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AUTOKOIDS
PROSTAGLANDIN’S
Prostaglandins
 Those agents/chemicals/local hormone which
are secreted from Prostate gland is called
prostaglandins.
 Also c/d Eicosanoids.
 Formed fromArachidonic acid.
 U.V.Euler got nobel prize for PG’s.
Membrane phospholipid
Arachidonic acid +2 O₂
[COX]
PGG₂
Cyclo [Peroxidase activity]
EndoPer PGH₂
OXIDASE
Isomerase Thromboxane Prostacyclin synthase
synthase
PGE₂ PGF₂α PGD₂ TXA₂ PGI₂
TxB₂ 6-keto PGF₁α
 Str. Of PG have –
.5 memb ring
.2 side chain
.A,B,C... Series-strl base
.subscripn1,2,3....-no. of double bond
.α- shows OH- grp orientation
COX
Cox-1 Cox-2 Cox-3
.GIT HEART- .Pain . C.C.of Brain
.Cnstitutive .Inflamn . Cox-3 is vari
.Basal-.Acid Inducible by .CK ent of Cox-1.
.Mucus .GF .Causes-.Fever
.House keeping .Other stimuli .Pain
.Hoemostatis
.maintain Renal
function
‘’All PG’s are derivative of Prostanic Acid’’
PATHWAY-
COX PATHWAY LOX PATHWAY
PG’s Formation LT’s Formation
Cyclic Str. Open chain Str.
Action,pathophysiological roles of
PG’s -
*Blood vessel – .PGE₂ -Vasodilation
.PGI₂ - vasodilatn , hypotentn
.PGF₂α- contraction
*‘PAD{Patent Arteriosus Ductus} - During faetal life PGE₂
keep Arteriosus ductus Patent(open).
*At birth PGE2 synthesis inhibit, then Ductus close.
*If ductus not closed after birth then called ‘Foramen Ovale
Disease’
*DRUG - .Indomethacin
.Aspirin Given after delivery if ductus not close
 Blood platelets -
TXA2 PGI2
Produced by platelets Produced by Endothelium
Cause agregation of
platelets
Do not agregate platelets
(potent inhibitor of platelet
agregation)
 Uterus- .PGF2α
.PGE2 Contraction
Pragnant & nonprgnt
 PGF2α is potent PG for abortion
these are used for terminate Pragnancy
*At term– PGF2α is found in maternal blood.
*Dismanhurrheia is due to PGE2.
.Aspirin- Prevention
.Methanemic acid -DOC
*PGF2α causes cervical ripening.
 GIT- .Longitudenal muscles_ E2
 F2α contrctn
 Circular ms. _E2 Relaxation
 F2α contraction
 PGE2- .Diarrhea
.watery fluid
. Acid secretion
. Antiulcergenic
 Specific drug-Mesoprostol
 DOC – PPI’s { Lansoprazole }
Classification of PG’s
Natural Analogue
Alprostadil Gemiprost
Dinoprostol Mesoprostol
Dinoprost Latanoprost
Prostacycline Carboprost
Travoprost
Bimatoprost
# F2 Analogue used in
Glaucoma treatment.
.Latanoprost
.Travoprost
.Bimatoprost
 Gemiprost , Carboprost
causes relaxation &
contraction . So used in
Abortion.
 Carboprost used in Post
Partam Haemorrhage.
 By- Drx Rishav Brijpuriya

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AUTOKOIDS assignment.pptx

  • 2. Prostaglandins  Those agents/chemicals/local hormone which are secreted from Prostate gland is called prostaglandins.  Also c/d Eicosanoids.  Formed fromArachidonic acid.  U.V.Euler got nobel prize for PG’s.
  • 3. Membrane phospholipid Arachidonic acid +2 O₂ [COX] PGG₂ Cyclo [Peroxidase activity] EndoPer PGH₂ OXIDASE Isomerase Thromboxane Prostacyclin synthase synthase PGE₂ PGF₂α PGD₂ TXA₂ PGI₂ TxB₂ 6-keto PGF₁α
  • 4.  Str. Of PG have – .5 memb ring .2 side chain .A,B,C... Series-strl base .subscripn1,2,3....-no. of double bond .α- shows OH- grp orientation
  • 5. COX Cox-1 Cox-2 Cox-3 .GIT HEART- .Pain . C.C.of Brain .Cnstitutive .Inflamn . Cox-3 is vari .Basal-.Acid Inducible by .CK ent of Cox-1. .Mucus .GF .Causes-.Fever .House keeping .Other stimuli .Pain .Hoemostatis .maintain Renal function ‘’All PG’s are derivative of Prostanic Acid’’
  • 6. PATHWAY- COX PATHWAY LOX PATHWAY PG’s Formation LT’s Formation Cyclic Str. Open chain Str.
  • 7. Action,pathophysiological roles of PG’s - *Blood vessel – .PGE₂ -Vasodilation .PGI₂ - vasodilatn , hypotentn .PGF₂α- contraction *‘PAD{Patent Arteriosus Ductus} - During faetal life PGE₂ keep Arteriosus ductus Patent(open). *At birth PGE2 synthesis inhibit, then Ductus close. *If ductus not closed after birth then called ‘Foramen Ovale Disease’ *DRUG - .Indomethacin .Aspirin Given after delivery if ductus not close
  • 8.  Blood platelets - TXA2 PGI2 Produced by platelets Produced by Endothelium Cause agregation of platelets Do not agregate platelets (potent inhibitor of platelet agregation)
  • 9.  Uterus- .PGF2α .PGE2 Contraction Pragnant & nonprgnt  PGF2α is potent PG for abortion these are used for terminate Pragnancy *At term– PGF2α is found in maternal blood. *Dismanhurrheia is due to PGE2. .Aspirin- Prevention .Methanemic acid -DOC *PGF2α causes cervical ripening.
  • 10.  GIT- .Longitudenal muscles_ E2  F2α contrctn  Circular ms. _E2 Relaxation  F2α contraction  PGE2- .Diarrhea .watery fluid . Acid secretion . Antiulcergenic  Specific drug-Mesoprostol  DOC – PPI’s { Lansoprazole }
  • 11. Classification of PG’s Natural Analogue Alprostadil Gemiprost Dinoprostol Mesoprostol Dinoprost Latanoprost Prostacycline Carboprost Travoprost Bimatoprost
  • 12. # F2 Analogue used in Glaucoma treatment. .Latanoprost .Travoprost .Bimatoprost  Gemiprost , Carboprost causes relaxation & contraction . So used in Abortion.  Carboprost used in Post Partam Haemorrhage.  By- Drx Rishav Brijpuriya