The document discusses ocular drug delivery systems. It describes the anatomy and physiology of the eye and factors that influence drug absorption through the cornea. Various ocular drug delivery formulations are discussed including solutions, suspensions, emulsions, ointments, polymeric solutions, and particulate/vesicular systems. Recent advances include bioadhesive systems, collagen shields, pseudolatices, and penetration enhancers. Ocular inserts provide sustained drug release and increased bioavailability. Evaluation methods for these systems include in vitro drug release and in vivo studies in animals.

1. Ocular Drug Delivery System Presented by, R.V.Deshmukh 1 st year M-Pharm Dept of Pharmaceutics

5. Anatomy and Physiology

12. Formulation of ocular drug delivery system Dosage form Advantages Disadvantages Solutions Convenience Rapid precorneal elimination, Loss of drug by drainage, Non sustained action Suspension Patient compliance, Best for drug with slow dissolution Drug properties decide performance loss of both solution and suspended solid Emulsion Prolonged release of drug from vehicle Blurred vision, patient non compliance, possible oil entrapment Ointment Flexibility in drug choice, Improved drug stability Sticking of eye lids, Blurred vision poor patient compliance, Drug choice limited by partition coefficient

39. Evaluation of OCDDS

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