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NUTAS – Non-invasive Ultrasound
Tumor Ablation System
Shenyang Changjiangyuan Technology Development Co., Ltd.
Contents
NUTAS Introduction1
NUTAS R&D Process Introduction
NUTAS Working Principal of Breast
Cancer Treatment3
2
NUTAS Features and Advantages for
Breast Cancer Treatment4
Current Industry Products Situation
on International Market5
Contents
NUTAS Introduction1
NUTAS R&D Process Introduction
NUTAS Working Principal of Breast
Cancer Treatment3
2
NUTAS Features and Advantages for
Breast Cancer Treatment4
Current Industry Products Situation
on International Market5
Appearance and Composition
Appearance and Composition
The design of NUTAS adheres to the simple, practical concepts.
Both R&D process as well as manufacturing procedure is in strict
accordance with China National Standards (YY0592-2005) and
guiding principles for high-intensity focused ultrasound therapy
system (SFDA2003) issued by China Food and Drug
Administration (short for "CFDA"), and other relevant standards.
NUTAS mainly consists of FOUR parts
•Console Unit
•Therapy Body Unit
•Water Process Unit
•Ultrasound Positioning and Monitoring System
 Generating tumor therapy
scheme in real time
 Controlling therapeutic
ultrasound transmission
 Monitoring the whole therapy
progress in real time
Console Unit
Console Unit
Console Unit
Therapy Body Unit
The front part is called
Treatment Bed
It is the carrier when
NUTAS treating cancer
patients. The patients
lie prone on the bed
surface to receive
treatment.The back part is called Workstation.
On both sides of workstation, there is
Nurse Workstation including two scalable
LCD screens, which is
responsible for the real-time monitoring of patient status on the bed.
The main role of the upper central LCD of Workstation is to display the
therapeutic process in real time.
Therapy Body Unit
Therapy Body Unit
Tumor positioning and real-time
monitoring system,
Color Doppler Ultrasound
Diagnostic Instrument
Positioning of GTV
Real-time monitoring of the
therapeutic process
Tumor Positioning and Real-time
Monitoring System
Providing medium water to meet the standard for
ultrasound transmission in therapeutic process.
Water Process Unit
Contents
NUTAS Introduction1
NUTAS R&D Process Introduction
NUTAS Working Principal of Breast
Cancer Treatment3
2
NUTAS Features and Advantages for
Breast Cancer Treatment4
Current Industry Products Situation
on International Market5
Changjiangyuan Technology Development Co., Ltd. (short for "CJY
Technology") is a nationally recognized high-tech enterprise specializing in
research & development, production and sales of large-scale
sophisticated medical equipment. Since founding in 1999, CJY Technology has
established long-term cooperation with Tsinghua University, Institute of Acoustics,
Chinese Academy of Sciences, Harbin Institute of Technology, Beijing Jiaotong
University, and other well-known domestic universities. We have built up
integrative scientific research and production system of industry, academia,
research; and developed the world's leading Non-invasive Ultrasound Tumor
Ablation System (hereinafter referred to as "NUTAS").
CJY T echnology i s located in high-tech industrial development Zone,
Shenyang City, Liaoning Province, China. Since its establishment, the company
has been keeping innovation as development guidance, "healthy therapy" as
direction, cutting-edge technology as foundation and benefiting mankind as
ultimate goal. Taking advantage of existing technology, CJY Technology has built
modern enterprise integrating R&D, production, training and clinic of high-end
medical equipment. The picture shows the company's manufacturing base in
Shenyang.
Company Profile
The R&D center of CJY Ttechnology is supported by academicians of
International Academy of Medical and Biological Engineering Sciences
and Chinese Academy of Engineering as chief scientists, and composed of a
group of senior professors, young and middle-aged experts with outstanding
scientific research capacity, most of whom come from key universities including
Tsinghua University, Beijing Institute of Technology, Harbin Institute of
Technology, etc. These provide strong technical support for technological
upgrading and product evolution.
R&D Team
Ni Guangnan, academician of Chinese Academy of Engineering, and
Yang Zibin, academician of the International Academy of Medical and
Biological Engineering Sciences are
giving guidance in the technology.
R&D Process of NUTAS
2000
First generation
prototype
2005
Second generation
prototype
2006
• Proved by ISO9001 and 13485
preliminary inspection
• It is proved by the registration testing of
Wuhan medical instrument quality
supervision and Inspection Center of
CFDA.Clinical verifications are allowed.
core technology
upgrade
standardized
work
clinical
preparations
2007
Third generation
prototype
Animal experiments and
human body clinical
preparations
2008
Clinical verifications are carried
out in the First Affiliated Hospital
of China Medical University
clinical trials stage I
finished
2011
• Fourth generation
prototype
• Preparatory work for export
certification
2012
• Obtain CE certification
preparation
for export
With its original creativity, NUTAS is regarded as world's leading
digital medical product. Part of the patent certificates are
demonstrated.
Our company has obtained:
Intellectual Property of CJY Tech.
No. Description Type Appl.No.
1
A remote-control high intensity focused ultrasound
therapy system
Patent for
invention
CN200510086302
2
Tumor positioning method and device designed for
high intensity focused ultrasound transducer
Patent for
invention
CN200710123329
3 A high intensity focused ultrasound transducer
Patent for utility
models
CN200420059430
4
Water container structure of focused ultrasound
therapy system
Patent for utility
models
CN201420406679
5
Spherical focused ultrasound transducer with
mobile focal region
Patent for utility
models
CN201420427137
6
A high intensity focused ultrasound transducer
& B ultrasound transducer fixture
Patent for utility
models
CN200520023221
7 Treatment bed Design patent CN201130358757
8 Water process case Design patent CN201130358759
9 Console unit Design patent CN201130358841
Since the beginning of 2015, as the performance of NUTAS being perfected,
protecting intellectual property has accordingly become a more important
task for our further development, as a result of which an all-around
intellectual property protection strategy has been initiated. The patent filing
work starting on June 2015 intends to declare the accumulated technology
achievements over the past R&D as a whole so as to make a complete
intellectual property rights protection system. The latest submitted undergoing
patents are as follows:
Intellectual Property of CJY Tech.
No. Description Type
1
Body position detecting method based on ultrasound
images
Patent for invention
2
Control system based on spherical focused ultrasound
transducer with mobile focal region
Patent for utility models
3
Torque measurement device of transducer lifting and
rotation mechanism
Patent for utility models
4 A portable high precision sound field scanning system Patent for utility models
5
A whole water process unit of high intensity focused
ultrasound therapy system
Patent for utility models
6
Water process unit pipeline system of high intensity
focused ultrasound therapy system
Patent for utility models
7
Water process unit security system of high intensity
focused ultrasound therapy system
Patent for utility models
8 High precision sound field scanning system Patent for utility models
Intellectual Property of CJY Tech.
The patent declaring has been continuously undergoing at the moment. The first
phase we intend to declare 84 patents, during which the patents will be divided
according to specific circumstances, thus achieving 150 China National Patents
(30 China National Invention Patents included) so as to forge a fully preservation
for our technology.
Intellectual Property of CJY Tech.
1 Virtual control method applied for ultrasound therapy Patent for invention
2 Optimal selected treatment method based on cloud computing Patent for invention
3 A monitoring and controlling method for ultrasound emission power Patent for invention
4 A monitoring and controlling method for movement mechanism Patent for invention
5 A monitoring and controlling method for water process unit Patent for invention
6 A software architecture based on task scheduling module Patent for invention
7 A fast sound field scanning method Patent for invention
8 Real time fault diagnosis method applied for medical equipment Patent for invention
9 Multiple nodes system assessing method based on Ethernet Patent for invention
10 A symmetry protection method for upper and lower computer software system Patent for invention
11 A software protection method based on program slicing Patent for invention
12 Motion state monitoring method based on cloud computing Patent for invention
13 Interface details optimization method based on users ’behavior analysis Patent for invention
14 Optimal interface scheme generating method based cloud computing Patent for invention
15 Body position monitoring method based on ultrasound images Patent for invention
16 Serial port expansion method based on software stimulating Patent for invention
17 A method for optimizing heater’s function Patent for invention
18 A method for breast cancer treatment Patent for invention
19 Fast marking method for breast cancer Patent for invention
20 A airborne sensor images adjustment method for ultrasound tumor therapy system Patent for invention
21 A high precision tumor outline algorithm Patent for invention
22 A water process method for medical equipment Patent for invention
23 A method for ultrasound transducer driving circuits cascading Patent for invention
24 A sealed method for focused ultrasound transducer Patent for invention
25 A body model making method Patent for invention
26 An element connection process of focused ultrasound transducer Patent for invention
27 A laser tubes sealing method Patent for invention
28 An element installment method for focused ultrasound transducer Patent for invention
29 A body position detecting method Patent for invention
30 A voltage automatic adjustment method for focused ultrasound transducer Patent for invention
31 A skeleton structure of medical equipment Patent for utility models
32 A high precision three axis movement mechanism applied for medical equipment Patent for utility models
33 Degassed water applied for medical equipment Patent for utility models
34 A lifting and rotation mechanism applied for medical equipment Patent for utility models
35 A water tank structure applied for medical eqipment Patent for utility models
36 A clamp mechanism for holding Color Doppler Ultrasound probes Patent for utility models
37 A moveable bed surface applied for medical equipment Patent for utility models
38 Patients’ holding surface applied for medical equipment Patent for utility models
39 A focused ultrasound transducer bracket Patent for utility models
40 A Color Doppler Ultrasound probes installation mechanism Patent for utility models
41 A high precision swinging mechanism applied for medical equipment Patent for utility models
42 A monitor installation structure Patent for utility models
43 An energy feedback system for focused ultrasound transducer Patent for utility models
44 A cooler system for focused ultrasound transducer Patent for utility models
45 A shell monitoring system for large medical equipment Patent for utility models
46 Wire continuity testing case Patent for utility models
47 friction testing devices for rotating mechanism Patent for utility models
48 Navigation plug-in installment fastening device Patent for utility models
49 All-around fixers of vibration table Patent for utility models
50 The liner of stretch mechanism testing device Patent for utility models
51 Fast measurement device of wire rod radian Patent for utility models
52 Fast hole site measurement device Patent for utility models
53 Automation temperature cycling test device Patent for utility models
54 A sealed rubber and sealing box for focused ultrasound transducer Patent for utility models
55 A comprehensive performance device designed for testing for each medical equipment part Patent for utility models
56 A debugging box using for circuit board Patent for utility models
57 A focused ultrasound transducer array element conducting resin Patent for utility models
58 Hydrophone with temperature measurement function Patent for utility models
59 Temperature measuring device of thermocouple Patent for utility models
60 A high intensity focused ultrasound drive device based on single-end fly back converter Patent for utility models
61 A high intensity focused ultrasound drive device based on full bridge drive Patent for utility models
62 A high intensity focused ultrasound drive device based on half bridge drive Patent for utility models
63 A high intensity focused ultrasound drive device based on resonance frequency Patent for utility models
64 A high precision motion control system for medical equipment Patent for utility models
65 Water process control system Patent for utility models
66 A infrared temperature measuring device for surface Patent for utility models
67 A client access device applied to medical instrument Patent for utility models
68 A component coordinate the treatment of lymph nodes Patent for utility models
69 Patient position fixation device for medical equipment Patent for utility models
70 A fast packing box for NUTAS Patent for utility models
71 A control panel preventing touch errors applied to medical instrument Patent for utility models
72 A water container with camera Patent for utility models
73 A full adjustment bracket for camera Patent for utility models
74 A positioning equipment for color doppler ultrasound probe Patent for utility models
75 A non - standard quick pipe joint for medical equipment Patent for utility models
76 A patient body position detector Patent for utility models
77 A real-time monitoring device and system for a patient's posture Patent for utility models
78 A software protection method for HIFU system based on program slicing Patent for utility models
79 A water storage buffer device for focused ultrasound system Patent for utility models
80 A full range fixture for vibrating table Patent for utility models
81 A automatic sealing device for focused ultrasound transducer Patent for utility models
82 A fixing device for focused ultrasound transducer Patent for utility models
83 A ultrasound power control system Patent for utility models
84 An embedded software automatic upgrade system Patent for utility models
NUTAS is awarded the Liaoning Science and Technology Research
Achievement, which is identified as international advanced product in 2007.
Leadership Concern
NUTAS has drawn high and close attention from National
Development and Reform Commission, the Ministry of Science
and Technology and national leaders at all levels since its birth.
Over the years, leaders and relevant experts have spoken highly
of NUTAS, required active support from various fields in order to
form industrial scale as soon as possible.
In March 2007, as representative of Chinese high-tech
enterprises, CJY Technology was designated by the Ministry of
Science and Technology to participate in the "Sino-Russian
Friendship Year" in Moscow. At the meeting, Hu Jintao, former
State President and Putin, President of Russia made a special
trip to view the demonstration of NUTAS on site and listened to
our report. NUTAS gained the attention of two heads of states.
Hu Jintao, former State President and Putin, President of
Russia viewed NUTAS demonstration on site.
CJY Technology was
designated by State Council to
company with Wu Yi, Vice
Premier of State Council to
attend "World Economic
Forum" held in St. Petersburg
in June 2007.
As delegation member of 19
Chinese enterprises, CJY
Technology was the first to
conduct business cooperation
talks with the special
representative of Russian
President, and won a good
reputation in the world.
Wu Yi, former Vice Premier of the State Council, had a cordial
conversation with the leader of our company. She was listening to the
introduction of NUTAS.
Zeng Peiyan, former Vice Premier of the State Council, Li Keqiang former
Party Secretary of Liaoning province (current Premier of State Council), Chen
Zhengao, former Governor of Liaoning Province(current Minister of Ministry
of Housing and Urban-Rural Development)listened to the introduction of
NUTAS by our leader.
Xu Guanhua, former Minister of the Ministry of Science
and Technology took photos with our leader.
Xu Guanhua, former Minister of the Ministry of Science and
Technology had a cordial conversation with the leader of our company.
Sheng Guangzu, former Director of General Administration of
Customs learnt about NUTAS.
Zhang Wenyue, former Party Secretary of Liaoning province and Chen
Zhenggao, former Secretary of Shenyang Municipal Committee
visited our company.
Xu Weiguo, former vice Governor of Liaoning Province visited our
company.
Zengwei, former Secretary of Shenyang Municipal Committee
(Current Party Secretary of Liaoning province ) visited our company.
CJY Technology was invited to participate in "International Science, Innovation and
Technology Exhibition (INSITE) ".
1
In 2007, China high-tech enterprise representatives are chosen by the Ministry of Science and Technology to participate
in the "Sino-Russian Friendship Year". Among 400 outstanding enterprises in 54 high-tech Zone, 13 companies were
selected as high-tech enterprise representatives.Changjiangyuan Technology Development Co., Ltd is one of them,
which draw attention of heads of states during the exhibition.
2 From 2008 to 2009, NUTAS was listed in National Torch Plan of the Ministry of Science and Technology,
project number 2008GH040121.
3 In 2010, Changjiangyuan Technology Development Co., Ltd was identified as Ultrasound Research Center of Liaoning
province by provincial Science and Technology Department .
4 In 2007, NUTAS was listed in government science and technology plan of Liaoning province, project number
2007302001
5 In 2008, NUTAS was listed in government science and technology plan of Liaoning province, project number 2008226
6 In 2008, Changjiangyuan Technology Development Co., Ltd was listed in science and technology innovation
demonstration enterprises of Liaoning province, gaining strong suppot in two consecutive years.
7 From 2005 to 2008, NUTAS was listed in science and technology plan of Shenyang project number 1053112-1-
03 ,1071041-9-00
8 In 2006, NUTAS was listed in science and technology scheme of Shenyang Economic and Trade Commission, project
number released by Shenyang Economic and Trade Commission [2006]105
9 In 2008, NUTAS was listed in informatization and information industry development fund plan of Shenyang by
Shenyang Economic and Information Commission, project number 200801020
10 In 2007, NUTAS is listed in high-tech science scheme of Shenyang by Shenyang High-tech zone , project number
20071007
11 In 2009, NUTAS was listed in high-tech zone science and technology scheme of Shenyang high-tech zone, project
number 2009020
12 In 2010, NUTAS was listed in high-tech zone science and technology scheme of Shenyang high-tech zone, project
number released by High-tech Commission of Shenyang 【2010】2
13 In 2011, NUTAS was listed in information product manufacturing development special fund of Shenyang by Shenyang
Economic and Information Commission, project number Z201101024
14 In 2013, NUTAS was listed in Shenyang high-tech industry development project plan by Shenyang Development and
Reform Commission, project number released by Shenyang Development and Reform Commission [2013] 192
15 In 2013, NUTAS was listed in SME development fund project of central financial local characteristic industry by
Shenyang Finance Bureau.
NUTAS is listed in many national plans
Contents
NUTAS Introduction1
NUTAS R&D Process Introduction
NUTAS Working Principal of Breast
Cancer Treatment3
2
NUTAS Features and Advantages for
Breast Cancer Treatment4
Current Industry Products Situation
on International Market5
In 2012, there were 1.67
billion new breast cancer
diagnoses, taking up 25% of all
the new cancer cases.
Altogether there were 458
thousand patients died of
breast cancer in 2008, taking
up about 14% of all the cancer
death that year.
Currently, half of the
world’s new patients and 60%
of the death cases are from
developing countries. On the
whole, West Europe, North
Europe and North America still
share a high morbidity, while
the Mid-Africa and East Asia
are relatively low.
Source:
GLOBOCAN 2012.
Global breast cancer
incidence and
mortality statistics
Current Situation of Clinical Breast
Cancer Treatment
All the traditional therapies on
breast cancer, including most
adopted radiotherapy, chemotherapy
and the like not only fail to realize
complete ablation of cancer cells, but
also employ obvious side effects.
However, the traditional surgery
treatment is of high probability to
cause implantation metastasis to the
patients.
In medical world worldwide,
there is still no way to completely
ablate cancer cells so as to
perform radical cure of breast
cancer for good.
NUTAS realizes complete ablation of cancer cells, meanwhile it fulfills the
notion of
Healthy Treatment, should cause no damage or toxic/side effect to human body;
Non-invasive treatment, avoid damage to normal tissue or organs
caused by surgery or other invasive or interventional therapies;
Practicability, which achieves the complete ablation of cancer cells for only one
time treatment.
Being rigorous and responsible for the human beings and society as
always, CJY technology has been committed to NUTAS development for more
than 10 years, which makes it possible to ablate tumor non-invasively, safely
and quickly, thus truly realizing safety and effectiveness to cancer patients. As a
highly mature core technology and craftsmanship, NUTAS complies with the
standards of clinical trials to assess safety and effectiveness for medical
devices. For now, the system has achieved varieties of national patents, making
itself one of the latest digital medical equipment worldwide.
NUTAS Breakthrough on Breast Cancer
Treatment
NUTAS Working System
focal
point
body
surface
ultrasound
source
target tumor
tissue
ultrasound
emission
The working principle is to transmit ultrasound which is emitted
by focused ultrasound source through body surface with acceptable
energy of normal tissue, then energy is accumulated in a very small
area, so as to ablate diseased tissue instantly.
NUTAS Working System
Under the guidance of Color Doppler ultrasound images, NUTAS
automatically generates treatment scheme by using tumor
tomography recognition and 3D reconstruction technologies
according to the size, shape, boundary and position of tumor. Then,
by controlling the movement of focused ultrasound by Console Unit
to cover the whole tumor, the complete tumor ablation is
accomplished.
It can convert electrical
energy into mechanical
energy, which achieves
transmission of ultrasound
waves by vibration and
formation of focal point in
the target region.
The left picture shows
the phenomenon of water
column and water mist
occurring when ultrasound
focus is on horizontal plane.
Ultrasound Transducer
NUTAS Obtained CE Certificate in 2012
Contents
NUTAS Introduction1
NUTAS R&D Process Introduction
NUTAS Working Principal of Breast
Cancer Treatment3
2
NUTAS Features and Advantages for
Breast Cancer Treatment4
Current Industry Products Situation
on International Market5
1. Safety and No Side Effects
NUTAS can realize complete ablation of cancer
cells in focal area through one time treatment and
bring no damage to normal tissues both outside
focus and in the ultrasound path, which is a non-
invasive technology of tumor therapy without toxic
or side effects in the real sense.
NUTAS Features and Advantages for
Breast Cancer Treatment
2. No Sugery
Patients can fully avoid the pain and risk as well as
damage to the body caused by surgery, and will not suffer
implantation metastasis during process of surgery.
NUTAS Features and Advantages for
Breast Cancer Treatment
Breast Conservation
Treatment
(complete response of
primary lesions)
Invasive Surgery
(implantation metastasis
risks involved)
3. Non-invasive and traceless
Intact preservation of breast organ will make women
achieve perfect cosmetic effect, maintain f a m i l y
harmony and provide guarantee for happy marriages.
Necrotic cancer cells in human body will be
absorbed gradually, and does not need to take out or
remove during the entire treatment process. NUTAS
guarantees no change of breast appearance, and will
not lead to deformation of breast organ.
NUTAS Features and Advantages for
Breast Cancer Treatment
NUTAS Features and Advantages for
Breast Cancer Treatment
Advantages:
NUTAS can fully replace the functions of local
surgery during the treatment; enhance the possibility
of breast-conserving therapy substantially; realize
complete ablation of primary lesions; and avoid the
risks of implantation metastasis during the surgery
and harm to normal tissues. And it will also help
release the heavy psychological burden to patients
who are suffering from cancer. It is truly a technology
that can achieve non-invasive breast-conserving
treatment.
Contents
NUTAS Introduction1
NUTAS R&D Process Introduction
NUTAS Working Principal of Breast
Cancer Treatment3
2
NUTAS Features and Advantages for
Breast Cancer Treatment4
Current Industry Products Situation
on International Market5
Current Industry Products Situation on
International Market
Currently, world existing traditional ultrasound tumor therapeutic products are
generally for the treatment of benign tumor only. Those devices can`t achieve the
goal of complete necrosis of tumor cells as a result of inaccurate control of
therapeutic dose in the process of treatment. Moreover, followed with frequently
occurred adverse events and other problems, there is no guarantee for safety and
definite effect. Some products produced by Chinese domestic manufacturers which
had the registration pass issued by China Food and Drug Administration (CFDA)
before 2000 can't really meet the needs of curing disease and saving lives since
their failure to fulfill the requirements of related industry standards.
Therefore, China Food and Drug Administration(CFDA)issued "the
announcement of issuance of the requirements of related technology on High
Intensity Focused Ultrasound Ablation Devices”, Regulation SFDA.ME [2003] No.
222, which is used to standardize the supervision and management of high
intensity focused ultrasound treatment equipment; and in early 2010, clear notes
have been made on the official website of CFDA for those manufacturers who
haven`t carried out independent clinical research in accordance with its
requirements. The following is the important content of the original:
After finishing the product registration, the enterprises should continue to make a thorough
research on the clinical use of the device and complete the following work: the clinical trials
made after registration should be made for each indication, such as the independent clinical
trials on liver tumor, bone tumor, soft tissue tumor, breast tumor, and uterus tumor.
Analysis and process of adverse events and complaints (including measures, effects and
measures taken to the market in-use products). (the following picture is the screen shot
of CFDA official website)
However, till 2014 the manufacturers who had domestic registration pass in
early time have not carried out independent clinical research on single
disease in accordance with the requirements of above mentioned documents
and regulations, therefore, their registration certificates have been canceled
by CFDA and relevant products are not allowed for sales in domestic market.
(the following picture is the screen shot of CFDA official website)
(picture taken from CFDA official website)
So far, the only two domestic manufacturers with registration pass are
respectively from Chongqing and Beijing, whose ultrasound tumor treatment
products only treat with one single kind of benign tumor--uterine fibroid, and require
patients to give up fertility rights. Regarding Chongqing products for breast cancer
treatment, the note of CFDA official website was: "for breast cancer, indications
should be further refined and clinical research should be made after registration. The
clinical research scheme shall refer to the request of " Medical Equipment Clinical
Trial Regulations”... , clinical research report..., submit the file when extending the
registration."
——This shows that Chongqing products has not carried out
independent clinical research on breast cancer until now.
In the international market, ultrasound tumor treatment products produced by
GE, Philips, Siemens and other traditional medical manufacturing
giants are only for treatment of uterine
Current Industry Products Situation on
International Market
As the only enterprise who perform the real independent
clinic for breast cancer, till 2015 CJY Technology is one and
the only company to carry out independent clinical trials on
single disease strictly in accordance with CFDA guiding
principles for ultrasound tumor treatment system (SFDA.ME
[2003] No.222). After years of clinical validation, on the
condition of safety guarantee, the whole process of NUTAS
treatment requires no surgery, no side effects, no radiation,
no epidermis injury, and no trauma to tissues around the
tumor. NUTAS can not only complete ablation of tumor
cells in the target region, in the meantime, it can also avoid
implantation metastasis caused by surgery. NUTAS
treatment efficacy is proved to be precise and effective.
Especially for malignant tumor -- the treatment of breast
cancer, NUTAS, with international leading technology, can
effectively destroy malignant tumor cell structure and achieve
complete ablation through only one time treatment so that
the goal to perform radical cure of breast cancer has been
accomplished. Currently, NUTAS has already met the conditions of
breast-conserving therapy for breast cancer patients, which brings
health and hope to them, especially to young women, and has
become the preferred method of breast-conserving treatment.
Above all, different from traditional ultrasound tumor treatment products,
NUTAS uses a number of exclusive technologies such as digitization, ultrasound
control system, multi-axis and high precision motion control system to guarantee
the safety of treatment. Clinical results has shown there is no adverse reactions of
NUTAS treatment, which is far superior to similar products and completely
eradicates the damage problems caused by inaccurate dose control of other
products. NUTAS is the only safe, effective and non-invasive tumor ablation system
all over the world.
As the leading product of CJY Technology, NUTAS owns the entire
independent intellectual property rights. Identified by experts, NUTAS has
integrated microelectronics, computer science, digital technology, medical imaging
and processing, precision machinery manufacture and physics, biomedical
engineering, electronics, mechanics, materials science, and many other advanced
technologies, which fills the blank of domestic and abroad in using ultrasound to
treat tumors, and the technology has reached the world leading level. The
popularization and application of this technology will be of great significance in
improving the level of cancer treatment technology, and promoting "healthy
therapy" as well as the sustainable development of digital medical industry.
Conclusion
Thank you for your attention!

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Introduction to cjy nutas

  • 1. NUTAS – Non-invasive Ultrasound Tumor Ablation System Shenyang Changjiangyuan Technology Development Co., Ltd.
  • 2. Contents NUTAS Introduction1 NUTAS R&D Process Introduction NUTAS Working Principal of Breast Cancer Treatment3 2 NUTAS Features and Advantages for Breast Cancer Treatment4 Current Industry Products Situation on International Market5
  • 3. Contents NUTAS Introduction1 NUTAS R&D Process Introduction NUTAS Working Principal of Breast Cancer Treatment3 2 NUTAS Features and Advantages for Breast Cancer Treatment4 Current Industry Products Situation on International Market5
  • 5. Appearance and Composition The design of NUTAS adheres to the simple, practical concepts. Both R&D process as well as manufacturing procedure is in strict accordance with China National Standards (YY0592-2005) and guiding principles for high-intensity focused ultrasound therapy system (SFDA2003) issued by China Food and Drug Administration (short for "CFDA"), and other relevant standards. NUTAS mainly consists of FOUR parts •Console Unit •Therapy Body Unit •Water Process Unit •Ultrasound Positioning and Monitoring System
  • 6.  Generating tumor therapy scheme in real time  Controlling therapeutic ultrasound transmission  Monitoring the whole therapy progress in real time Console Unit
  • 8. Therapy Body Unit The front part is called Treatment Bed It is the carrier when NUTAS treating cancer patients. The patients lie prone on the bed surface to receive treatment.The back part is called Workstation. On both sides of workstation, there is Nurse Workstation including two scalable LCD screens, which is responsible for the real-time monitoring of patient status on the bed. The main role of the upper central LCD of Workstation is to display the therapeutic process in real time.
  • 11. Tumor positioning and real-time monitoring system, Color Doppler Ultrasound Diagnostic Instrument Positioning of GTV Real-time monitoring of the therapeutic process Tumor Positioning and Real-time Monitoring System
  • 12. Providing medium water to meet the standard for ultrasound transmission in therapeutic process. Water Process Unit
  • 13. Contents NUTAS Introduction1 NUTAS R&D Process Introduction NUTAS Working Principal of Breast Cancer Treatment3 2 NUTAS Features and Advantages for Breast Cancer Treatment4 Current Industry Products Situation on International Market5
  • 14. Changjiangyuan Technology Development Co., Ltd. (short for "CJY Technology") is a nationally recognized high-tech enterprise specializing in research & development, production and sales of large-scale sophisticated medical equipment. Since founding in 1999, CJY Technology has established long-term cooperation with Tsinghua University, Institute of Acoustics, Chinese Academy of Sciences, Harbin Institute of Technology, Beijing Jiaotong University, and other well-known domestic universities. We have built up integrative scientific research and production system of industry, academia, research; and developed the world's leading Non-invasive Ultrasound Tumor Ablation System (hereinafter referred to as "NUTAS"). CJY T echnology i s located in high-tech industrial development Zone, Shenyang City, Liaoning Province, China. Since its establishment, the company has been keeping innovation as development guidance, "healthy therapy" as direction, cutting-edge technology as foundation and benefiting mankind as ultimate goal. Taking advantage of existing technology, CJY Technology has built modern enterprise integrating R&D, production, training and clinic of high-end medical equipment. The picture shows the company's manufacturing base in Shenyang. Company Profile
  • 15. The R&D center of CJY Ttechnology is supported by academicians of International Academy of Medical and Biological Engineering Sciences and Chinese Academy of Engineering as chief scientists, and composed of a group of senior professors, young and middle-aged experts with outstanding scientific research capacity, most of whom come from key universities including Tsinghua University, Beijing Institute of Technology, Harbin Institute of Technology, etc. These provide strong technical support for technological upgrading and product evolution. R&D Team
  • 16. Ni Guangnan, academician of Chinese Academy of Engineering, and Yang Zibin, academician of the International Academy of Medical and Biological Engineering Sciences are giving guidance in the technology.
  • 17. R&D Process of NUTAS 2000 First generation prototype 2005 Second generation prototype 2006 • Proved by ISO9001 and 13485 preliminary inspection • It is proved by the registration testing of Wuhan medical instrument quality supervision and Inspection Center of CFDA.Clinical verifications are allowed. core technology upgrade standardized work clinical preparations 2007 Third generation prototype Animal experiments and human body clinical preparations 2008 Clinical verifications are carried out in the First Affiliated Hospital of China Medical University clinical trials stage I finished 2011 • Fourth generation prototype • Preparatory work for export certification 2012 • Obtain CE certification preparation for export
  • 18. With its original creativity, NUTAS is regarded as world's leading digital medical product. Part of the patent certificates are demonstrated.
  • 19. Our company has obtained: Intellectual Property of CJY Tech. No. Description Type Appl.No. 1 A remote-control high intensity focused ultrasound therapy system Patent for invention CN200510086302 2 Tumor positioning method and device designed for high intensity focused ultrasound transducer Patent for invention CN200710123329 3 A high intensity focused ultrasound transducer Patent for utility models CN200420059430 4 Water container structure of focused ultrasound therapy system Patent for utility models CN201420406679 5 Spherical focused ultrasound transducer with mobile focal region Patent for utility models CN201420427137 6 A high intensity focused ultrasound transducer & B ultrasound transducer fixture Patent for utility models CN200520023221 7 Treatment bed Design patent CN201130358757 8 Water process case Design patent CN201130358759 9 Console unit Design patent CN201130358841
  • 20. Since the beginning of 2015, as the performance of NUTAS being perfected, protecting intellectual property has accordingly become a more important task for our further development, as a result of which an all-around intellectual property protection strategy has been initiated. The patent filing work starting on June 2015 intends to declare the accumulated technology achievements over the past R&D as a whole so as to make a complete intellectual property rights protection system. The latest submitted undergoing patents are as follows: Intellectual Property of CJY Tech.
  • 21. No. Description Type 1 Body position detecting method based on ultrasound images Patent for invention 2 Control system based on spherical focused ultrasound transducer with mobile focal region Patent for utility models 3 Torque measurement device of transducer lifting and rotation mechanism Patent for utility models 4 A portable high precision sound field scanning system Patent for utility models 5 A whole water process unit of high intensity focused ultrasound therapy system Patent for utility models 6 Water process unit pipeline system of high intensity focused ultrasound therapy system Patent for utility models 7 Water process unit security system of high intensity focused ultrasound therapy system Patent for utility models 8 High precision sound field scanning system Patent for utility models Intellectual Property of CJY Tech.
  • 22. The patent declaring has been continuously undergoing at the moment. The first phase we intend to declare 84 patents, during which the patents will be divided according to specific circumstances, thus achieving 150 China National Patents (30 China National Invention Patents included) so as to forge a fully preservation for our technology. Intellectual Property of CJY Tech.
  • 23. 1 Virtual control method applied for ultrasound therapy Patent for invention 2 Optimal selected treatment method based on cloud computing Patent for invention 3 A monitoring and controlling method for ultrasound emission power Patent for invention 4 A monitoring and controlling method for movement mechanism Patent for invention 5 A monitoring and controlling method for water process unit Patent for invention 6 A software architecture based on task scheduling module Patent for invention 7 A fast sound field scanning method Patent for invention 8 Real time fault diagnosis method applied for medical equipment Patent for invention 9 Multiple nodes system assessing method based on Ethernet Patent for invention 10 A symmetry protection method for upper and lower computer software system Patent for invention 11 A software protection method based on program slicing Patent for invention 12 Motion state monitoring method based on cloud computing Patent for invention 13 Interface details optimization method based on users ’behavior analysis Patent for invention 14 Optimal interface scheme generating method based cloud computing Patent for invention 15 Body position monitoring method based on ultrasound images Patent for invention 16 Serial port expansion method based on software stimulating Patent for invention 17 A method for optimizing heater’s function Patent for invention 18 A method for breast cancer treatment Patent for invention 19 Fast marking method for breast cancer Patent for invention 20 A airborne sensor images adjustment method for ultrasound tumor therapy system Patent for invention 21 A high precision tumor outline algorithm Patent for invention 22 A water process method for medical equipment Patent for invention 23 A method for ultrasound transducer driving circuits cascading Patent for invention 24 A sealed method for focused ultrasound transducer Patent for invention 25 A body model making method Patent for invention 26 An element connection process of focused ultrasound transducer Patent for invention 27 A laser tubes sealing method Patent for invention 28 An element installment method for focused ultrasound transducer Patent for invention 29 A body position detecting method Patent for invention 30 A voltage automatic adjustment method for focused ultrasound transducer Patent for invention 31 A skeleton structure of medical equipment Patent for utility models 32 A high precision three axis movement mechanism applied for medical equipment Patent for utility models 33 Degassed water applied for medical equipment Patent for utility models 34 A lifting and rotation mechanism applied for medical equipment Patent for utility models 35 A water tank structure applied for medical eqipment Patent for utility models 36 A clamp mechanism for holding Color Doppler Ultrasound probes Patent for utility models 37 A moveable bed surface applied for medical equipment Patent for utility models 38 Patients’ holding surface applied for medical equipment Patent for utility models 39 A focused ultrasound transducer bracket Patent for utility models 40 A Color Doppler Ultrasound probes installation mechanism Patent for utility models 41 A high precision swinging mechanism applied for medical equipment Patent for utility models 42 A monitor installation structure Patent for utility models
  • 24. 43 An energy feedback system for focused ultrasound transducer Patent for utility models 44 A cooler system for focused ultrasound transducer Patent for utility models 45 A shell monitoring system for large medical equipment Patent for utility models 46 Wire continuity testing case Patent for utility models 47 friction testing devices for rotating mechanism Patent for utility models 48 Navigation plug-in installment fastening device Patent for utility models 49 All-around fixers of vibration table Patent for utility models 50 The liner of stretch mechanism testing device Patent for utility models 51 Fast measurement device of wire rod radian Patent for utility models 52 Fast hole site measurement device Patent for utility models 53 Automation temperature cycling test device Patent for utility models 54 A sealed rubber and sealing box for focused ultrasound transducer Patent for utility models 55 A comprehensive performance device designed for testing for each medical equipment part Patent for utility models 56 A debugging box using for circuit board Patent for utility models 57 A focused ultrasound transducer array element conducting resin Patent for utility models 58 Hydrophone with temperature measurement function Patent for utility models 59 Temperature measuring device of thermocouple Patent for utility models 60 A high intensity focused ultrasound drive device based on single-end fly back converter Patent for utility models 61 A high intensity focused ultrasound drive device based on full bridge drive Patent for utility models 62 A high intensity focused ultrasound drive device based on half bridge drive Patent for utility models 63 A high intensity focused ultrasound drive device based on resonance frequency Patent for utility models 64 A high precision motion control system for medical equipment Patent for utility models 65 Water process control system Patent for utility models 66 A infrared temperature measuring device for surface Patent for utility models 67 A client access device applied to medical instrument Patent for utility models 68 A component coordinate the treatment of lymph nodes Patent for utility models 69 Patient position fixation device for medical equipment Patent for utility models 70 A fast packing box for NUTAS Patent for utility models 71 A control panel preventing touch errors applied to medical instrument Patent for utility models 72 A water container with camera Patent for utility models 73 A full adjustment bracket for camera Patent for utility models 74 A positioning equipment for color doppler ultrasound probe Patent for utility models 75 A non - standard quick pipe joint for medical equipment Patent for utility models 76 A patient body position detector Patent for utility models 77 A real-time monitoring device and system for a patient's posture Patent for utility models 78 A software protection method for HIFU system based on program slicing Patent for utility models 79 A water storage buffer device for focused ultrasound system Patent for utility models 80 A full range fixture for vibrating table Patent for utility models 81 A automatic sealing device for focused ultrasound transducer Patent for utility models 82 A fixing device for focused ultrasound transducer Patent for utility models 83 A ultrasound power control system Patent for utility models 84 An embedded software automatic upgrade system Patent for utility models
  • 25. NUTAS is awarded the Liaoning Science and Technology Research Achievement, which is identified as international advanced product in 2007.
  • 26. Leadership Concern NUTAS has drawn high and close attention from National Development and Reform Commission, the Ministry of Science and Technology and national leaders at all levels since its birth. Over the years, leaders and relevant experts have spoken highly of NUTAS, required active support from various fields in order to form industrial scale as soon as possible. In March 2007, as representative of Chinese high-tech enterprises, CJY Technology was designated by the Ministry of Science and Technology to participate in the "Sino-Russian Friendship Year" in Moscow. At the meeting, Hu Jintao, former State President and Putin, President of Russia made a special trip to view the demonstration of NUTAS on site and listened to our report. NUTAS gained the attention of two heads of states.
  • 27. Hu Jintao, former State President and Putin, President of Russia viewed NUTAS demonstration on site.
  • 28. CJY Technology was designated by State Council to company with Wu Yi, Vice Premier of State Council to attend "World Economic Forum" held in St. Petersburg in June 2007. As delegation member of 19 Chinese enterprises, CJY Technology was the first to conduct business cooperation talks with the special representative of Russian President, and won a good reputation in the world.
  • 29. Wu Yi, former Vice Premier of the State Council, had a cordial conversation with the leader of our company. She was listening to the introduction of NUTAS.
  • 30. Zeng Peiyan, former Vice Premier of the State Council, Li Keqiang former Party Secretary of Liaoning province (current Premier of State Council), Chen Zhengao, former Governor of Liaoning Province(current Minister of Ministry of Housing and Urban-Rural Development)listened to the introduction of NUTAS by our leader.
  • 31. Xu Guanhua, former Minister of the Ministry of Science and Technology took photos with our leader.
  • 32. Xu Guanhua, former Minister of the Ministry of Science and Technology had a cordial conversation with the leader of our company.
  • 33. Sheng Guangzu, former Director of General Administration of Customs learnt about NUTAS.
  • 34. Zhang Wenyue, former Party Secretary of Liaoning province and Chen Zhenggao, former Secretary of Shenyang Municipal Committee visited our company.
  • 35. Xu Weiguo, former vice Governor of Liaoning Province visited our company.
  • 36. Zengwei, former Secretary of Shenyang Municipal Committee (Current Party Secretary of Liaoning province ) visited our company.
  • 37. CJY Technology was invited to participate in "International Science, Innovation and Technology Exhibition (INSITE) ".
  • 38. 1 In 2007, China high-tech enterprise representatives are chosen by the Ministry of Science and Technology to participate in the "Sino-Russian Friendship Year". Among 400 outstanding enterprises in 54 high-tech Zone, 13 companies were selected as high-tech enterprise representatives.Changjiangyuan Technology Development Co., Ltd is one of them, which draw attention of heads of states during the exhibition. 2 From 2008 to 2009, NUTAS was listed in National Torch Plan of the Ministry of Science and Technology, project number 2008GH040121. 3 In 2010, Changjiangyuan Technology Development Co., Ltd was identified as Ultrasound Research Center of Liaoning province by provincial Science and Technology Department . 4 In 2007, NUTAS was listed in government science and technology plan of Liaoning province, project number 2007302001 5 In 2008, NUTAS was listed in government science and technology plan of Liaoning province, project number 2008226 6 In 2008, Changjiangyuan Technology Development Co., Ltd was listed in science and technology innovation demonstration enterprises of Liaoning province, gaining strong suppot in two consecutive years. 7 From 2005 to 2008, NUTAS was listed in science and technology plan of Shenyang project number 1053112-1- 03 ,1071041-9-00 8 In 2006, NUTAS was listed in science and technology scheme of Shenyang Economic and Trade Commission, project number released by Shenyang Economic and Trade Commission [2006]105 9 In 2008, NUTAS was listed in informatization and information industry development fund plan of Shenyang by Shenyang Economic and Information Commission, project number 200801020 10 In 2007, NUTAS is listed in high-tech science scheme of Shenyang by Shenyang High-tech zone , project number 20071007 11 In 2009, NUTAS was listed in high-tech zone science and technology scheme of Shenyang high-tech zone, project number 2009020 12 In 2010, NUTAS was listed in high-tech zone science and technology scheme of Shenyang high-tech zone, project number released by High-tech Commission of Shenyang 【2010】2 13 In 2011, NUTAS was listed in information product manufacturing development special fund of Shenyang by Shenyang Economic and Information Commission, project number Z201101024 14 In 2013, NUTAS was listed in Shenyang high-tech industry development project plan by Shenyang Development and Reform Commission, project number released by Shenyang Development and Reform Commission [2013] 192 15 In 2013, NUTAS was listed in SME development fund project of central financial local characteristic industry by Shenyang Finance Bureau. NUTAS is listed in many national plans
  • 39. Contents NUTAS Introduction1 NUTAS R&D Process Introduction NUTAS Working Principal of Breast Cancer Treatment3 2 NUTAS Features and Advantages for Breast Cancer Treatment4 Current Industry Products Situation on International Market5
  • 40. In 2012, there were 1.67 billion new breast cancer diagnoses, taking up 25% of all the new cancer cases. Altogether there were 458 thousand patients died of breast cancer in 2008, taking up about 14% of all the cancer death that year. Currently, half of the world’s new patients and 60% of the death cases are from developing countries. On the whole, West Europe, North Europe and North America still share a high morbidity, while the Mid-Africa and East Asia are relatively low. Source: GLOBOCAN 2012. Global breast cancer incidence and mortality statistics
  • 41. Current Situation of Clinical Breast Cancer Treatment All the traditional therapies on breast cancer, including most adopted radiotherapy, chemotherapy and the like not only fail to realize complete ablation of cancer cells, but also employ obvious side effects. However, the traditional surgery treatment is of high probability to cause implantation metastasis to the patients. In medical world worldwide, there is still no way to completely ablate cancer cells so as to perform radical cure of breast cancer for good.
  • 42. NUTAS realizes complete ablation of cancer cells, meanwhile it fulfills the notion of Healthy Treatment, should cause no damage or toxic/side effect to human body; Non-invasive treatment, avoid damage to normal tissue or organs caused by surgery or other invasive or interventional therapies; Practicability, which achieves the complete ablation of cancer cells for only one time treatment. Being rigorous and responsible for the human beings and society as always, CJY technology has been committed to NUTAS development for more than 10 years, which makes it possible to ablate tumor non-invasively, safely and quickly, thus truly realizing safety and effectiveness to cancer patients. As a highly mature core technology and craftsmanship, NUTAS complies with the standards of clinical trials to assess safety and effectiveness for medical devices. For now, the system has achieved varieties of national patents, making itself one of the latest digital medical equipment worldwide. NUTAS Breakthrough on Breast Cancer Treatment
  • 43. NUTAS Working System focal point body surface ultrasound source target tumor tissue ultrasound emission The working principle is to transmit ultrasound which is emitted by focused ultrasound source through body surface with acceptable energy of normal tissue, then energy is accumulated in a very small area, so as to ablate diseased tissue instantly.
  • 44. NUTAS Working System Under the guidance of Color Doppler ultrasound images, NUTAS automatically generates treatment scheme by using tumor tomography recognition and 3D reconstruction technologies according to the size, shape, boundary and position of tumor. Then, by controlling the movement of focused ultrasound by Console Unit to cover the whole tumor, the complete tumor ablation is accomplished.
  • 45. It can convert electrical energy into mechanical energy, which achieves transmission of ultrasound waves by vibration and formation of focal point in the target region. The left picture shows the phenomenon of water column and water mist occurring when ultrasound focus is on horizontal plane. Ultrasound Transducer
  • 46. NUTAS Obtained CE Certificate in 2012
  • 47. Contents NUTAS Introduction1 NUTAS R&D Process Introduction NUTAS Working Principal of Breast Cancer Treatment3 2 NUTAS Features and Advantages for Breast Cancer Treatment4 Current Industry Products Situation on International Market5
  • 48. 1. Safety and No Side Effects NUTAS can realize complete ablation of cancer cells in focal area through one time treatment and bring no damage to normal tissues both outside focus and in the ultrasound path, which is a non- invasive technology of tumor therapy without toxic or side effects in the real sense. NUTAS Features and Advantages for Breast Cancer Treatment
  • 49. 2. No Sugery Patients can fully avoid the pain and risk as well as damage to the body caused by surgery, and will not suffer implantation metastasis during process of surgery. NUTAS Features and Advantages for Breast Cancer Treatment Breast Conservation Treatment (complete response of primary lesions) Invasive Surgery (implantation metastasis risks involved)
  • 50. 3. Non-invasive and traceless Intact preservation of breast organ will make women achieve perfect cosmetic effect, maintain f a m i l y harmony and provide guarantee for happy marriages. Necrotic cancer cells in human body will be absorbed gradually, and does not need to take out or remove during the entire treatment process. NUTAS guarantees no change of breast appearance, and will not lead to deformation of breast organ. NUTAS Features and Advantages for Breast Cancer Treatment
  • 51. NUTAS Features and Advantages for Breast Cancer Treatment Advantages: NUTAS can fully replace the functions of local surgery during the treatment; enhance the possibility of breast-conserving therapy substantially; realize complete ablation of primary lesions; and avoid the risks of implantation metastasis during the surgery and harm to normal tissues. And it will also help release the heavy psychological burden to patients who are suffering from cancer. It is truly a technology that can achieve non-invasive breast-conserving treatment.
  • 52. Contents NUTAS Introduction1 NUTAS R&D Process Introduction NUTAS Working Principal of Breast Cancer Treatment3 2 NUTAS Features and Advantages for Breast Cancer Treatment4 Current Industry Products Situation on International Market5
  • 53. Current Industry Products Situation on International Market Currently, world existing traditional ultrasound tumor therapeutic products are generally for the treatment of benign tumor only. Those devices can`t achieve the goal of complete necrosis of tumor cells as a result of inaccurate control of therapeutic dose in the process of treatment. Moreover, followed with frequently occurred adverse events and other problems, there is no guarantee for safety and definite effect. Some products produced by Chinese domestic manufacturers which had the registration pass issued by China Food and Drug Administration (CFDA) before 2000 can't really meet the needs of curing disease and saving lives since their failure to fulfill the requirements of related industry standards. Therefore, China Food and Drug Administration(CFDA)issued "the announcement of issuance of the requirements of related technology on High Intensity Focused Ultrasound Ablation Devices”, Regulation SFDA.ME [2003] No. 222, which is used to standardize the supervision and management of high intensity focused ultrasound treatment equipment; and in early 2010, clear notes have been made on the official website of CFDA for those manufacturers who haven`t carried out independent clinical research in accordance with its requirements. The following is the important content of the original:
  • 54. After finishing the product registration, the enterprises should continue to make a thorough research on the clinical use of the device and complete the following work: the clinical trials made after registration should be made for each indication, such as the independent clinical trials on liver tumor, bone tumor, soft tissue tumor, breast tumor, and uterus tumor. Analysis and process of adverse events and complaints (including measures, effects and measures taken to the market in-use products). (the following picture is the screen shot of CFDA official website)
  • 55. However, till 2014 the manufacturers who had domestic registration pass in early time have not carried out independent clinical research on single disease in accordance with the requirements of above mentioned documents and regulations, therefore, their registration certificates have been canceled by CFDA and relevant products are not allowed for sales in domestic market. (the following picture is the screen shot of CFDA official website)
  • 56. (picture taken from CFDA official website) So far, the only two domestic manufacturers with registration pass are respectively from Chongqing and Beijing, whose ultrasound tumor treatment products only treat with one single kind of benign tumor--uterine fibroid, and require patients to give up fertility rights. Regarding Chongqing products for breast cancer treatment, the note of CFDA official website was: "for breast cancer, indications should be further refined and clinical research should be made after registration. The clinical research scheme shall refer to the request of " Medical Equipment Clinical Trial Regulations”... , clinical research report..., submit the file when extending the registration." ——This shows that Chongqing products has not carried out independent clinical research on breast cancer until now. In the international market, ultrasound tumor treatment products produced by GE, Philips, Siemens and other traditional medical manufacturing giants are only for treatment of uterine
  • 57. Current Industry Products Situation on International Market As the only enterprise who perform the real independent clinic for breast cancer, till 2015 CJY Technology is one and the only company to carry out independent clinical trials on single disease strictly in accordance with CFDA guiding principles for ultrasound tumor treatment system (SFDA.ME [2003] No.222). After years of clinical validation, on the condition of safety guarantee, the whole process of NUTAS treatment requires no surgery, no side effects, no radiation, no epidermis injury, and no trauma to tissues around the tumor. NUTAS can not only complete ablation of tumor cells in the target region, in the meantime, it can also avoid implantation metastasis caused by surgery. NUTAS treatment efficacy is proved to be precise and effective.
  • 58. Especially for malignant tumor -- the treatment of breast cancer, NUTAS, with international leading technology, can effectively destroy malignant tumor cell structure and achieve complete ablation through only one time treatment so that the goal to perform radical cure of breast cancer has been accomplished. Currently, NUTAS has already met the conditions of breast-conserving therapy for breast cancer patients, which brings health and hope to them, especially to young women, and has become the preferred method of breast-conserving treatment.
  • 59. Above all, different from traditional ultrasound tumor treatment products, NUTAS uses a number of exclusive technologies such as digitization, ultrasound control system, multi-axis and high precision motion control system to guarantee the safety of treatment. Clinical results has shown there is no adverse reactions of NUTAS treatment, which is far superior to similar products and completely eradicates the damage problems caused by inaccurate dose control of other products. NUTAS is the only safe, effective and non-invasive tumor ablation system all over the world. As the leading product of CJY Technology, NUTAS owns the entire independent intellectual property rights. Identified by experts, NUTAS has integrated microelectronics, computer science, digital technology, medical imaging and processing, precision machinery manufacture and physics, biomedical engineering, electronics, mechanics, materials science, and many other advanced technologies, which fills the blank of domestic and abroad in using ultrasound to treat tumors, and the technology has reached the world leading level. The popularization and application of this technology will be of great significance in improving the level of cancer treatment technology, and promoting "healthy therapy" as well as the sustainable development of digital medical industry. Conclusion
  • 60. Thank you for your attention!