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Mendel's Laws
 of Genetics

   How traits are passed
    from parents to
    offspring.
Genetics
   A gene is a
    segment of DNA
    that codes for a
    protein which
    determines one
    particular trait

   Genetics is the
    study of how genes
    are passed on from
    parents to offspring
Differentiation
   Genes signal
    different cells to
    create proteins
    that give them
    unique shapes
    & functions
   These cells grow
    & divide to make
    tissues that form
    the organs of the
    developing baby
Fertilization: new life is formed
 Life begins when two gametes (sperm + egg) join
 A complete set of chromosomes results (23 + 23)

 The zygote starts as a single cell, but soon begins
  to divide (via mitosis = identical cells)
 Genes are "turned" on and off, causing cells to
  differentiate (change to have different forms/jobs)
Heredity & Inherited Traits
 The chromosomes from your mom and dad have
  given your cells instructions to make YOU!
 Each characteristic you inherited from your
  parents is called a trait (eye color, earlobe shape,
  height, personality traits, etc.)
  For each trait, you have
 a pair of alleles (one
from your mother and
one from your father)
Alleles: variations of a gene

       Gene              Alleles
Eye Color         Blue, brown, green,
                  hazel
Pea height        Tall, short

Pea color         Yellow, green

Flower position   Axial, terminal
Gregor Mendel
               An Austrian scientist-turned-monk
                noticed patterns in the monastery's
                garden
               Studied the inherited traits of pea
                plants and found predictable,
                numerical ratios in the offspring
               Observed some traits were
                dominant over others (i.e. yellow
                peas overpowered or occurred
1822-1884       more often than green pea seeds)
Mendel's Experiments
   He wondered if traits seen in different
    generations of pea plants were
    • determined by environmental factors (soil
        composition, temperature, sunlight)
                OR
    •   "handed down" by parents (chromosomes weren't
        even discovered yet, so he had no idea how)
 In his highly controlled experiments, he tested the
  hypothesis that each trait was determined by a
  set (not one, but TWO) inherited factors from
  each parent
 Do you see the Scientific Method at work here?
Dominant and Recessive Traits
Mendel’s Crosses
   Observed phenotype,
    the outward expression
    of the genes
   the F1 generation are
    tall, showing that trait is
    dominant
   The dwarf plant has the
    recessive trait (it is
    overpowered by the tall
    allele)
Genotypes: Genes and Alleles
                       The genetic make-up
                        of an organism is its
                        genotype
                       Every organism is
                        diploid (has 2 copies
                        of each chromosome)
                       Each trait is
                        designated by a
                        different letter
                       DOMINANT ALLELES
                        ARE CAPITAL
                        LETTERS
                       recessive alleles are
                        lowercase letters
Genotype determines Phenotype
   Homozygous means the two alleles are the same
   Heterozygous means the two alleles are different

    Genotype        Genotype        Phenotype
    Homozygous      TT              Dominant
    dominant

    Homozygous      tt              Recessive
    recessive

    Heterozygous    Tt              Dominant
Punnet Square: Monohybrid Cross
   Used to predict the outcome of a genetic cross
Dihybrid Cross
   What happens to two genes on
    different chromosomes?
   Homologous pairs of meiotic
    chromosomes line up randomly at the
    equatorial plane in Metaphase I
   The two traits separate during
    meiosis, resulting in offspring with
    different combinations of traits
   This results in four different possible
    combinations of chromosomes and
    genes in the gametes
The Law of
    Segregation
   Diploid
    chromosomes of
    parents undergo
    meiosis
   Alleles separate as
    they become
    haploid egg or
    sperm
   They are combined
    again during
    fertilization to
    produce a diploid
    offspring
Which traits are dominant?
Independent Assortment & Segregation
Mendelian Genetics

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Mendelian Genetics

  • 1. Mendel's Laws of Genetics How traits are passed from parents to offspring.
  • 2. Genetics  A gene is a segment of DNA that codes for a protein which determines one particular trait  Genetics is the study of how genes are passed on from parents to offspring
  • 3. Differentiation  Genes signal different cells to create proteins that give them unique shapes & functions  These cells grow & divide to make tissues that form the organs of the developing baby
  • 4. Fertilization: new life is formed  Life begins when two gametes (sperm + egg) join  A complete set of chromosomes results (23 + 23)  The zygote starts as a single cell, but soon begins to divide (via mitosis = identical cells)  Genes are "turned" on and off, causing cells to differentiate (change to have different forms/jobs)
  • 5.
  • 6. Heredity & Inherited Traits  The chromosomes from your mom and dad have given your cells instructions to make YOU!  Each characteristic you inherited from your parents is called a trait (eye color, earlobe shape, height, personality traits, etc.)  For each trait, you have a pair of alleles (one from your mother and one from your father)
  • 7. Alleles: variations of a gene Gene Alleles Eye Color Blue, brown, green, hazel Pea height Tall, short Pea color Yellow, green Flower position Axial, terminal
  • 8. Gregor Mendel  An Austrian scientist-turned-monk noticed patterns in the monastery's garden  Studied the inherited traits of pea plants and found predictable, numerical ratios in the offspring  Observed some traits were dominant over others (i.e. yellow peas overpowered or occurred 1822-1884 more often than green pea seeds)
  • 9. Mendel's Experiments  He wondered if traits seen in different generations of pea plants were • determined by environmental factors (soil composition, temperature, sunlight) OR • "handed down" by parents (chromosomes weren't even discovered yet, so he had no idea how)  In his highly controlled experiments, he tested the hypothesis that each trait was determined by a set (not one, but TWO) inherited factors from each parent  Do you see the Scientific Method at work here?
  • 11. Mendel’s Crosses  Observed phenotype, the outward expression of the genes  the F1 generation are tall, showing that trait is dominant  The dwarf plant has the recessive trait (it is overpowered by the tall allele)
  • 12. Genotypes: Genes and Alleles  The genetic make-up of an organism is its genotype  Every organism is diploid (has 2 copies of each chromosome)  Each trait is designated by a different letter  DOMINANT ALLELES ARE CAPITAL LETTERS  recessive alleles are lowercase letters
  • 13. Genotype determines Phenotype  Homozygous means the two alleles are the same  Heterozygous means the two alleles are different Genotype Genotype Phenotype Homozygous TT Dominant dominant Homozygous tt Recessive recessive Heterozygous Tt Dominant
  • 14. Punnet Square: Monohybrid Cross  Used to predict the outcome of a genetic cross
  • 15. Dihybrid Cross  What happens to two genes on different chromosomes?  Homologous pairs of meiotic chromosomes line up randomly at the equatorial plane in Metaphase I  The two traits separate during meiosis, resulting in offspring with different combinations of traits  This results in four different possible combinations of chromosomes and genes in the gametes
  • 16. The Law of Segregation  Diploid chromosomes of parents undergo meiosis  Alleles separate as they become haploid egg or sperm  They are combined again during fertilization to produce a diploid offspring
  • 17. Which traits are dominant?

Notas do Editor

  1. There are roughly 20,000 genes in the human genome, which accounts for only about 1% of all the DNA found in a cell.
  2. "introns" turned on, "exons" are segments that are turned off (not used to code for proteins).
  3. P = parental, F1 = first filial, F2 = second filial generation