Cervical and broad ligament fibroids are rare; with incidence of only 2% and 1% respectively.
Cervical fibroid often present with pressure symptoms and often pose surgical difficulties due to its proximity to bladder and rectum.
Broad ligament fibroid though rare , but have the propensity of growing into large adnexal masses and may mimic ovarian malignancy.
2. Dr. Niranjan Chavan
MD, FCPS, DGO, DFP, MICOG, DICOG, FICOG
Professor and Unit Chief, L.T.M.M.C & L.T.M.G.H
Chairperson, FOGSI Oncology and TT Committee (2012-2014)
Treasurer, MOGS (2017- 2018)
Chair and Convener, FOGSI Cell- Violence against Doctors (2015-2016)
Chief Editor, AFG Times (2015-2017)
Editorial Board, European Journal of Gynecologic Oncology
Editor of FOGSI FOCUS, MOGS, AFG & IAGE Newsletters
Member, Managing Committee, IAGE (2013-2017)
Member , Oncology Committee, AOFOG (2013 -2015)
Recipient of 6 National & International Awards
Author of 15 Research Papers and 19 Scientific Chapters
Course Co-Ordinator, of 11 batches, of MUHS recognized Certificate Course of
Basic Infertility Management Including Endoscopy (BIMIE) at LTMGH
3. INTRODUCTION
• Fibroids(Myoma, Leiomyoma, Fibromyoma)
• Most common Monoclonal Benign tumors of
uterus arising in the smooth muscle cells of
myometrium.
• Contain large aggregation of extracellular
matrix consisting of collagen, elastin,
fibronectin and proteoglycan.
• Each fibroid is derived from smooth muscle
cells rests, either from vessel wall or uterine
musculature.
4. INCIDENCE
• Incidence of cervical fibroid is 2-3% and broad ligament fibroid is < 1%.
• 5-20% women in their reproductive age are reported to have fibroids.
• Most common----77% specimen of hysterectomy were having Fibroids
invariable number ,size (micro-macro) and site.
7. ETIOLOGY
GENETIC FACTORS
• Monoclonal
• 40% have chromosomal
abnormalities
• Translocation between
chromosome 12 and 14,
deletion of 7q, Trisomy of 12
HORMONAL FACTORS
• Both estrogen and progesterone
stimulates growth
• De novo production of estrogen in
fibroids
• Increased progesterone receptors
GROWTH FACTORS
They increase smooth muscle cell
proliferation, DNA synthesis and
angiogenesis
8. RISK FACTORS
• Age – incidence increases with age till on set of
menopause.
• Endogenous Hormonal factors
1. Early menarche
2. Late menopause
3. Hyper-estrogenic states
4. Increased expression and responsiveness of
progesterone receptors A & B.
• Family History—1st degree relatives are having 3.5 times
more risk of developing fibroids.
9. • Body weight
• Diet—diet rich in red meat, ham, beef
• Exercise – women doing regular exercise low risk
• OCS --- no definite relationship.
• ERT—variable reports
• Pregnancy
• Smoking
11. BROAD LIGAMENT FIBROID
• Extremely rare (< 1%).
• Broad ligament fibroids are divisible into two
types:
• True broad ligament fibroids: These spring
from the muscle fibers normally found in the
mesometrium. Such tumors may be found in at
least three situations, (1) In the round ligament, (2)
In the utero-ovarian ligament, and (3) In the
connective tissue surrounding the ovarian and the
uterine vessels.
• False broad ligament fibroids: These originate
mostly from the lateral walls of the uterus or cervix
12.
13. BROAD LIGAMENT FIBROID
True Broad Ligament False Broad Ligament
Originates from the muscle fibres
normally found in the mesometrium
(in the round ligament, ovario-
uterine ligament, and the connective
tissue around the uterine and
ovarian vessels)
Arises from the lateral wall of the
uterine corpus or of the cervix, and
bulges outward between the layers
of the broad ligament.
Ureter is medial to mass Ureter is lateral to mass
No groove felt between mass and
uterus
Groove felt between mass and
uterus
14. BROAD LIGAMENT FIBROID:
SYMPTOMS
• Often symptomatic
• Abdominal distension
• Menstrual irregularities
• Dysmenorrhoea
• Dyspareunia
• Broad ligament fibroids may extent laterally
and compress the ureter , causing pressure
symptoms like retention , increased
frequency etc.
15. BROAD LIGAMENT FIBROID:
DIAGNOSIS
• Transvaginal ultrasound : a typical leiomyoma
usually has a whorled appearance is seen.
“Bridging vessel sign” confirms uterine
origin.
• Ultrasound-guided percutaneous biopsy of the
tumour may be helpful for determining its exact
histologic composition before surgery.
16. BROAD LIGAMENT FIBROID:
DIAGNOSIS
• Magnetic resonance imaging (MRI),
with its multiplanar imaging
capabilities, may be extremely useful
for differentiating broad ligament
fibroids from masses of ovarian or tubal
origin and from broad ligament cysts.
17. BROAD LIGAMENT FIBROID :
DIFFERENTIAL DIAGNOSIS
• Parasitic leiomyoma involving the broad
ligament
• Pedunculated subserosal
leiomyoma projecting towards the broad
ligament
• Tubo - ovarian mass
• Hydrosalphinx
• Ectopic Pregnancy
18. • Solid ovarian neoplasms: particularly those
with dominant fibrous components
• Ovarian fibroma: fibrothecoma: tend to
inseparable from the ovary
• Brenner tumour: tend to be inseparable
from the ovary
• Malignant ovarian tumour
• Other ligamentous mesenchymal tumours
• Neurofibroma in the pelvis
19. BROAD LIGAMENT FIBROID:
COMPLICATIONS
• Torsion
• Psuedo meg syndrome
• Cystic degeneration mimicking ovarian
malignancy
• As broad ligament fibroids grow very
big in size, necrosis can occur in fibroid
causing symptoms of acute abdomen
• Huge broad ligament fibroid may cause
hydroureter and hydronephrosis.
21. Broad ligament myomectomy may be
preferred:
1. Large fibroids, or produce symptoms of
oppression.
2. Broad ligament fibroids are not associated
with uterine fibroids,
3. Suspected degeneration particularly
suspect.
4. Young patients, who need to preserve
fertility.
BROAD LIGAMENT FIBROID:
MANAGEMENT
22. BROAD LIGAMENT FIBROID:
MANAGEMENT
Hysterectomy is preferred in
following cases :
1. Family complete
2. Large no of fibroids in uteri along
with broad ligament fibroid
3. Suspected malignant fibroids.
4. Associated with endometrial
lesions.
5. Severe cervical lesions.
23. CASE REPORT
• A 45yr old P2L2 presented with complaints of heaviness in abdomen,
irregular heavy menses and dysmenorrhea , since 2 – 3 months
• On Examination:
P/A – soft, non tender
P/S - cervix , vagina healthy
P/V – uterus bulky firm mobile, AV, soft to cystic mass 10X 8 cm in left and
posterior fornix separate from uterus. Right fornix free and non tender.
P/R – bogginess felt anteriorly, rectal mucosa and parametrium free.
• Tumor Marker - WNL
24. CASE REPORT
• USG Pelvis: solid, hypoechoic, well-circumscribed right adnexal
mass of size 11.2 X 9 cm
25. CASE REPORT
• Intra-operatively, an abdomino-pelvic mass of
size approximately 11cm × 8 cm × 5cm was
seen with variable consistency and increased
vascularity, arising from the left side of the
uterus pushing the ureter laterally.
• Left fallopian tube, ovarian ligament, and
round ligament stretched over the mass. Left
ovary was normal.
• Right tube and ovary were normal.
• The mass was loosely adherent to the small
bowel loops.
28. CERVICAL FIBROID
• Cervical myomas accounts for 2% of all
uterine fibroids .
• They are classified depending on the location
into anterior , posterior, lateral and central
cervical myomas.
• Supravaginal cervical fibroid may be
interstitial or sub-peritoneal variety and
rarely polypoidal.
• Vaginal cervical fibroid is usually
pedunculated and rarely sessile.
29. CERVICAL FIBROID : SYMPTOMS
• Chronic pelvic pain
• Menstrual irregularities
• Dyspareunia
• Pressure symptoms
1. Anterior cervical fibroid produces symptoms like frequency or even
retention of urine. Retention is more due to pressure than the
elongation of the urethra.
2. Rectal symptoms are more common with posterior cervical fibroid
in the form of constipation
3. Lateral cervical fibroid causes vascular obstruction which may lead
to hemorrhoids and edema of legs (rare).
• Maternal dystocia, though rare during pregnancy
30. CERVICAL FIBROID: DIAGNOSIS
ULTRASONOGRAPHY
• Most readily available and is least costly
• It is reasonably reliable for evaluation of uterine volume less than
375 cc and containing four or fewer fibroids.
• Transvaginal sonography (sensitivity 83%, specificity 90%)
• Saline infusion sonography (sensitivity 90%, specificity 89%)
MRI
• Submucous fibroids are bets identifies with MRI.
• It can also evaluate the proximity of fibroid to the bladder, rectum
and endometrial cavity, thus giving a fair idea what can be
expected in surgery.
CT SCAN
31. CERVICAL FIBROID :DIFFERENTIAL
DIAGNOSIS
• Cervical polyp
• Pedunculated submucous fibroid
• Cervical cancer
• Lymphoma of the cervix: extremely rare
• Melanoma of the cervix: rare; usually involves
the vagina with invasion into the cervix
32. CERVICAL FIBROID : MANAGEMNT
• Treatment of cervical fibroid depends on the size , location and
the desire for fertility of patients.
• Preoperative GnRH analogues administration for 3 months
facilitate surgery and improve the haemoglobin status .
• In vaginal part fibroids if the tumour is sessile, myomectomy and
if pedunculated ,polypectomy is done.
33. CERVICAL FIBROID : MANAGEMNT
• For lateral fibroids if patient is desirous of fertility,
myomectomy may be attempted .
• For central fibroids, hysterectomy is required which may be
done laparoscopically or by open surgery or by vaginal route if
the size of the fibroid is small.
34. Victor Bonney was born in West London in
1872: both his father and his paternal
grandfather were family doctors.
He was on the Council of the Royal College
of Surgeons of England for a long time.
Bonney's professional achievements and his
fame among colleagues were firstly for his
extraordinary performance of 500
Wertheim radical extended hysterectomy
operations for cancer of the cervix and,
secondly, for his development of the
conservative operations of myomectomy
and ovarian cystectomy.
40. • A 55 year old female P3 L3 presented in
September, 2010 in Dr N N Chavan Unit with
complaints of mass coming out of vagina with
acute retention of urine .
• Case was suspected to a case of chronic uterine
inversion.
• The mass was ulcerated for which Acriflavine –
glycerine packing was done daily for a week.
• Patient was prepared for vaginal hysterectomy.
CASE REPORT 1
43. CONCLUSION
• Cervical and broad ligament fibroids are rare; with incidence of only
2% and 1% respectively.
• Cervical fibroid often present with pressure symptoms and often pose
surgical difficulties due to its proximity to bladder and rectum.
• Broad ligament fibroid though rare , but have the propensity of
growing into large adnexal masses and may mimic ovarian
malignancy.
44. • The choice of operation depends on the size , location and the family
status of the concerned patient.
• Both cervical and broad ligament can be managed by myomectomy or
hysterectomy either by laparoscopy or by open surgery .
45.
46. REFERENCES
1. Uterine leiomyomata. American College of Obstetricians and Gynecologists (ACOG) Technical
Bulletin. Number 192, May 1994
2. Monaghan JM, Lopes AB, Naik R. Total hysterectomy for cervical and broad ligament fibroids.
In: Huxley R, Taylor S, Chandler K, editors. Bonney's Gynaecological Surgery, 10th ed. Maiden,
USA: Blackwell Publishing Company; 2004. p.74-86.
3. Buttram VC Jr, Reiter RC. Uterine leiomyomata: etiology, symptomatology, and management.
Fertil Steril 1981; 36:433.
4. 1.Tiltman, Andrew J. Leiomyomas of the uterine cervix: A Study of frequency. International
Journal of Gynecological Pathology 1998; 231-4. 2.Kumar P, Malhothra N. Tumours of the
corpus uteri. In: Jeffcoate’s Principles of Gynecology. 7th Ed.; Jaypee Brothers Medical
Publisher (Pvt.) Ltd. New Delhi. 2008;p 487-516.
5. Barek JS. Novack's Gynaecology. 15th ed. New Delhi: Lippincott Williams and Wilkins, Wolters
Kluwer (India); 2007. Benign diseases of the female reproductive tract; p. 470.
6. 3. Fasih N, Prasad Shanbhogue AK, Macdonald DB, Fraser-Hill MA, Papadatos D, Kielar AZ, et
al. Leiomyomas beyond the uterus: Unusual locations, rare
manifestations. Radiographics. 2008;28:1931–48.