Salmonellosis

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Dr.Bharat Kalidindi

infection spread by salmonella, various types of disease and treatment

Saúde e medicina

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Polio: flaccid paralysis, major and minor disease, fecal-oral Coxsackievirus A: vesicular diseases, meningitis; coxsackievirus B (body): pleurodynia, myocarditis Other echovirus and enteroviruses: like coxsackievirus Rhinoviruses: common cold, acid labile, does not replicate above 33° C Biology, Virulence, and Disease • Small size, icosahedral capsid, positive RNA genome with terminal protein • Genome is sufficient for infection • Encodes RNA-dependent RNA polymerase, replicates in cytoplasm Enteroviruses • Capsid virus resistant to inactivation • Disease due to lytic infection of important target tissue • Polio: cytolytic infection of motor neurons of anterior horn and brainstem, paralysis • Coxsackievirus A: herpangina, hand-foot- and-mouth disease, common cold, meningitis • Coxsackievirus B: pleurodynia, neonatal myocarditis, type 1 diabetes Rhinoviruses • Acid labile and cannot replicate at body temperature • Restricted to upper respiratory tract • Common cold Epidemiology • Enteroviruses transmitted by fecal-oral route and aerosols • Rhinoviruses transmitted by aerosols and contact Diagnosis • Immune assays (ELISA) or RT-PCR genome analysis of blood, CSF, or other relevant sample Treatment, Prevention, and Control • OPV and IPV polio vaccines P icornaviridae is one of the largest families of viruses and includes some of the most important human and animal viruses (Box 46-1). As the name indicates, these viruses are small (pico) ribonucleic acid (RNA) viruses that have a naked capsid structure. The family has more than 230 members divided into nine genera, including Enterovirus, Rhinovirus, Hepatovirus (hepatitis A virus; discussed in Chapter 55), Cardiovirus, and Aphthovirus. The enteroviruses are distinguished from the rhinoviruses by the stabil- ity of the capsid at pH 3, the optimum temperature for growth, the mode of transmission, and their diseases

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These are simplified slides discussing the regulation of cardiac output and venous return. Learning objectives: 1. Comprehend the determinants of cardiac output and factors affecting cardiac output 2. Comprehend the factors affecting stroke volume and heart rate and total peripheral resistance 3. Identify the factors regulating venous return 4. Discuss the causes of high and low output cardiac failure 5. Enlist the functions of veins and recognise the significance of venous reservoirs Study Resources: 1. Chapter 20, Guyton and Hall Textbook of Medical Physiology, 14th edition 2. Chapter 30 and 32, Ganong’s Review of Medical Physiology, 26th edition 3. Chapter 10, Human Physiology by Lauralee Sherwood, 9th edition 4. Physiology, Cardiac Output - StatPearls https://www.ncbi.nlm.nih.gov/books/NBK470455/

Cardiac Output, Venous Return, and Their Regulation

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