Did you know, the health state of your mouth could influence and possibly determine the health of the rest of your body? First exploring the relationship of the gut microbiome and disease, at the 2017 Tri-Conference in San Francisco (Feb 2017), Bonnie explores the recent connections and research around the impact of the oral microbiome. Carefully curating the latest research around the oral microbiome, autoimmune disease, and personalized nutrition, we present to you our hyperlinked slides. Enjoy!

1. Your Autoimmunity ConnectionYour Autoimmunity Connection
The Gateway to Health and Disease
the oral microbiome, autoimmunity, and personalized nutrition

2. Your Autoimmunity Connection
Bonnie Feldman, DDS, MBA
DrBonnie360’s mission is to create a digitally
connected world of personalized care for autoimmune
patients.
We consult with start-up companies and entrepreneurs
who are bringing new products and services that will
improve research, diagnosis, and treatment for
autoimmunity
The Gateway to Health and Disease
+1.310.666.5312
drbonnie360@gmail.com
www.drbonnie360.com
@DrBonnie360
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Content and Visual Design by Tiffany Simms

3. Your Autoimmunity Connection
Special Thanks To:
Cindy Crowninshield,
Ellen M Martin, and Tiffany Simms

4. Your Autoimmunity ConnectionYour Autoimmunity Connection
Did You Know?
Microbial DNA can
represent 30-60% of
total saliva DNA
Over 700 different
species of bacteria
can live in your mouth
Nearly Half of American
adults have
periodontitis, (most severe
form of periodontal disease)
93% of people with gum
disease are at risk for
diabetes
Doi: 10.1177/0022034512457373
Doi: 10.1111/j.1752-7325.2009.00157.x
Doi: 10.1186/s40064-016-3728-6
Doi: 10.1128/JCM.43.11.5721-5732.2005

5. Your Autoimmunity Connection
What is the Microecology of
the Oral Cavity?

6. Your Autoimmunity Connection Pubmed Health Glossary

7. Your Autoimmunity Connection
-Omics Research
Sets the Stage for a
New View of the Oral
Ecosystem
Doi: 10.3402/jom.v7.28223

8. Your Autoimmunity Connection
Where Do We Find
the Microbiome in the
Body?
The Scientist: The Body’s Ecosystem

9. Your Autoimmunity Connection
What is the Body’s
Microbiome
Composed of?
Doi: 10.1038/nrg3182

10. Your Autoimmunity Connection Doi: 10.1016/j.imlet.2014.08.017
What Characterizes
the
Oral Microbiome?

11. Your Autoimmunity Connection Doi: 10.1111/j.1601-0825.2011.01851.x
The Oral Microbiome’s
Impact on
Personalized Health

12. Your Autoimmunity Connection Doi: 10.5772/63492
What’s the Functional Profile of Saliva Microbiome?

13. Your Autoimmunity Connection Doi: 10.1038/sj.bdj.2016.865
Can We Identify
Which Bacterial
Phyla Characterize
the Caries Prone
Person?

14. Your Autoimmunity Connection Doi: 10.1016/j.imlet.2014.08.017
The Oral
Microbiome in
Periodontal Disease

15. Your Autoimmunity Connection Doi: 10.1016/j.it.2013.09.001
Periodontitis
(bone resorption)
inflammation
Immunomicrobial
Pathogenesis of
Periodontitis

16. Your Autoimmunity Connection Doi: 10.1016/j.imlet.2014.08.017
Oral Microbiome
Changes in
Periodontal Disease

17. Your Autoimmunity Connection Doi: 10.1038/nri7385
Periodontitis and Systemic Disease

18. Your Autoimmunity Connection Doi: 10.1111/odi.12589
Autoimmunity & the
Oral Microbiome

19. Your Autoimmunity Connection Doi: 10.1038/nrmicro.2016.83
The Oral Microbiome
in
Rheumatoid Arthritis

20. Your Autoimmunity Connection Doi: 10.1016/j.cell.2015.11.001
Personalized
Nutrition

21. Your Autoimmunity Connection Defining the Spectrum of Personalized Nutriton Solutions

22. Your Autoimmunity Connection
Company What How For Whom
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on analysis of individual’s
microbiome. Personalize nutrition by
rating different foods through app.
Stool samples
Blood test
DNA sequence of gut
microbiome
Analysis using patented
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Consumers
Uses certified coaches to develop
personalized nutrition plans that help
meet your goals while chefs prepare
personalized meals delivered to your
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Home biomarker test kit
Questionaire
Patent pending engine
determines foods/nutrients
Coaching and Chefs
Consumers
Cognitive enhancing compounds that
produce minimal side effects.
Manufacture unique
combinations of
supplements to enhance
cognition
Consumers
Discovers natural active ingredients
that come from food sources
AI & DNA analysis to access
most health-benefitting
components in foods
(Bioactive Peptides)
Business

23. Your Autoimmunity Connection
Our Body’s Immune System
Starts in the Mouth
Your Autoimmunity Connection
Exploring the Link between the Oral Microbiome and Systemic Disease

24. Your Autoimmunity Connection
Devine, Deirdre A., Philip D. Marsh, and Josephine Meade. "Modulation of host responses by oral commensal bacteria."
Journal of oral microbiology 7 (2015). <http://www.journaloforalmicrobiology.net/index.php/jom/article/view/26941>.
The Overlooked Microbes in Your Mouth
What is the Oral Microbiome?
Oral vs Gut Microbiome
Dewhirst, Floyd E., et al. "The human oral microbiome." Journal of bacteriology 192.19 (2010): 5002-5017.
<http://jb.asm.org/content/192/19/5002.short>.
Krzyściak, Wirginia, Anna Jurczak, and Jakub Piątkowski. "The Role of Human Oral Microbiome in Dental Biofilm Formation."
InTech. N.p., n.d. Web. <http://www.intechopen.com/books/microbial-biofilms-importance-and-applications/the-role-of-human-
oral-microbiome-in-dental-biofilm-formation>.
Lloyd-Price, Jason, Galeb Abu-Ali, and Curtis Huttenhower. "The healthy human microbiome." Genome medicine 8.1 (2016): 1.
<https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-016-0307-y>.
Nelson-Dooley, Cass. "The Mouth, the Oral Microbiome, and Systemic Inflammation." Institute for Functional Medicine. N.p.,
n.d. Web. 18 Jan. 2017. <https://www.functionalmedicine.org/home/focus_on/oral_microbiome/>.
What is the Oral Microbiome

25. Your Autoimmunity Connection
Nelson-Dooley, Cass, and Stephen F. Olmstead. "The Microbiome and Overall Health Part 5: The Oropharyngeal Microbiota's
Far-Reaching Role in Immunity, Gut Health, and Cardiovascular Disease." Complementary Prescriptions. N.p., n.d. Web. 19
Jan. 2017. <http://www.cpmedical.net/newsletter/the-microbiome-and-overall-health-part-5-the-oropharyngeal>.
Zarco, Vess, and Ginsburg. “The Oral Microbiome in Health and Disease and the Potential Impact on Personalized Dental
Medicine.” Oral Diseases 18.2 (2012): 109–120. <http://onlinelibrary.wiley.com/doi/10.1111/j.1601-0825.2011.01851.x/full>.
The Hidden Gold Mine: Saliva’s Importance
Glurich, Ingrid et al. “Progress in Oral Personalized Medicine: Contribution of ‘omics.’” Journal of Oral Microbiology 7.0 (2015):
28223. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561229/>.
Yang, Fang et al. “Characterization of Saliva Microbiota’s Functional Feature Based on Metagenomic Sequencing.”
SpringerPlus 5.1 (2016): 2098. PMC. Web. 18 Jan. 2017. <http://link.springer.com/article/10.1186/s40064-016-3728-6>.
Zaura, Egija, et al. "On the ecosystemic network of saliva in healthy young adults." The ISME Journal (2017).
<http://www.nature.com/ismej/journal/vaop/ncurrent/full/ismej2016199a.html>.

26. Your Autoimmunity Connection
Costalonga, Massimo, and Mark C. Herzberg. "The oral microbiome and the immunobiology of periodontal disease and caries."
Immunology letters 162.2 (2014): 22-38. <http://www.sciencedirect.com/science/article/pii/S0165247814001874>.
Dewhirst, Floyd E. “The Oral Microbiome: Critical for Understanding Oral Health and Disease.” Journal of the California Dental
Association 44.7 (2016): 409–10. <https://www.ncbi.nlm.nih.gov/pubmed/27514152>.
Kilian, M., et al. "The oral microbiome–an update for oral healthcare professionals." British Dental Journal 221.10 (2016): 657-666.
<http://www.nature.com/bdj/journal/v221/n10/abs/sj.bdj.2016.865.html>.
Liu, Bo, et al. "Deep sequencing of the oral microbiome reveals signatures of periodontal disease." PloS one 7.6 (2012): e37919.
<http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037919>.
Our Disease Barometer
The Oral Microbiome in Caries & Periodontal Disease
Chicken or the Egg? The Oral Microbiome & Systemic Disease
Nikitakis, N. G., et al. "The autoimmunity–oral microbiome connection." Oral diseases (2016).
<http://onlinelibrary.wiley.com/doi/10.1111/odi.12589/full>.
Scher, Jose U., et al. "Periodontal disease and the oral microbiota in new‐onset rheumatoid arthritis." Arthri
& Rheumatism 64.10 (2012): 3083-3094. <http://onlinelibrary.wiley.com/doi/10.1002/art.34539/full>.
Zhang, Xuan et al. “The Oral and Gut Microbiomes Are Perturbed in Rheumatoid Arthritis and Partly Normalized
after Treatment.” Nature Medicine 21.8 (2015): 895–905.
<http://www.nature.com/nm/journal/v21/n8/abs/nm.3914.html>.

27. Your Autoimmunity Connection
Biesalski, Hans K. “Nutrition Meets the Microbiome: Micronutrients and the Microbiota.”
Annals of the New York Academy of Sciences 1372.1 (2016): 53–64.
<http://onlinelibrary.wiley.com/doi/10.1111/nyas.13145/full>.
Marshall, Lisa. "The Personalized-Nutrition Boom." Nutrition Business Journal XX.4 (2015): 1-4. PLM Institute. Apr. 2015. Web.
21 Jan. 2017. <http://plminstitute.org/wp-content/uploads/2015/05/NBJ-Personalized-Nutrition_final_April-2015-_Pages-1-
4.pdf>.
Shoaie, Saeed et al. “Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome.” Cell metabolism 22.2
(2015): 320–331. <http://www.sciencedirect.com/science/article/pii/S1550413115003307>.
vel Szic, Katarzyna Szarc, et al. "From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to
personalized nutrition?." Clinical epigenetics 7.1 (2015): 33.
<https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-015-0068-2>.
Wasielewski, Helen, Joe Alcock, and Athena Aktipis. “Resource Conflict and Cooperation between Human Host and Gut
Microbiota: Implications for Nutrition and Health.” Annals of the New York Academy of Sciences 1372.1 (2016): 20–8.
<http://onlinelibrary.wiley.com/doi/10.1111/nyas.13118/full>.
Zeevi, David, et al. "Personalized nutrition by prediction of glycemic responses." Cell 163.5 (2015): 1079-1094.
<http://www.sciencedirect.com/science/article/pii/S0092867415014816>.
Zmora, Niv, et al. "Taking it personally: personalized utilization of the human microbiome in health and disease." Cell host &
microbe 19.1 (2016): 12-20. <http://www.sciencedirect.com/science/article/pii/S1931312815005089>.
Dinnertime! The Personalized Nutrition Boom