Agenda slides of the Lorentz workshop "Biophysics, Biochemistry and Physiology of Fat Digestion"

1. Biophysics, Biochemistry and Physiology of Fat DigestionBiophysics, Biochemistry and Physiology of Fat Digestion
WELCOME
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Monday 16 September 2013
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• Welcome, overview, flash presentations
• Theme 1: Controlled fat digestion and health implications of fat
in food. Chair: Freddy Troost
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Tuesday 17 September 2013
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• Theme 2: Biophysics of fat digestion Chair: Peter Fischer
• Theme 3: Controlling fat digestion and modeling of fat digestion
Chair: Simeon Stoyanov
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Wednesday 18 September 2013
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• Theme 4: In vitro modeling of digestive processes in the gastro-
intestinal lumen Chair: George van Aken
• Boat trip at “Kaagse plassen”and Indonesian workshop dinner
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Thursday 19 September 2013
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• Theme 5: Bioaccessibility and pharmacokinetics of non-
triglyceride lipids Chair: Simeon Stoyanov
• Theme 6: Cholesterol, a functional lipid Chair: George van Aken
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Friday 20 September 2013
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• Theme 7: Designed food structures: Targets and Approaches
Chair: Peter Fischer

2. Biophysics, Biochemistry and Physiology of Fat Digestion
Monday 16 September 2013
Morning events
09.00 – 10.00 Arrival, office assignment, and coffee and tea
10.00 – 10.15 Welcome by Henriette Jensenius, Science Planning and
Evaluation, Lorentz Center
10.15 – 11.00 Overview, choices and coherence of the subjects of the
workshop George van Aken
11.00 – 12.00 Flash presentations: all students give a short one-slide
presentation of their posters
12.00 – 14.00 Lunch break and posters

3. Biophysics, Biochemistry and Physiology of Fat Digestion
Monday 16 September 2013
Afternoon events
Theme 1: Controlled fat digestion and health implications of fat in food,
Chair: Freddy Troost
14.00 – 14.45 Lecture: Ronald Mensink Dietary lipids and health
14.45 – 15.30 Lecture: Ad Masclee Studies on food intake regulation and
satiety in humans by targeted delivery of macronutrients in the
distal small intestine (ileal brake) a combined in vivo and ex vivo
approach
15.30-16.00 Coffee and tea break
16.00 – 17.30 Session: Is it possible to deliver an effective and feasible dose of
FA at the intended location in the human gastrointestinal tract?
Moderator: Harry Peters
17.30 - Wine and Cheese Party offered by the Lorentz Center

4. Biophysics, Biochemistry and Physiology of Fat Digestion
Tuesday 17 September 2013
Morning events
Theme 2: Biophysics of fat digestion,
Chair: Peter Fischer
09.00 – 09.45 Lecture: Frédéric Carrière Human digestive lipases:
biochemistry and contribution to gastrointestinal lipolysis
09.45 – 10.30 Lecture: Mischa Bonn Sapun Parekh Label free imaging
and visualization of lipolysis
10.30 – 11.00 Coffee and tea break
11.00 – 12.30 Session: How important is bile in fat digestion?
Moderator: Slavka Tcholakova
12.30 – 14.30 Lunch and informal discussions

5. Biophysics, Biochemistry and Physiology of Fat Digestion
Tuesday 17 September 2013
Afternoon events
Theme 3: Controlling fat digestion and modeling of fat digestion,
Chair: Simeon Stoyanov
14.30 – 15.15 Lecture: Nicolai Denkov Controlling fat digestion:
biophysical and chemical approaches
15.15 – 15.45 Coffee and tea break
15.45 – 17.15 Session: How can we control emulsion lipolysis, which
food factors are involved? Moderator: Peter Wilde

6. Biophysics, Biochemistry and Physiology of Fat Digestion
Wednesday 18 September 2013
Morning events
Theme 4: In vitro modeling of digestive processes in the gastro-intestinal
lumen, Chair: George van Aken
09.00 – 9.45 Lecture: Mans Minekus In vitro modeling of (fat) digestion,
existing models
09.45 – 10.30 Lecture: Tim Wooster How good are the models? Comparing in
vitro and in vivo fat digestion ad structure characterization.
Does the pylorus actually emulsify fat during trituration?
10.30 – 11.00 Coffee and tea break
11.00 – 11.45 Lecture: Andreas Steingötter In vivo studies of the
gastrointestinal tract: How does the digestive system actually
work according to in vivo MRI and probe studies?
11.45 – 12.30 Lecture: Alan Mackie Structure and function of the mucus
lining at the intestinal brush border
12.30 – 14.30 Lunch and informal discussions

7. Biophysics, Biochemistry and Physiology of Fat Digestion
Afternoon events
Theme 4 (continued),
Chair: George van Aken
14.30 – 15.15 Session: What is needed to translate in vitro modeled
digestion (of pure components) to in vivo digestion (of
whole foods)? Moderator: George van Aken
15.15 – 15.45 Coffee and tea break
15.45 – 17.15 Session continued
17.40 Departure by bus to boat (Zijldijk, Leiderdorp)
18.00 – 22.00 Boat trip at “Kaagse plassen”and Indonesian workshop
dinner
22.00 Return by bus from Leiderdorp to Leiden Central Station,
Lorentz Center and Hotel van der Valk
Wednesday 18 September 2013

8. Biophysics, Biochemistry and Physiology of Fat Digestion
Morning events
Theme 5: Bioaccessibility and pharmacokinetics of non-triglyceride lipids,
Chair: Simeon Stoyanov
09.00 – 09.45 Lecture: Véronique Préat Drug Research Institute, Louvain,
Belgium: The use of intestinal cell lines in digestion and
absorption studies
09.45 – 10.30 Lecture: Anette Müllertz In vitro gastric and intestinal lipolysis
models to assess lipid based drug delivery systems
10.30 – 11.00 Coffee and tea break
11.00 – 12.30 Session: To what extent can in vitro modeling help to predict
bioaccessability and pharmacokinetics?
Pharmacokinetics/Pharmacodynamics Moderator: Guus
Duchateau
12.30 – 14.30 Lunch and informal discussions
Thursday 19 September 2013

9. Biophysics, Biochemistry and Physiology of Fat Digestion
Afternoon events
Theme 6: Cholesterol, a functional lipid,
Chair: George van Aken
14.30 – 15.15 Lecture: Steven P. Wrenn Introducing the biological
functions of cholesterol: cellular lipid rafts and
cholesterol metabolism and housekeeping
15.15 – 15.45 Coffee and tea break
15.45 – 17.15 Session: Novel insights in the dynamics of whole body
cholesterol transport. Presenter/Moderator: Albert K.
Groen
Thursday 19 September 2013

10. Biophysics, Biochemistry and Physiology of Fat Digestion
Morning events
Theme 7: Designed food structures: Targets and Approaches,
Chair: Peter Fischer
09.00 – 09.45 Lecture: Evan Abrahamse & Bert van de Heijning Age
related aspects of lipid digestion
09.45 – 10.30 Lecture: Rob Hamer Approaches, what type of actions
and future directions are needed?
10.30 – 11.00 Coffee and tea break
11.00 – 12.30 Session: Heading for the future Moderator: Simeon
Stoyanov
12.30 – 12.45 Round off, conclusions (organizers)
12.45 Lunch and informal discussions
Friday 20 September 2013