1. The New Look of Calm
Gentle Rejuvenation™

2. ONLY FROM

3. Gentle Rejuvenation System: Overview
The Obagi® Gentle Rejuvenation System
is a gentle and effective skin care regimen
featuring unique, clinically proven
ingredients and exclusive technologies.
References: 1. McCall-Perez F, Stephens TJ, Herndon Jr JH. Efficacy and
tolerability of a facial serum for fine lines, wrinkles, and photodamaged skin. J Clin
Aesthet Dermatol. 2011;4(7):51-54. 2. McCullough JL, Weinstein GD. Clinical study
of safety and efficacy of using topical kinetin 0.1% (Kinerase® to treatphotodamaged
skin. Cosmet Dermatol. 2002;15(9):29-32. 3. Cruz Jr PD, Reece BT. A clinical study
of topical zeatin (0.10%, 0.025%) for improving the appearance of photo damaged
skin (RCTS Study #1837).12-week final analysis, September 2005. OMP, Inc. Data
on file. 4. Rattan SIS, Sodagam L. Gerontomodulatory and youth-preserving effects
of zeatin on human skin fibroblasts undergoing aging in vitro. Rejuvenation Res.
2005;8(1):46-57. 5. Katz BE, Bruck MC. Efficacy and tolerability of kinetin 0.1%
cream for improving the signs of photoaging in facial and neck skin. Cosmet
Dermatol. 2006;19(12):736-741. 6. Wu JJ, Weinstein GD, Kricorian GJ, Kormeili T,
McCullough JL. Topical kinetin 0.1% lotion for improving the signs and symptoms of
rosacea. Clin Exp Dermatol. 2007;32(6):693-695. 7. Dow Pharmaceutical Sciences,
Inc. In vitro release of kinetin and zeatin from Prosome Delivery System (study
protocol #2875-121). September 12, 2011. OMP, Inc. Data on file. 8. Skin Care
Exploratory Final Report, June 28, 2013. OMP, Inc. Data on file.

4. Gentle Rejuvenation System: Overview
Gentle Rejuvenation is ideal for
patients with varying degrees of
skin aging concerns
• Dry skin and sensitive skin 1,2
• Mild-to-moderate photodamage
and hyperpigmentation 1-3
• The appearance of fine lines
and wrinkles 1-3
• Concerns about exploring more
aggressive treatments

5. Gentle Rejuvenation System: Clinical Action
The Kinetin-Zeatin Complex in Gentle
Rejuvenation formulations provides
plant-sourced natural growth factors
that have demonstrated efficacies in:
• Improving the appearance of sun-damaged
and prematurely aged skin 1,4,5
• Promoting healthy rejuvenated,
youthful-looking skin 1-3
Here you can see how key ingredients
Kinetin and Zeatin visibly improve the
appearance of fine wrinkling, blotchiness
and skin texture.
*Study results for twice-daily application of topical Kinetin 0.1%.
†Photos have not been retouched. Results may vary.
‡Study results for twice-daily application of topical Zeatin 0.1%.

6. Gentle Rejuvenation System: Clinical Action
The Unique Efficacy of the
Kinetin-Zeatin Complex
In clinical studies, Kinetin 0.1%:
• Increased skin’s ability to retain moisture
by 26% over 24 weeks2
• Diminished spots by an average of 60%5
• Improved mottled hyperpigmentation by
27% over 24 weeks2
• Significantly reduced facial erythema by 32%8
• Showed moderate-to-marked improvement
in overall appearance and symptoms
associated with rosacea in a most patients6
*Study results for twice-daily application of topical Kinetin 0.1%.
†Photos have not been retouched. Results may vary.

7. Gentle Rejuvenation System: Clinical Action
Clinical studies with Zeatin 0.1%
demonstrated improvements in:
• Skin roughness by 86%6
• Fine lines and wrinkles by 34%3
• Mottled hyperpigmentation by 25%3
• Zeatin was also shown to have slowed
down fibroblast aging (in vitro), which
resulted in a youth-preserving effect4
‡Study results for twice-daily application of topical Zeatin 0.1%.
†Photos have not been retouched. Results may vary.

8. Gentle Rejuvenation System: Clinical Action
The exclusive Prosome Delivery System transports
the Kinetin-Zeatin Complex deep into the skin7
• Prosomes encapsulate nearly twice the
amount of ingredients compared to conventional
liposome delivery
• They release the Kinetin-Zeatin Complex slowly,
over a 12 hour period, to help improve the visible
signs of aging

9. Gentle Rejuvenation System: The 3 C’s
Obagi® Gentle Rejuvenation is the ideal system
for patients with sensitive skin who:
• Are CONCERNED about premature aging
• Have visible signs of the CONDITION
• Are pregnant, nursing, allergic or won’t
COMMIT to more aggressive therapies

10. Gentle Rejuvenation System: Products
The Gentle Rejuvenation
System features a core
portfolio of advanced skin
care products for daily use
to cleanse, moisturize,
protect and rejuvenate.

11. Gentle Rejuvenation System: Products
• Gently removes makeup and
everyday impurities
• Cleanses while soothing skin
• Rinses cleanly to leave skin
feeling comfortable and soft.

12. Gentle Rejuvenation System: Products
• Non-irritating moisturizing
formulation
• Contains plant-derived growth
factors Kinetin & Zeatin
• Proven to improve the texture,
tone and blotchiness in
sun-damaged skin
• Leaves the complexion feeling
smooth and soft
• For sensitive and all skin types,
is non-comedogenic, hypoallergenic

13. Gentle Rejuvenation System: Products
• Helps provide protection against
harmful UVA and UVB rays
• Decreases the risk of skin
damage and early signs of aging
caused by the sun
• Fortified with 10% L-ascorbic
acid (Vitamin C)

14. Gentle Rejuvenation System: Products
• With ingredients proven to improve the
appearance of sun-damaged skin for a
more healthy, youthful look
• Harnesses the power of peptides plus
the Kinetin-Zeatin Complex
• Provides deep hydration during sleep,
allowing exclusive ingredients and
technologies to gently rejuvenate skin’s
appearance as it complements the
body’s natural nightly repair process

15. Gentle Rejuvenation System: Products
For added customization
these stand alone products
can be incorporated into
your patients’ programs:

16. Gentle Rejuvenation System: Products
• Diminishes redness, itching
burning and stinging that are
common in compromised skin*
• Formulated with plant-derived
growth factors Kinetin and Zeatin
* Not intended to treat underlying skin
disease or dermatoses

17. Gentle Rejuvenation System: Products
• An innovative serum that helps
complement cellular turnover and
skin’s natural repair process
• Includes plant-derived natural
growth factors Kinetin & Zeatin,
and Swiss apple stem cell extract

18. Gentle Rejuvenation System: Products
• Protects skin from damaging
rays of the sun
• Moisturizes and helps correct
visible signs of photoaging
• Gently rejuvenates
skin’s appearance

19. Gentle Rejuvenation System: Products
• Noticeably improves the
appearance of wrinkles around
the delicate eye area
• Gently rejuvenates skin’s
appearance and helps improve
the visible signs of photoaging

20. Gentle Rejuvenation System: User Satisfaction
In a nationwide consumer survey,
100% of Gentle Rejuvenation
users were either extremely or
very satisfied with the products.8
• 92% of users felt the products
purified their skin
• 88% of users felt the products made
their skin look younger
• 82% of users felt the products
rejuvenated the appearance of their skin

21. Gentle Rejuvenation System: More Information
For more information about Gentle
Rejuvenation products, how they work,
frequently asked questions, clinical results,
protocol for use and individual product
profiles, click on the links below or visit:
www.obagi.com/patients/product-line/
Gentle-Rejuvenation
www.Obagi.com/professional
or call 1.800.636.7546