The document lists 5 things to inspect if your car's brakes lock up while driving: 1) damaged brake components like rotors, pads, and calipers, checking for rust or wear; 2) overheated brakes from overuse or aggressive braking; 3) a failed anti-lock braking system; 4) a damaged master cylinder; and 5) a lack of hydraulic fluid. It advises bringing your car to a mechanic to properly diagnose and fix the issue if brakes start locking up while driving.