Details of blood, hemostasis, clotting factors, heavy menstrual bleeding, causes of heavy menstrual bleeding, treatment options of heavy menstrual bleeding and menorrhagia, mode of action of tranexamic acid.

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2. BLOOD
MENORRHAGIA
HEMOSTASIS
MAXNA (The Product)

3.  Blood is a specialized body fluid.
 Blood is the fluid pumped by the heart that
circulates throughout the body via the arteries,
veins, and capillaries
 Blood is a connective tissue. It provides
communication between the cells of different part
of the body and the external environment.
 An adult male of average size normally has about
5.6 liters of blood
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4.  The blood carries oxygen and nutrients to the
body tissues and removes carbon dioxide and
other wastes
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5.  Fluid, known as Plasma.(55%)
 Blood cells(45%), (Red cells,White cells,
Platelets.)
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11.  Gases
 Nutrients
 Hormones
 Heat
 Productive substances
 Clotting material
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12.  Respiration
 Nutrition
 Removal of waste products
 Regulation Of Body Temperature
 Hormones transportion
 Defense of body
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13.  HEMOSTASISHEMOSTASIS
 PlateletPlatelet
 FibrinogenFibrinogen
 SerumSerum
 IMMUNOLOGYIMMUNOLOGY
 LymphocytesLymphocytes
 PHAGOCYTOSISPHAGOCYTOSIS
 LuecocytesLuecocytes
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14.  Events in Hemostasis
 1) vasoconstriction
 2) platelet plug formation
 3) blood clotting
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16. 1) Acitvation of plasminogen into plasmin
2) Lysis of a clot or thrombus
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17. 1) Intrinsic – begins with activation of (Hagman)
Factor XII
2) Extrinsic – starts with tissue injury and release
ofTissue Factor (thromboplastin)
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18. I.I. FibrinogenFibrinogen
II.II. ProthrombinProthrombin
III.III. ThromboplastinThromboplastin
IV.IV. Ca++Ca++
V.V. Labile factorLabile factor
VI.VI. Number no longerNumber no longer
usedused
VII.VII. Stable factorStable factor
viii.viii. AntihaemophilicAntihaemophilic
factorfactor
ix.ix. Christmas factorChristmas factor
x.x. Stuart-prowerStuart-prower
fcatorfcator
xi.xi. PTAPTA
xii.xii. Hagman factorHagman factor
xiii.xiii. Fibrin stabilizingFibrin stabilizing
factorfactor
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19. BLOOD CLOT
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20. 1) Menstruation at regular cyclic intervals but with
excessive flow and duration
2) Total blood loss exceeding 80ml per cycle or
menses lasting longer than 7 days
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21.  Organic causes
 1)Infections= STDs
 2)PIDs
 Coagulation disorders
 Hepatic failure
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22.  Hypothyriodism
 Hyperthyriodism
 Anovulatory cycles
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23.  Uterine fibroids
 Endometrial hyperplasia
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24.  IUDs
 Steriod hormones
 Anticoagulatns
 PG E
 Progesterone
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25.  A)Drug treatment
 1)NSAIDs (20-24%)
 2)Antifibrinolytics (Tranexamic acid 58%)
 B)Hormones (progesterone30%) (COCP
43%)
 C)Surgical options(D&C)
(Hysterectomy)
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26.  Synthetic amino acid
 Tranexamic acid
 Antiplasminic
 Absorption 30-50% (oral)
 PHL ~1.4h
 Excreted unchanged through kidney
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27.  Maxna inhibits conversion of plasminogen to
plasmin by blocking the lysine binding sites of
plasminogen, hence prevents breakdown of clot.
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28. Tissue ThromboplastinTissue Thromboplastin BloodBlood
ThromboplastinThromboplastin
ProthrombinProthrombin
ThrombinThrombin
FibronogenFibronogen Fibrin or ClotFibrin or Clot
Tisse ActivitorTisse Activitor Blood ActivitorBlood Activitor
PLASMINOGENPLASMINOGEN
PLASMINPLASMIN
F.D.PF.D.P

29. PROTHROMBINPROTHROMBIN
FIBRINOGENFIBRINOGEN FIBRIN OR CLOTFIBRIN OR CLOT
TISSUE TTHROMBOPLASTINTISSUE TTHROMBOPLASTIN
THROMBINTHROMBIN
PLASMINOGENPLASMINOGEN
PLASMINPLASMIN
F.D.PF.D.P
BLOOD ACTIVITORBLOOD ACTIVITOR
BLOOD THROMBOPLASTINBLOOD THROMBOPLASTIN
TISSUE ACITVATORTISSUE ACITVATOR
COAGULATION & FIBRINOLYTIC SYSTEMCOAGULATION & FIBRINOLYTIC SYSTEM
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Lysine BindingLysine Binding
SiteSite
FIBRINFIBRIN

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32. PlasminogenPlasminogentPAtPA
FibrinFibrin
Maxna blocks
lysing-binding
site and
prevents
bleeding
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33.  To prevent blood loss in
 DUB
 IUd
 PPh
 APH
 During and after surgery.
 In trauma
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34.  Maxna capsulesMaxna capsules
 Moderate bleeding= 250-500mg 3-4 times daily
 Severe bleeding= 500-1000mg 3-4 times daily
 InjectionInjection
 250-500mg I.V or I.M 1-2 times daily.
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35.  Generally well tolerated
 May cause G.I. disorder, nausea, vomiting, and
headache after oral administration.
 Increased risk of adverse thrombotic events
 No increase risk of DVT.
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36.  Maxna capsules: 250mg *20’s
 Maxna capsules:500mg*20’s
 Maxna injection:500mg*10’s
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37. THANK YOU.THANK YOU.
GNKGNK
By Gul Nawaz Khan
gulnawazpk@gmail.com
0333-9151163
3737