A biological Database is a convenient system to properly store, search and retrieve any type of data. It helps in easily handling and sharing large amounts of data. It contains information from genomics, proteomics, microarray gene expression, etc.

1. Presentation 1
On
Biological Databases
Code: BSBT205
Submitted By:
Name: Gunjit Setia
Date: 19 September 2019
Reg.No.:ASU2019010100022
Submitted To:
Dr. Atul Kathait
Apeejay Stya University

2. Contents
 Biological Database
 Types of Biological Database
 Names of Primary Databases
 File Format every Database
 Applications of Databases

3. What do you mean by Nucleotide Database?
 It is a convenient system to properly store, search and
retrieve any type of data.
 It helps in easily handling and sharing large amount of
data.
 It contain information from genomics, proteomics ,
microarray gene expression etc.

4. Variants of Biological Database
1. Primary Database
2. Secondary Database
3. Composite Database

5. Primary and Secondary Databases
Primary Databases Secondary Databases
• Contains original data
from the researchers.
• Public or open access
mostly.
• Eg: NCBI GenBank,
EmBL, DDBJ, etc
• It contains additional
information derived
from the analysis of data
available in primary
databases.
• Manually created or
automatically generated
data are available.
• Eg: TrEMBL, Pfam,
Profiles, Scop, CATH,
etc.

6. GenBank (Genetic Sequence Databank)
 It is a genetic sequence database at National Center
for Biotechnology Information (NCBI).
 Established in year 1982 and now maintained by
NCBI.
 DNA sequence can be submitted to GenBank using
several different methods.
 It contains publicly available nucleotide sequences
for more than 240000 named organisms, obtained
primarily through submissions from individual
laboratories and batch submissions from large scale
sequencing projects.

7. Gen Bank File Format
It consists of an annotation section and a sequence section. The start of the
annotation section is marked by a line beginning with the word ‘LOCUS’. The start
of sequence section is marked by a line beginning with the word ‘Origin’ and the
end of the section is marked by a line with only “//”.

8. European Molecular Biology Laboratory
(EMBL)
 It is a molecular biology research institution supported by 22
member states, four prospect and two associate member
states.
 It was created in 1974 and is an inter-governmental
organization funded by public research money from its
member states.
 Laboratory operates from 5 sites: main laboratory in
Hheidelberg, and outstations in Hinxton (The European
Bioinformatics Institute (EBI), in England).
 The EBIs Sequence Retrieval System (SRS) integrates and
links the main nucleotide and protein databases as well as
many other specialist molecular biology databases.
 All available resources can be accessed via the EBI home page
at http://www.ebi.ec.uk.

9. EMBL File Format
Some entries do not contain all of the line types, and some line types occur many
times in a single entry. Each entry must begin with an identification line (ID) and
end with a terminator line(//).