1. “Cell division discovery could
offer fresh insight into cancer”
and “Blood test to locate gene
defects associated with cancer
may not be far off”
Danny Arroyave Zuluaga
Medicine student
III semester
Molecular biology

4. INTRODUCTION
news dealing with the different
forms
and
types
we
have
studied the DNA and the major
influence
These
on
cellular
newswire
activity.
are
clear
examples of how sophisticated
new
methods
for
a
large
component of the body such as
the blood can give us new
solutions to major pathologies.

5. Cell division discovery could offer fresh insight into
cancer
sciencedaily, January 14, 2014
• In molecular biology, mitosis is
a process that occurs in the
nucleus of eukaryotic cells and
immediately preceding cell
division comprising the
characteristic equal distribution
of genetic material (DNA)
• there are 4 different stages:
prophase, metaphase, anapha
se and telophase

6. Cell division discovery could offer fresh insight into
cancer
sciencedaily, January 14, 2014
• Ska
complex
(proteins), help anchor
DNA,
the
form
of
chromosomes,
by
interacting with strands of
cell
material.
Chromosomes
remain
attached to these strands
as they are separated, in
a process that helps
distribute DNA correctly
to the newly formed cells.

7. Cell division discovery could offer fresh insight into
cancer
sciencedaily, January 14, 2014
• Scientists determined
the structure of the
relevant part of the
protein complex by
analysing crystals of it
with lab tools and cellbased experiments. This
showed how the Ska
complex attaches to
the strands, helping to
bind the DNA material.

8. Cell division discovery could offer fresh insight into
cancer
sciencedaily, January 14, 2014
• "Our findings represent
a milestone in resolving
the mystery of how
these
key
proteins
enable new cells to
separate properly and
equally, in this essential
process for life. The
findings of our work
have the potential to
create new avenues in
drug discovery towards
fighting cancer."

9. observation
I think the meaning of
this important discovery
at the molecular level,
shows us the advances
in medical science and
through this will come at
last to save lives from
something such as the
cancer

10. Blood test to locate gene defects associated with cancer may not be far
off
sciencedaily January 8, 2014
• simple blood test
could be developed
to determine whether
gene
mutations
associated
with
pancreatic
cancer
exist
without
the
need of locating and
testing tumor tissue.

11. Blood test to locate gene defects associated with cancer
may not be far off
sciencedaily January 8, 2014
• the discovery that tiny
particles the size of
viruses
called
'exosomes,' which are
shed by cancer cells
into the blood, contain
the
entire
genetic
blueprint of cancer
cells.

12. Blood test to locate gene defects associated with cancer
may not be far off
sciencedaily January 8, 2014
• that DNA derived
from exosomes
carried the same
cancer-related
genetic
mutations
compared to the
cancer cells
taken from
tumor.

13. Blood test to locate gene defects associated with cancer may not be far off
sciencedaily January 8, 2014
• The analysis of exosome
DNA taken from blood
samples may not only
help
determine
the
presence of a cancerous
tumor somewhere in the
body but also identify
mutations without a need
for tumor sample

14. observation
this study seems very interesting as
it talked about how to identify a
possible cancer will be easier and
faster by the greater chance of cure
for people who suffer from this.

15. Cell division discovery could offer fresh insight into
cancer
• with the discovery of
these proteins that play
an important role in a
process such as the cell
division, should make
the most as these
could be a great start
to lessen a disease
such as cancer and
better able to deal
effectively with these.

16. Blood test to locate gene defects associated with cancer
may not be far off
• with
this
new
opportunity to discover
mutations in an early
stage, it should be
performed
in
all
individuals even so you
have no suspicion as
they would be talking
about prevention of
disease which today
claims thousands of
lives.

17. Blood test to locate gene defects associated with cancer
may not be far off
• a very important thing to consider in this discovery is
that this method to detect cancer in patients is
minimally invasive, and not to take samples of the
tumor, avoiding costly and unnecessary risks.

18. Blood test to locate gene defects associated with cancer
may not be far off
• with the discovery that
cells cencerigenas
leave "traces" are drugs
and should make this
road may lead us to
the probable site of the
tumor in the body and
thus act more quickly
and effectively

19. BIBLIOGRAPHY
•
•
•
Martínez S, Lina María. Biología Molecular. 7 ed. Medellín: UPB.
Facultad de Medicina, 2012. 59-67.P
Maria Alba Abad, Bethan Medina, Anna Santamaria, Juan Zou,
Carla Plasberg-Hill, Arumugam Madhumalar, Uma Jayachandran,
Patrick Marc Redli, Juri Rappsilber, Erich A. Nigg, A. Arockia
Jeyaprakash. Cell division discovery could offer fresh insight into
cancer. Sciencedaily, (online magazine), 2014(January 14) available
online:
http://www.sciencedaily.com/releases/2014/01/140114103013.htm
C. Kahlert, S. A. Melo, A. Protopopov, J. Tang, S. Seth, M. Koch, J.
Zhang, J. Weitz, L. Chin, A. Futreal, R. Kalluri. Blood test to locate gene
defects associated with cancer may not be far off. Sciencedaily,
(online magazine), 2014 (January 8) available online:
http://www.sciencedaily.com/releases/2014/01/140108154041.htm

20. THANKS