Effects of shock

1. Case II - Shock
Fatima Al Awadh

2. Shock is a state of organ hypoperfusion with
resultant cellular dysfunction and death.
This deprives the organs and tissues of
oxygen and allows the buildup of waste
products.
Symptoms include altered mental status,
tachycardia, hypotension, and oliguria.

3. 4. What is the effect of this
kind of shock on the
kidneys, the heart, the
lungs, the brain and the
intestine?

4. Brain
Heart Lungs
Intestine
Kidneys

5. Low BP
activates activates
Hypothalamus
release
acts on
Aldosterone Release
Water/and Sodium retention
Decreased Urine Output;
Raised Urea and Creatinine
Baroreceptors
activates
Sympathetic Nervous System
causes
Vasoconstriction
causes
Decreased Renal Blood Flow
causes
Renin Release
Produces
Angiotensin II
causes
ADH
acts on

6. Critical Renal Hypoperfusion
results in
Kidney Injuries
Acute Tubular Necrosis
Renal Insufficiency

7. Brain
Heart Lungs
Intestine
Kidneys

8. Low BP
activates
Baroreceptors
activates
Sympathetic Nervous System
acts on
Raised Heart Rate, myocardial contractility, and vasoconstriction
Tachycardia; weak thready pulse

9. Coronary Hypoperfusion
acts on
Depress Contractility, and Worsen Myocardial Compliance
results in
Decreased Cardiac Output
initiating
A Vicious Cycle- Further Hypoperfusion

10. Brain
Heart Lungs
Intestine
Kidneys

11. Low pH
(why?)
activates
Chemoreceptors
activates
Respiratory Center
acts on
Raised Respiration Rate and Depth

12. Increased Membrane Permeability
leads to
Flooding of Alveoli
stimulates
Further Inflammation
acts on
Resistant Hypoxia
Acute Lung Injury; or
Acute Respiratory Distress Syndrome

13. Brain
Heart Lungs
Intestine
Kidneys

14. Low pH
causes
Restlessness (early)
Coma (late)
Neuronal Depression
leading to
Cerebral Hypoperfusion
Inhibation of metabolism and cell volume regulation
stimulates
leading to

15. Brain
Heart Lungs
Intestine
Kidneys

16. Low BP
activates
Baroreceptors
activates
Sympathetic Nervous System
causes
Vasoconstriction
causes
Decreased Blood Flow
acts on
leading to Decreased Motility
and Permeability

17. Decreased Motility
and Permeability
causes
Ileus and Submucosal Hemorrhage

18. The human body responds to acute
hemorrhage by activating some major
physiologic systems resulting in
changes in kidneys, heart, lungs, brain,
and intestine.

19. “Thank
You”