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INSTITUT DE RECHERCHES CLINIQUES DE MONTRÉAL
Affiliated with the Université de Montréal

2010-2011 ANNUAL REPORT




                                               1
THE IRCM
                                                                             a leading biomedical research institute
                                                                             located in the heart of Montréal

                                                                             Our priorities
    institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                             Conquering cancer | Living with a
                                                                             healthy heart | Fighting infectious
                                                                             diseases | Understanding embryonic
                                                                             development and the nervous system
                                                                             | Exploring the complexity of biological
2                                                                            systems | Accelerating clinical research   3

                                                                             | Participating in ethical debates
35
                                                                             researchers –
                                                                                     IRCM
                                                                                  research
    institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                                professors




discovering
4
                                                                               152
                                                                                 scientific
                                                                               publications
                                                                                              5




                                                                             $18.8  million
                                                                                in research
                                                                                    funding
20,000       yearly visits at
                                                                             the IRCM clinic
    institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                                      40
6                                                                                     health
                                                                               professionals
                                                                                                    treating
                                                                                                  									
                                                                                                               7




                                                                                      20
                                                                                  physicians
                                                                               specialized in
                                                                               hypertension,
                                                                                 cholesterol,
                                                                                 obesity and
                                                                                   diabetes
7
                                                                                   core
    institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                               facilities




8
    innovating
									
                                                                                    5
                                                                             specialized
                                                                               services
                                                                                            9




                                                                                    3
                                                                               research
                                                                              platforms
7
     institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                                           new
                                                                                declarations of



                                                                                                   contributing
                                                                                      invention

10                                                                                                                11




                                                                                        11
                                                                              new patent filings
                                                                               (or applications)
113

                                                                                                                           }
                                                                                                          Master’s
                                                                                                          and PhD
                                                                                                          students


                                                                                                               57
     institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                                                            61
                                                                                                            61             scholarship
                                                                                                                             holders



                                                                              training
                                                                                                     postdoctoral
                                                                                                          fellows
12                                                                                                                                       13




									
                                                                                                      408* teaching
                                                                                                              hours


                                                                                         * at the Université de Montréal
                                                                                                              316 hours
                                                                                                (25 of our researchers)

                                                                                                    at McGill University
                                                                                                              92 hours
                                                                                                (13 of our researchers)
institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                                                                                                                                                                 Independent non-profit institution




                                                                                                                                                                          Founded in
                                                                                                                                                                                                                 Affiliated with the Université de




                                                                                                                                                                          1967
                                                                                                                                                                                                                 Montréal
                                                                                                                                                                                                                 Associated with McGill University
                                                                                                                                                                                                                 IRCM Clinic affiliated with the
                                                                                                                                                                                                                 Centre hospitalier de l’Université
                                                                                                                                                                                                                 de Montréal (CHUM)
14                                                                                                                                                                                                                                                  15



                                                                                                                                                                           425
                                                                                                                                                                                                                 Funded by Quebec ministry
                                                                                                                                                                                                                 of Economic Development,
                                                                                                                                                                                                                 Innovation and Export Trade
                                                                                                                                                                                                                 (MEDIE)
                                                                                                                                                                                                                 Supported by the Fonds de
                                                                                                                                                                           researchers, students and employees   recherche du Québec – Santé



                                                                                                                                                                                         38
                                                                                                                                                                                                                 (FRQS)
                                                                                                                                                                                                                 Member of the Université
                                                                                                                                                                                                                 de Montréal’s RUIS (Réseau
                                                                                                                                                                           A budget of        million dollars    universitaire intégré de santé)




                                                                              Dr. Jacques Genest, founder of the IRCM, surrounded by doctors from Montréal’s Hôtel-Dieu
MISSION
     institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                              2011
                                                                              To understand the causes of diseases
                                                                              To find diagnostic tools and means of prevention
                                                                              and treatment
16                                                                                                                               17
                                                                              To train a new generation of high-calibre
                                                                              scientists
                                                                              To contribute to Quebec’s socio-economic
                                                                              development by facilitating the commercial
                                                                              development of new discoveries
Messages from management					19
                                                                              Planning the future						26

                                                                              discovering							
                                                                              	Research programs					29

                                                                              treating
                                                                              	IRCM Clinic						45

                                                                              innovating
                                                                              	   Core facilities and technology platforms			   55
     institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                              contributing
                                                                              	Technology transfer					59

                                                                              training
                                                                              	Tomorrow’s researchers					63

                                                                              participating
18                                                                            	Science for all						73                                                  19
                                                                              Research funding						77
                                                                              Administration							78
                                                                              	IRCM Board of Directors					80
                                                                              	IRCM Management					82
                                                                              	Organizational charts					86
                                                                              	Financial statements					88

                                                                              IRCM Foundation						90
                                                                              Messages from management					99

                                                                              supporting
                                                                              	Benefit activities						103

                                                                              volunteering
                                                                              	
                                                                              	
                                                                                  IRCM Foundation Board of Directors			
                                                                                  Give for Life campaign Board				
                                                                                                                                107
                                                                                                                                108
                                                                                                                                      Messages
                                                                              giving
                                                                              	

                                                                              	
                                                                                The impact of your donations				
                                                                              	Partners and donors					116
                                                                                Research Funds and Chairs				
                                                                                                                 111

                                                                                                                 123
                                                                                                                                      from management
20
institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                  21
Message                                 new laboratories and a new clinic,        two new Board members: Monique          Message                                                                           a PhD in bioinformatics and who is
                                                                                                                      review of our governance rules and        Jérôme-Forget, an important figure                                                 STRATEGIC PLANNING                     currently working as a postdoctoral
                                                                              from the Chairman                       revision of our bylaws, in-depth          in Quebec’s political scene and         from the President                                                                fellow at the Dana-Farber Cancer
                                                                              of the Board                            review of our affiliation contract with   currently Special Advisor at Osler,     and Scientific                             When the Board of Directors            Institute and Harvard Public School
                                                                                                                      the Université de Montréal, creation      Hoskin & Harcourt, and Michel                                                      adopted our strategic plan, we         of Health in Boston. He will join
                                                                              This message will be my last            of the ombudsman position and             Lespérance, a lawyer who pursued        Director                                   quickly got to work to set up the      the institute in January 2012 as
                                                                              as Chairman of the Institut de          appointment of its first title-holder,    his career at the Université de                                                    elements required for us to complete   Assistant IRCM Research Professor
                                                                                                                      establishment of a Communications         Montréal.                               The year 2010-2011 was marked by           all measures planned for 2010-         and Director of the Bioinformatics
                                                                              recherches cliniques de Montréal’s
                                                                                                                      Committee to improve the Institut’s                                               the implementation of the elements         2015. It is my pleasure to present     and Computational Genomics
                                                                              Board of Directors. After six
                                                                                                                      visibility.                                                                       required to carry out the projects         to you, in the following pages, the    research unit. His laboratory will be
                                                                              wonderful years chairing this Board,
                                                                                                                                                                On behalf of the entire management      defined by our 2010-2015 strategic         challenges of this strategic plan.     part of the IRCM’s Systems Biology
                                                                              the time has come for me to pass on
                                                                                                                      Following the IRCM’s 40th                 team and all Board members, I           plan.                                                                             and Medicinal Chemistry research
     institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                              the torch.
                                                                                                                      anniversary, which we celebrated in       wish to sincerely thank Claude A.                                                  RECRUITMENT                            program.
                                                                                                                      2007 in the presence of its founder,      Garcia, who left after serving on       Before presenting you with a report
                                                                              With Louise Lambert-Lagacé now
                                                                                                                      Dr. Jacques Genest, we launched           the Board for numerous years, for       of this year’s activities, I would like    I was honoured to welcome two          INSTITUTIONAL FILES
                                                                              at the helm, I am confident it is in
                                                                                                                      a major fundraising campaign              his contributions and continued         to take this opportunity to sincerely      new researchers this year. Hua Gu,
                                                                              excellent hands.
                                                                                                                      in collaboration with the IRCM            commitment, particularly on the Audit   thank Gérard A. Limoges, outgoing          with a PhD in genetics from the        Website
                                                                                                                      Foundation that will continue until       Committee.                              Chairman of the IRCM’s Board of            University of Cologne in Germany       Our management team, as well as
                                                                              During my time on the IRCM’s Board,
                                                                                                                      2015.                                                                             Directors.                                 and Professor of immunology at         employees in the Communications
                                                                              I have had the pleasure to meet
                                                                              outstanding individuals: passionate                                               Thank you to everyone and long live                                                Columbia University before his         and Information Technology
22                                                                                                                    Finally, I had the pleasure of            the IRCM!                               THANK YOU TO                               arrival at the Institut, is now Full   departments, persistently worked        23
                                                                              researchers, devoted nurses and
                                                                                                                      confirming the renewal of Dr. Tarik                                               GÉRARD A. LIMOGES                          IRCM Research Professor, holder        on the development and launch of
                                                                              doctors, promising students and
                                                                              postdoctoral fellows, knowledgeable     Möröy’s term of office as President                                                                                          of the André-Aisenstadt Chair of       our new website. Today, we are very
                                                                                                                      and Scientific Director. Since his        Gérard A. Limoges, C.M., FCA            For five years, I have had the             Excellence, and Director of the new    happy to offer a website with a new
                                                                              and hard-working management
                                                                                                                      arrival, he has shown remarkable                                                  pleasure of working with Gérard,           Molecular Immunology research          look and user-friendly appearance:
                                                                              and staff members. With them, I
                                                                                                                      leadership skills that have been                                                  an energetic man who truly cares           unit. He is part of the Immunity and   www.ircm.qc.ca.
                                                                              have shared the pride of belonging
                                                                                                                      evidently reflected in all sectors of                                             for the future of the Institut. In fact,   Viral Infections research program.
                                                                              to a prestigious institution known
                                                                                                                      activity at the Institut, and which I                                             the summary of accomplishments             Jennifer Estall, who received a        IRCM’s evaluation by the FRSQ
                                                                              the world over for the quality of
                                                                                                                      would hereby like to recognize.                                                   included in his message accurately         PhD in molecular biology from          Following a visit in February 2011
                                                                              its research, and one where a
                                                                                                                                                                                                        describes his commitment to our            the University of Toronto and who      by the Fonds de recherche en santé
                                                                              stimulating and convivial environment
                                                                                                                      ACKNOWLEDGMENTS                                                                   institution. I am very grateful for        was a postdoctoral fellow at the       du Québec (FRSQ), known today as
                                                                              prevails.
                                                                                                                                                                                                        his warm welcome upon my arrival,          Dana-Farber Cancer Institute and       the Fonds de recherche du Québec
                                                                                                                      I would like to earnestly thank my                                                as well as for the support he has          Harvard Medical School in Boston, is   – Santé (FRQS), we received our
                                                                              MY TIME AT THE INSTITUT
                                                                                                                      colleagues on the Board of Directors                                              provided me over the past five years.      currently Assistant IRCM Research      research centre’s evaluation report
                                                                                                                      for their support. I wish them success                                            I would therefore like to thank him        Professor and Director of the          and are extremely proud of its
                                                                              I think I can rightly congratulate
                                                                                                                      in the pursuit of their respective                                                personally, and on behalf of everyone      Molecular Mechanisms of Diabetes       results, the conclusions of which led
                                                                              myself for what we accomplished
                                                                                                                      mandates under the chairmanship                                                   at the IRCM. On behalf of us all, on       research unit in the Cardiovascular    the evaluation committee’s chairman
                                                                              during my chairmanship: revision
                                                                                                                      of Louise Lambert-Lagacé who will,                                                whom Gérard has made a lasting             and Metabolic Diseases research        to qualify the IRCM as a “jewel
                                                                              of the Institut’s legal status,
                                                                                                                      undoubtedly, perform her duties                                                   impression, I wish him success in the      program. I also had the pleasure       of Quebec” and recommend the
                                                                              implementation of a new alliance
                                                                                                                      with characteristic effectiveness and                                             future and, once again, thank you.         of announcing the recruitment of       restitution, or even the increase, of
                                                                              with Univalor to support the transfer
                                                                              of our technologies, inauguration of    enthusiasm. I welcome the arrival of                                                                                         Benjamin Haibe-Kains, who obtained     the IRCM’s funding. This is excellent
news, as this financial support is         the Cardiovascular and Metabolic          by the Montreal Council on Foreign
                                                                              crucial to the proper functioning of       Diseases research program. Jean-          Relations (MCFR). It was a great
                                                                              our institute.                             François Côté was appointed               opportunity for me to share my
                                                                                                                         Associate Director of scientific          concerns about research funding in
                                                                              Agreement with McGill                      activities in the Academic Affairs        general, and particularly in Canada. I
                                                                              University                                 office. I thank him for accepting this    would like to thank Pierre Lemonde,
                                                                                                                         new challenge and also thank Benoit       MCFR’s President and CEO, for
                                                                              Historically, the Institut and McGill      Coulombe who previously held the          inviting me to this prestigious
                                                                              University have engaged in an              title.                                    platform.
                                                                              informal arrangement, by which
                                                                              IRCM researchers, holding an               RESEARCH PROGRAM CHANGES                  In closing, I would like to note that,
                                                                              adjunct professor status in McGill’s                                                 once again this year, our researchers
     institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                              Faculty of Medicine, held certain          The year 2010-2011 saw numerous           obtained excellent results in their
                                                                              privileges allowing them to supervise      changes in the IRCM’s research            grant applications, especially those
                                                                              graduate students registered at the        programs. Some of our researchers         for the Canadian Institutes of Health
                                                                              University. I am pleased to announce       retired while others reoriented           Research (CIHR) where their
                                                                              that an agreement has now been             their scientific careers to hold new      success rate was high above the
                                                                              formalized by way of an official letter,   positions, either within the Institut     national average.
                                                                              signed by both institutions – McGill       or in prestigious research centres
                                                                              University and the IRCM – and              abroad. I wish to thank them for          Finally, I want to thank the entire
24                                                                            now includes the supervision of            their work and accomplishments at         IRCM community, researchers,             25
                                                                              postdoctoral fellows registered at the     the IRCM and for the quality of their     students, employees and Board
                                                                              University.                                research projects.                        members, for their commitment and
                                                                                                                                                                   dedication. Each in our own way, we
                                                                              INTERNAL APPOINTMENTS                      GIVE FOR LIFE MAJOR                       are contributing to our institution’s
                                                                                                                         FUNDRAISING CAMPAIGN                      development and success.
                                                                              Management changes were made
                                                                              in the Academic Affairs department.        The IRCM Foundation’s major               Tarik Möröy, PhD
                                                                              Timothy L. Reudelhuber accepted            fundraising campaign continues.
                                                                              to become the new Executive                Many donations have been
                                                                              Director of Academic Affairs. As           confirmed. In this respect, I would
                                                                              such, he became a part of the              like to thank everyone who supports
                                                                              Institut’s administrative management       the Institut. Your contribution is very
                                                                              team and a member of the                   important.
                                                                              Management Committee. He is
                                                                              also responsible for the academic          MEETING THE BUSINESS
                                                                              staff. I wish to thank him, as well        COMMUNITY
                                                                              as Christian F. Deschepper who
                                                                              held the position over the past few        I was privileged to meet members
                                                                              years. Dr. Deschepper took over            of Montréal’s business community
                                                                              for Dr. Reudelhuber as Director of         when I spoke at a conference held
Clinical research boost                                       A new and innovative training program for international
                                                                                                                                                                                                                             graduate students has been submitted to the Université
                                                                                                                                                               Boosting clinical research requires collaboration between     de Montréal, and planning is underway at the IRCM for its
                                                                                                                                                               basic science researchers and clinical researchers in         implementation.
                                                                                                                                                               a synergistic approach. To achieve this, we must better
                                                                                                                                                               support and accelerate communication between basic            Strategic Projects Advisor
                                                                                                                                                               and clinical research by exploiting their complementarity.
                                                                                                                                                                                                                             The IRCM created the position of Strategic Projects
                                                                                                                                                               An ad hoc committee was created in partnership with           Advisor, which will be held by Martin Godbout, former
                                                                                                                                                               CHUM to make recommendations for a clinical and               President and CEO of Genome Canada. He will assist
     institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                                                                                                               translational research model including appropriate            the Institut in developing projects for extensive strategic
                                                                                                                                                               performance indicators and conditions for success.            grant applications. His services will also enable the IRCM
                                                                                                                                                                                                                             and its scientists to identify new funding possibilities and
                                                                                                                                                               Creation of a formal hospital alliance                        seize opportunities that might otherwise be lost.
                                                                                                                                                               with CHUM

                                                                                                                                                               Successful clinical and translational research at the         Scientific Advisory Board
                                                                                                                                                               IRCM must assuredly involve increased access to a
26                                                                                                                                                             hospital environment and clinical researchers. Thus, a        A Scientific Advisory Board, chaired by Alan Bernstein,                    27
                                                                                                                                                               formal alliance with the Centre hospitalier de l’Université   has been formed. Made up of seven members, this
                                                                                                                                                               de Montréal (CHUM) as a main partner in clinical              committee’s main objective will be to advise the Institut on
                                                                                                                                                               research will give both organisations an important            its scientific orientation, clinical and translational research,
                                                                              In recent years, the field of life sciences saw major transformations, as        strategic advantage. For the IRCM, CHUM will offer            technology transfer strategies and means of forging
                                                                                                                                                               privileged access to a clinical environment and patients      successful alliances with other research institutions.
                                                                              well as a rapid and substantial expansion in Quebec and Canada. Analysis of      with complex medical conditions, as well as a potential       This committee will also conduct a full institutional and
                                                                              the Institut’s recent evolution, in parallel with that of biomedical research,   pool of clinical researchers. For its part, the IRCM will     scientific review of the IRCM every five years.
                                                                                                                                                               provide CHUM with its world-renowned expertise in basic
                                                                              allowed for certain observations and led us to conduct a strategic planning      science and its modern research equipment.                    comMiTTEE MEMBERS: Alain Bernstein, Chair; John Aitchison (Institute
                                                                                                                                                                                                                             for Systems Biology, USA); Peter Bruns (Howard Hughes Medical Institute,
                                                                              exercise.                                                                                                                                      USA); Gordon Fishell (New York University, USA); Paul Frenette (Albert
                                                                                                                                                               Consolidation of our alliance with the
                                                                                                                                                                                                                             Einstein College of Medicine, USA); Roderick R. McInnes (Lady Davis
                                                                                                                                                               Université de Montréal and training                           Research Institute, Canada); Walter Rosenthal (Max-Delbrück Center for




                                                                              PLANNING
                                                                                                                                                               prioritisation                                                Molecular Medicine, Germany); Alfred Singer (National Cancer Institute,
                                                                                                                                                                                                                             USA). 
                                                                                                                                                               The IRCM must consolidate its university affiliation
                                                                                                                                                               with the Université de Montréal in order to maximize
                                                                                                                                                               collaboration between the Université and the Institut,


                                                                              THE FUTURE
                                                                                                                                                               and reassert its position as a leading research centre for
                                                                                                                                                               graduate studies.
The Institut de recherches cliniques de Montréal was the
                                                                                            first research centre in Quebec to bring together basic
                                                                                            science researchers and clinical researchers
                                                                                            under one roof, thereby becoming the forerunner for
     institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                                            translational research centres.


                                                                                            --   5	
                                                                              discovering
                                                                                                               research programs


                                                                                            - 35
28




                                                                                            152	
                                                                                                            	 research units

                                                                                                                                     *
                                                                                                               scientific publications
                                                                                                                                                                 29




                                                                                            262
                                                                                            *
                                                                                                             	 researchers and clinicians



                                                                                             39 laboratories were operational in 2010-2011
                                                                                                                                                       **
                                                                                            **   including postdoctoral fellows and students - August 31, 2011
institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                              “In 2010, we published the results of a study in the scientific journal Current
                                                                              Biology, from the Cell Press group, which demonstrates that a key mechanism
                                                                              in the control of cell motility could eventually lead to the development of
                                                                              new cancer-treating drugs that could block the spread of tumours. As many
                                                                              as 90% of cancer patient deaths are attributable to metastasis, which explains
30                                                                            the importance of understanding the molecular mechanisms at the basis of this                 31

                                                                              harmful process.”

                                                                              JEAN-FRANÇOIS CÔTÉ, PhD
                                                                              Associate IRCM Research Professor
                                                                              Director of the Cytoskeletal Organization and Cell Migration research unit




                                                                              Jean-François Côté, Nadine Fradet, research assistant, and Manishha Patel, doctoral student
“In our laboratory, much like many other scientists around the world, we are
     institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                              trying to uncover our nervous system’s innumerable mysteries. Our work focuses
                                                                              on motor neurons, which control muscles and are located in the spinal cord.
                                                                              Recently, we discovered a new piece of the puzzle in the development of our
                                                                              nervous system, which was published in the scientific journal Neuron of the Cell
                                                                              Press group. Our experiments shed light on poorly-understood mechanisms of
32                                                                            neuronal development. In fact, our breakthrough offers the scientific community a   33

                                                                              new basis for explaining how the function of very few molecules can be modulated
                                                                              to produce a vast array of neuronal connections.”

                                                                              ARTUR KANIA, PhD
                                                                              Associate IRCM Research Professor
                                                                              Director of the Neural Circuit Development research unit




                                                                              Artur Kania and Tzu-Jen Kao, postdoctoral fellow
CONQUERING
                                                                                                                                                                       Cancer research program

                                                                                                                                                                       “The Cancer research program brings together researchers interested in basic cell


                                                                                                CANCER
                                                                                                                                                                       proliferation and signalling mechanisms, breast cancer and tumor suppressor genes,
                                                                                                                                                                       leukemia and lymphoma, tumour angiogenesis, cell migration and metastasis.
                                                                                                                                                                       The general research objective of our program’s members is to understand the
                                                                                                                                                                       molecular mechanisms governing the neoplastic process, such as normal and
                                                                                                Research units                                                         pathological hematopoiesis, ciliopathies, cell motility and dissemination, and
                                                                                                                                                                       signalling in normal and cancerous epithelial and endothelial cells. Projects in
     institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                                                Jean-François Côté, PhD – Director, Cytoskeletal Organization and
                                                                                 marie trudel
                                                                                                Cell Migration – Associate IRCM Research Professor                     this research program aim to discover new molecular targets and develop new
                                                                                                Jean-Philippe Gratton, PhD – Director, Endothelial Cell Biology        therapeutic approaches and/or molecules to counter cancer progression.”
                                                                                                – Associate IRCM Research Professor – Canada Research Chair in
                                                                                                Endothelial Cell Signalling and Angiogenesis                           MARIE TRUDEL, PhD
                                                                                                Tarik Möröy, PhD – Director, Hematopoiesis and Cancer – Full IRCM      Director of the Cancer research program
                                                                                                Research Professor – Canada Research Chair in Hematopoiesis and        Full IRCM Research Professor
                                                                                                Immune Cell Differentiation                                            Director of the Molecular Genetics and Development research unit
34                                                                                                                                                                                                                                                                                                35
                                                                                                Katrina Podsypanina, MD, PhD – Director, Breast Cancer Biology –
                                                                                                Assistant IRCM Research Professor
                                                                                                Marie Trudel, PhD – Director, Molecular Genetics and Development
                                                                                                – Full IRCM Research Professor
                                                                                                William Y. Tsang, PhD – Director, Cell Division and Centrosome
                                                                                                Biology – Assistant IRCM Research Professor
                                                                                                Jean Vacher, D.Sc. – Director, Cellular Interactions and Development



                                                                                                                                                                       2010-2011
                                                                                                – Full IRCM Research Professor




                                                                                                                                                                       7 teams                                                        2 scholarship holders from the Fonds de recherche
                                                                                                                                                                                                                                      du Québec – Santé (FRQS): Jean-François Côté and
                                                                              “Projects in this research program aim                                                   2 Canada Research Chairs
                                                                                                                                                                       17 publications by the program’s researchers
                                                                                                                                                                                                                                      William Y. Tsang

                                                                              to discover new molecular targets and                                                    1 researcher honoured: Tarik Möröy was selected by
                                                                                                                                                                                                                                      1 New Investigator Award from the Canadian Institutes of
                                                                                                                                                                                                                                      Health Research (CIHR): William Y. Tsang
                                                                              develop new therapeutic approaches                                                       Canadians for Health Research (CHR) as Researcher
                                                                                                                                                                       of the Month in January 2011.                                  6 operating grants from the Canadian Institutes of Health

                                                                              and/or molecules.”                                                                       CHR is a national organisation dedicated to promoting health
                                                                                                                                                                       research in Canada.
                                                                                                                                                                                                                                      Research (CIHR), 3 recipients, $3.2 million: Jean-
                                                                                                                                                                                                                                      Philippe Gratton, Tarik Möröy, William Y. Tsang
LIVING WITH
                                                                                                                                                                            Cardiovascular and Metabolic Diseases research program

                                                                                                                                                                            “The cardio-metabolic research program groups together researchers working


                                                                                                            A HEALTHY
                                                                                                                                                                            on the biology of cardiovascular diseases and diabetes. Collectively, our projects
                                                                                                                                                                            lead to a better understanding of risk factors for cardiovascular diseases, including
                                                                                                                                                                            genetic factors, hypertension, dyslipidemia, endothelial cell dysfunctions and

                                                                                                                HEART                                                       metabolic disorders. This research is conducted by basic researchers as well as
                                                                                                                                                                            clinical researchers, thereby increasing the clinical relevance of our work. This
     institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                                                                                                                            year, our research program was enriched by the arrival of Dr. Jennifer Estall,
                                                                              CHRISTIAN F. DESCHEPPER
                                                                                                        Research units                                                      allowing us to benefit from her expertise in the molecular pathophysiology of
                                                                                                        Christian F. Deschepper, MD – Director, Experimental                type-2 diabetes.”
                                                                                                        Cardiovascular Biology – Full IRCM Research Professor
                                                                                                        Louis-Gilles Durand, O.Q., PhD, ing. – Director, Biomedical         CHRISTIAN F. DESCHEPPER, MD
                                                                                                        Engineering (laboratory closed on December 31, 2010)                Director of the Cardiovascular and Metabolic Diseases research program
                                                                                                                                                                            Full IRCM Research Professor
                                                                                                        Jennifer Estall, PhD – Director, Molecular Mechanisms of Diabetes
36                                                                                                                                                                          Director of the Experimental Cardiovascular Biology research unit                                                  37
                                                                                                        – Assistant IRCM Research Professor
                                                                                                        Pierre Larochelle, MD, PhD, FRCPC, FACP, FAHA – Director,
                                                                                                        Cardiovascular Pharmacology
                                                                                                        Claude Lazure, PhD – Director, Neuropeptide Structure and
                                                                                                        Metabolism – Full IRCM Research Professor
                                                                                                        Rémi Rabasa-Lhoret, MD, PhD – Director, Metabolic Diseases –
                                                                                                        J.A. DeSève Chair of Excellence



                                                                                                                                                                            2010-2011
                                                                                                        Timothy L. Reudelhuber, PhD – Director, Molecular Biochemistry
                                                                                                        of Hypertension – Full IRCM Research Professor
                                                                                                        M. Ram Sairam, PhD – Director, Molecular Endocrinology – Full
                                                                                                        IRCM Research Professor
                                                                                                        Nabil G. Seidah, C.M., O.Q., PhD, MSRC – Director, Biochemical
                                                                                                                                                                            10 teams                                                  2 researchers honoured: Pierre Larochelle is appointed
                                                                                                        Neuroendocrinology – Full IRCM Research Professor – Canada
                                                                                                                                                                                                                                      Professor Emeritus, a rare honour granted by the
                                                                                                        Research Chair in Precursor Proteolysis
                                                                                                                                                                            1 Canada Research Chair                                   Université de Montréal; and Timothy L. Reudelhuber is
                                                                                                        Gaétan Thibault, PhD – Director, Cellular Biology of Hypertension                                                             honoured by the American Heart Association’s Council
                                                                                                        (laboratory closed on January 31, 2011)                             1 IRCM Research Chair                                     for High Blood Pressure Research as honorary speaker
                                                                                                                                                                                                                                      for the 2010 Arthur C. Corcoran Memorial Lecture
                                                                                                                                                                            56 publications by the program’s researchers
                                                                                                                                                                                                                                      1 grant of $20,000 from Diabetes Québec: Rémi
                                                                                                                                                                                                                                      Rabasa-Lhoret
FIGHTING
                                                                                                                                                                               Immunity and Viral Infections research program

                                                                                                                                                                               “The Immunity and Viral Infections research program integrates researchers


                                                                                                                INFECTIOUS
                                                                                                                                                                               interested not only by the development of immune cells and the regulation of
                                                                                                                                                                               their functions, but also by viral infections, especially those involving viruses
                                                                                                                                                                               that infect immune cells. The scientific mission of our research program is

                                                                                                                  DISEASES
                                                                                                                                                                               to understand the signalling mechanisms that play an important role in the
                                                                                                                                                                               development, the function and the diseases of the immune system as well as to
                                                                                                                                                                               explore how viral infections, namely HIV/AIDS, lead to immune dysfunctions.
     institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                                 Éric A. Cohen
                                                                                                                                                                               Collectively, our studies have led to a better understanding of immune cell
                                                                                                 Research units                                                                regulation in normal and pathological conditions such as during autoimmune
                                                                                                 Éric A. Cohen, PhD – Director, Human Retrovirology – Canada Research Chair    diseases, viral infections and immunodeficiency. This year, Dr. Hua Gu, a
                                                                                                 in Human Retrovirology                                                        renowned senior immunologist, joined our research program. Dr. Gu’s work on
                                                                                                 Vibhuti P. Dave, PhD – Director, Lymphocyte Development (laboratory closed
                                                                                                 on December 31, 2010)
                                                                                                                                                                               antitumor immunotherapy will help strengthen our translational research.”
38                                                                                                                                                                                                                                                                                                    39
                                                                                                 Javier Marcelo Di Noia, PhD – Director, Mechanisms of Genetic Diversity       ÉRIC A. COHEN, PhD
                                                                                                 – Associate IRCM Research Professor – Canada Research Chair in Genetic        Director of the Immunity and Viral Infections research program
                                                                                                 Diversity                                                                     Director of the Human Retrovirology research unit
                                                                                                 Hua Gu, PhD – Director, Molecular Immunology – Full IRCM Research Professor   Canada Research Chairholder in Human Retrovirology
                                                                                                 – André-Aisenstadt Chair of Excellence in Immunology
                                                                                                 Paul Jolicoeur, MD, PhD, MSRC – Director, Molecular Biology – Full IRCM
                                                                                                 Research Professor – Canada Research Chair in Studies of Pathogenesis of
                                                                                                 Retrovirus-Induced Diseases
                                                                                                 Woong-Kyung Suh, PhD – Director, Immune Regulation – Assistant IRCM
                                                                                                 Research Professor




                                                                                                                                                                               2010-2011
                                                                                                 André Veillette, MD, MSRC – Director, Molecular Oncology – Full IRCM
                                                                                                 Research Professor – Canada Research Chair in Immune System Signalling



                                                                              “our studies have led to a better                                                                7 teams                                                     17 publications by the program’s researchers
                                                                              understanding of immune cell                                                                     3 Canada Research Chairs                                    1 operating grant from the Canadian Institutes of Health

                                                                              regulation in normal and pathological                                                            1 IRCM Research Chair
                                                                                                                                                                                                                                           Research (CIHR), $700,000: Éric A. Cohen


                                                                              conditions...”
UNDER-
                                                                                                                                                                          Neurobiology and Development research program
                                                                                                                                                                          Understanding embryonic development and the nervous system
                                                                                                                                                                          Participating in ethical debates


                                                                                                    STANDING                                                              “Researchers in the Neurobiology and Development research program focus their
                                                                                                                                                                          efforts on understanding the cellular and molecular mechanisms that control the


                                                                                                 THE NERVOUS
                                                                                                                                                                          development of different organs. Certain groups are interested in mechanisms
                                                                                                                                                                          controlling cell proliferation, differentiation, polarity and death during the
                                                                                                                                                                          development of the nervous system, pituitary gland, limbs, bones, kidneys and
     institut de recherches cliniques de Montréal _ 2010-2011 annual report




                                                                                                      SYSTEM
                                                                              michel cayouette                                                                            epithelial tissues, while others study hormone action mechanisms or guidance
                                                                                                                                                                          mechanisms that allow axons to find their target within a complex neural network.
                                                                                                                                                                          One of our teams also explores ethical questions related to neurosciences. Hence,
                                                                                                                                                                          our researchers’ work is based on simple reasoning: in order to better understand
                                                                                                                                                                          the pathology of diseases and develop effective therapeutic strategies, it is
40                                                                                               Research units                                                           absolutely necessary to know, in detail, the mechanisms that control the normal                                     41

                                                                                                 Michel Cayouette, PhD – Director, Cellular Neurobiology – Associate      development of our organs. The knowledge acquired should thereby have a major
                                                                                                 IRCM Research Professor                                                  impact on diagnostic, prevention and treatment strategies.”
                                                                                                 Frédéric Charron, PhD – Director, Molecular Biology of Neural
                                                                                                 Development – Associate IRCM Research Professor                          MICHEL CAYOUETTE, PhD
                                                                                                 Jacques Drouin, D.Sc., MSRC – Director, Molecular Genetics – Full IRCM   Director of the Neurobiology and Development research program
                                                                                                 Research Professor                                                       Associate IRCM Research Professor
                                                                                                                                                                          Director of the Cellular Neurobiology research unit
                                                                                                 David R. Hipfner, PhD – Director, Epithelial Cell Biology – Assistant
                                                                                                 IRCM Research Professor
                                                                                                 Marko Horb, PhD – Director, Molecular Organogenesis (laboratory closed



                                                                                                                                                                          2010-2011
                                                                                                 on June 1, 2011)
                                                                                                 Artur Kania, PhD – Director, Neural Circuit Development – Associate
                                                                                                 IRCM Research Professor
                                                                                                 Marie Kmita, PhD – Director, Genetics and Development – Assistant
                                                                                                 IRCM Research Professor – Canada Research Chair in Molecular
                                                                                                                                                                          8 teams                                                 3 operating grants from the Canadian Institutes of Health
                                                                                                 Embryology and Genetics
                                                                                                                                                                                                                                  Research (CIHR), $1.6 million: Michel Cayouette,
                                                                                                 Éric Racine, PhD – Director, Neuroethics – Associate IRCM Research       1 Canada Research Chair
                                                                                                                                                                                                                                  Jacques Drouin, Marie Kmita
                                                                                                 Professor                                                                36 publications by the program’s researchers
                                                                                                                                                                                                                                  1 grant of $120,000 from the Cancer Research Society:
                                                                                                                                                                          1 scholarship holder from the Fonds de recherche du     Frédéric Charron
                                                                                                                                                                          Québec — Santé (FRQS): Michel Cayouette
                                                                                                                                                                                                                                  1 grant of $45,000 from Parkinson Society Canada:
                                                                                                                                                                          1 New Investigator Award from the Canadian Institutes   Jacques Drouin
                                                                                                                                                                          of Health Research (CIHR): David R. Hipfner
2010-2011 IRCM Annual Report
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2010-2011 IRCM Annual Report

  • 1. INSTITUT DE RECHERCHES CLINIQUES DE MONTRÉAL Affiliated with the Université de Montréal 2010-2011 ANNUAL REPORT 1
  • 2. THE IRCM a leading biomedical research institute located in the heart of Montréal Our priorities institut de recherches cliniques de Montréal _ 2010-2011 annual report Conquering cancer | Living with a healthy heart | Fighting infectious diseases | Understanding embryonic development and the nervous system | Exploring the complexity of biological 2 systems | Accelerating clinical research 3 | Participating in ethical debates
  • 3. 35 researchers – IRCM research institut de recherches cliniques de Montréal _ 2010-2011 annual report professors discovering 4 152 scientific publications 5 $18.8 million in research funding
  • 4. 20,000 yearly visits at the IRCM clinic institut de recherches cliniques de Montréal _ 2010-2011 annual report 40 6 health professionals treating 7 20 physicians specialized in hypertension, cholesterol, obesity and diabetes
  • 5. 7 core institut de recherches cliniques de Montréal _ 2010-2011 annual report facilities 8 innovating 5 specialized services 9 3 research platforms
  • 6. 7 institut de recherches cliniques de Montréal _ 2010-2011 annual report new declarations of contributing invention 10 11 11 new patent filings (or applications)
  • 7. 113 } Master’s and PhD students 57 institut de recherches cliniques de Montréal _ 2010-2011 annual report 61 61 scholarship holders training postdoctoral fellows 12 13 408* teaching hours * at the Université de Montréal 316 hours (25 of our researchers) at McGill University 92 hours (13 of our researchers)
  • 8. institut de recherches cliniques de Montréal _ 2010-2011 annual report Independent non-profit institution Founded in Affiliated with the Université de 1967 Montréal Associated with McGill University IRCM Clinic affiliated with the Centre hospitalier de l’Université de Montréal (CHUM) 14 15 425 Funded by Quebec ministry of Economic Development, Innovation and Export Trade (MEDIE) Supported by the Fonds de researchers, students and employees recherche du Québec – Santé 38 (FRQS) Member of the Université de Montréal’s RUIS (Réseau A budget of million dollars universitaire intégré de santé) Dr. Jacques Genest, founder of the IRCM, surrounded by doctors from Montréal’s Hôtel-Dieu
  • 9. MISSION institut de recherches cliniques de Montréal _ 2010-2011 annual report 2011 To understand the causes of diseases To find diagnostic tools and means of prevention and treatment 16 17 To train a new generation of high-calibre scientists To contribute to Quebec’s socio-economic development by facilitating the commercial development of new discoveries
  • 10. Messages from management 19 Planning the future 26 discovering Research programs 29 treating IRCM Clinic 45 innovating Core facilities and technology platforms 55 institut de recherches cliniques de Montréal _ 2010-2011 annual report contributing Technology transfer 59 training Tomorrow’s researchers 63 participating 18 Science for all 73 19 Research funding 77 Administration 78 IRCM Board of Directors 80 IRCM Management 82 Organizational charts 86 Financial statements 88 IRCM Foundation 90 Messages from management 99 supporting Benefit activities 103 volunteering IRCM Foundation Board of Directors Give for Life campaign Board 107 108 Messages giving The impact of your donations Partners and donors 116 Research Funds and Chairs 111 123 from management
  • 11. 20 institut de recherches cliniques de Montréal _ 2010-2011 annual report 21
  • 12. Message new laboratories and a new clinic, two new Board members: Monique Message a PhD in bioinformatics and who is review of our governance rules and Jérôme-Forget, an important figure STRATEGIC PLANNING currently working as a postdoctoral from the Chairman revision of our bylaws, in-depth in Quebec’s political scene and from the President fellow at the Dana-Farber Cancer of the Board review of our affiliation contract with currently Special Advisor at Osler, and Scientific When the Board of Directors Institute and Harvard Public School the Université de Montréal, creation Hoskin & Harcourt, and Michel adopted our strategic plan, we of Health in Boston. He will join This message will be my last of the ombudsman position and Lespérance, a lawyer who pursued Director quickly got to work to set up the the institute in January 2012 as as Chairman of the Institut de appointment of its first title-holder, his career at the Université de elements required for us to complete Assistant IRCM Research Professor establishment of a Communications Montréal. The year 2010-2011 was marked by all measures planned for 2010- and Director of the Bioinformatics recherches cliniques de Montréal’s Committee to improve the Institut’s the implementation of the elements 2015. It is my pleasure to present and Computational Genomics Board of Directors. After six visibility. required to carry out the projects to you, in the following pages, the research unit. His laboratory will be wonderful years chairing this Board, On behalf of the entire management defined by our 2010-2015 strategic challenges of this strategic plan. part of the IRCM’s Systems Biology the time has come for me to pass on Following the IRCM’s 40th team and all Board members, I plan. and Medicinal Chemistry research institut de recherches cliniques de Montréal _ 2010-2011 annual report the torch. anniversary, which we celebrated in wish to sincerely thank Claude A. RECRUITMENT program. 2007 in the presence of its founder, Garcia, who left after serving on Before presenting you with a report With Louise Lambert-Lagacé now Dr. Jacques Genest, we launched the Board for numerous years, for of this year’s activities, I would like I was honoured to welcome two INSTITUTIONAL FILES at the helm, I am confident it is in a major fundraising campaign his contributions and continued to take this opportunity to sincerely new researchers this year. Hua Gu, excellent hands. in collaboration with the IRCM commitment, particularly on the Audit thank Gérard A. Limoges, outgoing with a PhD in genetics from the Website Foundation that will continue until Committee. Chairman of the IRCM’s Board of University of Cologne in Germany Our management team, as well as During my time on the IRCM’s Board, 2015. Directors. and Professor of immunology at employees in the Communications I have had the pleasure to meet outstanding individuals: passionate Thank you to everyone and long live Columbia University before his and Information Technology 22 Finally, I had the pleasure of the IRCM! THANK YOU TO arrival at the Institut, is now Full departments, persistently worked 23 researchers, devoted nurses and confirming the renewal of Dr. Tarik GÉRARD A. LIMOGES IRCM Research Professor, holder on the development and launch of doctors, promising students and postdoctoral fellows, knowledgeable Möröy’s term of office as President of the André-Aisenstadt Chair of our new website. Today, we are very and Scientific Director. Since his Gérard A. Limoges, C.M., FCA For five years, I have had the Excellence, and Director of the new happy to offer a website with a new and hard-working management arrival, he has shown remarkable   pleasure of working with Gérard, Molecular Immunology research look and user-friendly appearance: and staff members. With them, I leadership skills that have been an energetic man who truly cares unit. He is part of the Immunity and www.ircm.qc.ca. have shared the pride of belonging evidently reflected in all sectors of for the future of the Institut. In fact, Viral Infections research program. to a prestigious institution known activity at the Institut, and which I the summary of accomplishments Jennifer Estall, who received a IRCM’s evaluation by the FRSQ the world over for the quality of would hereby like to recognize. included in his message accurately PhD in molecular biology from Following a visit in February 2011 its research, and one where a describes his commitment to our the University of Toronto and who by the Fonds de recherche en santé stimulating and convivial environment ACKNOWLEDGMENTS institution. I am very grateful for was a postdoctoral fellow at the du Québec (FRSQ), known today as prevails. his warm welcome upon my arrival, Dana-Farber Cancer Institute and the Fonds de recherche du Québec I would like to earnestly thank my as well as for the support he has Harvard Medical School in Boston, is – Santé (FRQS), we received our MY TIME AT THE INSTITUT colleagues on the Board of Directors provided me over the past five years. currently Assistant IRCM Research research centre’s evaluation report for their support. I wish them success I would therefore like to thank him Professor and Director of the and are extremely proud of its I think I can rightly congratulate in the pursuit of their respective personally, and on behalf of everyone Molecular Mechanisms of Diabetes results, the conclusions of which led myself for what we accomplished mandates under the chairmanship at the IRCM. On behalf of us all, on research unit in the Cardiovascular the evaluation committee’s chairman during my chairmanship: revision of Louise Lambert-Lagacé who will, whom Gérard has made a lasting and Metabolic Diseases research to qualify the IRCM as a “jewel of the Institut’s legal status, undoubtedly, perform her duties impression, I wish him success in the program. I also had the pleasure of Quebec” and recommend the implementation of a new alliance with characteristic effectiveness and future and, once again, thank you. of announcing the recruitment of restitution, or even the increase, of with Univalor to support the transfer of our technologies, inauguration of enthusiasm. I welcome the arrival of Benjamin Haibe-Kains, who obtained the IRCM’s funding. This is excellent
  • 13. news, as this financial support is the Cardiovascular and Metabolic by the Montreal Council on Foreign crucial to the proper functioning of Diseases research program. Jean- Relations (MCFR). It was a great our institute. François Côté was appointed opportunity for me to share my Associate Director of scientific concerns about research funding in Agreement with McGill activities in the Academic Affairs general, and particularly in Canada. I University office. I thank him for accepting this would like to thank Pierre Lemonde, new challenge and also thank Benoit MCFR’s President and CEO, for Historically, the Institut and McGill Coulombe who previously held the inviting me to this prestigious University have engaged in an title. platform. informal arrangement, by which IRCM researchers, holding an RESEARCH PROGRAM CHANGES In closing, I would like to note that, adjunct professor status in McGill’s once again this year, our researchers institut de recherches cliniques de Montréal _ 2010-2011 annual report Faculty of Medicine, held certain The year 2010-2011 saw numerous obtained excellent results in their privileges allowing them to supervise changes in the IRCM’s research grant applications, especially those graduate students registered at the programs. Some of our researchers for the Canadian Institutes of Health University. I am pleased to announce retired while others reoriented Research (CIHR) where their that an agreement has now been their scientific careers to hold new success rate was high above the formalized by way of an official letter, positions, either within the Institut national average. signed by both institutions – McGill or in prestigious research centres University and the IRCM – and abroad. I wish to thank them for Finally, I want to thank the entire 24 now includes the supervision of their work and accomplishments at IRCM community, researchers, 25 postdoctoral fellows registered at the the IRCM and for the quality of their students, employees and Board University. research projects. members, for their commitment and dedication. Each in our own way, we INTERNAL APPOINTMENTS GIVE FOR LIFE MAJOR are contributing to our institution’s FUNDRAISING CAMPAIGN development and success. Management changes were made in the Academic Affairs department. The IRCM Foundation’s major Tarik Möröy, PhD Timothy L. Reudelhuber accepted fundraising campaign continues. to become the new Executive Many donations have been Director of Academic Affairs. As confirmed. In this respect, I would such, he became a part of the like to thank everyone who supports Institut’s administrative management the Institut. Your contribution is very team and a member of the important. Management Committee. He is also responsible for the academic MEETING THE BUSINESS staff. I wish to thank him, as well COMMUNITY as Christian F. Deschepper who held the position over the past few I was privileged to meet members years. Dr. Deschepper took over of Montréal’s business community for Dr. Reudelhuber as Director of when I spoke at a conference held
  • 14. Clinical research boost A new and innovative training program for international graduate students has been submitted to the Université Boosting clinical research requires collaboration between de Montréal, and planning is underway at the IRCM for its basic science researchers and clinical researchers in implementation. a synergistic approach. To achieve this, we must better support and accelerate communication between basic Strategic Projects Advisor and clinical research by exploiting their complementarity. The IRCM created the position of Strategic Projects An ad hoc committee was created in partnership with Advisor, which will be held by Martin Godbout, former CHUM to make recommendations for a clinical and President and CEO of Genome Canada. He will assist institut de recherches cliniques de Montréal _ 2010-2011 annual report translational research model including appropriate the Institut in developing projects for extensive strategic performance indicators and conditions for success. grant applications. His services will also enable the IRCM and its scientists to identify new funding possibilities and Creation of a formal hospital alliance seize opportunities that might otherwise be lost. with CHUM Successful clinical and translational research at the Scientific Advisory Board IRCM must assuredly involve increased access to a 26 hospital environment and clinical researchers. Thus, a A Scientific Advisory Board, chaired by Alan Bernstein, 27 formal alliance with the Centre hospitalier de l’Université has been formed. Made up of seven members, this de Montréal (CHUM) as a main partner in clinical committee’s main objective will be to advise the Institut on research will give both organisations an important its scientific orientation, clinical and translational research, In recent years, the field of life sciences saw major transformations, as strategic advantage. For the IRCM, CHUM will offer technology transfer strategies and means of forging privileged access to a clinical environment and patients successful alliances with other research institutions. well as a rapid and substantial expansion in Quebec and Canada. Analysis of with complex medical conditions, as well as a potential This committee will also conduct a full institutional and the Institut’s recent evolution, in parallel with that of biomedical research, pool of clinical researchers. For its part, the IRCM will scientific review of the IRCM every five years. provide CHUM with its world-renowned expertise in basic allowed for certain observations and led us to conduct a strategic planning science and its modern research equipment. comMiTTEE MEMBERS: Alain Bernstein, Chair; John Aitchison (Institute for Systems Biology, USA); Peter Bruns (Howard Hughes Medical Institute, exercise. USA); Gordon Fishell (New York University, USA); Paul Frenette (Albert Consolidation of our alliance with the Einstein College of Medicine, USA); Roderick R. McInnes (Lady Davis Université de Montréal and training Research Institute, Canada); Walter Rosenthal (Max-Delbrück Center for PLANNING prioritisation Molecular Medicine, Germany); Alfred Singer (National Cancer Institute, USA).  The IRCM must consolidate its university affiliation with the Université de Montréal in order to maximize collaboration between the Université and the Institut, THE FUTURE and reassert its position as a leading research centre for graduate studies.
  • 15. The Institut de recherches cliniques de Montréal was the first research centre in Quebec to bring together basic science researchers and clinical researchers under one roof, thereby becoming the forerunner for institut de recherches cliniques de Montréal _ 2010-2011 annual report translational research centres. --   5 discovering research programs - 35 28 152 research units * scientific publications 29 262 * researchers and clinicians 39 laboratories were operational in 2010-2011 ** ** including postdoctoral fellows and students - August 31, 2011
  • 16. institut de recherches cliniques de Montréal _ 2010-2011 annual report “In 2010, we published the results of a study in the scientific journal Current Biology, from the Cell Press group, which demonstrates that a key mechanism in the control of cell motility could eventually lead to the development of new cancer-treating drugs that could block the spread of tumours. As many as 90% of cancer patient deaths are attributable to metastasis, which explains 30 the importance of understanding the molecular mechanisms at the basis of this 31 harmful process.” JEAN-FRANÇOIS CÔTÉ, PhD Associate IRCM Research Professor Director of the Cytoskeletal Organization and Cell Migration research unit Jean-François Côté, Nadine Fradet, research assistant, and Manishha Patel, doctoral student
  • 17. “In our laboratory, much like many other scientists around the world, we are institut de recherches cliniques de Montréal _ 2010-2011 annual report trying to uncover our nervous system’s innumerable mysteries. Our work focuses on motor neurons, which control muscles and are located in the spinal cord. Recently, we discovered a new piece of the puzzle in the development of our nervous system, which was published in the scientific journal Neuron of the Cell Press group. Our experiments shed light on poorly-understood mechanisms of 32 neuronal development. In fact, our breakthrough offers the scientific community a 33 new basis for explaining how the function of very few molecules can be modulated to produce a vast array of neuronal connections.” ARTUR KANIA, PhD Associate IRCM Research Professor Director of the Neural Circuit Development research unit Artur Kania and Tzu-Jen Kao, postdoctoral fellow
  • 18. CONQUERING Cancer research program “The Cancer research program brings together researchers interested in basic cell CANCER proliferation and signalling mechanisms, breast cancer and tumor suppressor genes, leukemia and lymphoma, tumour angiogenesis, cell migration and metastasis. The general research objective of our program’s members is to understand the molecular mechanisms governing the neoplastic process, such as normal and Research units pathological hematopoiesis, ciliopathies, cell motility and dissemination, and signalling in normal and cancerous epithelial and endothelial cells. Projects in institut de recherches cliniques de Montréal _ 2010-2011 annual report Jean-François Côté, PhD – Director, Cytoskeletal Organization and marie trudel Cell Migration – Associate IRCM Research Professor this research program aim to discover new molecular targets and develop new Jean-Philippe Gratton, PhD – Director, Endothelial Cell Biology therapeutic approaches and/or molecules to counter cancer progression.” – Associate IRCM Research Professor – Canada Research Chair in Endothelial Cell Signalling and Angiogenesis MARIE TRUDEL, PhD Tarik Möröy, PhD – Director, Hematopoiesis and Cancer – Full IRCM Director of the Cancer research program Research Professor – Canada Research Chair in Hematopoiesis and Full IRCM Research Professor Immune Cell Differentiation Director of the Molecular Genetics and Development research unit 34 35 Katrina Podsypanina, MD, PhD – Director, Breast Cancer Biology – Assistant IRCM Research Professor Marie Trudel, PhD – Director, Molecular Genetics and Development – Full IRCM Research Professor William Y. Tsang, PhD – Director, Cell Division and Centrosome Biology – Assistant IRCM Research Professor Jean Vacher, D.Sc. – Director, Cellular Interactions and Development 2010-2011 – Full IRCM Research Professor 7 teams 2 scholarship holders from the Fonds de recherche du Québec – Santé (FRQS): Jean-François Côté and “Projects in this research program aim 2 Canada Research Chairs 17 publications by the program’s researchers William Y. Tsang to discover new molecular targets and 1 researcher honoured: Tarik Möröy was selected by 1 New Investigator Award from the Canadian Institutes of Health Research (CIHR): William Y. Tsang develop new therapeutic approaches Canadians for Health Research (CHR) as Researcher of the Month in January 2011. 6 operating grants from the Canadian Institutes of Health and/or molecules.” CHR is a national organisation dedicated to promoting health research in Canada. Research (CIHR), 3 recipients, $3.2 million: Jean- Philippe Gratton, Tarik Möröy, William Y. Tsang
  • 19. LIVING WITH Cardiovascular and Metabolic Diseases research program “The cardio-metabolic research program groups together researchers working A HEALTHY on the biology of cardiovascular diseases and diabetes. Collectively, our projects lead to a better understanding of risk factors for cardiovascular diseases, including genetic factors, hypertension, dyslipidemia, endothelial cell dysfunctions and HEART metabolic disorders. This research is conducted by basic researchers as well as clinical researchers, thereby increasing the clinical relevance of our work. This institut de recherches cliniques de Montréal _ 2010-2011 annual report year, our research program was enriched by the arrival of Dr. Jennifer Estall, CHRISTIAN F. DESCHEPPER Research units allowing us to benefit from her expertise in the molecular pathophysiology of Christian F. Deschepper, MD – Director, Experimental type-2 diabetes.” Cardiovascular Biology – Full IRCM Research Professor Louis-Gilles Durand, O.Q., PhD, ing. – Director, Biomedical CHRISTIAN F. DESCHEPPER, MD Engineering (laboratory closed on December 31, 2010) Director of the Cardiovascular and Metabolic Diseases research program Full IRCM Research Professor Jennifer Estall, PhD – Director, Molecular Mechanisms of Diabetes 36 Director of the Experimental Cardiovascular Biology research unit 37 – Assistant IRCM Research Professor Pierre Larochelle, MD, PhD, FRCPC, FACP, FAHA – Director, Cardiovascular Pharmacology Claude Lazure, PhD – Director, Neuropeptide Structure and Metabolism – Full IRCM Research Professor Rémi Rabasa-Lhoret, MD, PhD – Director, Metabolic Diseases – J.A. DeSève Chair of Excellence 2010-2011 Timothy L. Reudelhuber, PhD – Director, Molecular Biochemistry of Hypertension – Full IRCM Research Professor M. Ram Sairam, PhD – Director, Molecular Endocrinology – Full IRCM Research Professor Nabil G. Seidah, C.M., O.Q., PhD, MSRC – Director, Biochemical 10 teams 2 researchers honoured: Pierre Larochelle is appointed Neuroendocrinology – Full IRCM Research Professor – Canada Professor Emeritus, a rare honour granted by the Research Chair in Precursor Proteolysis 1 Canada Research Chair Université de Montréal; and Timothy L. Reudelhuber is Gaétan Thibault, PhD – Director, Cellular Biology of Hypertension honoured by the American Heart Association’s Council (laboratory closed on January 31, 2011) 1 IRCM Research Chair for High Blood Pressure Research as honorary speaker for the 2010 Arthur C. Corcoran Memorial Lecture 56 publications by the program’s researchers 1 grant of $20,000 from Diabetes Québec: Rémi Rabasa-Lhoret
  • 20. FIGHTING Immunity and Viral Infections research program “The Immunity and Viral Infections research program integrates researchers INFECTIOUS interested not only by the development of immune cells and the regulation of their functions, but also by viral infections, especially those involving viruses that infect immune cells. The scientific mission of our research program is DISEASES to understand the signalling mechanisms that play an important role in the development, the function and the diseases of the immune system as well as to explore how viral infections, namely HIV/AIDS, lead to immune dysfunctions. institut de recherches cliniques de Montréal _ 2010-2011 annual report Éric A. Cohen Collectively, our studies have led to a better understanding of immune cell Research units regulation in normal and pathological conditions such as during autoimmune Éric A. Cohen, PhD – Director, Human Retrovirology – Canada Research Chair diseases, viral infections and immunodeficiency. This year, Dr. Hua Gu, a in Human Retrovirology renowned senior immunologist, joined our research program. Dr. Gu’s work on Vibhuti P. Dave, PhD – Director, Lymphocyte Development (laboratory closed on December 31, 2010) antitumor immunotherapy will help strengthen our translational research.” 38 39 Javier Marcelo Di Noia, PhD – Director, Mechanisms of Genetic Diversity ÉRIC A. COHEN, PhD – Associate IRCM Research Professor – Canada Research Chair in Genetic Director of the Immunity and Viral Infections research program Diversity Director of the Human Retrovirology research unit Hua Gu, PhD – Director, Molecular Immunology – Full IRCM Research Professor Canada Research Chairholder in Human Retrovirology – André-Aisenstadt Chair of Excellence in Immunology Paul Jolicoeur, MD, PhD, MSRC – Director, Molecular Biology – Full IRCM Research Professor – Canada Research Chair in Studies of Pathogenesis of Retrovirus-Induced Diseases Woong-Kyung Suh, PhD – Director, Immune Regulation – Assistant IRCM Research Professor 2010-2011 André Veillette, MD, MSRC – Director, Molecular Oncology – Full IRCM Research Professor – Canada Research Chair in Immune System Signalling “our studies have led to a better 7 teams 17 publications by the program’s researchers understanding of immune cell 3 Canada Research Chairs 1 operating grant from the Canadian Institutes of Health regulation in normal and pathological 1 IRCM Research Chair Research (CIHR), $700,000: Éric A. Cohen conditions...”
  • 21. UNDER- Neurobiology and Development research program Understanding embryonic development and the nervous system Participating in ethical debates STANDING “Researchers in the Neurobiology and Development research program focus their efforts on understanding the cellular and molecular mechanisms that control the THE NERVOUS development of different organs. Certain groups are interested in mechanisms controlling cell proliferation, differentiation, polarity and death during the development of the nervous system, pituitary gland, limbs, bones, kidneys and institut de recherches cliniques de Montréal _ 2010-2011 annual report SYSTEM michel cayouette epithelial tissues, while others study hormone action mechanisms or guidance mechanisms that allow axons to find their target within a complex neural network. One of our teams also explores ethical questions related to neurosciences. Hence, our researchers’ work is based on simple reasoning: in order to better understand the pathology of diseases and develop effective therapeutic strategies, it is 40 Research units absolutely necessary to know, in detail, the mechanisms that control the normal 41 Michel Cayouette, PhD – Director, Cellular Neurobiology – Associate development of our organs. The knowledge acquired should thereby have a major IRCM Research Professor impact on diagnostic, prevention and treatment strategies.” Frédéric Charron, PhD – Director, Molecular Biology of Neural Development – Associate IRCM Research Professor MICHEL CAYOUETTE, PhD Jacques Drouin, D.Sc., MSRC – Director, Molecular Genetics – Full IRCM Director of the Neurobiology and Development research program Research Professor Associate IRCM Research Professor Director of the Cellular Neurobiology research unit David R. Hipfner, PhD – Director, Epithelial Cell Biology – Assistant IRCM Research Professor Marko Horb, PhD – Director, Molecular Organogenesis (laboratory closed 2010-2011 on June 1, 2011) Artur Kania, PhD – Director, Neural Circuit Development – Associate IRCM Research Professor Marie Kmita, PhD – Director, Genetics and Development – Assistant IRCM Research Professor – Canada Research Chair in Molecular 8 teams 3 operating grants from the Canadian Institutes of Health Embryology and Genetics Research (CIHR), $1.6 million: Michel Cayouette, Éric Racine, PhD – Director, Neuroethics – Associate IRCM Research 1 Canada Research Chair Jacques Drouin, Marie Kmita Professor 36 publications by the program’s researchers   1 grant of $120,000 from the Cancer Research Society: 1 scholarship holder from the Fonds de recherche du Frédéric Charron Québec — Santé (FRQS): Michel Cayouette 1 grant of $45,000 from Parkinson Society Canada: 1 New Investigator Award from the Canadian Institutes Jacques Drouin of Health Research (CIHR): David R. Hipfner