STUDY IN YOUR WAY ANTILEPROTIC DRUGS
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Antileprotic Drugs are given.
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STUDY IN YOUR WAY ANTILEPROTIC DRUGS
- 1. ANTILEPROTIC DRUGS CLASSIFICATION:- 1. SULPHONES :- DAPSONE , SOLAPSONE 2. PHENAZINE DERIVATIVE : - CLOFAZIMINE 3. DI SUBSTITUTED :- THIAMBUTOSINE 1
- 2. DAPSONE(DDS) • Dapsone is derivative from diphenylsulphone and is actually bis(4-aminophenyl) sulphone • PHYSICAL PROPERTIES :- • It is white or creamy white crystalline powder . • Slightly soluble in water • It is freely soluble in ethanol. • It is soluble in mineral acids. • It melts at 175-176*c.
- 3. CHEMICAL PROPERTIES :- • Since it contains two aromatic primary amino groups . • It can be diazotised by treatment with HCL and sodium nitrate and the resulting compound coupled with b-naphthol to give an orange red azo dye.
- 4. STABILITY AND STORAGE :- • Since it is affected by light, store it in well closed light resistant container • Use: - • Antileprotic drugs • It is also used in combination with pyrimethamine in the treatment of chloroquine resistant malaria.
- 5. OFFICIAL PREPRATIONS:- • Dapsone, I.P., B.P. • Dapsone tablets ,I.P. ,B.P. • Brand names – • Dapsone , DDS , novophone , diphenasone.
- 6. SOLAPSONE • Solapsone Is The Tetrasodium Sulphonate Derivative Of Dapsone. • It Is Also Used In The Treatment of Leprosy But It Is Consider As Less Potent. • Physical Properties :- • It Is White Powder. • Soluble In Water • Insoluble In Alcohol
- 7. • Acid Catalysed Hydrolysis Decomposes Solapsone Giving Cinnamaldehyde , Sulphurous Acid And A Dapsone Salt. Due To Presence Of Cinnamaldehyde And Sulpharous Acid , The Resulting Solutions Answers The Reactions Of Unsaturated Compounds. • Stability And Storage :- • Stored In Well Closed Container. • Uses : - • Antileprotic Drugs . It I less Potent Than Dapsone And Is Used When There Is A Gastric Intolerance To Dapsone. • Brand Names – • Sulphetrone , Solusulfone ,Salapsone Etc.
- 8. CLOFAZIMINE • This is iminophenazine dye which is used as an antileprotic agent. • BRAND NAMES : -- • Lamprine , Clofozine , Hansepran. • PHYSICAL PROPERTIES : - • Dark Red Crystal Or Reddish Brown • It Is Fine Powder Without Odour. • It Is Practically Insoluble In Water But Soluble In Chloroform , Dioxan , And Dimethylformamide. • It is slightly soluble in ethanol (95%) and very slightly soluble in ether.
- 9. CHEMICAL PROPERTIES:-- • When it is dissolve in water and hydrochloric acid is added , an intense violet colour is produced . if the sodium hydroxide solution is added to this , the colour changes to orange red. • STABILITY AND STORAGE :-- • Store in well closed container. • USE:- • Antileprotic drug . it is orally active and is used as a component of multidrug therapy of leprosy. • It is also used as a second line drugs in dapsone resistant cases • It has inflammatory action also.
- 10. THIAMBUTOSINE • Thiambutosine is a thiourea derivative • It is also a phenolic ether and a tertiary aromatic amine. • PROPERTIES :-- • White powder • Insoluble in water • Soluble in chloroform , and ether • Odourless • Bitter taste • STORAGE :-- • Store in well closed container USES :-- Antileprotic drug.