Fast-track the end of AIDS in the EU - practical evidence-based interventions.
Presentation by: Masoud Dara, WHO Regional Office for Europe
In a two-day meeting under the auspices of the Maltese Presidency of the Council of the European Union (30-31 January 2017), HIV experts from across the European Union discussed how to reverse this trend and how to prepare Europe to achieve the set target of ending AIDS by 2030.
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Fast-tracking the end of AIDS in Europe
1. Fast-tracking the end of
AIDS in Europe
Dr Masoud Dara
Coordinator, Communicable Diseases & Programme Manager, TB, HIV and viral Hepatitis
Division of Health Emergencies & Communicable Diseases
Fast-track the end of AIDS in the EU – practical evidence-based interventions
HIV Conference organised in collaboration with the ECDC
Malta, 30-31 January 2017
2. Outline
• Overview of HIV in the WHO European Region
• Key achievements and challenges
• New action plan for the health sector response to HIV
in the WHO European Region
• New developments and opportunities
• Next steps
3. • Region: 153 000 new HIV
diagnoses in 2015 (17.6/100
000): highest number and
rate ever
• East: 79% of new cases
(64% in Russian Federation
alone)
• Centre: rate more than
doubled
• West: modest decline
• EU/EEA: rate remained
largely stable
HIV remains a major public health issue in Europe
and of serious public health concern in the East
Source: ECDC/WHO. HIV/AIDS surveillance in Europe 2015; Russian Federal Scientific and Methodological Center for Prevention and Control of
AIDS. Information note ‘Spravka’ on HIV infection in the Russian Federation as of 31 December 2015.
Rate of new HIV diagnoses, by year of diagnosis, WHO European Region, 2006-2015
0
5
10
15
20
25
30
35
40
45
50
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
Casesper100000population
West
Centre
East
WHO European Region
4. New HIV diagnoses by transmission mode in
West, Centre and East, 2015
Source: ECDC/WHO. HIV/AIDS surveillance in Europe 2015; Russian Federal Scientific and Methodological Center for Prevention and Control of
AIDS. Information note ‘Spravka’ on HIV infection in the Russian Federation as of 31 December 2015.
0
2000
4000
6000
8000
10000
12000
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
0
200
400
600
800
1000
1200
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
0
10000
20000
30000
40000
50000
60000
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
Sex between men Injecting drug use
Heterosexual Mother-to-child
Other/undetermined
5. HIV increasing in natives and European
migrants, decreasing in non-European migrants
New HIV diagnoses among natives, European migrants and non-European migrants, WHO European Region, 2006-2015
Source: ECDC/WHO. HIV/AIDS surveillance in Europe 2015. Stockholm: ECDC; 2016.
Data from Bosnia and Herzegovina, Bulgaria, Estonia, Italy, Russia, Spain, Turkmenistan, Ukraine and Uzbekistan excluded due to inconsistent reporting or incomplete reporting on
country of birth and region of origin during the period.
• 47% increase among
natives
• 59% increase among
European migrants (mainly
among people from central
and eastern Europe)
• 29% decrease among non-
European migrants (mainly
among people from sub-
Saharan Africa) 0
5000
10000
15000
20000
25000
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
Natives (originating
from the reporting
country)
Non-European
migrants (originating
from outside the WHO
European Region)
European migrants
(originating from
another European
country)
6. Antiretroviral therapy (ART) coverage remains far
below global average in eastern Europe and central Asia
Source: UNAIDS/WHO estimates 2016
46%
16%
29%
41%
53%
55%
21%
72%
0% 10% 20% 30% 40% 50% 60% 70% 80%
Global average
Middle East and North Africa
Western and central Africa
Asia and the Pacific
Eastern and southern Africa
Latin America and Caribbean
Eastern Europe and central Asia
Western and central Europe
Percentage of people living with HIV receiving ART, 2015
7. HIV continuum of care
100%
58%
45%
31% 24%
0
50000
100000
150000
200000
250000
Estimated
PLHIV
Diagnosed
PLHIV
In care On ART Virally
suppressed
78%54%58% 90%
90%
90%
Ukraine 2015
Russia 2015
Switzerland 2013
Croatia 2014
100%
61%
48%
18% 15%
0
200000
400000
600000
800000
1000000
1200000
1400000
Estimated
PLHIV
Diagnosed
PLHIV
In care On ART Virally
suppressed
85%29%61%
90%
90%
90%
Sources: Ukrainian Center for Socially Dangerous Disease Control of the MOH of Ukraine. HIV Infection Bulletin no. 45. Kyiv, 2016. Russian Federal Scientific and Methodological Center for Prevention and Control of AIDS.
Information note ‘Spravka’ on HIV infection in the Russian Federation as of 31 December 2015. Kohler P et al. AIDS, 2015. Begovac J, Nemeth-Blazic T, Dominkovic Z,, Handanagic S, Lepej Zidovec S, Kosanovic ML,
Lukas D, Bozicevic I. The improving trend in the HIV continuum of care in Croatia in the period 2010-2014. 25th ECCMID, Amsterdam 2015, April 9-12. O265.
100%
81% 78% 71% 68%
0
2000
4000
6000
8000
10000
12000
14000
16000
Estimated
PLHIV
Diagnosed
PLHIV
In care On ART Virally
suppressed
96%
88%81%
90%
90%
90%
100%
76%
65% 61%
48%
0
200
400
600
800
1000
1200
1400
Estimated
PLHIV
Diagnosed
PLHIV
In care On ART Virally
suppressed
78%81%76% 90%
90%
90%
8. Tuberculosis is a common AIDS-defining illness in
the East of the Region but also in some EU countries
Source: ECDC/WHO. HIV/AIDS surveillance in Europe 2015. Stockholm: ECDC; 2016.
Countries that did not report AIDS (Sweden and Belgium) or reported no cases of TB as an AIDS-defining illness (Croatia, Cyprus, Estonia, Hungary, Luxembourg, Norway, Slovenia,
Slovakia) or did not report AIDS-defining illnesses at all (Greece) are not shown in the EU/EEA country specific figure.
Percentage of persons diagnosed with AIDS with TB as an AIDS-defining illness
0% 20% 40% 60% 80%
Hungary
Czech Republic
United Kingdom
Italy
Netherlands
Germany
Finland
Austria
Poland
France
EU/EEA average
Ireland
Spain
Denmark
Portugal
Bulgaria
Latvia
Romania
Malta
Lithuania
40%
East
16% in EU/EEA
13%
West
27%
Centre
9. Regional success: Elimination of mother-to-
child transmission of HIV and syphilis
Out of 5 countries who validated elimination globally, 3
countries are from the WHO European Region:
10. HIV in Europe: key challenges
• Lack of national strategies and political commitment in some countries
• Many people remain unaware of their infection
• Late HIV diagnosis and delayed linkage to care and treatment
• HIV treat-all approach not implemented in all countries
• Epidemic among MSM in Europe not under control despite significant efforts in
many countries
• Unequal access to harm reduction across the Region growing epidemics among
PWID in the East
• Cross-border collaboration and information exchange to ensure uninterrupted
access to services for all in need.
11. Action plans for the health sector response to HIV
• Zero new HIV infections, zero HIV-related
deaths and zero HIV-related
discrimination in a world where people
living with HIV are able to live long and
healthy lives
2030
Vision
• To end the AIDS epidemic as a public
health threat by 2030, within the context
of ensuring healthy lives and promoting
well-being for all at all ages
2030
Goal
Frameworks for action: Universal health coverage,
the continuum of services, a public health approach
12. Action plans for the health sector response to HIV
and viral hepatitis in the WHO European Region
Adopted by the 66th Session of Regional Committee in September 2016
• Provide a new framework for the next phase of the HIV
response in the Region
• Advocate for renewed political leadership, commitment and
partnerships
• Calls for fast-track actions to end AIDS as a public health
threat by 2030
• Ask countries to define and deliver an essential package of
interventions, prioritizing key populations and guided by the
local context
• Promotes comprehensive combination prevention and a
“treat all” approach
13. HIV: Science and innovation support ambitious
targets
New commodities (medicines,
rapid tests)
New technologies (mobile, point-
of-care)
New science (PrEP, Treat-All)
Service delivery (communities)
Strategic choices (targeted
testing, ART optimization)
New approaches (self-testing)
Global indicator set
Consistent cascades
Data for decision making
14. Global and regional strategies, plans, targets and
guidelines in place – moving to implementation
• Countries to review and
revise national HIV
strategies and targets
• Implement an essential
package of services
• Reinforce political
commitment and ensure
sustainable financing
• WHO to provide technical
leadership; facilitate
partnership and exchange
of best practices
• Monitor and report on
progress toward regional
and global targets
15. Towards ending AIDS in Europe
• Target the unreached – focus key populations
• Test early – treat all
• Foster innovation and community involvement
• Implement comprehensive combination prevention
• Scale up integrated people centered care
• Ensure sustainability of national HIV programmes
16. Thank you very much
for your attention
Acknowledgements:
• WHO: Annemarie Stengaard, Elena Vovc, Lali Khotenashvili, Martin
Donoghoe, Andrei Dadu.
• ECDC (joint HIV surveillance): Anastasia Pharris, Andrew Amato.
Contact: eurohiv@who.int
Notas do Editor
Few key points on the epidemic in the EU/EEA:
The HIV epidemic persists with little fluctuation in the rate per 100 000 population over the last decade
MSM account for the largest number of new HIV diagnoses and are the only population in the EU/EEA where HIV cases have not declined (both in native and foreign-born MSM)
Substantial decrease in cases transmitted through heterosexual contact, particularly among women. Part of this decline is probably the result of a decline in heterosexually-acquired cases in persons originating from countries with generalised HIV epidemics.
Migrants (persons originating from outside of the reporting country) constituted 37% of new HIV diagnoses in the EU/EEA. Evidence suggest that a considerable proportion of migrants, even those originating from HIV-endemic areas, acquire HIV after arrival in the EU/EEA.
Transmission among people who inject drugs continues to decline and remains at a low level in most countries, thanks to well-established harm reduction programmes.
West:
heterosexual decline even steeper among migrants
MSM the transmission category with no decrease
Centre:
MSM related transmission prevails in 10 of 13 countries
Heterosexual increase driven by one larger country (Turkey)
largest relative overall increase of the three Regions (133% increase)
East:
Transmission through injecting drug use remains substantial (declining in most countries but not in the Russian Federation where IDU related transmission remained the main transmission mode)
High percentage of undetermined tr.mode – due to Russia
MSM related transmission is underreported but a huge relative increase was observed during the decade (10-fold, not visible).
In 2015, 27% of new HIV diagnoses in the WHO European Region were among people originating from outside the reporting country (‘non-natives’), including 18% who originated from outside the European Region and 9% who originated from a European country other than the country of report.
Between 2006 and 2015, new diagnoses among non-natives decreased by 16% overall. However, among migrants originating from outside the WHO European Region, new diagnoses decreased by 29%, while among European migrants (i.e. people originating from a European country other than the country of report) new diagnoses increased by 59%.
There is evidence that a certain proportion of migrants, even those originating from HIV-endemic areas, acquire HIV after arrival in Europe. The extent to which the observed decreases can be explained by a lower incidence of HIV in migrant populations, reduced testing, changed migration patterns, or a combination of factors, is unclear.
Despite these decreasing trends, the public health challenge of ensuring access to health services for migrant populations in general, and to HIV prevention, testing, treatment and care services specifically, remains a public health priority.
Percentage of persons diagnosed with AIDS with TB as an AIDS-defining illness:
> 40% in four EU countries
< 10% or no cases in 14 EU/EEA countries
The good news is that progress has been made towards eliminating mother to child transmission of HIV and congenital syphilis.
Three European countries - Armenia, Belarus and Moldova - were awarded with elimination certificates at the High Level Meeting on HIV in New York in June this year. This is a notable achievement that we hope can be replicated in other areas and more countries and we know that many more are working towards validating elimination.
Bullet 1: National strategies, notably for viral hepatitis, do not need to be stand-alone strategies or plans but can well be integrated into broader health plans.
Bullet 3: Late detection and linkage to care/treatment has negative consequences for the effectiveness of antiretroviral treatment, AIDS incidence, mortality and the onward transmission of HIV to other people.
In response to an HIV epidemic that is moving faster than the current programmes established to address it;
considering the many remaining challenges in the current HIV response;
to support implementation of the Global Health Sector Strategy on HIV 2016-21:
A new action plan for the health sector response to HIV in the WHO European Region was developed and adopted by the 66 Session of Regional Committee in September 2016.
The Action plan is built around three organizing frameworks for action: universal health coverage; the continuum of HIV services; and the promotion of a public health approach in accordance with the Global Health Sector Strategy for HIV 2016-21.
The action plan also includes key regional targets for 2020, contributing towards achieving the 2030 goal:
Strengthening prevention efforts (reducing new infections by 75% or an appropriate numerical target for low-prevalence countries)
Scaling up testing and treatment – the global 90-90-90 targets (90% of people living with HIV know their HIV status; 90% of people diagnosed with HIV receive ART; 90% of people living with HIV on ART achieve viral load suppression)
Reduction of AIDS related deaths
Eliminating discrimination
Ensuring financial sustainability
The action plan calls for an urgent and accelerated people-centered fast-track response to HIV in the health sector.
It provides a new framework for the next phase of HIV response in the Region. It advocates to end the AIDS epidemic in the Region as a public health threat by 2030. It also calls for fast-track actions to stop the increasing rate of new HIV cases and reduce the public health burden of HIV. The Plan asks countries to define and deliver an essential package of interventions, focusing on key populations as defined by the local context. It promotes comprehensive, prevention and a “treat all” approach; universal health coverage, the continuum of HIV services supported by political leadership and partnerships. Each country is required to develop their national Action Plan.
We have new global strategies and regional action plans with targets and we have many new and updated WHO consolidated guidelines.
Now what needs to be done to implement the plans and reach the targets?
To accelerate progress towards ending the HIV/AIDS epidemic we need fast and immediate actions:
We must target all those who are not reached by expanding and optimizing the effective HIV testing approaches
We have to start testing early and assure treatment for all those in need.
We must implement evidence based preventive interventions.
We all have work towards scaling up people centered services.
We must ensure sustainability of HIV Programs and help reach universal health coverage.