Dr Gerry Chader - AGM 2011 - Research Advancements

Two Decades of Progress in Retinal Degeneration Research: 1990-2011 From Scientific Darkness to the Light of Clinical Trials ohenetihool L Gerald J. Chader, Ph.D., M.D.hc Doheny Eye Institute Los Angeles, CA USA os Angeles, CA University atlo October 22, 2009

What is Our Goal? ,[object Object]

How do we get to our Goal? ,[object Object],[object Object],[object Object],[object Object]

So Let’s look at some of the Progress in RP Genetics….. ,[object Object],[object Object],[object Object]

Genes for Rare Diseases ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Also, Progress in Cell Biology ,[object Object],[object Object],[object Object]

Now, What Are the Major Contributing Factors To The AMD Disease Process? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Basic Science Summary ,[object Object],[object Object],[object Object],[object Object],[object Object]

The first disease situation is… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

The second disease situation is… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

1) Photoreceptor Transplantation ,[object Object],[object Object],[object Object],[object Object]

1) Stem Cell Transplantation ,[object Object],[object Object],[object Object]

Q.: For RP, Can We Actually Transform Stem Cells into Mature Photoreceptor Cells? ,[object Object],[object Object]

Q.: Are There Sources of Stem Cells Other Than Embryonic? ,[object Object],[object Object],[object Object],[object Object]

In AMD, the Focus is on Stem Cells Replenishing the RPE Cell L ayer ,[object Object],[object Object],[object Object],[object Object]

Clinical Trials? ,[object Object],[object Object],[object Object],[object Object]

Future Treatment? ,[object Object],[object Object],[object Object],[object Object]

2 ) Artificial Vision ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Clinical Trials? ,[object Object],[object Object]

Status of Present SSMP Clinical Trial and Future Work to Restore More Useful Vision ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Testing: Object Recognition with Argus 1

Testing: Comparing Object Recognition using Argus 1 vs. Argus 2 Argus I (16 Electrodes)* Argus II (60 Electrodes) *AJO 2007, 143:820-827 Visual performance using a retinal prosthesis in three subjects with retinitis pigmentosa. Yani et al. 15 sec 2 sec

Argus II patients Can Read Letters and Words Courtesy Drs. da Cruz and Webster (Moorfields Eye Hospital, London)

Argus II Subjects Can Identify Numbers Courtesy Drs Sahel, Barale, Said, Scheer (Quinze-Vingts, Paris, France)

[object Object],[object Object],[object Object],Improvement in Orientation and Mobility Tasks with the Argus 2:

Future Treatments? ,[object Object],[object Object],[object Object]

This is NOT Vision of Terminator or Geordi from Star Trek…..Yet

3) Optical Photoswitches ,[object Object],[object Object],[object Object],[object Object]

Future Treatments? ,[object Object],[object Object],[object Object],[object Object]

Remember that the second disease situation is…… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

4) Neuroprotection ,[object Object],[object Object],[object Object],[object Object]

Neuroprotection: Clinical Trials? ,[object Object],[object Object],[object Object],[object Object]

Drugs: Valproic Acid ,[object Object],[object Object],[object Object],[object Object],[object Object]

For dry AMD , there Are Possible Treatments Using Small Molecule Drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

AMD: A Complex Disease ,[object Object],[object Object],[object Object]

5) Wet AMD Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

What’s New? ,[object Object],[object Object],[object Object],[object Object]

New Player in Field: VEGF Trap from Regeneron ,[object Object],[object Object],[object Object]

Trials using Gene Therapy: ,[object Object],[object Object],[object Object],[object Object]

6) Antioxidants ,[object Object],[object Object],[object Object]

Antioxidant Trial ,[object Object],[object Object],[object Object],[object Object],[object Object]

Are There Other Antioxidant Trials? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

7) Gene Therapy ,[object Object],[object Object],[object Object]

Extensive Preclinical Gene Therapy Studies ,[object Object],[object Object],[object Object]

Gene Therapy Clinical Trials ,[object Object],[object Object],[object Object],[object Object]

Future Treatments? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

In Conclusion…. ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],In Conclusion….

So, looking back on 1990-today…. ,[object Object],[object Object]

Another Wet AMD Clinical Trial - RPE Cell Transplantation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Other Trials include… ,[object Object],[object Object],[object Object],[object Object],[object Object]

Dr Gerry Chader - AGM 2011 - Research Advancements

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