For pharma students

1. Methods of Enhancing Bioavailability
Of Drugs
Presented By-Debasish Ghadei
M.B.A. (Pharmaceutical Management) (2nd Sem)
Roll No-21142
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2. Contents:
• Introduction to Bioavailability
• Enhancement of Bioavailability
• Approaches used in overcoming Bioavailability
Problems
• Methods of Enhancing Bioavailability
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3. Bioavailability
• It is defined as the rate and extent
amount of absorption of unchanged
drug from dosage form.
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4. Enhancement of Bioavailability
• As far as the bioavailability is concerned, a drug
with poor bioavailability is the one with :
• Poor aqueous solubility or slow dissolution rate
in biological fluid.
• Poor permeability through the bio membrane
owing to inadequate partition coefficient or
lipophilicity or large molecular size such as that
of protein or peptide drug like insulin.
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5. Biopaharmaceutics classification system (BCS)
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6. Approaches used in overcoming
Bioavailability Problems:
• The pharmaceutical Approach
• The pharmacokinetic Approach
• The biological Approach

7. Methods of Enhancing Bioavailability
(The pharmaceutical Approach)
• Enhancement of drug solubility or
dissolution rate
• Enhancement of drug permeability
• Enhancement of drug stability
• Enhancement of gastrointestinal
retentions.
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8. Enhancement of Drug stability or dissolution rate
 Micronization
 Nano suspension
 Supercritical fluid process
 Spray freezing into liquid(SFL)
 Evaporate precipitation into aqueous
solution(EPAS)
 Use of surfactant
 Use of salt forms
 Use of precipitation inhibitors
 Alteration of pH of drug
microenvironment
 Use of amorphs,anhydrates,solvetes
& metastable polymorphs
 Solvent deposition
 Precipitation
 Selective absorption on insoluble
carriers
 Solid solutions
 Eutectic mixture
 Solid dispersions
 Molecular encapsulation with
cyclodextrins
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9. Enhancement of drug permeability
• Lipid technologies
• Ion Pairing
• Penetration enhancers
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10. Enhancement of drug stability
• Enteric coating
• Complexation
• Use of metabolism inhibitors
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11. Enhancement of gastrointestinal
retention
• Increased contact with epithelial
surface
• Prolonged residence time in the
stomach
• Delaying intestinal transit
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12. Enhancement of Drug stability or dissolution rate
 Micronization
 Nano suspension
 Supercritical fluid process
 Spray freezing into liquid(SFL)
 Evaporate precipitation into aqueous
solution(EPAS)
 Use of surfactant
 Use of salt forms
 Use of precipitation inhibitors
 Alteration of pH of drug
microenvironment
 Use of amorphs,anhydrates,solvetes
& metastable polymorphs
 Solvent deposition
 Precipitation
 Selective absorption on insoluble
carriers
 Solid solutions
 Eutectic mixture
 Solid dispersions
 Molecular encapsulation with
cyclodextrins
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Enhancement of drug permeability
• Lipid technologies
• Ion Pairing
• Penetration enhancers

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32. 32
Enhancement of drug stability
• Enteric coating
• Complexation
• Use of metabolism inhibitors

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34. Enhancement of
gastrointestinal retention
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