delivery system
Antibodies drug delivery systemAntibodies drug delivery system
Antibodies drug delivery systemJamia Hamdard
 
Validation of solid oral dosage form, tablet 1
Validation of solid oral dosage form, tablet 1Validation of solid oral dosage form, tablet 1
Validation of solid oral dosage form, tablet 1Jamia Hamdard
 
Mucoadhesive drug delivery system
Mucoadhesive drug delivery systemMucoadhesive drug delivery system
Mucoadhesive drug delivery systemJamia Hamdard
 
Packaging designs and specifications
Packaging designs and specificationsPackaging designs and specifications
Packaging designs and specificationsJamia Hamdard
 
OPTIMIZATION IN PHARMACEUTICS,FORMULATION & PROCESSING
OPTIMIZATION IN PHARMACEUTICS,FORMULATION & PROCESSINGOPTIMIZATION IN PHARMACEUTICS,FORMULATION & PROCESSING
OPTIMIZATION IN PHARMACEUTICS,FORMULATION & PROCESSINGJamia Hamdard
 

Mais de Jamia Hamdard (11)

Research report on small molecules in multiple myeloma treatment
Research report on small molecules in multiple myeloma treatmentResearch report on small molecules in multiple myeloma treatment
Research report on small molecules in multiple myeloma treatment
 
Control of component, containers and closures
Control of component, containers and closuresControl of component, containers and closures
Control of component, containers and closures
 
Resealed erytrocytes
Resealed erytrocytesResealed erytrocytes
Resealed erytrocytes
 
Antibodies drug delivery system
Antibodies drug delivery systemAntibodies drug delivery system
Antibodies drug delivery system
 
Drying
DryingDrying
Drying
 
Nanoemulsion
NanoemulsionNanoemulsion
Nanoemulsion
 
Validation of solid oral dosage form, tablet 1
Validation of solid oral dosage form, tablet 1Validation of solid oral dosage form, tablet 1
Validation of solid oral dosage form, tablet 1
 
Mucoadhesive drug delivery system
Mucoadhesive drug delivery systemMucoadhesive drug delivery system
Mucoadhesive drug delivery system
 
Mixing muheem
Mixing muheemMixing muheem
Mixing muheem
 
Packaging designs and specifications
Packaging designs and specificationsPackaging designs and specifications
Packaging designs and specifications
 
OPTIMIZATION IN PHARMACEUTICS,FORMULATION & PROCESSING
OPTIMIZATION IN PHARMACEUTICS,FORMULATION & PROCESSINGOPTIMIZATION IN PHARMACEUTICS,FORMULATION & PROCESSING
OPTIMIZATION IN PHARMACEUTICS,FORMULATION & PROCESSING
 

Último

Student login on Anyboli platform.helpin
Student login on Anyboli platform.helpinStudent login on Anyboli platform.helpin
Student login on Anyboli platform.helpinRaunakKeshri1
 
Paris 2024 Olympic Geographies - an activity
Paris 2024 Olympic Geographies - an activityParis 2024 Olympic Geographies - an activity
Paris 2024 Olympic Geographies - an activityGeoBlogs
 
A Critique of the Proposed National Education Policy Reform
A Critique of the Proposed National Education Policy ReformA Critique of the Proposed National Education Policy Reform
A Critique of the Proposed National Education Policy ReformChameera Dedduwage
 
Organic Name Reactions for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions  for the students and aspirants of Chemistry12th.pptxOrganic Name Reactions  for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions for the students and aspirants of Chemistry12th.pptxVS Mahajan Coaching Centre
 
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptx
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptxPOINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptx
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptxSayali Powar
 
Introduction to Nonprofit Accounting: The Basics
Introduction to Nonprofit Accounting: The BasicsIntroduction to Nonprofit Accounting: The Basics
Introduction to Nonprofit Accounting: The BasicsTechSoup
 
Web & Social Media Analytics Previous Year Question Paper.pdf
Web & Social Media Analytics Previous Year Question Paper.pdfWeb & Social Media Analytics Previous Year Question Paper.pdf
Web & Social Media Analytics Previous Year Question Paper.pdfJayanti Pande
 
Measures of Central Tendency: Mean, Median and Mode
Measures of Central Tendency: Mean, Median and ModeMeasures of Central Tendency: Mean, Median and Mode
Measures of Central Tendency: Mean, Median and ModeThiyagu K
 
Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...
Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...
Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...EduSkills OECD
 
microwave assisted reaction. General introduction
microwave assisted reaction. General introductionmicrowave assisted reaction. General introduction
microwave assisted reaction. General introductionMaksud Ahmed
 
Russian Call Girls in Andheri Airport Mumbai WhatsApp 9167673311 💞 Full Nigh...
Russian Call Girls in Andheri Airport Mumbai WhatsApp  9167673311 💞 Full Nigh...Russian Call Girls in Andheri Airport Mumbai WhatsApp  9167673311 💞 Full Nigh...
Russian Call Girls in Andheri Airport Mumbai WhatsApp 9167673311 💞 Full Nigh...Pooja Nehwal
 
Activity 01 - Artificial Culture (1).pdf
Activity 01 - Artificial Culture (1).pdfActivity 01 - Artificial Culture (1).pdf
Activity 01 - Artificial Culture (1).pdfciinovamais
 
mini mental status format.docx
mini    mental       status     format.docxmini    mental       status     format.docx
mini mental status format.docxPoojaSen20
 
JAPAN: ORGANISATION OF PMDA, PHARMACEUTICAL LAWS & REGULATIONS, TYPES OF REGI...
JAPAN: ORGANISATION OF PMDA, PHARMACEUTICAL LAWS & REGULATIONS, TYPES OF REGI...JAPAN: ORGANISATION OF PMDA, PHARMACEUTICAL LAWS & REGULATIONS, TYPES OF REGI...
JAPAN: ORGANISATION OF PMDA, PHARMACEUTICAL LAWS & REGULATIONS, TYPES OF REGI...anjaliyadav012327
 
Q4-W6-Restating Informational Text Grade 3
Q4-W6-Restating Informational Text Grade 3Q4-W6-Restating Informational Text Grade 3
Q4-W6-Restating Informational Text Grade 3JemimahLaneBuaron
 
Call Girls in Dwarka Mor Delhi Contact Us 9654467111
Call Girls in Dwarka Mor Delhi Contact Us 9654467111Call Girls in Dwarka Mor Delhi Contact Us 9654467111
Call Girls in Dwarka Mor Delhi Contact Us 9654467111Sapana Sha
 
CARE OF CHILD IN INCUBATOR..........pptx
CARE OF CHILD IN INCUBATOR..........pptxCARE OF CHILD IN INCUBATOR..........pptx
CARE OF CHILD IN INCUBATOR..........pptxGaneshChakor2
 
Software Engineering Methodologies (overview)
Software Engineering Methodologies (overview)Software Engineering Methodologies (overview)
Software Engineering Methodologies (overview)eniolaolutunde
 
Disha NEET Physics Guide for classes 11 and 12.pdf
Disha NEET Physics Guide for classes 11 and 12.pdfDisha NEET Physics Guide for classes 11 and 12.pdf
Disha NEET Physics Guide for classes 11 and 12.pdfchloefrazer622
 
Arihant handbook biology for class 11 .pdf
Arihant handbook biology for class 11 .pdfArihant handbook biology for class 11 .pdf
Arihant handbook biology for class 11 .pdfchloefrazer622
 

Último (20)

Student login on Anyboli platform.helpin
Student login on Anyboli platform.helpinStudent login on Anyboli platform.helpin
Student login on Anyboli platform.helpin
 
Paris 2024 Olympic Geographies - an activity
Paris 2024 Olympic Geographies - an activityParis 2024 Olympic Geographies - an activity
Paris 2024 Olympic Geographies - an activity
 
A Critique of the Proposed National Education Policy Reform
A Critique of the Proposed National Education Policy ReformA Critique of the Proposed National Education Policy Reform
A Critique of the Proposed National Education Policy Reform
 
Organic Name Reactions for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions  for the students and aspirants of Chemistry12th.pptxOrganic Name Reactions  for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions for the students and aspirants of Chemistry12th.pptx
 
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptx
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptxPOINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptx
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptx
 
Introduction to Nonprofit Accounting: The Basics
Introduction to Nonprofit Accounting: The BasicsIntroduction to Nonprofit Accounting: The Basics
Introduction to Nonprofit Accounting: The Basics
 
Web & Social Media Analytics Previous Year Question Paper.pdf
Web & Social Media Analytics Previous Year Question Paper.pdfWeb & Social Media Analytics Previous Year Question Paper.pdf
Web & Social Media Analytics Previous Year Question Paper.pdf
 
Measures of Central Tendency: Mean, Median and Mode
Measures of Central Tendency: Mean, Median and ModeMeasures of Central Tendency: Mean, Median and Mode
Measures of Central Tendency: Mean, Median and Mode
 
Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...
Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...
Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...
 
microwave assisted reaction. General introduction
microwave assisted reaction. General introductionmicrowave assisted reaction. General introduction
microwave assisted reaction. General introduction
 
Russian Call Girls in Andheri Airport Mumbai WhatsApp 9167673311 💞 Full Nigh...
Russian Call Girls in Andheri Airport Mumbai WhatsApp  9167673311 💞 Full Nigh...Russian Call Girls in Andheri Airport Mumbai WhatsApp  9167673311 💞 Full Nigh...
Russian Call Girls in Andheri Airport Mumbai WhatsApp 9167673311 💞 Full Nigh...
 
Activity 01 - Artificial Culture (1).pdf
Activity 01 - Artificial Culture (1).pdfActivity 01 - Artificial Culture (1).pdf
Activity 01 - Artificial Culture (1).pdf
 
mini mental status format.docx
mini    mental       status     format.docxmini    mental       status     format.docx
mini mental status format.docx
 
JAPAN: ORGANISATION OF PMDA, PHARMACEUTICAL LAWS & REGULATIONS, TYPES OF REGI...
JAPAN: ORGANISATION OF PMDA, PHARMACEUTICAL LAWS & REGULATIONS, TYPES OF REGI...JAPAN: ORGANISATION OF PMDA, PHARMACEUTICAL LAWS & REGULATIONS, TYPES OF REGI...
JAPAN: ORGANISATION OF PMDA, PHARMACEUTICAL LAWS & REGULATIONS, TYPES OF REGI...
 
Q4-W6-Restating Informational Text Grade 3
Q4-W6-Restating Informational Text Grade 3Q4-W6-Restating Informational Text Grade 3
Q4-W6-Restating Informational Text Grade 3
 
Call Girls in Dwarka Mor Delhi Contact Us 9654467111
Call Girls in Dwarka Mor Delhi Contact Us 9654467111Call Girls in Dwarka Mor Delhi Contact Us 9654467111
Call Girls in Dwarka Mor Delhi Contact Us 9654467111
 
CARE OF CHILD IN INCUBATOR..........pptx
CARE OF CHILD IN INCUBATOR..........pptxCARE OF CHILD IN INCUBATOR..........pptx
CARE OF CHILD IN INCUBATOR..........pptx
 
Software Engineering Methodologies (overview)
Software Engineering Methodologies (overview)Software Engineering Methodologies (overview)
Software Engineering Methodologies (overview)
 
Disha NEET Physics Guide for classes 11 and 12.pdf
Disha NEET Physics Guide for classes 11 and 12.pdfDisha NEET Physics Guide for classes 11 and 12.pdf
Disha NEET Physics Guide for classes 11 and 12.pdf
 
Arihant handbook biology for class 11 .pdf
Arihant handbook biology for class 11 .pdfArihant handbook biology for class 11 .pdf
Arihant handbook biology for class 11 .pdf
 

Penetration enhencers

  • 1. Presentation on Penetration enhancers Dr. Sanjula Baboota Abdul Muheem Deptt of pharmaceutics M.Pharma(pharmaceutics) JAMIA HAMDARD F/O PHARMACY JAMIA HAMDARD
  • 2. Introduction • Permeation of drugs throughout epithelial barriers could be promoted by ‘penetration enhencers’capable of decreasing barrier properties of the mucosa by different mechanisms. • Enhancement is founded on different techniques that are usually divided in chemical or physical methods. Chemical methods- chemical enhancers are through to improve absorption without irritation or damage the mucosa by-
  • 3. • Alteration the rheology of the mucus layer. • Transiently altering the lipid bilayer membrane. • Increasing cell membrane fluidity. • Extracting structural lipids. • Altering cellular proteins. • Increasing the thermodynamics activity of the permeate. • Overcoming the enzymatic barrier. -chemical enhancers could be added to a formulation, alone or in combination ;their efficacy depends on the physiochemical properties of both the drug & vehicle.
  • 4.
  • 5. -various chelators ,surfactants, bile salts &fatty acids, have been used as permeation enhancers ;chitosan & its derivatives have been used as enhancers of small polar moiety & hydrophobic large molecules. recently lysalbinic acid ,a product of egg albumin ,hydrolysis ,has been successfully used as enhancers for protein & peptides. Enzymatic drug inactivation is neither rapid nor extensive as the enzymatic activity of buccal mucosa is relatively low . Nevertheless ,enzymes of the oral cavity could degrades some peptide & protein drugs Co- administration of enzyme inhibitors such as aprotinin ,could be effective as they reduce the activity of proteolytic enzymes.
  • 6. S.No Penetration Enhancers S.No Penetration Enhancers 1 Aprotinin 8 Phosphotidyl choline 2 Azone 9 Polyoxyethylene 3 Lauric acids 10 Sod. Glycocholate 4 Glycol 11 Sod. Taurocholate 5 Cyclodextrin 12 Sod.glycodeoxycholate 6 Cetyltrimethyl ammonium 13 Sod.EDTA bromide 7 Polysrbate 80 14 Sod.taurodeoxycholine
  • 7. S.N. Drug Enhancers results Methods 1 Insulin Sod.glycocholate F=0.5% Dog in-vivo 2 Glucose SLS, polysorbate 80 SLS increased the Rat in-vivo permeability, polysorbate 80 less effective 3 Insulin 5% sod. Glycocholate Increased F buccal Rat in vivo from 0.7% -26% 4 insulin 5% laureth-9,aprotinin, Increased F from 0.7- Rat in vivo sod.salicylate 3.6% ,laureth-9 ,other had no effect 5 Calcitonin Various bile salts Increased Rat in vivo pharmacologic effect, increased stability 6 Interferon 1-4% sod.taurocholate Increased F from Rat in vivo ,5% cyclodextrin 0.014% to 0.25% with sod.taurocholate, other have less effect