Advance therapy of psychosis. Ayurveda treatment, therapy, drugs in clinical trial...

1. Mr. JAVED SHAIKH
F.Y.M.PHARM (Q.A)
GUIDED BY: MR AMEY
DESHPANDE
ORIENTAL COLLEGE OF
PHARMACY
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2. PSYCHOSIS
Defination
Psychosis refers to an abnormal condition of the mind described
as involving a "loss of contact with reality".
characterized by :
 Disturbances of reality and perception
 Impaired cognitive functioning
 Inappropriate or diminished affect (mood) 2

3. signs and symptoms
 Delusion
 Hallucinations
 Catotonia
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4. ANTIPSYCHOTIC DRUGS
Typical antipsychotic drugs :
 Also called as first generation antipsychotics drug
 Drugs first developed in the 1950s
 Used to treat psychosis.
 Typical antipsychotics may also be used for the treatment
of acute mania, agitation
 Drugs act by blocking the receptors in the brains
dopamine pathway
 Eg. – chlorpromazine, Triflupromazine, Haloperidole,
Pimozide
 Side effects : These drugs can cause extra pyramidal
motor control disabilities in patients
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5. Atypical antipsychotic drugs :
 Also called as second generation antipsychotics drug
 Drugs first developed in the 1960s
 Used to treat psychosis.
 Atypical antipsychotics approved by FDA for use in the
treatment of depression, bipolar and acute mania.
 Drugs act by blocking the receptors in the brains dopamine
pathway
 Eg. – Clozapine, Risperidone, Olanzapine
 It is less likely to cause extra pyramidal motor control
disabilities in patients
 Side effects : These drugs can cause weight gain, dry
mouth, muscle cramping and stiffness.
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6. NEW DRUGS
 Pimavanserine –
 TRADE NAME : NUPLAZID
 Indication – for treatment parkinson induce
psychosis
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7.  BL-1020 (BioLineRx)
 ITI-007 (Bristol-Myers Squibb)
 RP-5063 (Reviva Pharmaceuticals )
RECENT DRUGS UNDER CLINICAL TRIAL
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8. AYURVEDIC TREATMENT
Jatamansi
 powder form are given to the patient in the dose of one
teaspoonful three times a day with milk or cold water. This
helps in bringing the tranquility of mind.
Vatakulantaka Rasa
 Is one Ayurvedic Medicine usually prescribed by Ayurvedic
Doctors to treat schizophrenia. One tablet can be given to
the patient with honey three times a day.
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9.  One of the best treatment that can be given to
schizophrenia patient.
 In this Kshirabala Taila is kept in an adjusted
vessel over the forehead of the patient in such a
way that drops of medicated oil fall from the
bottom of the vessel on to the place between the
two eyebrows of the patient.
 This is advised to be done once daily.
 This helps patient sleep well and get rid of this
disease slowly
Dhara treatment
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10. AROMATHERAPY
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Aromatherapy uses plant materials and aromatic plant oils,
including essential oils, and other aroma compounds for the
purpose of altering one's mood, cognitive, psychological or
physical well-being.
Modes of application
o Aerial diffusion: for environmental fragrancing or aerial
disinfection
o Direct inhalation: for respiratory disinfection, decongestant,
expectoration as well as psychological effects
o Topical applications: for general massage, baths, compresses,
therapeutic skin care[82]

11. MUSIC THERAPY
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Musical therapy is a sub-type of psychotherapy that involves an individual
listening to music as a means of improving both communication and
interpersonal skills. Most types of music therapy are based loosely around
traditional cognitive-behavioral therapy. Music therapy involves both listening
as well as expression. It was noted that “active participation” among individuals
with mental illness showed better results than individuals that remained
passive. The majority of music therapy treatments occur over a three month
period.[

12. ELECTROCONVULSIVE
THERAPY
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Electroconvulsive therapy (ECT) uses an electric current to treat serious
mental disorders. This type of therapy is usually considered only if a patient's
illness has not improved after other treatments (such as antidepressant
medication or psychotherapy) are tried, or in cases where rapid response is
needed (as in the case of suicide risk and catatonia, for example).

13. DEEP BRAIN STIMULATION
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At present, the procedure is used
only for patients whose
symptoms cannot be adequately
controlled with medications, or
whose medications have severe
side-effects

14. REFERENCE
1) American Psychiatric Association, 1994 The Diagnostic and Statistical Manual
Revision IV
2) Sarris, J; Panossian, A; Schweitzer, I; Stough, C; Scholey, A (December 2011).
"Herbal medicine for depression, anxiety, and insomnia: a review of
psychopharmacology and clinical evidence". European
neuropsychopharmacology
3) National Institute of Neurological Disorders and Stroke. Deep brain
stimulation for Parkinson's Disease information page. Retrieved November 23,
2006.
4) Herrington TM, Cheng JJ, Eskandar EM (2016). "Mechanisms of deep brain
stimulation". J. Neurophysiol.
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