6. آنزیم فعالیت
1کهاست آنزیمی مقدار آنزیم فعالیت واحد1در ارارسوبست لمو1می تبدیلدهراورف به ثانیه
کند.
The SI unit is the katal
1 katal = 1 mol s−1
But this is an excessively large unit
32. نوع تشخیص ایرب آلفاآمانیتینRNA POL
RNA polymerase I is insensitive
RNA polymerase II is highly sensitive (inhibited at 1μg/ml)
RNA polymerase III is moderately sensitive (inhibited at 10μg/ml)
RNA polymerase IV is slightly sensitive (inhibited at 50μg/ml)
Tipranavir (TPV) is a non-peptidic HIV-1 protease inhibitor that inhibits the processing of the viral Gag and Gag-Pol polyproteins in HIV-1 infected cells, thus preventing formation of mature virions. Two mechanisms are suggested in regards to the potency of tipranavir: 1. Tipravanir may bind to the active site of the protease enzyme with fewer hydrogen bonds than peptidic protease inhibitors, which results in increased flexibility, allowing it to fit into the active site of the enzyme in viruses that have become resistance to other protease inhibitors. This also enables tipranavir to adjust to amino acid substitutions at the active site. 2. Tipranavir's strong hydrogen bonding interaction with the amide backbone of the protease active site Asp30 may lead to its activity against resistant viruses.
Oseltamivir is an ethyl ester prodrug requiring ester hydrolysis for conversion to the active form, oseltamivir carboxylate. The proposed mechanism of action of oseltamivir is inhibition of influenza virus neuraminidase with the possibility of alteration of virus particle aggregation and release.
اسیکلوویر : این دارو پس از ورود به سلول به توسط تیمیدین کیناز ویروس فعال می شود (اسیکلوویر تری فسفات) و موجب مهار عملکرد DNA پلی مراز ویروس می شود.