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Advance therapy of psychosis

Advance therapy of psychosis. Ayurveda treatment, therapy, drugs in clinical trial...

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Advance therapy of psychosis

  1. 1. Mr. JAVED SHAIKH F.Y.M.PHARM (Q.A) GUIDED BY: MR AMEY DESHPANDE ORIENTAL COLLEGE OF PHARMACY 1
  2. 2. PSYCHOSIS Defination Psychosis refers to an abnormal condition of the mind described as involving a "loss of contact with reality". characterized by :  Disturbances of reality and perception  Impaired cognitive functioning  Inappropriate or diminished affect (mood) 2
  3. 3. signs and symptoms  Delusion  Hallucinations  Catotonia 3
  4. 4. ANTIPSYCHOTIC DRUGS Typical antipsychotic drugs :  Also called as first generation antipsychotics drug  Drugs first developed in the 1950s  Used to treat psychosis.  Typical antipsychotics may also be used for the treatment of acute mania, agitation  Drugs act by blocking the receptors in the brains dopamine pathway  Eg. – chlorpromazine, Triflupromazine, Haloperidole, Pimozide  Side effects : These drugs can cause extra pyramidal motor control disabilities in patients 4
  5. 5. Atypical antipsychotic drugs :  Also called as second generation antipsychotics drug  Drugs first developed in the 1960s  Used to treat psychosis.  Atypical antipsychotics approved by FDA for use in the treatment of depression, bipolar and acute mania.  Drugs act by blocking the receptors in the brains dopamine pathway  Eg. – Clozapine, Risperidone, Olanzapine  It is less likely to cause extra pyramidal motor control disabilities in patients  Side effects : These drugs can cause weight gain, dry mouth, muscle cramping and stiffness. 5
  6. 6. NEW DRUGS  Pimavanserine –  TRADE NAME : NUPLAZID  Indication – for treatment parkinson induce psychosis 6
  7. 7.  BL-1020 (BioLineRx)  ITI-007 (Bristol-Myers Squibb)  RP-5063 (Reviva Pharmaceuticals ) RECENT DRUGS UNDER CLINICAL TRIAL 7
  8. 8. AYURVEDIC TREATMENT Jatamansi  powder form are given to the patient in the dose of one teaspoonful three times a day with milk or cold water. This helps in bringing the tranquility of mind. Vatakulantaka Rasa  Is one Ayurvedic Medicine usually prescribed by Ayurvedic Doctors to treat schizophrenia. One tablet can be given to the patient with honey three times a day. 8
  9. 9.  One of the best treatment that can be given to schizophrenia patient.  In this Kshirabala Taila is kept in an adjusted vessel over the forehead of the patient in such a way that drops of medicated oil fall from the bottom of the vessel on to the place between the two eyebrows of the patient.  This is advised to be done once daily.  This helps patient sleep well and get rid of this disease slowly Dhara treatment 9
  10. 10. AROMATHERAPY 10 Aromatherapy uses plant materials and aromatic plant oils, including essential oils, and other aroma compounds for the purpose of altering one's mood, cognitive, psychological or physical well-being. Modes of application o Aerial diffusion: for environmental fragrancing or aerial disinfection o Direct inhalation: for respiratory disinfection, decongestant, expectoration as well as psychological effects o Topical applications: for general massage, baths, compresses, therapeutic skin care[82]
  11. 11. MUSIC THERAPY 11 Musical therapy is a sub-type of psychotherapy that involves an individual listening to music as a means of improving both communication and interpersonal skills. Most types of music therapy are based loosely around traditional cognitive-behavioral therapy. Music therapy involves both listening as well as expression. It was noted that “active participation” among individuals with mental illness showed better results than individuals that remained passive. The majority of music therapy treatments occur over a three month period.[
  12. 12. ELECTROCONVULSIVE THERAPY 12 Electroconvulsive therapy (ECT) uses an electric current to treat serious mental disorders. This type of therapy is usually considered only if a patient's illness has not improved after other treatments (such as antidepressant medication or psychotherapy) are tried, or in cases where rapid response is needed (as in the case of suicide risk and catatonia, for example).
  13. 13. DEEP BRAIN STIMULATION 13 At present, the procedure is used only for patients whose symptoms cannot be adequately controlled with medications, or whose medications have severe side-effects
  14. 14. REFERENCE 1) American Psychiatric Association, 1994 The Diagnostic and Statistical Manual Revision IV 2) Sarris, J; Panossian, A; Schweitzer, I; Stough, C; Scholey, A (December 2011). "Herbal medicine for depression, anxiety, and insomnia: a review of psychopharmacology and clinical evidence". European neuropsychopharmacology 3) National Institute of Neurological Disorders and Stroke. Deep brain stimulation for Parkinson's Disease information page. Retrieved November 23, 2006. 4) Herrington TM, Cheng JJ, Eskandar EM (2016). "Mechanisms of deep brain stimulation". J. Neurophysiol. 14
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