WEBINAR:
Enhance Your
Fitness Goals
With THCV
20 JANUARY 2022
12:00PM CST PRESENTED BY:
Co-Founder Shayda Torabi

WHO IS
RESTART CBD?
Founded by sisters, Shayda, Sydney & Nika in Aug 2018
One of first operators in Texas
Shayda won cannabis best Educator, Influencer, & Advocate
RESTART voted Best CBD shop by Statesman + Chronicle
#1 Rated shop on Yelp + Google

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2521 RUTLAND DRIVE #150A
AUSTIN, TX 78721
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Shopping for
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overwhelming.

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of RESTART CBD, it
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*DISCLAIMER*
I am not a doctor, and encourage you to do further
research on everything I share, at the end of the
presentation I'll provide more resources for you to
continue to explore your canna curiosity!

WHAT IS THCV?

What is THCV?
THCV stands for Tetrahydrocannabivarin,
one of 100+ different cannabinoids found in
the cannabis plant
1
Researchers discovered THCV in 1973
2
It's been called "diet weed" for it's appetite-
suppressing properties, and "weederal" for
its energy enhancing properties.
3
THCV is federally legal as long as it is hemp-
derived. But legislation is changing fast, so
it’s vital to research laws in your locality.
4

THCV is a naturally occurring cannabinoid. It
can be synthesized completely organically
and naturally in the cannabis plant.
The main reason for the excitement and
anticipation around THCV is simply because
many people are half-expecting each new
cannabinoid to offer a valuable medical use.

Most known cannabinoids are synthesized
from cannabigerol (CBG), a compound found
in all forms of cannabis. CBG goes through a
metabolic process from which CBD, THC, and
several other cannabinoids are created.
However, THCV forms after the joining of
divarinolic acid and geranyl phosphate.
The resulting THCVA is decarboxylated to
create THCV. CBGV converts to THCVA,
which eventually becomes THCV when
exposed to heat or light.

What’s the
difference between
THC and THCV?
THC enhances appetite. THCV may suppress appetite
THC is strongly psychoactive. THCV is thought to be less psychoactive
THCV is closely related to THC. THCV has a similar
chemical makeup to THC. THCV uses a side chain with 3
carbon atoms, whereas THC has a side chain with 5
carbon atoms. This small difference in the chemical
makeup of THCV vs THC does have big differences in
the way the body metabolizes and uses them.
Studies have shown that THCV can limit the effects of THC.

THCV acts as an antagonist of the CB1
receptor in low doses, which means you
won’t experience a ‘high.’ When you increase
the dose, though, something very strange
happens; THCV switches behavior and acts
as a CB agonist, activating the CB1 and CB2
receptors, like THC. This means you WILL get
intoxicated.

One of the main reasons for THCV’s effects in this field is that
it suppresses CB1 receptors. A study published in the Journal
of Cannabis Research found that THCV decreases appetite,
increases feelings of fullness, and up-regulates energy
metabolism. The researchers concluded that THCV for weight
loss showed a lot of promise.
A small weight loss study funded by the National Institute of
Health in 2021 tested the benefits of Nitro-V, a hemp extract
microcapsule containing THCV. At the end of the 90-day trial
period, participants who used the extract experienced weight
loss without changes to diet or exercise.
STUDY: Δ9-Tetrahydrocannabivarin (THCV): a commentary on potential therapeutic
benefit for the management of obesity and diabetes. Jan 2020, PubMed
THCV + Appetite

STUDY: Δ9-Tetrahydrocannabivarin (THCV): a commentary on potential therapeutic
benefit for the management of obesity and diabetes. Jan 2020, PubMed

THCV + Appetite
A human study from 2015 suggested there isn’t enough evidence
to claim THCV suppresses appetite. The researchers found that
10mg of THCV was enough to affect food reward and aversion.
The cannabinoid increased the activation of various brain regions
in response to aversive food stimuli and chocolate. However,
THCV didn’t impact how users perceived a food’s pleasantness,
nor did it impact the desire for the food stimuli.
STUDY: Neural Effects of Cannabinoid CB1 Neutral Antagonist
Tetrahydrocannabivarin on Food Reward and Aversion in Healthy Volunteers, NIH

STUDY: Neural Effects of Cannabinoid CB1 Neutral Antagonist
Tetrahydrocannabivarin on Food Reward and Aversion in Healthy Volunteers, NIH

THCV +
Inflammation
A study published in the British Journal of Pharmacology
in 2010 found that THCV reduces swelling and pain in
mice. These are two of the main symptoms of
inflammation after exposure to inflammatory chemicals.
This is a sign that THCV activates cannabinoid receptors.
During the study, the mice received THCV after
inflammatory exposure each day for four consecutive
days. The scientists found that the compound reduced
inflammation, and the mice did not build up a tolerance.
STUDY: The plant cannabinoid Delta9-tetrahydrocannabivarin can decrease
signs of inflammation and inflammatory pain in mice

Another benefit that we have research to
back is THCV’s ability to suppress tremors
associated with illnesses such as ALS,
multiple sclerosis, and Parkinson’s disease.
Scientific research also supports the fact
that THCV can reduce seizures associated
with epilepsy. Moreover, research indicates
that THVC could reduce not only the
frequency but also the severity of seizures
when they occur. A study in the Epilepsia
journal found that THCV worked when taken
during a seizure as well as prior to seizures
as a preventive measure.
STUDY: Δ⁹-Tetrahydrocannabivarin suppresses in vitro epileptiform and in
vivo seizure activity in adult rats
THCV + TREMORS
There is also evidence that THCV may help
those who suffer from diabetes. In 2013, the
Nutrition and Diabetes Journal studied
THCV’s potential effects on Type 2 diabetes
in mice. The study found that THCV
produced an increase in energy expenditure
and reduced glucose intolerance in obese
mice. THCV also increased insulin sensitivity
in the mice with diabetes. The study
concluded that THVC may be a “treatment
against obesity-associated glucose
intolerance.” Another study in 2016 found
that THCV improved pancreatic cell function
in patients with Type 2 diabetes.
THCV + DIABETES
STUDY: Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on
Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A
Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study

In reality, there isn’t enough research to determine the answer.
Appetite suppression is a THCV side effect of concern in individuals with existing
eating disorders. Therefore, anyone falling into that category should avoid the
cannabinoid.
If you use THCV, it is wise to begin with no more than 10mg. This is a dosage
potentially capable of reducing certain THC side effects. It is mildly intoxicating,
probably 25% as strong as delta-9-THC, and provides a clear-headed high.
Does THCV Have Negative Effects?

ADDITIONAL
RESOURCES
EMAIL US AT INFO@RESTARTCBD.COM
01
SECRET RESTART CBD FACEBOOK GROUP
02

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Thank you!
Do you have any
questions?