Jaideep Sarkar- Buccomucosal Drug Delivery System

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GlaxoSmithKline Pharma GmbH

DEFINITION, PROCEDURE, ADVANTAGE, CONS, FUTURE AND RESEARCH

Saúde e medicina Negócios Tecnologia

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],INTRODUCTION

[object Object],[object Object],[object Object],[object Object],ENVIRONMENT AND ROLE OF BUCCAL MUCOSA

[object Object],[object Object],[object Object],[object Object],[object Object],BUCCAL DRUG DELIVERY AND MUCOADHESIVITY

Bioadhesive polymer chains Mucus polymer chains FUSION OF MUCUS LAYER AND BIOADHESIVE POLYMER APPROACHING POLYMERS MECHANISM OF BIOADHESIVE FOR MUCOSAL DRUG DELIVERY

[object Object],MUCOADHESIVE POLYMERS Predominantly anionic hydrophilicity , suitable surface property, sufficient flexibility Carboxymethyl cellulose Carbopol Polycarbophil Sodium Alginate Hydroxyethyl cellulose Hydroxypropyl methylcellulose Chitosan Gelatin Pectin

[object Object],BUCCAL MUCOADHESIVE DOSAGE FORMS

Drug + Mucoadhesive Matrix ………………………………………………………………… . ………………………………………………………………… . DESIGN OF BUCCAL DOSAGE FORM ,[object Object],Bi-directional patches release drug in both the mucosa and the mouth

[object Object],Impermeable backing is applied to control the direction of drug delivery; to reduce patch deformation and disintegration while in the mouth; and to prevent drug loss Backing Layer Drug + Mucoadhesive Matrix ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Contd…

ACTIVE INGREDIENTS DELIVERED VIA A BUCCAL ROUTE

[object Object],[object Object],[object Object],[object Object],[object Object],RECENT & FUTURE OF BDDS

THIS RECENT SCAN IMAGE OF PFIZER PROVES THAT BMDDS HAS SYSTEMIC EFFECT AND SO IS BENEFICIAL FOR THOSE PATIENTS THAT ARE UNCOOPERATIVE FOR OTHER DOSAGE FORM

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ADVANTAGES

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],DISADVANTAGES

[object Object],[object Object],CONCLUSION

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