Victoria Taylor, British Heart Foundation, "Bridging the gap between discovery and commercialisation: A charity's perspective" - slides from Journeys of Health-Tech Innovation: Products to Market
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Victoria Taylor, British Heart Foundation at "Journeys of Health-Tech Innovation" Nov 30th 2015
1. BRIDGING THE GAP BETWEEN
DISCOVERY AND
COMMERCIALISATION:
a charity’s perspective
Victoria Taylor – Research Translation Advisor
2. ♥ Research spend of approx.
£100m a year
♥ Traditionally hypothesis-
driven basic research
♥ Now have a Translational
Award to support
development of innovative
medicines and treatments
Who are we?
3. Why is BHF supporting translational
research?
Discovery
research
Pre-clinical
development
Clinical
development
Approval and
market
IndustryAcademia
IndustryFunding gapAcademia
Traditionally:
Now:
♥ Significant clinical unmet needs remain
♥ BHF now playing a key role to support early stage CV innovation
BHF Translational
Award
4. The BHF now has:
♥ A new Translational Award
♥ A Translational Advisory
Group
5. How did we get there?
♥ We did our own due diligence
♥ Sought advice from experts
♥ Found our niche
6. Aim: to de-risk projects so they attract
further investment:
Basic
research
Pre-clinical
development
Clinical
dev.
♥ We want to ensure projects we fund continue along the
development pathway (e.g. further charitable funding, industry
investment)
7. Experts help us select and shape
projects:
Translational
Award Advisory
Group
Scientific and
clinical
experts
♥ Key to our process: Flexibility, support, mentorship
8. Application tips:
♥ Target validation and clinical relevance
♥ Think beyond project you want funding for – what does your
proof of concept clinical trial look like? Have you spoken to the
regulatory agencies?
♥ Would it make sense to outsource some of the work?
♥ Competitive advantage (proof of relevance)
9. Project examples:
♥ Changing clinical end-points
♥ Fund regulatory consultant and FDA meeting to understand if
development plan is sensible
♥ Lead optimisation of a small molecule
♥ Outsource work and hire a project manager
Often the science is not the hurdle…
♥ 20 outlines 9 invited to full application so far made 4 awards
10. Next steps.. more than just a funding
scheme:
♥ Engaging with industry and
involving them early on in the
process
♥ Education workshops for
academics
♥ Mind-set change
Kickstart academic research – we have direct links with academia
Small award value
Pre-clinical development of novel technologies that address an unmet clinical need
Up to £250,000; milestone driven
The key differentiator for this award scheme is our commitment to support and mentor academics through the award process and beyond. We recognise the mind-set change required from basic science grants, so work closely and informally with academics, drawing on our Advisory Group’s experience and contacts to ensure that each project is designed with the right goals to ensure the best chance of success.
Backgrounds: VC, biotech, pharma, consultancy, CROs, patent attorneys
Expertise: pre-clinical development of small and large molecules, repurposing, devices, diagnostics, biomarkers, biologics; IP
Internal BHF Medical Directors
>650 principal investigators
30 KOLs (BHF Professors)
3 BHF Committees (Projects, Fellowships, Chairs & Programmes)
Strong relationships with international academics and clinicians
The BHF has a unique specialist expertise in CVS science.
It also has:
Substantial contacts in pharma, biotech, imaging, devices and diagnostic companies that can be shared
Regular updates of industry needs and changing priorities
Growing contacts with institutional/ VC investors to help with exit strategies at pre-clinical
Affiliations with other charities to help more continuous funding schemes