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George Perry
Aaron Sorensen
Hunting Valley, Ohio 28 January 2012
 Alzheimer/Parkinson connection
 Toxic/Diabetic neuropathy
 Cytoskeletal protein ultrastructural localization
 Ubiquitin
 AβPP 695/770 expression
 Fatal Familial Insomnia
 Vascular involvement
 Oxidative damage and response
 In situ hybridization for AβPP
 AβPP processing: Aβ40/42
 Cell cycle reentry
 Mitochondria autophagy/fusion-fission
 Increased iron and copper link to oxidation
 Novel Prion diseases
 RNA as the major site of oxidative damage
 CITATIONS 5th
 PAPERS 2nd
 CITES/PAPER 18th
Rank Institution
Total
Cites
Number
of Papers
Cites Per
Paper
1 HARVARD UNIV 26351 578 45.59
2 DUKE UNIV 17640 345 51.13
3 MASSACHUSETTS GEN HOSP 14246 289 49.29
4 UNIV CALIF SAN DIEGO 11383 402 28.32
5 CASE WESTERN RESERVE UNIV 10666 453 23.55
6 UNIV WASHINGTON 9345 348 26.85
7 JOHNS HOPKINS UNIV 8607 260 33.1
8 UNIV TORONTO 8562 244 35.09
9 BRIGHAM & WOMENS HOSP 7923 115 68.9
10 UNIV CALIF LOS ANGELES 7847 280 28.03
11 WASHINGTON UNIV 7750 253 30.63
12 UNIV KENTUCKY 7715 270 28.57
13 UNIV SO CALIF 7585 251 30.22
14 VET ADM MED CTR 7504 183 41.01
15 VET AFFAIRS MED CTR 6423 194 33.11
16 COLUMBIA UNIV 6249 153 40.84
17 UNIV CALIF IRVINE 6120 184 33.26
18 ATHENA NEUROSCI INC 5990 49 122.24
19 UNIV S FLORIDA 5928 181 32.75
20 UNIV PENN 5876 269 21.84
 Citations 10th
 Papers 20th
 Cites/Paper 14th
Rank Institution Citations Papers Cites/paper
1 Harvard Univ 84,312 1,700 49.60
2 MAYO CLIN & MAYO FDN* 44,471 1,096 40.58
3 Univ Calif San Diego 39,157 1,089 35.96
4 Johns Hopkins Univ 37,754 1,029 36.69
5 UNIV CALIF LOS ANGELES 36,940 1,086 34.01
6 Washington Univ 35,915 761 47.19
7 Univ Penn 34,865 1,055 33.05
8 Univ Washington 32,210 798 40.36
9 NIA 31,850 718 44.36
10 Case Western Reserve Univ 31,640 688 45.99
11 Univ Pittsburgh 28,606 853 33.54
12 Univ Calif San Francisco 28,504 850 33.53
13 Brigham & Womens Hosp 26,759 418 64.02
14 Univ Kentucky 26,504 737 35.96
15 Columbia Univ 26,404 798 33.09
16 UCL 26,326 910 28.93
17 Massachusetts Gen Hosp 25,913 579 44.75
18 Univ Cambridge 24,829 636 39.04
19 NEW YORK UNIV 23,789 694 34.28
20 Stanford Univ 23,470 454 51.70
MAYO CLIN & MAYO FDN*: these statistics include all three locations (Rochester, MN; Jacksonville, FL; and
Scottsdale, AZ)
Rank Institution Citations Papers Cites/paper
1 Harvard Univ 84,312 1,700 49.60
2 MAYO CLIN & MAYO FDN* 44,471 1,096 40.58
3 Univ Calif San Diego 39,157 1,089 35.96
4 UNIV CALIF LOS ANGELES 36,940 1,086 34.01
5 Univ Penn 34,865 1,055 33.05
6 Johns Hopkins Univ 37,754 1,029 36.69
7 UCL 26,326 910 28.93
8 Karolinska Inst 20,753 859 24.16
9 Univ Toronto 20,316 856 23.73
10 Univ Pittsburgh 28,606 853 33.54
11 KINGS COLL LONDON 19,056 852 22.37
12 Univ Calif San Francisco 28,504 850 33.53
13 Univ Washington 32,210 798 40.36
14 Columbia Univ 26,404 798 33.09
15 Washington Univ 35,915 761 47.19
16 Univ Kentucky 26,504 737 35.96
17 NIA 31,850 718 44.36
18 NEW YORK UNIV 23,789 694 34.28
19 Duke Univ 19,148 690 27.75
20 Case Western Reserve Univ 31,640 688 45.99
MAYO CLIN & MAYO FDN*: these statistics include all three locations (Rochester, MN; Jacksonville, FL; and
Scottsdale, AZ)
Rank Institution Citations Papers Cites/paper
1 MIT 15,136 185 81.82
2 Baylor Coll Med 20,396 293 69.61
3 YESHIVA UNIV 19,406 299 64.90
4 Brigham & Womens Hosp 26,759 418 64.02
5 RIKEN 18,295 287 63.75
6 UT SOUTHWESTERN MED CTR 17,980 310 58.00
7 Max Planck Society 22,909 417 54.94
8 UNIV TEXAS SAN ANTONIO 15,325 294 52.13
9 CNRS 15,006 290 51.74
10 Stanford Univ 23,470 454 51.70
11 Harvard Univ 84,312 1,700 49.60
12 Univ Oxford 20,834 426 48.91
13 Washington Univ 35,915 761 47.19
14 Case Western Reserve Univ 31,640 688 45.99
15 Nathan S Kline Inst Psychiat Res 10,225 224 45.65
16 Massachusetts Gen Hosp 25,913 579 44.75
17 MRC 15,536 348 44.64
18 NIA 31,850 718 44.36
19 Univ Michigan 19,066 454 42.00
20 Cornell Univ 16,217 402 40.34
Looking at only the last year, Case is tied for 37th
Looking at the last three years, Case is 21st
 Sami Harik
 Raj Kalaria
 Lucilo Autilio-Gabetti
 Andrea Leblanc
 Steven Younkin
 Todd Golde
 Chris Eckman
 Peter Whitehouse (changed fields)
 Karl Herrup
 George Perry
 Lawrence Sayre
 Vern Anderson
 Mark Smith
For PD, Case is not ranked high enough to generate a chart showing
the other schools, and no one is ranked among the top 100
Last 20
Years
Last 10
Years
Last 5
Years
Last 3
Years
Last Year
Case PD
rank (# of
papers)
98 95 111 117 120
Looking at only the last year, Case would be tied for 32nd
A. Focus of Top Programs in AD
UCSD
UCSF
MGH
Karolinska
UCLA
UCL
Mayo
B. Focus of Science and Nature papers
C. Areas of greatest recent impact:
Imaging, MCI, biomarkers
1. Shared synergistic goals – to develop/maintain
novel areas
2. Institutional support
3. NIH and other major support - Alzheimer or
Udall Center
4. Philanthropy
5. Faculty development/retention
6. Excellent clinical foundation

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Brain Health Retreat, Case Western Reserve University

  • 1. George Perry Aaron Sorensen Hunting Valley, Ohio 28 January 2012
  • 2.  Alzheimer/Parkinson connection  Toxic/Diabetic neuropathy  Cytoskeletal protein ultrastructural localization  Ubiquitin  AβPP 695/770 expression  Fatal Familial Insomnia  Vascular involvement  Oxidative damage and response  In situ hybridization for AβPP  AβPP processing: Aβ40/42  Cell cycle reentry  Mitochondria autophagy/fusion-fission  Increased iron and copper link to oxidation  Novel Prion diseases  RNA as the major site of oxidative damage
  • 3.
  • 4.  CITATIONS 5th  PAPERS 2nd  CITES/PAPER 18th
  • 5. Rank Institution Total Cites Number of Papers Cites Per Paper 1 HARVARD UNIV 26351 578 45.59 2 DUKE UNIV 17640 345 51.13 3 MASSACHUSETTS GEN HOSP 14246 289 49.29 4 UNIV CALIF SAN DIEGO 11383 402 28.32 5 CASE WESTERN RESERVE UNIV 10666 453 23.55 6 UNIV WASHINGTON 9345 348 26.85 7 JOHNS HOPKINS UNIV 8607 260 33.1 8 UNIV TORONTO 8562 244 35.09 9 BRIGHAM & WOMENS HOSP 7923 115 68.9 10 UNIV CALIF LOS ANGELES 7847 280 28.03 11 WASHINGTON UNIV 7750 253 30.63 12 UNIV KENTUCKY 7715 270 28.57 13 UNIV SO CALIF 7585 251 30.22 14 VET ADM MED CTR 7504 183 41.01 15 VET AFFAIRS MED CTR 6423 194 33.11 16 COLUMBIA UNIV 6249 153 40.84 17 UNIV CALIF IRVINE 6120 184 33.26 18 ATHENA NEUROSCI INC 5990 49 122.24 19 UNIV S FLORIDA 5928 181 32.75 20 UNIV PENN 5876 269 21.84
  • 6.  Citations 10th  Papers 20th  Cites/Paper 14th
  • 7. Rank Institution Citations Papers Cites/paper 1 Harvard Univ 84,312 1,700 49.60 2 MAYO CLIN & MAYO FDN* 44,471 1,096 40.58 3 Univ Calif San Diego 39,157 1,089 35.96 4 Johns Hopkins Univ 37,754 1,029 36.69 5 UNIV CALIF LOS ANGELES 36,940 1,086 34.01 6 Washington Univ 35,915 761 47.19 7 Univ Penn 34,865 1,055 33.05 8 Univ Washington 32,210 798 40.36 9 NIA 31,850 718 44.36 10 Case Western Reserve Univ 31,640 688 45.99 11 Univ Pittsburgh 28,606 853 33.54 12 Univ Calif San Francisco 28,504 850 33.53 13 Brigham & Womens Hosp 26,759 418 64.02 14 Univ Kentucky 26,504 737 35.96 15 Columbia Univ 26,404 798 33.09 16 UCL 26,326 910 28.93 17 Massachusetts Gen Hosp 25,913 579 44.75 18 Univ Cambridge 24,829 636 39.04 19 NEW YORK UNIV 23,789 694 34.28 20 Stanford Univ 23,470 454 51.70 MAYO CLIN & MAYO FDN*: these statistics include all three locations (Rochester, MN; Jacksonville, FL; and Scottsdale, AZ)
  • 8. Rank Institution Citations Papers Cites/paper 1 Harvard Univ 84,312 1,700 49.60 2 MAYO CLIN & MAYO FDN* 44,471 1,096 40.58 3 Univ Calif San Diego 39,157 1,089 35.96 4 UNIV CALIF LOS ANGELES 36,940 1,086 34.01 5 Univ Penn 34,865 1,055 33.05 6 Johns Hopkins Univ 37,754 1,029 36.69 7 UCL 26,326 910 28.93 8 Karolinska Inst 20,753 859 24.16 9 Univ Toronto 20,316 856 23.73 10 Univ Pittsburgh 28,606 853 33.54 11 KINGS COLL LONDON 19,056 852 22.37 12 Univ Calif San Francisco 28,504 850 33.53 13 Univ Washington 32,210 798 40.36 14 Columbia Univ 26,404 798 33.09 15 Washington Univ 35,915 761 47.19 16 Univ Kentucky 26,504 737 35.96 17 NIA 31,850 718 44.36 18 NEW YORK UNIV 23,789 694 34.28 19 Duke Univ 19,148 690 27.75 20 Case Western Reserve Univ 31,640 688 45.99 MAYO CLIN & MAYO FDN*: these statistics include all three locations (Rochester, MN; Jacksonville, FL; and Scottsdale, AZ)
  • 9. Rank Institution Citations Papers Cites/paper 1 MIT 15,136 185 81.82 2 Baylor Coll Med 20,396 293 69.61 3 YESHIVA UNIV 19,406 299 64.90 4 Brigham & Womens Hosp 26,759 418 64.02 5 RIKEN 18,295 287 63.75 6 UT SOUTHWESTERN MED CTR 17,980 310 58.00 7 Max Planck Society 22,909 417 54.94 8 UNIV TEXAS SAN ANTONIO 15,325 294 52.13 9 CNRS 15,006 290 51.74 10 Stanford Univ 23,470 454 51.70 11 Harvard Univ 84,312 1,700 49.60 12 Univ Oxford 20,834 426 48.91 13 Washington Univ 35,915 761 47.19 14 Case Western Reserve Univ 31,640 688 45.99 15 Nathan S Kline Inst Psychiat Res 10,225 224 45.65 16 Massachusetts Gen Hosp 25,913 579 44.75 17 MRC 15,536 348 44.64 18 NIA 31,850 718 44.36 19 Univ Michigan 19,066 454 42.00 20 Cornell Univ 16,217 402 40.34
  • 10.
  • 11.
  • 12.
  • 13. Looking at only the last year, Case is tied for 37th Looking at the last three years, Case is 21st
  • 14.  Sami Harik  Raj Kalaria  Lucilo Autilio-Gabetti  Andrea Leblanc  Steven Younkin  Todd Golde  Chris Eckman  Peter Whitehouse (changed fields)  Karl Herrup  George Perry  Lawrence Sayre  Vern Anderson  Mark Smith
  • 15.
  • 16. For PD, Case is not ranked high enough to generate a chart showing the other schools, and no one is ranked among the top 100 Last 20 Years Last 10 Years Last 5 Years Last 3 Years Last Year Case PD rank (# of papers) 98 95 111 117 120
  • 17.
  • 18.
  • 19.
  • 20.
  • 21. Looking at only the last year, Case would be tied for 32nd
  • 22.
  • 23.
  • 24.
  • 25.
  • 26.
  • 27.
  • 28.
  • 29. A. Focus of Top Programs in AD UCSD UCSF MGH Karolinska UCLA UCL Mayo B. Focus of Science and Nature papers C. Areas of greatest recent impact: Imaging, MCI, biomarkers
  • 30. 1. Shared synergistic goals – to develop/maintain novel areas 2. Institutional support 3. NIH and other major support - Alzheimer or Udall Center 4. Philanthropy 5. Faculty development/retention 6. Excellent clinical foundation