Body Fluids Composition and Regulation

[object Object],Body composition % of body weight Body composition 18% Protein, & related substances 15% Fat 7% Mineral 60% Water

Body Fluids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Fluid Compartments  60% of body weight ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Transcellular fluid CSF Intraocular Pleural Peritoneal Pericardial Synovial Digestive secretions

Example: How to calculate total body water (TBW)? ,[object Object],[object Object],[object Object]

Differences between ECF & ICF ECF Anions : Cl - (108) HCO 3 - (24) Cations : Na + (142 mmol/L ) K + (4.2) Mg 2+ (0.8) Nutrients : O 2 , glucose, fatty acids, & amino acids. Wastes : CO 2 , Urea, uric acid, excess water, & ions. ICF Anions : Cl - (4) HCO 3 - (10) Phosphate ions Cations : Na + (14) K + (140) Mg 2+ (20) Nutrients : High concentrations of proteins.

COMPOSITION OF BODY FLUIDS CATIONS (mmol/l) Plasma Interstitial Intracellular Na 142 139 14 K 4.2 4.0 140 Ca 1.3 1.2 0 Mg 0.8 0.7 20 ANIONS (mmol/l) Cl 108 108 4.0 HCO3 24.0 28.3 10 Protein 1.2 0.2 4.0 HPO4 2.0 2.0 11

Extracellular and Intracellular Fluids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

IMPORTANCE ,[object Object],[object Object],[object Object],[object Object]

Basic Definitions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Basic Definitions Tonicity Osmolality Physiological term (effective Os P relative to plasma) Solutes that do not cross the cell membrane only counts Chemical term All solutes contributes to Osmolality 2 x Na + + Glucose 285 mOsm/kg Na + x 2 + glucose + BUN 290 mOsm/kg

VOLUME OF BODY FLUIDS IN 70 kg MAN ,[object Object],[object Object],INTRA CELLUAR FLUID 28 L (ROUGHLY 2/3 OF TBW) EXTRA CELLULAR FLUID 14 L (ROUGHLY 1/3 OF TBW) PLASMA 4 L (ROUGHLY ¼ OF ECF)

METHODS OF MEASUREMENTS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],INDIRECT METHOD – INDICATOR (DYE) DILUTION TECHNIQUE FORMULA V=A-E/C

[object Object],[object Object],VOLUME MEASUREMENT OF VARIOUS FLUIDS COMPARTMETNS INTRACELLULAR FLUID TBW – ECF

CRITERIA FOR A SUITABEL DYE. ,[object Object],[object Object],[object Object],[object Object],[object Object]

VOLUME MEASUREMENT OF VARIOUS FLUIDS COMPARTMETNS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],VOLUME MEASUREMENT OF VARIOUS FLUIDS COMPARTMETNS

[object Object],[object Object],[object Object],VOLUME MEASUREMENT OF VARIOUS FLUIDS COMPARTMETNS TOTAL BLOOD VOLUME PLASME VOL X 100 100 -HCT

FACTORS AFFECTING ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Dehydration ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Disorders of Water Balance: Hypotonic Hydration ,[object Object],[object Object],[object Object],[object Object]

Disorders of Water Balance: Edema ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Regulation of ECF Volume ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ECF volume receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Hormonal Regulation of Blood Volume 27-

Regulation of Water Intake Figure 27.5

Body Fluids Composition and Regulation

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Body Fluids Composition and Regulation