1. PUBLICATIONS
1987
1. Kok FJ, Duijn CM van, Hofman A, Vermeeren R,Bruijn AM de, Valkenburg HA.
Micronutrients and the risk of lung cancer (Letter). N EnglJ Med 1987;316:1416.
1988
2. Duijn CM van, Steensel Moll HA van, Does-van der Berg A van der, Wering ER van, Zanen
GE van, Valkenburg HA,Rammeloo JA. Infant feeding and childhood cancer (Letter). Lancet
1988;ii:796 7.
3. Hofman A, Duijn CM van, Rocca WA. Is Alzheimer's disease distinct from normal ageing?
(Letter). Lancet 1988;ii:226 7.
4. Kok FJ, Duijn CM van, Hofman A, Wolf FA de, Valkenburg HA. Serum copper and zinc
predict death from cancer and cardiovascular disease. Am J Epidemiol 1988;128:352 9.
1989
5. Hofman A, Schulte W, Tanja TA, Duijn CM van, Haaxma R,Lameris AJ, Otten VM, Saan
RJ. History of dementia and Parkinson's disease in 1st degree relatives of patients with
Alzheimer's disease. Neurology 1989;39:1589 92.
1990
6. Duijn CM van, Hofman A, Nagelkerken L. Serum levels of interleukin 6 are not elevated in
patients with Alzheimer's disease. NeurosciLett 1990;108:350 4.
7. Hofman A, Duijn CM van, Schulte W, Tanja TA, Haaxma R,Lameris AJ, Saan RJ. Is
parental age related to the risk of Alzheimer's disease? Br J Psychiatry 1990;157:273 5.
1991
8. Boerrigter METI, Duijn CM van, Mullaart E, Eikelenboom P,Togt CMA van der, Knook
DL, Hofman A, Vijg J. Decreased DNA repair capacity in familial, but not in sporadic
Alzheimer's disease. Neurobiol Aging 1991;12:367 70.
9. Breteler MMB, Duijn CM van, Chandra V, Fratiglioni L, Graves AB,Heyman A, Jorm AF,
Kokmen E, Kondo K, Mortimer JA, Rocca WA,Shalat SL, Soininen H, Hofman A. Medical
history and Alzheimer's disease: A collaborative re analysis of 11 case control studies. Int J
Epidemiol 1991;20:S36 S42.
10. Duijn CM van, Hofman A. Relation between nicotine intake and Alzheimer's disease? BMJ
1991;302:1491 4.
11. Duijn CM van, Hendriks L, Cruts M, Hardy JA, Hofman A, Broeckhoven C van. Amyloid
precursor protein gene mutation in early-onset Alzheimer's disease (Letter). Lancet
1991;337:978.

2. 12. Duijn CM van, Broeckhoven C van, Hardy JA, Goate AM, Rossor MN, Vandenberghe A,
Martin J J, Hofman A, Mullan MJ. Evidence for allelic heterogeneity in familial early onset
Alzheimer's disease. Br J Psychiatry 1991;158:471 4.
13. Duijn CM van, Farrer LA, Cupples LA, Hofman A. Risk of dementia in first degree relatives
of patients with Alzheimer's disease. In: Iqbal K, McLachlan DRC,Winblad B, Wisniewski
HM (eds); Alzheimer's disease: Basic mechanism, diagnosis and therapeutic strategies. John
Wiley & Sons, Chichester, 1991, 423 6.
14. Duijn CM van, Hofman A (eds). Prologue. Int J Epidemiol 1991;20:S3.
15. Duijn CM van, Stijnen T, Hofman A. Risk factors for Alzheimer's disease: Overview of the
EURODEM collaborative re analysis of case control studies. Int J Epidemiol 1991;20:S4 S12.
16. Duijn CM van, Clayton D, Chandra V,Fratiglioni L, Graves AB,Heyman A, Jorm AF,
Kokmen E, Kondo K, Mortimer JA, Rocca WA,Shalat SL, Soininen H, Hofman A. Familial
aggregation of Alzheimer's disease and related disorders: A collaborative re analysis of case
control studies. Int J Epidemiol 1991;20:S13 S20.
17. Graves AB, Duijn CM van, Chandra V, Fratiglioni L, Heyman A, Jorm AF, Kokmen E,
Kondo K, Mortimer JA, Rocca WA,Shalat SL, Soininen H, Hofman A. Alcohol and tobacco
consumption as risk factors for Alzheimer's disease: A collaborative re analysis of case
control studies. Int J Epidemiol 1991;20:S48 S57.
18. Graves AB, Duijn CM van, Chandra V, Fratiglioni L, Heyman A, Jorm AF, Kokmen E,
Kondo K, Mortimer JA, Rocca WA,Shalat SL, Soininen H, Hofman A. Occupational
exposures to solvents and lead as risk factors for Alzheimer's disease: A collaborative re
analysis of case control studies. Int J Epidemiol 1991;20:S58 S61.
19. Jorm AF, Duijn CM van, Chandra V, Fratiglioni L, Graves AB,Heyman A, Kokmen E,
Kondo K, Mortimer JA, Rocca WA,Shalat SL, Soininen H, Hofman A. Psychiatric history
and related exposures as risk factors for Alzheimer's disease: A collaborative re analysis of
case control studies. Int J Epidemiol 1991;20:S43 S47.
20. Mortimer JA, Duijn CM van, Chandra V, Fratiglioni L, Graves AB, Heyman A, Jorm AF,
Kokmen E, Kondo K, Rocca WA,Shalat SL, Soininen H, Hofman A. Head trauma as a risk
factor for Alzheimer's disease: A collaborative re analysis of case control studies. Int J
Epidemiol 1991;20:S28 S35.
21. Nijhuis E, Duijn CM van, Witteman C, Hofman A, Rozing J, Nagelkerken L. T cell reactivity
in patients with Alzheimer's disease. In: Iqbal K, McLachlan DRC, Winblad B, Wisniewski
HM (eds); Alzheimer's disease: Basic mechanism, diagnosis and therapeutic strategies. John
Wiley & Sons, Chichester, 1991,581 6.
22. Rocca WA,Duijn CM van, Clayton D, Chandra V, Fratiglioni L, Graves AB,Heyman A,
Jorm AF, Kokmen E, Kondo K, Mortimer JA, Shalat SL, Soininen H, Hofman A. Maternal
age as a risk factor of Alzheimer's disease: A collaborative re analysis of case control studies.
Int J Epidemiol 1991;20:S21 S27.
1992

3. 23. Breteler MMB, Claus J, Duijn CM van, Launer LJ, Hofman A. Epidemiology of Alzheimer's
disease and dementia. Epidemiol Rev 1992;14:59-82.
24. Clayton D, Duijn CM van. Case control studies of environmental influences in diseases with
genetic determinants (Letter). Am J Epidemiol 1992;135:1315-7.
25. Duijn CM van, Hofman A. Risk factors for Alzheimer's disease: The EURODEM
collaborative analysis of case control studies. Neuroepidemiol 1992;11(suppl 1):106-13.
26. Duijn CM van, Tanja TA, Haaxma R, Schulte W, Saan RJ, Lameris AJ, Antonides Hendriks
G, Hofman A. Head trauma and the risk of Alzheimer's disease. Am J Epidemiol
1992;135:775-83.
27. Hendriks L, Duijn CM van, Cras P,Cruts M, Hul W van, Harskamp F van, Warren A,
McInnis MG, Antonarakis SE, Martin J-J, Hofman A, Broeckhoven C van. Presenile
dementia and cerebralhaemorrhage linked to a mutation at codon 692 of the beta-amyloid
precursor protein gene. Nat Genet 1992;1:218-21.
28. Leeuwen FE van, Duijn CM van, Camps MH, Kempers BA, Mentjens MF, Mulder HB,
Schouten EG, Zwijsen RM, Rookus MA. Agreement between oral contraceptive users and
prescribers: implications for case control studies. Contraception 1992;45:399 408.
29. Steensel Moll HA van, Duijn CM van, Valkenburg HA, Zanen GE van. Predominance of
hospital deliveries among children with acute lymphocytic leukemia: speculations about
neonatal exposure to fluorescent light. Cancer Causes Control 1992;3:389 90.
1993
30. Duijn CM van, Farrer LA, Cupples LA, Hofman A. Genetic transmission of Alzheimer
disease among families in a Dutch population-based study. J Med Genet 1993;30:640-6.
31. Duijn CM van, Hendriks L, Farrer LA,Backhovens H, Cruts M, Wehnert A, Hofman A,
Broeckhoven C van. Linkage to chromosome 14, 19 and 21 in families derived from a
population-based study of Alzheimer's disease. Am J Hum Genet 1993;53:871.
32. Duijn CM van, Samson WN, Hop WCJ, Hofman A. Family history and concomitant clinical
features in early-onset Alzheimer's disease. Genet Epidemiol 1993;10:342.
33. Rao VS, Connor L, Duijn CM van, Growdon JH,Farrer LA. Segregation analysis of
Alzheimer's disease shows evidence for dominant transmission, phenocopies and age at onset
heterogeneity. Am J Hum Genet 1993;53:846.
34. Duijn CM van. Genetic epidemiology of Alzheimer's disease and Parkinson's disease. In:
European Communities Science, Research and Development Report, EUR 14848 EN, 1993.
1994
35. Berberian KM,Duijn CM van, Hoes AW,Valkenburg HA, Hofman A. Alcohol and
mortality: results from the EPOZ follow-up study. Eur J Epidemiol 1994;10:587-93.

4. 36. Duijn CM van, Knijff P de, Cruts M, Wehnert A, Havekes LM,Hofman A, Broeckhoven C
van. Apolipoprotein E E4 allele in a population-based study of early-onset Alzheimer's
disease. Nat Genet 1994;7:74-8.
37. Duijn CM van, Hendriks L, Farrer LA,Backhovens H, Cruts M, Wehnert A, Hofman A,
Broeckhoven C van. A population-based study of familial Alzheimer's disease: linkage to
chromosome 14, 19 and 21. Am J Hum Genet 1994;55:714-27.
38. Duijn CM van, Broeckhoven C van. Alzheimer's disease and the family effect
(Correspondence). Nat Genet 1994;8:115.
39. Duijn CM van, Clayton D, Chandra V,Fratiglioni L, Graves AB,Heyman A, Jorm AF,
Kokmen E, Kondo K, Mortimer JA, Rocca WA,Shalat SL, Soininen H, Hofman A.
Interaction between genetic and environmental risk factors for Alzheimer's disease: a re
analysis of case control studies. Genet Epidemiol 1994;11:539-51.
40. Duijn CM van, Steensel Moll HA van, Coebergh JWW, Zanen GE van. Risk factors for
childhood acute non-lymphocytic leukaemia: an association to maternal alcohol consumption
during pregnancy? Cancer Epidemiol Biomarkers Prev 1994;3:457-60.
41. Haan J, Broeckhoven C van, Duijn CM van, Voorhoeve E, Harskamp F van, Swieten JC van,
Maat-Schieman MLC, Roos RAC,Bakker E. The ap
influence the clinical expression of the amyloid precursor protein-gene codon 693 or 692
mutations. Ann Neurol 1994;36:434-7.
42. Nijhuis E, Hinloopen B, Duijn CM van, Hofman A, Rozing J, Nagelkerken L. Decreased
sensitivity to dexamethasone in lymphocytes from patients with Alzheimer's disease. Clin
Immunol Immunopathol 1994;73:45-52.
43. Rao VS, Duijn CM van, Connor-Lacke L, Cupples LA, Growdon JH, Farrer LA. Multiple
etiology for Alzheimer disease revealed by segregation analysis. Am J Hum Genet
1994;55:991-1000.
1995
44. Bromberg JEC, Rinkel GJE, Algra A, Duijn CM van, Greebe P,Ramos LMP, Gijn J van.
Familial subarachnoid haemorrhage: distinctive features and pattern of inheritance. Ann
Neurol 1995;38:929-34.
45. Bromberg JEC, Rinkel GJE, Algra A, Greebe P, Duijn CM van, Hasan D,Limburg M, Berg
HWM ter, Wijdicks EFM, Gijn J van. Subarachnoid haemorrhage in first and second degree
relatives of patients with subarachnoid haemorrhage. BMJ 1995;311:288-289.
46. Commenges D, Jacqmin H,Letenneur L, Duijn CM van. Score test for familial aggregation in
probands studies: application to Alzheimer's disease. Biometrics 1995;51:542-51.
47. Cruts M, Backhovens H, Gassen G van, Theuns J, Wang S-Y, Wehnert A, Duijn CM van,
Nylander P-O,Hofman A, Adolfson R, Martin J-J, Broeckhoven C van. Mapping and
sequencing the chromosome 14q24.3 dihydrolipoyl succinyltransferase (DLST) gene in
patients with early-onset Alzheimer's disease. NeurosciLett 1995;199:73-7.

5. 48. Duijn CM van, Knijff P de, Cruts M, Wehnert A, Voecht J de, Havekes LM, Hofman A,
Broeckhoven C van. The apolipoprotein E gene and the risk of early-onset Alzheimer's
disease. In: Iqbal K, Mortimer JA, Winblad B, Wisniewski HM (eds); Research Advances in
Alzheimer's disease and related disorders. John Wiley & Sons, Chichester, 1995, 97-101.
49. Duijn CM van, Knijff P de, Wehnert A, Voecht J de, Bronzova JB, Havekes LM,Hofman A,
Broeckhoven C van. The apolipoprotein E ε2 allele is associated with an increased risk of
early-onset Alzheimer's disease and a reduced survival. Ann Neurol 1995;37:605-10.
50. Duijn CM van, Broeckhoven C van, Knijff P de, Cruts M, Wehnert A, Havekes LM,Hofman
A. Smoking and Apolipoprotein E ε4 allele and the risk of early-onset Alzheimer's disease.
BMJ 1995;310:627-31.
51. Farrer LA,Cupples A, Duijn CM van, Kurz A, Zimmer R, Mulller U, Green RC, Clarke V,
Shoffner J, Wallace DC, Chui H, Flanagan SD, Duara R, St George Hyslop P,Auerbach SA,
Volicer L, Well JM, Broeckhoven C van, Growdon JH, Haines JL. APOE genotype in
patients with Alzheimer's disease: implications for the risk of dementia among relatives. Ann
Neurol 1995;38:797-808.
52. Farrer LA,Cupples LA, Duijn CM van, Connor-Lacke L, Kiely DK, Growdon JH. Rate of
progression of Alzheimer disease is associated with genetic risk. Arch Neurol 1995;52:918-
23.
53. Gool WA van, Evenhuis HM, Duijn CM van, for the Study Group Down Syndrome &
Ageing. A case-controlstudy of apolipoprotein E genotypes in Alzheimer's disease associated
with Down syndrome. Ann Neurol 1995;38:225-30.
54. Stevens M, Swieten JC van, Duijn CM van, Tibben A, Niermeijer MF. De fronto-temporale
dementie: onderzoek naar het familiair voorkomen. Ned Tijdschr Geneesk 1995;139:871-5.
1996
55. Bronzova J, Duijn CM van, Havekes LM,Knijff P de, Broeckhoven C van, Hofman A.
Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's
disease. J Neurol 1996;243:465-8.
56. Duijn CM van, Broeckhoven C van.
increased risk of early-onset Alzheimer's disease and a reduced survival. Ann Neurol
1996;39:415-6.
57. Duijn CM van. Epidemiology of the dementia: recent developments and new approaches. J
Neurol Neurosurg Psychiatr 1996;60:478-88.
58. Rao V, Cupples L, Duijn CM van, Kurz A, Green RC, Chui H, Duara R, Auerbach SA,
Volicer L, Wells J, Broeckhoven C van, Growdon JH, Haines JL, Farrer LA. Evidence for
major gene inheritance of Alzheimer disease in families of patients with and without APOE
-75.
59. Samson WN, Duijn CM van, Hop WCJ, Hofman A. Clinical features and mortality in patients
with early-onset Alzheimer's disease. Eur Neur 1996;36:103-6.

6. 60. Slooter A, Breteler MMB, Ott A,Broeckhoven C van, Duijn CM van. APOE genotyping in
differential diagnosis of Alzheimer's disease, (Letter). Lancet 1996;348:334.
61. Slooter AJC,Gool WA van, Duijn CM van. De plaats van apolipoproteine-E-genotypering in
de differentiaaldiagnostiek van dementie. Ned Tijdschr Geneesk 1996;140:2073-6.
62. Uitterlinden AG, Pols HAP,Burger H, Huang O, Daele PLA van, Duijn CM van, Hofman A,
Birkenhager JC, Leeuwen JPTM van. A large-scale population-based study of the association
of vitamin D receptor gene polymorphisms with bone mineral density. J Bone Miner Res
1996;11:1241-8.
63. Wientjens DPWM,Davanipour Z, Hofman A, Kondo K, Matthews WB,Will RG, Duijn CM
van. Risk factors for Creutzfeldt-Jakob disease: a re-analysis of case-controlstudies.
Neurology 1996;46:1287-91.
1997
64. Duijn CM van. Menopause and the brain. J Psychosom Obstet Gynecol 1997;18:121-5.
65. Farrer LA,Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH,Pericak-
Vance MA,Risch N, Duijn CM van; for APOE and Alzheimer Disease Meta-analysis
Consortium. Effects of age,gender and ethnicity on the association between apolipoprotein E
genotype and Alzheimer disease. JAMA 1997;278:1349-56.
66. Harskamp F van, Cras P,Hendriks L, Kros JM, Hofman A, Broeckhoven C van, Duijn CM
van. A family with early-onset Alzheimer's disease and cerebral haemorrhage due to a
-amy¬loid precursor protein gene. In: Iqbal K, Mortimer JA,
Winblad B, Nishimura T,Wisniewski HM (eds); Alzheimer's disease: Biology, Diagnosis and
Therapeutics. John Wiley & Sons, Chichester, 1997:155-9.
67. Heutink P,Stevens M, Rizzu P, Bakker E, Kros JM, Tibben A, Niermeijer MF, Duijn CM
van, Oostra BA,Swieten JC van. Hereditary Fronto-Temporal Dementia is linked to
chromosome 17q21-q22. A genetic and clinico-pathological study of three Dutch families.
Ann Neurol 1997;41:150-9.
68. Hofman A, Ott A, Breteler MMB, Bots ML, Slooter AJC, Harskamp F van, Duijn CM van,
Broeckhoven C van, Grobbee DE. Atherosclerosis, apolipoprotein E and the prevalence of
dementia and Alzheimer's disease in a population-based study: the Rotterdam Study. Lancet
1997;349:151-4.
69. Meulenbelt I, Bijkerk C, Wildt SCM de, Miedema H,Valkenburg HA, Breedveld FC, Pols
HA, Te Koppele J, Sloos VFG, Hofman A, Slagboom PE,Duijn CM van. Investigation of the
association of the CRTM and CRTL1 genes with radiological evident osteoarthritis in
subjects from the Rotterdam Study. Arthr Rheum 1997;40:1760-5.
70. Murphy GM Jr, Sullivan EV, Gallagher-Thompson D, Thompson LW, Duijn CM van, Forno
LS, Ellis WG, Jagust WJ, Yesavage J,Tinklenberg JR. No association between the alpha 1-
antichymotrypsin A allele and Alzheimer’s disease. Neurology 1997;48:1313-6.

7. 71. Samren EB, Duijn CM van, Koch S, Hiilesma VK, Klepel H, Bardy AH, Mannegetta B,
Deichl AW, Gaily E, Granstrom ML, Meinardi H, Grobbee DE, Hofman A, Lindhout D.
Maternal use of anti-epileptic drugs and the risk of major congenital malformations: A Joint
European Prospective study on human teratogenesis associated with maternal epilepsy.
Epilepsia 1997;38:981-90
72. Slooter AJC,Duijn CM van. Genetic epidemiology of Alzheimer's Disease. Epidemiol Rev
1997;19:107-19.
73. Slooter AJC,Tang MX, Duijn CM van, Stern Y, Ott A, Bell K, Breteler MMB, Broeckhoven
C van, Tatemichi TK, Tycko B, Hofman A, Mayeux R. Apolipoprotein E4 increases the risk
of dementia with stroke. A population-based investigation. JAMA 1997;277:818-21.
74. Stevens M, Duijn CM van, Knijff P de, Broeckhoven C van, Heutink P, Oostra BA,
Niermeijer MF, Swieten JC van. Apolipoprotein E gene and sporadic frontal lobe dementia.
Neurology 1997;48:1526-9.
75. Tibben A, Steven M, Wert GMWR de, Niermeijer MF, Duijn CM van, Swieten JC van.
Preparing for presymptomatic DNA testing for early onset Alzheimer's disease /cerebral
haemorrhage and hereditary Pick disease. J Med Genet 1997;34:63-72.
76. Uitterlinden A, Burger H, Huang Q, Odding E, Duijn CM van, Hofman A, Birkenhager JC,
Leeuwen JPTM van, Pols AP. Vitamin D receptor genotype is associated with osteoarthritis. J
Clin Invest 1997;100:259-63.
1998
77. Cammen TJM van der, Verschoor CJ, Loon CPM van, Harskamp F van, Koning I de,
Schudel WJ, Slooter AJC,Broeckhoven C van, Duijn CM van. Risk of left ventricular
dysfunction in patients with probable Alzheimer's disease with APOE*4 allele. J Am Geriatr
Soc 1998;46:962-7.
78. Cras P,Harskamp F van, Hendriks L, Ceuterick C, Duijn CM van, Stefanko SZ, Hofman A,
Kros JM, Broeckhoven C van, Martin JJ. Presenile Alzheimer dementia characterized by
amyloid angiopathy and large amyloid core type senile plaques in the APP 692 Ala => Gly
mutation. Acta Neuropathol 1998;96:253-60.
79. Cruts M, Duijn CM van, Backhovens H, Brooke M van den, Wehnert A, Serneels S,
Sherrington R, Hutton M, Hardy J, Hyslop PH,Hofman A, Broeckhoven C van. Estimation
of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of
presenile Alzheimer disease. Hum Mol Genet 1998;7:43-51.
80. Duijn CM van, Delasnerie Laupretre N,Masullo C, Zerr I, Silva R de, Wientjens DPWM,
Brandel J-P,Weber T, Bonavita V, Zeidler M, Alperovitch A, Poser S, Granieri E, Hofman
A, Will RG. For the EU Collaborative Study Group for CJD. Case-controlstudy of risk
factors of Creutzfeldt Jakob disease in Europe during 1993 95. Lancet 1998;351:1081-5.
81. Esch A, Steyerberg EW, Duijn CM van, Offringa M, Derksen-Lubsen G, Steensel-Moll HA.
Prediction of febrile seizures in siblings: a practical approach. Eur J Pediatrics 1998;157:340-
4.

8. 82. Fahim S, Duijn CM van, Baker FM, Launer L, Breteler MMB, Schudel WJ, Hofman A. A
study of familial aggregation of depression, dementia and Parkinson's disease. Eur J
Epidemiol 1998;14:233-8.
83. Farrer LA,Duijn CM van, Mayeux R, Haines JL, Kukull WA, Hyman B, Pericak-Vance MA,
JAMA 1998;279:581-2.
84. Klaver CCW,Assink JJM, Bergen AAB,Duijn CM van. ABCR gene and age-related
macular degeneration (Correspondence). Science 1998;279:1107.
85. Klaver CCW,Kliffen M, Duijn CM van, Hofman A, Cruts M, Grobbee DE, Broeckhoven C
van, Jong PTVM de. Genetic association of apolipoprotein E with age related macular
degeneration. Am J Hum Genet 1998;63:200-6.
86. Klaver CCW,Wolfs RC, Assink JJM, Duijn CM van, Hofman A, Jong PTVM de. Genetic
Risk of age-related maculopathy. A population-based familial aggregation study. Arch
Opthalmol 1998;116:1646-51.
87. Knijff P de, Duijn CM van. Role of APOE in dementia: a critical reappraisal. Haemostasis
1998;28:195-201.
88. Meulenbelt I, Bijkerk C, Miedema H, Breedveld FC, Hofman A,Valkenburg HA, Pols HAP
Slagboom PE, Duijn CM van. The IGF-1 gene and radiological osteoarthritis (ROA) in a
population-based cohort study (Rotterdam Study). Ann Rheum Dis 1998;57:371-4.
89. Ott A, Slooter AJC, Hofman A, Harskamp F van, Witteman JCM, Broeckhoven C van, Duijn
CM van, Breteler MMB. Smoking and the risk of dementia and Alzheimer's disease in a
population based cohort study: the Rotterdam study. Lancet 1998;351:1840-3.
90. Roks G, Cruts M, Bullido MJ, Backhovens H, Artiga MJ, Hofman A, Valdivieso F,
Broeckhoven C van, Duijn CM van. The –491 A/T polymorphism in the regulatory region of
the apolipoprotein E gene and early-onset Alzheimer’s disease. NeurosciLett 1998;258:65-8.
91. Slooter AJC,Cruts M, Kalmijn S, Hofman A, Breteler MMB, Broeckhoven C van, Duijn CM
van. Risk estimates of dementia by apolipoprotein E genotype from a population-based
incidence study: the Rotterdam Study. Arch Neurol 1998;55:964-8.
92. Slooter AJC,Duijn CM van, Bots ML, Ott A, Breteler MMB, Voecht J de, Wehnert A, Knijff
P de, Havekes LM, Grobbee DE, Broeckhoven C van, Hofman A. Apolipoprotein E
genotype, atherosclerosis, and cognitive decline: the Rotterdam study. J NeuralTransm
1998;S53:17-29.
93. Slooter AJC,Knijff P de, Hofman A, Cruts M, Breteler MMB, Broeckhoven C van, Havekes
LM, Duijn CM van. Serum apolipoprotein E level is not increased in Alzheimer's disease.
Neurosci Lett 1998;248:21-4.
94. Stevens M, Duijn CM van, Kamphorst W, Knijff P de, Heutink P, Gool WA van, Scheltens
Ph, Ravid R, Oostra BA,Niermeijer MF, Swieten JC van. Familial aggregation in fronto-
temporal dementia. Neurology 1998;50:1541-5.

9. 95. Will RG, Alperovitch A, Poser S, Pocchiari M, Hofman A, Mitrova E, Silva R de,
D'Alesandro M, Brandel J-P,Zerr I, Duijn CM van. Creutzfeldt Jakob disease in Europe 1993
1995. Descriptive epidemiology. For the EU Collaborative Study Group for CJD. Ann Neurol
1998;43:763-7.
96. Wolfs RC,Klaver CCW, Ramrattan R, Duijn CM van, Hofman A, Jong PTVM de. Genetic
Risk of primary open-angle glaucoma. A population-based familial aggregation study. Arch
Opthalmol 1998;116:1640-5.
1999
97. Alperovitch A, Zerr I, Pocchiari M, Mitrova E, Cuesta J de Pedro, Hegyi I, Collins S,
Kretzschmar H, Duijn CM van, Will RG. Codon 129 prion protein genotype and sporadic
Creutzfeldt Jakob disease. Lancet 1999;353:1673-4.
98. Bijkerk C, Houwing-Duistermaat JJ,Valkenburg HA, Meulenbelt I, Hofman A, Breedveld
FC, Pols HAP,Duijn CM van, Slagboom PE. Heritabilities of radiologic OA in peripheral
joins and of disc degeneration of the spine. Arthr Rheum 1999;42:1729-35.
99. Dermaut B, Cruts M, Slooter AJC,Gestel S van, Jonghe C de, Vanderstichele H,
Vanmechelen E, Breteler MMB, Hofman A,Duijn CM van, Broeckhoven C van. The
glu318gly mutation in presenilin 1 is not causally related to Alzheimer’s disease. Am J Hum
Genet;1999:64:290-2.
100. Duijn CM van. Hormone replacement therapy and Alzheimer’s disease. Maturitas
1999;31:201-5.
101. Duijn CM van, Cruts M, Theuns J, Gassen G van, Backhovens H, Broeck M van den,
Wehnert A, Serneels S, Hofman A, Broeckhoven C van. Genetic association of the
presenilin-1 regulatory region with early-onset Alzheimer’s disease. Eur J Hum
Genet;1999:7:806-7.
102. Harhangi BS, Oostra BA,Heutink P, Duijn CM van, Hofman A, Breteler MMB. N-
acetyltransferase 2 polymorphism in Parkinson’s disease. The Rotterdam study. J Neurol
Neurosurg Psychiatry 1999;67:518-20.
103. Houlden H, Rizzu P, Stevens M, Knijff P de, Duijn CM van, Swieten JC van, Heutink P,
Perez-Tur J,Thomas V, Baker M, Morris H, Rossor M, Jannsen JC, Petersen RC,Dodd P,
Dark F, Boeve B, Dickson D, Davies P,Pickering-Brown S, Mann D, Adamson J, Lynch T,
Payami H, Poorkaj P,Bird TD, Schellenberg GD, Chadraverty S, Norton J, Morris FC, Goate
A, Hutton M, Hardy J. Apolipoprotein E genotype does not affect the age of onset of
dementia in families with define tau mutations. Neurosci Lett 1999;260:193-5.
104. Mehta KM, Ott A,Slooter AJC,Duijn CM van, Hofman A, Breteler MMB. Head trauma
with loss of consciousness and risk of dementia and Alzheimer's disease. The Rotterdam
Study. Neurology 1999;53:1959-62.
105. Meulenbelt I, Bijkerk C, Wildt SCM de, Miedema HS, Breedveld FC, Pols HAP,Hofman A,
Duijn CM van, Slagboom PE. Haplotype analysis of three polymorphisms of the COL2A1
gene and associations with generalised radiological osteoarthritis. An Hum Genet
1999;63:303-400.

10. 106. Rizzu P,Swieten JC van, Joosse M, Hasegawa M,Stevens M, Tibben A, Niermeijer MF,
Hillebrand M, Ravid R, Oostra BA,Goedert M, Duijn CM van, Heutink P. High prevalence
of mutations in the microtubule-associated protein tau in a population study of frontotemporal
dementia in the Netherlands. Am J Hum Genet;1999:64:414-21.
107. Roks G, Dermaut B, Heutink P,Julliams A, Backhovens H, Broeck M van den, Serneels S,
Hofman A, Broeckhoven C van, Duijn CM van, Cruts M. Mutation screening of the tau gene
in patients with early-onset Alzheimer’s disease. Neurosci Lett 1999;277:137-9.
108. Samren EB, Duijn CM van, Christiaens CGML, Hofman A, Lindhout D. Anti-epileptic drug
regimens and major congenital abnormalities in the offspring. Ann Neurol 1999: 46:739-46.
109. Slooter AJC,Houwing-Duistermaat JJ, Harskamp F van, Cruts M, Broeckhoven C van,
Breteler MMB, Hofman A, Stijnen T, Duijn CM van. Apolipoprotein E genotype and the
progression of Alzheimer’s disease: the Rotterdam Study. J Neurol 1999;246:304-8.
110. Slooter AJC,Cruts M, Ott A, Bots ML, Witteman JCM, Hofman A, Broeckhoven C van,
Breteler MMB, Duijn CM van. The effect of APOE on dementia is not through
atherosclerosis: the Rotterdam Study. Neurology 1999;53:1593-5.
111. Slooter AJC,Bronzova J, Witteman JCM, Hofman A, Broeckhoven C van, Duijn CM van.
Estrogen and early-onset Alzheimer’s disease. J Neurol Neurosurg Psychiatry 1999;67:779-
81.
112. Stuijvenberg van M, Beijeren E van, Wils NH,Derksen-Lubsen G, Duijn CM van, Moll HA.
Characterisitcs of the initial seizure in familial in febrile seizures siblings. Arch Dis Child
1999;80:178-80.
113. Tol J, Roks G, Slooter AJC,Duijn CM van. Genetic and environmental factors in
Alzheimer’s disease. Rev Neurol 1999;155:10-6.
114. Tol J, Slooter AJC, Duijn CM van. Genetic Factors in early-onset and late-onset Alzheimer’s
disease. In: R Mayeux, Christen Y (eds); Epidemiology of Alzheimer’s disease: from gene to
prevention. Springer-Verlag, Berlin Heidelberg New York, 1999, 33-39.
2000
115. Croes EA, Dermaut B, Cammen TJM van der, Broeckhoven C van, Duijn CM van. Genetic
testing should not be advocated as a diagnositic tool in familial forms of dementia. Am J
Hum Genet 2000;67:1033-5.
116. Gestel S van, Houwing-Duistermaat JJ, Adolfsson R, Duijn CM van, Broeckhoven C van.
Power of selective genotyping in genetic association analysis of quantitative traits. Behav
Genet 2000;30:141-6.
117. Harhangi BS, Rijk MC de, Duijn CM van, Broeckhoven C van, Hofman A, Breteler MMB.
Apolipoprotein E genotype, Parkinson's disease, and dementia in Parkinson's disease: the
Rotterdam study. Neurology 2000;54:1272-6.

11. 118. Knittweis JW, McMullen WA, Romas SN, Mayeux R, Slooter AJC, Ruitenberg A, Duijn CM
van, Breteler MMB, Liu HC. The effect of apoE on dementia is not through atherosclerosis:
the Rotterdam Study. Neurology 2000;54:2353-8.
119. Koster MN, Dermaut B, Munteanu G, Houwing-Duistermaat JJ, Roks G, Tol J, Ott A,
Hofman A, Cruts M, Breteler MMB, Duijn CM van, Broeckhoven C van. The alpha-2-
macroglobuline gene: a population-based study and meta-analysis. Neurology 2000;55:678-
84.
120. Roks G, Harskamp F van, Koning I de, Cruts M, Jonghe C de, Kumar-Singh S, Tibben A,
Tanghe H, Niermeijer MF, Hofman A, Swieten JC van, Broeckhoven C van, Duijn CM van.
Presentation of amyloidosis in carriers of the codon 692 mutation in the amyloid precursor
protein gene (APP692). Brain 2000;123:2130-40.
121. Roks G, Duijn CM van. Genetic Epidemiology of Alzheimer’s disease. In ‘Analysis of
Multifactorial Disease’. Eds T Bishop and P Sham. Pages 85-100.
122. Theuns J, Del-Favero J, Dermaut B, Duijn CM van, Backhovens H, Broeck M van der,
Serneels S, Corsmit E, Broeckhoven C van, Cruts M. Genetic variability in the regulatory
region of presenilin 1 associated with risk for Alzheimer’s disease and variable expression.
Hum Mol Genet 2000;9:325-31.
123. Uitterlinden AG, Burger H,Duijn CM van, Huang Q, Hofman A, Birkenhager JC, Leeuwen
JPTM van, Pols HAP.
receptor,are associated with separate features of the radiographic osteoarthritis at the knee.
Arthr Rheum 2000;43:1456-64.
124. Zerr I, Brandel J-P,Masullo C, Wientjens DPWM,Silva R de, Zeidler M, Granieri E,
Sanpaolo S, Duijn CM van, Delasnerie-Laupretre N,Will R, Poser S. European Surveillance
on Creutzfeldt-Jakob disease: a case-control study for medical risk factors. J Clin Epidemiol
2000;53:747-54.
2001
125. Beck JA,Mead S, Campbell TA, Dickinson A, Wientjens DPWM,Croes EA, Duijn CM van,
Collinge J.Two-octapeptide repeat deletion of the prion protein gene associated with a rapidly
progressive dementia. Neurology 2001;2:354-6.
126. Cataldo A, Rebeck GW, Ghetri B, Hulette C, Lippa C, Broeckhoven C van, Duijn CM van,
Cras P,Bogdanovic N, Bird T, Peterhoff C,Nixon R. Endocytic disturbances distinguish
among subtypes of Alzheimer's disease and related disorders. Ann Neurol 2001;50:661-5.
127. Croes EA, Jansen GH, Lemstra AW, Frijns CJM,Gool WA van, Duijn CM van. The first two
patients with dura mater associated Creutzfeldt-Jakob disease in the Netherlands. J Neurol
2001;248:877-80.
128. Cruts M, Dermaut B, Rademakers R,Roks G, Broeck M van den, Munteanu G, Duijn CM
van, Broeckhoven C van. Amyloid beta secretase gene (BACE) is neither mutated in nor
associated with early-onset Alzheimer's disease. NeurosciLett 2001;313:105-7.

12. 129. Dermaut B, Roks G, Theuns J, Rademakers R,Houwing-Duistermaat JJ, Serneels S, Hofman
B, Breteler MMB, Cruts M, Broekchoven C van, Duijn CM van. Variable expression of
presenilin 1 is not a major determinant of risk for late-onset Alzheimer’s Disease. J Neurol
2001;248:935-9
130. Duijn CM van, Dekker MCJ, Bonifati V, Galjaard RJ, Houwing-Duistermaat JJ, Snijders
PJLM,Testers L, Breedveld GJ, Horstink M, Sandkuijl LA,Swieten JC van, Oostra BA,
Heutink P. PARK7,a novel locus for autosomal recessive early-onset parkinsonism on
chromosome 1p36. Am J Hum Genet 2001;69:629-34.
131. Everbroeck B van, Croes EA, Pals P, Dermaut B, Jansen G, Duijn CM van, Cruts M,
BroeckhovenC van, Martin J-J,Cras P. Influence of the prion protein and the apolipoprotein
E genotype on the Creutzfeldt-jakob Disease phenotype. Neurosci Lett 313 2001;69-72.
132. The EUROCJD Group. Genetic epidemiology of Creutzfeldt-Jakob disease in Europe. Rev
Neurol 2001;157:6-7.
133. Geerlings MI, Ruitenberg A, Witteman JC, Swieten JC van, Hofman A,Duijn CM van,
Breteler MMB, Launer LJ.Reproductive period and risk of dementia in postmenopausal
women. JAMA 2001;285:1475-81.
134. Harhangi BS, Oostra BA,Heutink P, Duijn CM van, Hofman A, Breteler MMB. CYP2D6
polymorphism in Parkinson’s disease: The Rotterdam Study. Mov Disord 2001;16:290-3.
135. Jong PT de, Bergen AA, Klaver CC,Duijn CM van, Assink JM. Age-related maculopathy: its
genetic basis. Eye 2001;15:396-400.
136. Kramers C,Danilov SM, Deinum J, Balvasnikova IV, Scharenborg N, Looman M, Boomsma
F, Keijzer MB de, Duijn CM van, Martin S, Soubrier F, Adema GJ. Point mutation in the
stalk of angiotensin-converting enzyme causes a dramatic increase in serum angiotensin-
converting enzyme but no cardiovascular disease. Circulation 2001;104:1236-40.
137. Njajou OT, Vaessen N,Joosse M,Berghuis B, Dongen JWF van, Breuning MH, Snijders
PJLM,Rutten WPF, Sandkuijl LA, Oostra BA, Duijn CM van, Heutink P. A mutation in
SLC11A3 gene is associated with autosomal dominant hemochromatosis. Nat Genet
2001;28:214-15.
138. Osborne RH, Houben MPWA,Tijssen CC, Coebergh JWW, Duijn CM van. The genetic
epidemiology of glioma. Neurology 2001;57:1751-55.
139. Roks G, Cruts M, Slooter AJC,Dermaut B, Hofman A, Broeckhoven C van, Duijn CM van.
The Cystatin C polymorphism is not associated with early-onset Alzheimer's disease.
Neurology 2001;57:366-7.
140. Schmidt H, Fazekas F, Kostner GM, Duijn CM van, Gradert A, Schmidt R. Angiotensinogen
Gene Promoter Haplotype and Microangiopathy-Related CerebralDamage: Results of the
Austrian Stroke Prevention Study. Stroke 2001;32:405-12.
141. Sleegers K, Duijn CM van. Alzheimers’s Disease: Genes, pathogenesis and risk prediction.
Community Genet 2001;4:197-203.

13. 142. Slooter AJC,M Cruts, A Hofman, Broeckhoven C van, Duijn CM van. Apoplipoprotein E
and longevity: the Rotterdam study. J Am Geriatr Soc 2001;49:1-2.
143. Slooter AJC,Bots ML, Havekes LM, Iglesias del Sol A, Cruts M, Grobbee DE, Hofman A,
Broeckhoven C van, Witteman JCM, Duijn CM van. Apolipoprotein E and Carotid Artery
Atherosclerosis. The Rotterdam Study. Stroke 2001;32:1947-52.
144. Theuns J, Feuk L, Dermaut B, Del-Favero J, Roks G, Bossche D van den, Corsmit E, Broeck
van den, Duijn CM van, Cruts M, Brookes A, Broeckhoven C van.The TNFRSF6 gene is not
implicated in familial early-onset Alzheimer’s disease. Hum Genet 2001;108:552-3.
145. Uitterlinden AG, Weel AEAM,Burger H, Yue F, Duijn CM van, Hofman A, Leeuwen PTM
van, Pols HAP. Interaction between the vitamin D receptor gene and collagen type I alpha1
gene in susceptibility for fracture. J Bone Miner Res 2001;16:379-85.
146. Vaessen N,Heuting P, Janssen J,Witteman JCM, Testers L,Hofman A, Oostra BA,
Lamberts SWJ, Pols HAP,Duijn CM van. Association between a polymorphism in the gene
for insulin-like growth factor-I,diabetes and myocardial infarction. Diabetes 2001;50:637-42.
147. Vaessen N,Duijn CM van. Opportunities for population-based studies of complex genetic
disorders after the human genome project. Epidemiology 2001;12:360-4.
148. Veld BA in ‘t, Ruitenberg A, Hofman A, Launer LJ, Duijn CM van, Stijnen Th, Breteler
MMB, Stricker BHCh. Nonsteroidal anti-inflammatory drugs and the risk of Alzheimer’s
disease. New Engl J Med 2001;345:1515-1521.
2002
149. Arends N, Johnston L, Hokken-Koelega A, Duijn CM van, Ridder M de, Sa Vage M, Clark
A. Polymorphism in the IGF-I gene: Clinical Relevance for short children born small for
gestational age (SGA). J Clin Endocrinol Metab 2002;87:2720-4.
150. Beer F de, Stalenhoef AF, Hoogerbrugge N, Kastelein JJ, Gevers Leuven JA, Duijn CM van,
Havekes LM, Smelt AH. Expression of type III hyperlipoproteinemia in apolipoprotein E2
(Arg158--> Cys) homozygotes is associated with hyperinsulinemia.Arterioscler Thromb Vasc
Biol 2002;22:294-9.
151. Bertoli Avella AM, Marcheco TeruelB, Llibre Rodriguez JJ, Gomez Viera N, Borrajero
Martinez I, Severijnen EA, Joosse M, Duijn CM van, Heredero Baute L,Heutink P. A novel
presenilin 1 mutation (L174M) in a large Cuban family with early onset Alzheimer disease.
Neurogenetics 2002;4:97-104.
152. Bonifati V, Breedveld GJ, Squitieri F, Vanacore N,Brustenghi P,Harhangi BS, Montagna P,
Canella, Fabbrini CG, Rizzu P, Duijn CM van, Oostra BA,Meco G, Heutink P. Localization
of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an
independent dataset. Ann Neurol 2002;51:253-6.
153. Bonifati V, Dekker MC, Vanacore N,Fabbrini G, Squitieri F, Marconi R, Antonini A,
Brustenghi P, Dalla Libera A, Mari M de, Stocchi F, Montagna P, Gallai V, Rizzu P, Swieten
JC van, Oostra B, Duijn CM van, Meco G, Heutink P. Autosomal recessive early onset

14. parkinsonism is linked to three loci: PARK 2, PARK 6 and PARK7. NeurolSci 2002;23:59-
60
154. Budka H, Dormont D, Kretzschmar H,Pocchiari M, Duijn CM van. BSE and variant
Creutzfeldt-Jakob disease: never say never. Acta Neuropathol 2002;103:627-8.
155. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L,Palicio M, Abderrahim H,
Bougueleret L, Barry C, Tanaka H, La Rosa P,Puech A, Tahri N, Cohen-Akenine A,
Delabrosse S, Lissarrague S, Picard FP, Maurice K, Essioux L, Millasseau P,Grel P,
Debailleul V, Simon AM, Caterina D, Dufaure I, Malekzadeh K, Belova M, Luan JJ,Bouillot
M, Sambucy JL, Primas G, Saumier M, Boubkiri N, Martin-Saumier S, Nasroune M, Peixoto
H, Delaye A, Pinchot V, BastucciM, Guillou S, Chevillon M, Sainz-Fuertes R, Meguenni S,
Aurich-Costa J, Cherif D, Gimalac A, Duijn CM van, Gauvreau D, Ouelette G, Fortier I,
Realson J, Sherbatich T, Riazanskaia N, Rogaev E, Raeymaekers P,Aerssens J,Konings F,
Luyten W, Macciardi F, Sham PC,Straub RE, Weinberger DR, Cohen N, Cohen D. Genetic
and physiological data implicating the new human gene G72 and the gene for D-amino acid
oxidase in schizophrenia. Proc Natl Acad Sci 2002;99:13675-80
156. Croes EA, Cammen TJ van der, Sleegers K, Duijn CM van. From gene to disease; presenilins
and Alzheimer disease. Ned Tijdschr Geneeskd 2002;146:494-5.
157. Croes EA, Duijn CM van, Gool WA van, Jansen GH. Ziekte van Creutzfeld-Jakob:
diagnostiek, incidentie, preventie en behandeling. Ned Tijdschr Geneeskd 2002;146:750-4.
158. Croes EA, Roks G, Jansen GH, Nijssen PC,Duijn CM van. Creutzfeldt-Jakob disease 38
years after diagnostic use of human growth hormone. J Neurol Neurosurg Psychiatry
2002;72:792-3.
159. Dermaut B, Theuns J, Sleegers K, Hasegawa H,Broeck M van den, Vennekens K, Corsmit E,
St George-Hyslop P, Cruts M, Duijn CM van, Broeckhoven C van. The gene encoding
nicastrin, a major gamma-secretase component modifies risk for familial early-onset
Alzheimer disease in a Dutch population-based sample. Am J Hum Genet 2002;70:1568-74.
160. Gestel S van, Forsgren T, Claes T, Del-Favero J, Duijn CM van, Sluijs S, Nilsson LG,
Aldofsson R, Broeckhoven C van. Epistatic effect of genes from the dopamine and serotonin
systems on the temperament straits of Novelty Seeking and Harm Avoidance. Mol Psychiatry
2002;7:448-50.
161. Heijer T den, Oudkerk M, Launer LJ, Duijn CM van, Hofman A, Breteler MMB.
Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes.
Neurology 2002;59:746-8.
162. Hottenga JJ, Houwing-Duistermaat JJ, Duijn CM van. Unintentional population stratification
in genetic case-controlstudies. Ned Tijdschr Geneeskd 2002;146:17-22.
163. Houben MPWA,Tijssen CC, Duijn CM van, Coebergh JWW. Genetic and Epidemiological
Strategies in the Study of Glioma Etiology. South West Cancer News 2002;11:9-10.
164. Hulsman CAA,Jong PTVM de, Lettink M, Duijn CM van, Hofman A, Bergen AAB.
Myocilin mutations in a population-based sample of cases with open-angle glaucoma: the
Rotterdam Study. Graefe’s Arch Clin Exp Ophthalmol 2002;240:468-74.

15. 165. Hulsman CA,Houwing-Duistermaat JJ, Duijn CM van, Wolfs R, Borger PH,Hofman A,
Jong PT de. Family score as an indicator of genetic risk of primary open-angle glaucoma.
Arch Ophthalmol 2002;120:1726-31.
166. Johnston LB, Arends N, Dahlgren J, Leger J, Czernichow P,Albertsson-Wikland K, Duijn
CM van, Hokken-Koelega A, Savage MO, Clark AJ. Gene association studies in small for
gestational age infants. J Pediatr Endocrinol Metab 2002;15 Suppl 5:1459.
167. Kumar-Singh S, Cras P,Wang R, Kros JM, Swieten J van, Lübke U, Ceuterick C, Serneels,
S, Vennekens K, Timmermans JP,Marck E van, Martin JJ, Duijn CM van, Broeckhoven C
van. Dense-core senile plaques in the flemish variant of Alzheimer’s disease are vasocentric.
Am J Pathol 2002;161:507-20.
168. Maitland-Van Der Zee AH,Stricker BH, Klungel OH,Kastelein JJ, Hofman A, Leufkens
HG, Broeckhoven C van, Duijn CM van, Boer A de. The effectiveness of HMG-CoA
reductase inhibitors in an elderly population is independent of apolipoprotein E-genotypes. Br
J Clin Pharmacol 2002;53:548.
169. Maitland-Van Der Zee AH,Stricker BH, Klungel OH,Kastelein JJ, Hofman A, Witteman JC,
Breteler MMB, Leufkens HG, Duijn CM van, Boer A de. The effectiveness of hydroxy-
methylglutaryl coenzyme A reductaseinhibitors (statins) in the elderly is not influenced by
apolipoprotein E genotype. Pharmacogenetics 2002;12:647-53.
170. Meijers-Heijboer H, Ouweland A van den, Klijn J, Wasielewski M, Snoo A de, Oldenburg R,
Hollestelle A, Houben M, Crepin E, Veghel-Plandsoen M van, Elstrodt F, Duijn CM van,
Bartels C, Meijers C, Schutte M, McGuffog L, Thompson D, Easton D, Sodha N, Seal S,
Barfoot R, Mangion J, Chang-Claude J, Eccles D, Eeles R, Evans DG, Houlston R, Murday
V, Narod S, Peretz T,Peto J, Phelan C, Zhang HX, Szabo C, Devilee P,Goldgar D, Futreal
PA,Nathanson KL,Weber B, Rahman N, Stratton MR. Low-penetrance susceptibility to
breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nat
Genet 2002;31:55-9.
171. Njajou OT, Hollander M, Koudstaal PJ, Hofman A, Witteman JCM, Breteler MMB, Duijn
CM van. Mutations in the hemochromatosis gene (HFE) and stroke. Stroke 2002;10:2363-6.
172. Njajou OT, Jong G de, Berghuis B, Vaessen N,Snijders PJLM, Goossens JP,Wilson JHP,
Breuning MH, Oostra BA, Heutink P,Sandkuijl LA, Duijn CM van. Dominant
hemochromatosis due to N144H mutations of SLC11A3: Clinical and biological
characteristics. Blood Cells Mol Dis 2002;29:439-43.
173. Njajou OT, Vaessen N,Oostra B,Heutink P,Duijn CM van. The hemochromatosisis N144H
mutation of SLC11A3 gene in patients with type 2 diabetes. Mol Genet Metab 2002;75:290-
1.
174. Njajou OT, Alizadeh BZ, Vaessen N,Vergeer J,Houwing-Duistermaat J, Hofman A, Pols
HA, Duijn CM van. The role of hemochromatosis C282Y and H63D gene mutations in type
2diabetes: findings from the Rotterdam Study and meta-analysis. Diabetes Care
2002;25:2112-3

16. 175. Rademakers R,Cruts M, Dermaut B, Sleegers K, Rosso SM, Broeck M van den, Backhovens
H, Swieten J van, Duijn CM van, Broeckhoven C van. Tau negative frontal lobe dementia at
17q21: significant finemapping of the candidate region to a 4.8 cM interval. Mol Psychiatry
2002:7;1064-74.
176. Roks G, Cruts M, Houwing-Duistermaat JJ,Dermaut B, Serneels S, Havekes LM, Hofman A,
Breteler MMB, Broeckhoven C van, Duijn CM van. Effect of the APOE-491A/T promoter
polymorphism on apolipoprotein E levels and risk ofAlzheimer disease: The Rotterdam
Study. Am J Med Genet 2002;114:570-3.
177. Rosso SM, Roks G, Broeckhoven C van, Cruts M, Duijn CM van, Swieten JC van.
Apolipoprotein E4 in the temporal variant of frontotemporal dementia. J Neurol Neurosurg
Psychiatry 2002;72:820.
178. Rossum EF van, Koper JW, Huizenga NA, Uitterlinden AG, Janssen JA,Brinkmann AO,
Grobbee DE, Jong FH de, Duijn CM van. A polymorphism in the glucocorticoid receptor
gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin
and cholesterol levels. Diabetes 2002;51:3128-34.
179. Ruitenberg A, Swieten JC van, Witteman JCM, Mehta KM, Duijn CM van, Hofman A,
Breteler MMB. Alcohol consumption and risk of dementia: the Rotterdam Study. Lancet
2002;359:281-6.
180. Schmidt S, Klaver CCW,Saunders AM, PostelEA, Paz M de la, Agarwal A,Small KW,
Udar N, Ong JM, Chalukya MV, Nesburn A, Kenney MC, Domurath RM, Hogan M, Mah
TS, Ferrell RE, Weeks DE, Jong PTVM de, Duijn CM van, Haines JL, Pericak-Vance MA,
Gorin MA. A pooled case-controlstudy of the apolipoprotein E (APOE) gene in age-related
maculopathy. Ophthalmic Genet 2002;23:209-23.
181. Slooter AJC,Roks G, Duijn CM van. Genetic association studies. Genes in search of
diseases. Neurology 2002;58:1577.
182. Vaessen N,Janssen JA,Heutink P,Hofman A, Lamberts SWJ, Oostra BA,Pols HAP,Duijn
CM van. Association between genetic variation in the gene for insulin-like growth factor-I
and low birthweight. Lancet 2002;23:1036-7.
183. Vaessen N,Peter Heutink P, Houwing-Duistermaat JJ,Snijders PJLM,Rademaker T, Testers
L, Batstra MR, Sandkuijl LA, Duijn CM van, Oostra BA. A genome-wide search for linkage-
disequilibrium with type 1 diabetes in a recent genetically isolated population from the
Netherlands. Diabetes 2002;51:856-9.
184. Ward HJT, Everington D, Croes EA,Alperovithc A, Delasnerie-Lauprêtre,Zerr I, Poser S,
Duijn CM van. The European Union (EU) Collaborative Study Group of Creutzfedt-Jakob
Disease (CJD). Sporadic Creutzfeldt-Jakob disease and surgery. A case-controlstudy using
community controls. Neurology 2002:59;543-8.
2003
185. Aulchenko YS, Axenovich TI, Mackay I, Duijn CM van. Mild and boold programs for
calculation and analysis of corrected linkage disequilibrium. Ann Hum Genet 2003;67:372-5.

17. 186. Aulchenko YS, Vaessen N,Heutink P,Pullen J, Snijders PJLM,Hofman A, Sandkuijl LA,
Houwing-Duistermaat JJ, Edwards M, Bennett S, Oostra BA,Duijn CM van. A genome-wide
search for genes involved in type 2 diabetes in a recently genetically isolated population from
the Netherlands. Diabetes 2003;52:3001-4.
187. Bergink AP,Meurs JB van, Loughlin J, Arp PP,Fang Y, Hofman A, Leeuwen JPTM van,
Duijn CM van, Uitterlinden AG, Pols HAP. Estrogen receptor and gene haplotype is
associated with radiographic osteoarthritis of the knee in the elderly men and woman. Arthr
Rheum 2003;48:1913-22.
188. Bertoli-Avella AM, Giroud-Benitez JL, Bonifati V, Alvarez-Gonzalez E, Heredero-Baute L,
Duijn CM van, Heutink P. Suggestive linkage to chromosome 19 in a large Cuban family
with late-onset parkinson’s disease. Mov Disord 2003;18:1240-9.
189. Bonifati V, Rizzu P,Baren J van, Schaap O, Breedveld GJ, Krieger E, Dekker MCJ, Squitieri
F, Ibanez P, Joosse M, Dongen JW van, Vanacore N,Swieten JC van, Brice A, Meco G,
Duijn CM van, Oostra BA, Heutink P. Mutations in the DJ-1 gene associated with autosomal
rececessive early-onset parkinsonism. Science 2003;299:256-9.
190. Bonifati V, Rizzu P,Squitieri F, Krieger E, Vanacore N,Swieten JC van, Brice A, Duijn CM
van, Oostra B,Meco G, Heutink P. DJ-1( PARK7), a novel gene for autosomal recessive,
early onset parkinsonism. Neurol Sci 2003;24:159-60.
191. Croes EA, Duijn CM van. Variant Creutzfeldt-Jakob disease. Eur J Epidemiol 2003;18:473-7.
192. Croes EA, Dermaut B, Houwing-Duistermaat JJ, Broeck M van den, Cruts M, Breteler
MMB, Hofman A, Broeckhoven C van, Duijn CM van. Early cognitive decline is associated
with prion protein codon 129 polymorphism. Ann Neurol 2003;54:275-6.
193. Dekker MCJ, Bonifati V, Swieten J van, Leenders N, Galjaard RJ, Snijders P, Horstink M,
Heutink P,Oostra BA, Duijn CM van. Clinical features and neuroimaging of PARK7-linked
Parkinsonism. Mov Disord 2003;18:751-7.
194. Dekker MCJ, Bonifati V, Duijn CM van. Parkinson’s disease: piecing together a genetic
jigsaw. Brain 2003;126:1722-33.
195. Dekker MCJ, Swieten JC van, Houwing-Duistermaat JJ, Snijders PJLM,Boeren E, Hofman
A, Breteler MMB, Heutink P, Oostra BA,Duijn CM van. A clinical-genetic study of
Parkinson’s disease in a genetically isolated community. J Neurol 2003;250:1056-62.
196. Dekker MC, Giesbergen PC,Njajou OT, Swieten JC van, Hofman A, Breteler MMB, Duijn
CM van. Mutations in the hemochromatosis gene (HFE), Parkinson's disease and
parkinsonism. Neurosci Lett 2003;348:117-9.
197. Dekker MCJ, Duijn CM van. Prospects of genetic epidemiology in the 21st century. Eur J
Epidemiol 2003;18:607-16.
198. Dermaut B, Croes EA, Rademakers R,Broeck M van den, Cruts M, Hofman A, Duijn CM
van, Broeckhoven van C. PRNP Val129 homozygosity increases risk for early-onset
Alzheimer’s disease. Ann Neurol 2003;53:409-12.

18. 199. Duijn CM van, Porta M. Good prospects for genetic and molecular epidemiologic studies in
the European Journal of Epidemiology. Eur J Epidemiol 2003;18:285-6.
200. Fang Y, Meurs JBJ van, Bergink A, Hofman A, Duijn CM van, Leeuwen JPTM van, Pols,
HAP,Uitterlinden A. Cdx-2 polymorphism in the promoter region of the human vitamin D
receptor gene determines susceptibility of fracture in the elderly. J Bone Miner Res
2003;18:1632-41.
201. Houwing-Duistermaat JJ, Bijkerk C, Hsu L, Stijnen T, Slagboom EP,Duijn CM van. A
unified approach to modelling linkage to quantitative and qualitative traits. Ann Hum Genet
2003;67:457-63.
202. Maitland-van der Zee AH,Stricker BH, Klungel OH, Mantel-Teeuwisse AK,Kastelein JJ,
Hofman A, Leufkens HG, Duijn CM van, Boer A de. Adherence to and dosing of beta-
hydroxy-beta-methylglutaryl coenzyme a reductase inhibitors in the general population
differs according to apolipoprotein E-genotypes. Pharmacogenetics 2003;13:219-23.
203. Meurs JBJ van, Schuit SCE, Weel AEAM,Klift M van der, Bergink AP,Arp PP,Colin EM,
Fang Y, Hofman A, Duijn CM van, Leeuwen JPTM van,Pols HAP,Uitterlinden AG.
Association of 5’ estrogen receptor alpha gene polymorphisms with bone mineral density,
vertebral bone area and fracture risk. Hum Mol Genet 2003;12:1745-54.
204. Njajou OT, Behrooz ZA, Duijn CM van. Genetic screening for common mutations: Lessons
from hereditary hemochromatosis. Eur J Epidemiol 2003;18:3-4.
205. Njajou OT, Houwing-Duistermaat JJ, Osborne RH,Vaessen N,Vergeer J,Heeringa J, Pols
HAP,Hofman A, Duijn CM van. A population-based study of the effect of the HFE C282Y
and H63D mutations on iron metabolism. Eur J Hum Genet2003;11:225-31.
206. Rietveld I, Janssen JAMJL,Hofman A, Pols HAP,Duijn CM van, Lamberts SWJ. A
polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I
levels. Eur J Endocrinol 2003;148:171-5.
207. Rietveld I, Janssen JAMJL,Duijn CM van, Lamberts SW. A polymorphic CA repeat in the
promoter region of the insulin-like growth factor-I (IGF-I) gene. Eur J Epidemiol
2003;18:191-3.
208. Rivadeneira F, Houwing-Duistermaat JJ, Vaessen N,Vergeer-Drop JM,Hofman A, Pols HA,
Duijn CM van, Uitterlinden AG. Association between an insulin-like growth factor I gene
promoter polymorphism and bone mineral density in the elderly: the Rotterdam Study. J Clin
Endocrinol Metab 2003;88:3878-84.
209. Rosso SM, Kaat LD,Baks T, Joosse M, Koning I de, Pijnenburg Y,Jong D de, Dooijes D,
Kamphorst W, Ravid R, Niermeijer, MF, Verheij F, Kremer HP Scheltens P,Duijn CM van,
Heutink P,Swieten JC van. Frontotemporal dementia in The Netherlands: patient
characteristics and prevalence estimates from a population-based study. Brain
2003;126:2016-22.
210. Rosso SM, Landweer EJ,Houterman M, Donker Kaat L, Duijn CM van, Swieten JC van..
Medical and environmental risk factors for sporadic frontotemporal dementia: a retrospective
case-controlstudy. J Neurol Neurosurg Psychiatry 2003;74:1574-6.

19. 211. Rosso SM, Donker Kaat L,Baks T, Joosse M, Koning I de, Pijnenburg Y, Jong D de, Dooijes
D, Kamphorst W, Ravid R, Niermeijer MF, Verheij F, Kremer HP,Scheltens P, Duijn CM
van, Heutink P, Swieten JC van. Frontotemporal dementia in The Netherlands: patient
characteristics and prevalence estimates from a population-based study. Brain
2003;126:2016-22.
212. Sayed-TabatabaeiFA, Houwing-Duistermaat JJ, Duijn CM van, Witteman JCM.
Angiotensin-converting enzyme gene polymorphism and carotid artery wall thickness a meta-
analysis. Stroke 2003;34:1634-9.
213. Schut AFC, Janssen JAMJL,Deinum J, Vergeer JM,Hofman A, Lamberts SWJ, Oostra BA,
Pols HAP,Witteman JCM, Duijn CM van. Polymorphism in the promoter region of the
insulin-like growth factor I gene is related to carotid intima-media thickness and aortic pulse
wave velocity in subjects with hypertension. Stroke 2003;34:1623-7.
2004
214. Alizadeh BZ, Njajou OT, Houwing-Duistermaat JJ, Jong G de, Vergeer JM,Hofman A, Pols
AP,Duijn CM van. Does Bilirubin protect against hemochromatosis gene (HFE) related
mortality? Am J Med Genet 2004;129:39-43.
215. Arias Vásquez A, Sleegers K, Dekker MCJ, Gool WA van, Swieten JC van, Aulchenko YS,
Oostra BA, Duijn CM van. A deletion in DJ-1 and the risk of dementia – a population-based
survey. Neurosci Lett 2004;372:196–9.
216. Aulchenko YS, Heutink P, Mackay I, Bertoli-Avella AM, Pullen J, Vaessen N,Rademaker
TA, Sandkuijl LA, Cardon L, Oostra B, Duijn CM van. Linkage disequilibrium in young
genetically isolated Dutch population. Eur J Hum Genet 2004;12:527-34.
217. Bleumink GS, Duijn CM van, Kingma JH,Witteman JC, Hofman A, Stricker BH.
Apolipoprotein E epsilon4 allele is associated with left ventricular systolic dysfunction. Am
Hear J 2004;147:685-9.
218. Bleumink GS, Rietveld I, Janssen JAMJL, Rossum EFC van, Deckers JW,Hofman A,
Witteman JCM,Duijn CM van, Stricker BHCh. Insulin-like growth factor-I gene
polymorphism and risk of heart failure (the Rotterdam Study). Am J Cardiol 2004;94:384-6.
219. Bleumink GS, Schut AF, Sturkenboom MC, Deckers JW,Duijn CM van, Stricker BH.
Genetic polymorphisms and heart failure. Genet Med 2004;6:465-74.
220. Cammen TJ van der, Croes EA, Dermaut B, Jager MC de, Cruts M, Broeckhoven C van,
Duijn CM van. Genetic testing has no place as a routine diagnotic test in sporadic and
familial cases of Alzheimer’s disease. J Am Geriatr Soc 2004;52:2110-3.
221. Croes EA, Theuns J, Houwing-Duistermaat JJ,Dermaut B, Sleegers K, Roks G, Broeck M
van den, Harten B van, Swieten JC van, Cruts M, Broeckhoven C van, Duijn CM van.
Octapeptide repeat insertions in the prion protein gene and early onset dementia. J Neurol
Neurosurg Psychiatry 2004;75:1166-70.

20. 222. Croes EA, Alizadeh BZ, Bertoli-Avella AM, Rademaker T, Vergeer-Drop J,Dermaut B,
Houwing-Duistermaat JJ, Wientjens DP,Hofman A, Broeckhoven C van, Duijn CM van.
Polymorphisms in the prion protein gene and in the doppel gene increase susceptibility for
Creutzfeldt-Jakob disease. Eur J Hum Genet 2004;12:389-94.
223. Dekker MC, Galjaard RJ, Snijders PJ,Heutink P,Oostra BA, Duijn CM van. Brachydactyly
and short stature in a kindred with early-onset parkinsonism. Am J Med Genet
2004;130A:102-4.
224. Dekker MC, Eshuis SA, Maguire RP, Veenma-van der Duijn L, Pruim J, Snijders PJ, Oostra
BA, Duijn CM van, Leenders KL. PET neuroimaging and mutations in the DJ-1 gene. J
Neural Transm 2004;111:1575-81.
225. Dekker MCJ, Nelson LM, Duijn CM van. Genetic Epidemiology of Neurologic Disease.
Book Neuroepidemiology From Principles to Practice (Nelson LM, Tanner CM, Eeden SK
van den McGuire VM);2004:85-101.
226. Dijk EJ van, Prins ND, Vermeer SE,Hofman A, Duijn CM van, Koudstaal PJ, Breteler
MMB. Plasma amyloid beta, apolipoprotein E, lacunar infarcts and white matter lesions Ann
Neurol 2004;55:570-5.
227. Duijn CM van. Prospects of genetic research of mild cognitive impairment. J Intern Med
2004;256:235-9.
228. Geleijnse K, Brouwer BA, Jacobs BC,Houwing-Duistermaat JJ, Duijn CM van, Doorn PA
van. The occurrence of Guillain-Barre syndrome within families. Neurology 2004;63:1747-
50.
229. ‘t Hart LM, Fritsche A, Rietveld I, Dekker JM, Nijpels G, Machicao F, Stumvoll M, Duijn
CM van, Haring HU, Heine RJ, Maassen JA,Haeften TW van. Genetic factors and insulin
secretion: gene variants in the IGF genes. Diabetes 2004;53:26-30.
230. Heijer T den, Schuit SCE, Pols HAP,Meurs JBJ van, Hofman A, Koudstaal PJ,Duijn CM
van, Uitterlinden AG, Breteler MMB.
dementia, and brain volumes on MRI. Mol Psychiatry 2004;1129-35.
231. Heijer T den, Vermeer SE, Dijk EJ van, Prins ND, Koudstaal PJ,Duijn CM van, Hofman A,
Breteler MMB. Alcohol intake in relation to brain magnetic resonance imaging findings in
older persons whithout dementia. Am J Clin Nutr 2004;80:992-7.
232. Houben MPWA,Louwman WJ, Tijssen CC, Teepen JLJM, Duijn CM van, Coebergh JWW.
Hypertension as a risk factor for glioma? Evidence from a population-based study of
comorbidity in glioma patients. Ann Oncol 2004;15:1256-60.
233. Isaacs A,Sayed-TabatabaeiFA,Njajou OT, Witteman JC, Duijn CM van. The –514C->T
hepatic lipase prmotor region polymorphosm and plasma lipids: a meta-analysis. J Clin
Endocrinol Metab 2004;89:3858-63.
234. Janssens AC,Pardo MC, Steyerberg EW, Duijn CM van. Revisiting the clinical validity of
multiplex genetic testing in complex diseases. Am J Hum Genet 2004;74:585-8.

21. 235. Leeuw FE de, Richard F, Groot JC de, Duijn CM van, Hofman A, Gijn J van, Breteler MMB.
Interaction between hypertension, apoE and cerebralwhite matter lesions. Stroke,
2004;35:1057-60.
236. Leeuwen R van, Klaver CC, Vingerling JR, Hofman A, Duijn CM van, Stricker BH, Jong PT
de. Cholesterol and age-related macular degeneration: is there a link? Am J Ophthalmol
2004;137:750-2.
237. Maitland-van der Zee AH,Klunger OH, Stricker BH,Veenstra DL,Kastelein JJ, Hofman A,
Witteman JC,Leufkens HG, Duijn CM van, Boer A de. Pharmacoeconomic evaluation of
testing for angiotensin-converting enzyme genotype before starting beta-hydroxy-beta-
methylglutaryl coenzyme A reductase inhibitor therapy in men. Pharmacogenetics
2004;14:53-60.
238. Maitland-van der Zee AH,Stricker BH, Klungel OH, Kastelein JJ,Hofman A, Witteman JC,
Leufkens HG, Duijn CM van, Boer AA. Effectiveness of HMG-CoA reductase inhibitors is
modified by the ACE insertion deletion polymorphism. Atherosclerosis 2004;175:377-9.
239. Mattace-Raso FU,Cammen TJ van der, Sayed-TabatabaeiFA, Popele NM van, Asmar R,
Schalekamp MA, Hofman A, Duijn CM van, Witteman JC. Antiotensin-converting enzyme
gene polymorphism and common carotid stiffness. The Rotterdam Study. Atheroclerosis
2004;174:121-6.
240. Meulenbelt I, Seymour AB, Nieuwland M, Huizinga TW, Duijn CM van, Slagboom PE.
Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the
hip. Arthritis Rheum 2004;50:1179-86.
241. Nijs PF de, Ferdinand RF, Bruin EI de, Dekker MC, Duijn CM van, Verhulst DC. Attention-
deficit/hyperactivity disorder (ADHD):parents’ judgment about school, teacher’s judgement
about home. Eur Child Adolesc Psychiatry 2004;13:315-20.
242. Njajou OT, Alizadeh BZ, Duijn CM van. Is genetic screening for hemochromatosis
worthwhile? Eur J Epidemiol 2004;19:101-8.
243. Pocchiari M, Puopolo M, Croes EA, Budka H. Gelpi E, Collins S, Lewis V, Sutcliffe T,
Guilivi A, Delasnerie-Laupretre N,Brandel JP,Alperovitch A,Zerr I, Poser S,Kretzschmar
HA, Ladogana A, Rietvald I, Mitrova E, Martinez-Martin P, Pedro-Cuesta J de,Glatzel M,
Aguzzi A, Cooper S, Mackenzie J, Duijn CM van, Will RG. Predictors of survival in sporadic
Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies. Brain
2004:127;2348-59.
244. Rademakers R,Broeck M van den, Sleegers K, Duijn CM van, Broeckhoven C van, Cruts M.
Absence of pathogenic mutations in presenilin homologue 2 in a conclusively 17-linked tau-
negative dementia family. Neurogenetics 2004;5:79-80.
245. Rietveld I, Janssen JAMJL,Rossum EFC van, Houwing-Duistermaat JJ, Rivadeneira F,
Hofman A, Pols HAP,Duijn CM van, Lamberts SWJ. A polymorphic CA repeat in the IGF-I
gene is associated with gender-specific differences in body height, but has no effect on the
secular trend in body height. Clin Endocrinol 2004;61:195-203.

22. 246. Rivadeneira F, Houwing-Duistermaat JJ, Beck TJ, Janssen JA,Hofman A, Pols HA, Duijn
CM van, Uitterlinden AG. The influence of an insulin-like growth factor I gene promotor
polymorphism on hip bone geometry and the risk of nonvertebral fracture in the elderly: the
Rotterdam Study. J Bone Miner Res 2004;19:1280-90.
247. Sayed-TabatabaeiFA, Schut AF, Hofman A, Bertoli-Avella AM, Vergeer J,Witteman JC,
Duijn CM van. A study of gene-environment interaction on the gene for angiotensin
converting enzyme: a combined functional and population based approach. J Med Genet
2004;41:99-103.
248. Schelleman H, Stricker BH, Boer A de, Kroon AA,Verschuren MW, Duijn CM van, Psaty
BM, Klungel OH. Drug-gene interactions between generic polymorphisms and
antihypertensive therapy. Drugs 2004;64:1801-16.
249. Schmidt H, Aulchenko YS, Schweighofer N, Schmidt R, Frank S, Kostner GM Ott E, Duijn
CM van. Angiotensinogen promoter B-haplotype associated with cerebralsmall vessel
disease enhances basaltranscriptional activity. Stroke 2004;35:2592-7.
250. Schoofs MW, Klift M van der, Hofman A, Duijn CM van, Stricker BH, Pols HA,Uitterlinden
AG. ApoE gene polymorphisms, BMD, and fracture risk in elderly men and women: the
Rotterdam Study. J Bone Miner Res 2004;19:1490-6.
251. Schut AF, Sayed-TabatabaeiFA, Witteman JC,Avella AM, Vergeer JM,Pols HA, Hofman
A, Deinum J, Duijn CM van. Smoking-dependent effects of the antiotensin-converting
enzyme gene insertion/deletion polymorphism on blood pressure. J Hypertens 2004;22:313-9.
252. Schut AF, Bleumink GS, Stricker BH, Hofman A, Witteman JC, Pols HA,Deckers JW,
Deinum J. Duijn CM van. Angiotensin converting enzyme insertion/deletion polymorphism
and the risk of heart failure in hypertensive subjects. Eur Heart J 2004;2143-8.
253. Sleegers K, Roks G, Theuns J. Aulchenko YS, Rademakers R,Cruts M. Gool WA van,
Broeckhoven C van, Heutink P,Oostra BA, Swieten JC van, Duijn CM van. Familial
clustering and genetic risk for dementia in a genetically isolated Dutch population. Brain
2004;127:1641-9.
254. Sleegers K, Weber WEJ, Duijn CM van. Neuro-epidemiologie. Book Praktische
Huisartsgeneeskunde Neurologie (Ree van JW, Martin JJ) 2004;25-37.
255. Slooter AJ, Cruts M, Hofman A, Koudstaal PJ, Kuip D van der, Ridder MA de, Witteman JC,
Breteler MMB, Broeckhoven C van, Duijn CM van. The impact of APOE on myocardial
infarction, stroke and dementia: the Rotterdam Study. Neurology 2004;62:1196-8.
256. Winblad B, Palmer K,Kivipelto M, Jelic V,Fratiglioni L, Wahlund LO, Nordberg A,
Backman L, Albert M, Almkvist O, Arai H, Basun H, Blennow K, Leon M de, DeCarli C,
Erkinjuntti T, Giacobini E, Graff C, Hardy J, Jack C, Jorm A, Ritchie K, Duijn CM van,
Visser P, Petersen RC. Mild cognitive impairment – beyond controversies, towards a
consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern
Med 2004;256:240-6.
257. West D van, Del-Favero J, Aulchenko Y, Oswald P,Souery D, Forsgren T, Sluijs S, Bel-
Kacem S, Adolfsson R, Mendlewicz J. Duijn CM van, Deboutte D, Broeckhoven C van. A

23. major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major
depression. Mol Psychiatry 2004;9:287-92.
258. Visser LE, Vliet M van, Schaik RHN van, Kasbergen AAH,Smet PAGM de, Vulto AG,
Homan A, Duijn CM van, Stricker BHCh. The risk of overanticoagulation in patients with
cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon.
Pharmacogenetics 2004;14:27-33.
259. Visser LE, Schaik RHN van, Vliet M van, Trienekens PH,Smet PAGM de, Vulto AG,
Hofman A, Duijn CM van. The risk of bleeding complications in patients with cytochrome
P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol of phenprocoumon. Thromb
Haemost 2004;92:61-6.
260. Zhai G, Rivadeneira F, Houwing-Duistermaat JJ, Meulenbelt I, Bijkerk C, Hofman A, Meurs
JBJ van, Uitterlinden AG, Pols HAP,Slagboom PE, Duijn CM van. Insulin-like growth factor
I gene promoter polymorphism, collagen type II α1 (COL2A1) gene, and the prevalence of
radiographic osteoarthritis: the Rotterdam Study. Ann Rheum Dis 2004;63:544-8.
2005
261. Alizadeh BZ, Njajou OT, Bijkerk C, Meulenbelt I, Wildt SC, Hofman A, Pols HA,Slagboom
PE,Duijn CM van. Evidence for a role of the genomic region of the gene encoding for the
alphal chain of type IX collagen (COL9A1) in hip osteoarthritis: A population-based study.
Arthritis Rheum 2005;52:1437-42.
262. Arias-Vasquez A, Sayed-TabatabaeiFA, Schut AF, Hofman A, Bertoli-Avella AM, Vergeer
JM, Aulchenko YS, Witteman JC, Duijn CM van. Angiotensin converting enzyme gene,
smoking and mortality in a population-based study. Eur J Clin Invest 2005;35:444-9.
263. Assink JJ, Klaver CC, Houwing-Duistermaat JJ,Wolfs RC, Duijn CM van, Hofman A, Jong
PT de. Heterogeneity of the genetic risk in age-related macular disease: a population-based
familial risk study. Ophthalmology 2005;112:482-7.
264. Aulchenko YS, Bertoli-Avella AM, Duijn CM van. A method for pooling alleles from
different genotyping experiments. Ann Hum Genet 2005;69:233-8.
265. Bertoli-Avella AM, Giroud-Benitez JL, Akyol A, Barbosa E, Schaap O, Linde HC van der,
Martignoni E, Lopiano L, Lamberti P, Fincati E, Antonini A, Stocchi F, Montagna P,
Squitieri F, Marini P, Abbruzzese G, Fabbrini G, Marconi R, Dalla Libera A, Trianni G,
Guidi M, Gaetano A de, Boff Maegawa G, Leo A de, Gallai V, Rosa G de, Vanacore N,
Meco G, Duijn CM van, Oostra BA, Heutink P,Bonifati V. Novel parkin mutations detected
in patients with early-onset Parkinson’s disease. Mov Disord 2005;20:424-31.
266. Bertoli-Avella A, Dekker MCJ, Aulchenko YS, Houwing-Duistermaat JJ, Simons E, Testers
L, Pardo LM, Rademaker TAM,Snijders PJLM,Swieten JC van, Bonifati V, Heutink P,
Duijn CM van, Oostra BA. Evidence for novel loci for late-onset Parkinson’s disease in a
genetic isolate from the Netherlands. Hum Genet 2005;14:1-10.
267. Bleumink GS, Schut AF, Sturkenboom MC, Duijn CM van, Deckers JW,Hofman A, Kingma
JH, Witteman JC, Stricker BH. Mortality in patients with hypertension on angiotensin-I

24. converting enzyme (ACE)-inhibitor treatment is influenced by the ACE insertion/deletion
polymorphism. Pharmacogenet Genomics 2005;15:75-81.
268. Bleumink GS, Schut AF, Sturkenboom MC, Janssen JA,Witteman JC, Duijn CM van,
Hofman A, Stricker BH. A promoter polymorphism of the insulin-like growth factor-I gene is
associated with left ventricular hypertrophy. Heart 2005;91:239-40.
269. Bunce C, Hitchings RA, Duijn CM van, Jong PT de, Vingerling JF. Associations between the
deletion polymorphism of the angiotensin 1-converting enzyme gene and ocular signs of
primary open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol 2005;243:294-9.
270. Croes EA, El Galta R, Houwing-Duistermaat JJ, Ferdinand RF, Lopez Leon S, Rademaker
TA, Dekker MC, Oostra BA,Verhulst F, Duijn CM van. Phenotypic subtypes in attention
deficit hyperactivity disorder in an isolated population. Eur J Epidemiol 2005;20:789-94.
271. El Galta R, Duijn CM van, Houwelingen C van, Houwing-Duistermaat JJ. Score statistic to
test for genetic correlation for proband-family design. Ann Hum Genet 2005;69:373-381.
272. González-Zuloeta Ladd AM, Arias Vásquez A, Sayed-TabatabaeiFA, Coebergh JW, Hofman
A, Njajou O,Stricker B, Duijn CM van. Angiotensin-converting enzyme gene
insertion/deletion polymorphism and breast cancer risk. Cancer Epidemiol Biomarkers Prev
2005;14:2143-6.
273. 't Hart LM, Hansen T, Rietveld I, Dekker JM, Nijpels G, Janssen GM, Arp PA,Uitterlinden
AG, Jorgensen T, Borch-Johnsen K, Pols HA,Pedersen O,Duijn CM van, Heine RJ,
Maassen JA. Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene
represents a novel type 2 diabetes susceptibility gene. Diabetes 2005;54:1892-5.
274. Houben MPWA,Coebergh JWW, Birch JM, Tijssen CC, Duijn CM van, McNally RJQ.
Space-time clustering patterns of gliomas in the Netherlands suggest an infectious aetiology.
Eur J Cancer 2005;41:2917-23.
275. Houben MPWA,Duijn CM van, Coebergh JW, Tijssen CC. Gliomas: the role of
environmental risk factors and genetic predisposition. Ned Tijdschr Geneeskd
2005;149:2268-72.
276. Jansen C, Houben MPWA,Hoff JI, Sanchez-Juan P,Rozemuller AJ, Duijn CM van. The first
patient with the new variant of Creutzfeldt-Jakob’s disease in The Netherlands. Ned Tijdschr
Geneeskd 2005;149:2949-54.
277. Kovács GG, Puopolo M, Ladogana A, Pocchiari M, Budka H, Duijn CM van, Collins SJ,
Boyd A, Giulivi A, Coulthart M, Delasnerie-Laupretre N,Brandel JP, Zerr I, Kretzschmar
HA, Pedro-Cuesta J de,Calero-Lara M, Glatzel M, Aguzzi A, Bishop M, Knight R, Belay G,
Will R, Mitrova E; EUROCJD. Genetic prion disease: the EUROCJD experience. Hum Genet
2005;118:166-74.
278. Ladogana A,Puopolo M, Croes EA, Budka H, Jarius C, Collins S, Klug GM, Sutcliffe T,
Giulivi A, Alperovitch A, Delasnerie-Laupretre N,Brandel JP,Poser S, Kretzschmar H,
Rietveld I, Mitrova E, Cuesta JP de,Martinez-Martin P,Glatzel M, Aguzzi A, Knight R,
Ward H, Pocchiari M. Duijn CM van, Will RG, Zerr I. Mortality from Creutzfeldt-Jakob
disease and related disorders in Europe, Australia, and Canada. Neurology 2005:64;1586-91.

25. 279. Lehmann DJ, Cortina-Borja M, Warden DR, Smith AD,Sleegers K, Prince JA,Duijn CM
van, Kehoe PG. Large Meta-Analysis Establishes the ACE Insertion-Deletion Polymorphism
as a Marker of Alzheimer’s Disease. Am J Epidemiol 2005;162:305-317.
280. Lopez Leon S, Croes EA,Sayed-TabatabaeiFA, Claes S, Broeckhoven C van, Duijn CM
van. The dopamine D4 receptor gene 48-base-pair-repeat polymorphism and mood disorders:
a meta-analysis. Biol Psychiatry 2005;57:999-1003.
281. Min JL, Meulenbelt I, Riyazi N, Kloppenburg M, Houwing-Duistermaat JJ, Seymour AB,
Pols HA,Duijn CM van, Slagboom PE. Association of the Frizzled-related protein gene with
symptomatic osteoarthritis at multiple sites. Arthritis Rheum 2005;52:1077-80.
282. Oei HH,Sayed-TabatabaeiFA, Hofman A, Oudkerk M, Duijn CM van, Witteman JC. The
association between angiotensin-converting enzyme gene polymorphism and coronary
calcification. The Rotterdam Coronary Calcification Study. Atherosclerosis 2005;182:169-73.
283. Pardo LM, Duijn CM van. In search of genes involved in neurodegenerative disorders. Mutat
Res 2005;592:89-101.
284. Pardo LM, MacKay I, Oostra B, Duijn CM van, Aulchenko YS. The effect of genetic drift in
a young genetically isolated population. Ann Hum Genet 2005;69:288-95.
285. Rademakers R,Cruts M, Sleegers K,Dermaut B, Theuns J, Aulchenko Y, Weckx S,
DePooter T,Broeck M van den, Corsmit E, Rijk P de, Del-Favero J, Swieten J van, Duijn
CM van, Broeckhoven C van. Linkage and association studies identify a novel locus for
Alzheimer disease at 7q36 in a Dutch population-based sample. Am J Hum Genet
2005;77:643-52.
286. Rademakers R,Sleegers K, Theuns J, Broeck M van den, Bel Kacem S,Nilsson LG,
Adolfsson R, Duijn CM van, Broeckhoven C van, Cruts M. Association of cyclin-dependent
kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer’s disease
Neurobiol Aging 2005;26:1145-51.
287. Rijn MJE van, Slooter AJ, Schut AF, Isaacs A,Aulchenko YS, Snijders PJ,Kappelle LJ,
Swieten JC van, Oostra BA,Duijn CM van. Familial aggregation, the PDE4D gene,and
ischemic stroke in a genetically isolated population. Neurology 2005;65:1203-9.
288. Rijn MJE van, Duijn CM van, Slooter AJC. The impact of genetic testing on complex
diseases. Eur J Epidemiol 2005;20:383-8.
289. Sayed-TabatabaeiFA, Rijn MJ van, Schut AF, Aulchenko YS, Croes EA, Zillikens MC, Pols
HA, Witteman JC, Oostra BA,Duijn CM van. Heritability of the function and structure of the
arterial wall: findings of the Erasmus Rucphen Family (ERF) study. Stroke 2005;36:2351-6.
290. Sayed-TabatabaeiFA, Schut AF, Vasquez AA, Bertoli-Avella AM, Hofman A, Witteman JC,
Duijn CM van. Angiotensin converting enzyme gene polymorphism and cardiovascular
morbidity and mortality: the Rotterdam Study. J Med Genet 2005;42:26-30.

26. 291. Schelleman H, Klungel OH, Duijn CM van, Witteman JC, Hofman A, Boer A de, Stricker
BH. Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors. Br J
Clin Pharmacol2005;59:483-5.
292. Sleegers K, Heijer T den, Dijk EJ van, Hofman A, Bertoli-Avella AM, Koudstaal PJ,Breteler
MMB, Duijn CM van. ACE gene is associated with Alzheimer’s disease and atrophy of
hippocampus and amygdala. Neurobiol Aging 2005;26:1153-9.
293. Venken T, Claes S, Sluijs S, Paterson AD,Duijn CM van, Adolfsson R, Del-Favero J,
Broeckhoven C van. Genomewide scan for affective disorder susceptibility loci in families of
a northern Swedish isolated population. Am J Hum Genet 2005;76:237-48.
294. Visser LE, Trienekens PH,Smet PA de, Vulto AG, Hofman A, Duijn CM van, Stricker BH.
Patients with an ApoE epsilon4 allele require lower doses of coumarin anticoagulants.
Pharmacogenet Genomics 2005;15:69-74.
295. Visser LE, Schaik RHN van, Vliet M van, Trienekens PH,Smet PAGM de, Vulto AG,
Hofman A, Duijn CM van, Stricker BHCh. Allelic variants of cytochrome P450 2C9 modify
the interaction between nonsteroidal anti-inflammatory drugs and coumarin anticoagulants.
Clin PharmacolTher 2005;77:479-85.
2006
296. Bertoli-Avella AM, Dekker MC, Aulchenko YS, Houwing-Duistermaat JJ, Simons E, Testers
L, Pardo LM, Rademaker TA,Snijders PJ,Swieten JC van, Bonifati V, Heutink P, Duijn CM
van. Evidence for novel loci for late-onset Parkinson’s disease in a genetic isolate from the
Netherlands. Hum Genet 2006;119:51-60.
297. Brouwers N, Sleegers K, Engelborghs S, Bogaerts V, Duijn CM van, Deyn PP de,
Broeckhoven C van, Dermaut B. The UBQLN1 polymorphism, UBQ-8i, at 9q22 is not
associated with Alzheimer’s disease with onset before 70 years. NeurosciLett 2006;392:72-4.
298. Collins SJ, Sanchez-Juan P,Masters CL,Klug GM, Duijn CM van, Poleggi A, Pocchiari M,
Almonti S, Cuadrado-Corrales N, Pedro-Cuesta J de, Budka H, Gelpi E, Glatzel M, Tolnay
M, Hewer E,Zerr I, Heinemann U, Kretszchmar HA,Jansen GH, Olsen E, Mitrova E,
Alpérovitch A, Brandel JP,Mackenzie J, Murray K, Will RG. Determinants of diagnostic
investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt-Jakob disease.
Brain. 2006;129:2278-87.
299. Coppus AMW,Evenhuis H, Verberne GJ,Visser F, Gool P van, Eikelenboom P, Duijn CM
van. Dementia and mortality in persons with Down’s syndrome. J Intellect Disabil Res
2006;50:768-77.
300. Cruts M, Gijselinck I, Zee J van der, Engelborghs S, Wils H, Pirici D, Rademakers R,
Vandenberghe R, Dermaut B, Martin JJ, Duijn CM van, Peeters K,Sciot R, Santens P, Pooter
T de, Mattheijssens M, Broeck M van den, Cuijt I, Vennekens K, Deyn PP de,Kumar-Singh
S, Broeckhoven C van. Null Mutations in progranulin cause ubiquitin-positive frontotemporal
dementia linked to chromosome 17q21. Nature 2006;442:920-4.
301. Despriet DD, Klaver CC,Witteman JC, Bergen AA,Kardys I, Maat MP de, Boekhoorn SS,
Vingerling JR, Hofman A, Oostra BA,Uitterlinden AG, Stijnen T, Duijn CM van, Jong PT

27. de. Complement factor H polymorphism, complement activators, and risk of age-related
macular degeneration. JAMA 2006;296:301-9.
302. Duijn CM van, Ruijs H, Timen A. Second probable case of vCJD in the Netherlands. Euro
Surveill 2006;11:E060629.4.
303. Gonzalez-Zuloeta Ladd AM, Arias Vasquez AA, Witteman J, Uitterlinden AG, Coebergh
CW, Hofman A, Stricker BH, Duijn CM van. Interleukin 6 G-174 C polymorphism and
breast cancer risk. Eur J Epidemiol 2006;21:373-6.
304. Hofman A, Jong PTVM de, Duijn CM van, Breteler MMB. Epidemiology of neurological
diseases in elderly people: what did we learn from the Rotterdam Study? Lancet Neurol
2006;5:545-50.
305. Houben MPWA,Coebergh JWW, Birch JM, Tijssen CC, Duijn CM van, McNally RJQ.
Space-time clustering of glioma cannot be attributed to specific histological subgroups. Eur J
Epidemiol 2006;21:197-201.
306. Houben MPWA,Aben KK,Teepen JL, Schouten-Van Meeteren AY,Tijssen CC, Duijn CM
van, Coebergh JW. Stable incidence of childhood and adult glioma in The Netherlands, 1989-
2003. Acta Oncol 2006;45:272-9.
307. Houben MPWA,Coebergh JW, Herings RM, Casparie MK, Tijssen CC, Duijn CM van,
Stricker BH. The association between antihypertensive drugs and glioma. Br J Cancer
2006;94:752-6.
308. Ikram MK, Janssen JA,Roos AM, Rietveld I, Witteman JC, Breteler MMB, Hofman A,
Duijn CM van, Jong PT van. Retinal vesseldiameters and risk of impaired fasting glucose or
diabetes: the Rotterdam Study. Diabetes 2006;55:506-10.
309. Janssens ACJW,Aulchenko YS, Elefante S, Borsboom GJJM, Steyerberg EW, Duijn CM
van. Predictive testing for complex diseases using multiple genes: Fact or fiction. Genet Med
2006;8:395-400.
310. Janssens ACJW,Duijn CM van. Towards predictive genetic testing of complex diseases
(Editorial). Eur J Epidemiol 2006;21:869-870.
311. Janssens ACJW,Steyerberg EW, Jiang Y,Habbema JD, Duijn CM van, Criswell LA. Value
of the HLA-DRB1 shared epitope for predicting radiographic damage in rheumatoid arthritis
depends on the individual patient risk profile. J Rheumatol 2006;33:2383-9.
312. Kardys I, Klaver CC, Despriet DD, Bergen AA,Uitterlinden AG, Hofman A, Oostra BA,
Duijn CM van, Jong PTVM de,Witteman JC. A common polymorphism in the complement
factor H gene is associated with increased risk of myocardial infarction: the Rotterdam Study.
J Am Coll Cardiol 2006;47:1568-75.
313. Liu F, Elefante S, Duijn CM van, Aulchenko YS. Ignoring distant genealogic loops leads to
false-positives in homozygosity mapping. Ann Hum Genet 2006;70:965-70.

28. 314. Lopez-Leon S, Janssens ACJW,Hofman A, Claes S, Breteler MMB, Tiemeier H, Duijn CM
van. No association between the angiotensin-converting enzyme gene and major depression: a
case-controlstudy and meta-analysis. Psychiatr Genet 2006;16:225-6.
315. Meulenbelt I. Min JL, Duijn CM van, Kloppenburg M, Breeveld FC, Slagboom PE. Strong
linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two
positional candidate genes. Eur J Hum Genet 2006;14:1280-7.
316. Min JL, Meulenbelt I, Riyazi N, Kloppenburg M, Houwing-Duistermaat JJ, Seymour AB,
Duijn CM van, Slagboom PE. Association of matrilin-3 polymorphisms with spinal disc
degeneration and osteoarthritis of the first carpometacarpaljoint of the hand. Ann Rheum Dis
2006;65:1060-6.
317. Njajou OT, Alizadeh BZ, Aulchenko Y, Zillikens MC, Pols HA, Oostra BA,Swinkels DW,
Duijn CM van. Heritability of serum iron, ferritin and transferrin saturation in a genetically
isolated population, the Erasmus Rucphen Family (ERF) Study. Hum Hered 2006;61:222-8.
318. Pedro-Cuesta J de,Glatzel M, Almazán J, Stoeck Katharina, Mellina V, Puopolo M,
Pocchiari M, Zerr I, Kretszchmar HA,Brandel JP,Delasnerie-Lauprêtre N,Alpérovitch A,
Duijn CM van, Sanchez-Juan P, Collins S, Lewis V, Jansen GH, Coulthart MB, Gelphi E,
Budka H, Mitrova E. Human transmissible spongiform encephalopahties in eleven countries:
diagnostic pattern across time, 1993-2002. BMC Public Health 2006;6:278.
319. Rietveld I, Hofman A, Pols HA, Duijn CM van, Lamberts SW, Janssen JA. An insulin-like
growth factor-I gene polymorphism modifies the risk of microalbuminuria in subjects with an
abnormal glucose tolerance. Eur J Endocrinol 2006;154:715-21.
320. Rietveld I, Ikram MK, Vingerling JR,Hofman A, Pols HA, Lamberts SW, Jong PT de, Duijn
CM van, Janssen JA. An ifg-I gene polymorphism modifies the risk of diabetic retinopathy.
Diabetes 2006;55:2387-91.
321. Rijn MJ van, Slooter AJ, Bos MJ, Catarino CF, Koudstaal PJ,Hofman A, Breteler MMB,
Duijn CM van. Insulin-like growth factor I promoter polymorphism, risk of stroke, and
survival after stroke: the Rotterdam Study. J Neurol Neurosurg Psychiatry 2006;77:24-7.
322. Rijn MJ, Bos MJ, Yazdanpanah M, Isaacs A,Arias-Vasquez A,Koudstaal PJ,Hofman A,
Witteman JC,Duijn CM van, Breteler MMB. Alpha-adducin polymorphism, atherosclerosis,
and cardiovascular and cerebrovascular risk. Stroke 2006;37:2930-4.
323. Rivadeneira F, Meurs JB van, Kant J, Zillikens MC, Stolk L, Beck TJ, Arp P, Schuit SC,
Hofman A, Houwing-Duistermaat JJ,Duijn CM van, Leeuwen JP,Pols HA, Uitterlinden AG.
Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha
(ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in
postmenopausal women. J Bone Miner Res 2006;21:1443-56.
324. Sanchez-Juan P, Green A, Ladogana A, Cuadrado-Corrales N, Saanchez-Valle R, Mitrovaa E,
Stoeck K, Sklaviadis T, Kulczycki J, Hess K,Bodemer M, Slivarichova D, Saiz A, Calero M,
Ingrosso L, Knight R, Janssens ACJW,Duijn CM van, Zerr I. CSF tests in the differential
diagnosis of Creutzfeldt-Jakob disease. Neurology 2006;67:637-43.

29. 325. Santos RLP,Zillikens MC, Rivadeneira FR, Pols HAP,Oostra BA,Duijn CM van,
Aulchenko YS. Heritability of fasting glucose levels in a young genetically isolated
population. Diabetologia 2006;49:667-72.
326. Sayed-TabatabaeiFA, Oostra BA,Isaacs A,Duijn CM van, Witteman JCM. ACE
Polymorphisms. Circ Res 2006;98:1123-33.
327. Schelleman H, Klungel OH, Duijn CM van, Witteman JC, Hofman A, Boer A de, Stricker
BH. Drug-Gene interaction between the insertion/deletion polymorphism of the angiotensin-
converting enzyme gene and antihypertensive therapy. Ann Pharmacother 2006;40:212-8.
328. Schelleman H, Klungel OH, Witteman JC, Hofman A, Duijn CM van, Boer A de, Stricker
BH. The influence of the alpha-adducin G460W polymorphism and angiotensinogen M235T
polymorphism on antihypertensive medication and blood pressure. Eur J Hum Genet
2006;14:860-6.
329. Service S, DeYoung J, Karayiorgou M, Roos JL, Pretorious H, Bedoya G, Ospina J, Ruiz-
Linares A, Macedo A,Palha JA,Heutink P, Aulchenko Y, Oostra B, Duijn CM van, Jarvelin
MR, Varilo T, Peddle L, Rahman P, Piras G, Monne M, Murray S, Galver L, Peltonen L,
Sabatti C, Collins A, Freimer N. Magnitude and distribution of linkage disequilibrium in
population isolates and implications for genome-wide association studies. Nat Genet
2006:556-60.
330. Sie MP, Uitterlinden AG, Bos MJ, Arp PP,Breteler MM, Koudstaal PJ, Pols HA, Hofman A,
Duijn CM van, Witteman JC. TGF-beta 1 polymorphisms and risk of myocardial infarction
and stroke: the Rotterdam Study. Stroke 2006;37:2667-71
331. Sie MP, Sayed-TabatabaeiFA, Oei HH. Uitterlinden AG, Pols HA, Hofman A,Duijn CM
van, Witteman JC. Interleukin 6-174 g/c promoter polymorphism and risk of coronary heart
disease: result from the rotterdam study and a meta-analysis. Arterioscler Thromb Vasc Biol
2006;26:212-7.
332. Sleegers K, Brouwers N, Gijselinck I, Theuns J, Goossens D, Wauters J, Del-Favero J, Cruts
M, Duijn CM van, Broeckhoven C van. APP duplication is sufficient to cause early onset
Alzheimer’s dementia with cerebralamyloid angiopathy. Brain 2006;129:2977-83.
333. Theuns J, Brouwers N, Engelborghs S, Sleegers K, Bogaerts V, Corsmit E, Poorter T de,
Duijn CM van, Deyn PP de,Broeckhoven C van. Promoter mutations that increase amyloid
precursor-protein expression are associated with Alzheimer disease. Am J Hum Genet
2006;78:936-46.
334. West D van, Eede F van den, Del-Favero J, Souery D, Norrback KF, Duijn CM van, Sluijs S,
Adolfsson R, Mendlewicz J, Deboutte D, Broeckhoven C van, Claes S. Glucocorticoid
receptor gene-based SNP analysis in patients with recurrent major depression.
Neuropsychopharmacology 2006;31:620-7.
335. Yazdanpanah M, Rietveld I, Janssen JA,Njajou OT, Hofman A, Stijnen T, Pols HA,
Lamberts SW, Witteman JC, Duijn CM van. An insulin-like growth factor-I promoter
polymorphism is associated with increased mortality in subjects with myocardial infarction in
an elderly Caucasian population. Am J Cardiol 2006;97:1274-6.

30. 336. Yazdanpanah M, Sayed-TabatabaeiFA, Janssen JAMJL,Rietveld I, Hofman A, Stijnen Th,
Pols HAP,Lamberts SWJ, Witteman JCM, Duijn CM van. IGF-I gene promoter
polymorphism is a predictor of survival after myocardial infarction in patients with type 2
diabetes. Eur J Endocrinol 2006;155:1-7.
337. Yazdanpanah M, Sayed-TabatabaeiFA, Hofman A,Aulchenko YS, Oostra BA,Stricker BH,
Pols HA,Lamberts SW, Witteman JC, Janssen JA,Duijn CM van. The{alpha}–adducin gene
is associated with macrovascular complications and mortality in patients with type 2 diabetes.
Diabetes 2006;55:2922-7.
2007
338. Alizadeh BZ, Njajou OT, Hazes JM, Hofman A, Slagboom PE,Pols HAP,Duijn CM van.
The H63D mutation in the HFE gene predisposes to arthralgia, chondrocalcinosis, and
osteoarthritis. Ann Rheum Dis 2007;66:1436-42.
339. Amin N, Duijn CM van, Aulchenko YS. A genomic background based method for
association analysis in related individuals. PLoS ONE. 2007;2:e1274.
340. Arias-Vasquez A, Isaacs A,Aulchenko YS, Hofman A, Oostra BA, Breteler M, Duijn CM
van. The cholesteryl ester transfer protein (CETP) gene and the risk of Alzheimer's disease.
Neurogenetics 2007;8:189-93.
341. Arias-Vasquez A, Lau L de, Pardo L, Liu F, Feng BJ, Bertoli-Avella A, Isaacs A,Aulchenko
Y, Hofman A, Oostra B, Breteler M, Duijn CM van. Relationship of the Ubiquilin 1 gene
with Alzheimer's and Parkinson's disease and cognitive function. NeurosciLett 2007;424:1-5.
342. Aulchenko YS, Ripke S, Isaacs A,Duijn CM van. GenABEL: an R library for genome-wide
association analysis. Bioinformatics 2007;23:1294-6.
343. Aulchenko YS, Pullen J, Kloosterman WP,Yazdanpanah M, Hofman A, Vaessen N,Snijders
PJ,Zubakov D, Mackay I, Olavesen M, Sidhu B, Smith VE,Carey A, Berezikov E,
Uittenlinden AG, Plasterk RH,Oostra BA, Duijn CM van. LPIN2 is associated with type 2
diabetes, glucose metabolism and body composition. Diabetes 2007;56:3020-6.
344. Berends A, Bertoli-Avella A, Groot C de, Duijn CM van, Oostra B, Steegers E. STOX1 gene
in pre-eclampsia and intrauterine growth restriction. BJOG 2007;114:1163-7.
345. Boccia S, Sayed-TabatabaeiFA, Persiani R, Gianfagna F, Rausei S, Arzani D, La Greca A,
D'Ugo D, La Torre G, Duijn CM van, Ricciardi G. Polymorphisms in metabolic genes, their
combination and interaction with tobacco smoke and alcohol consumption and risk of gastric
cancer:a case-control study in an Italian population. BMC Cancer 2007;7:206.
346. Boccia S, Torre G la, Persiani R, D’Ugo D, Duijn CM van, Ricciardi G. A critical appraisal
of epidemiological studies comes from basic knowledge: a readers guide to assess potential
for biases. World J Emerg Surg 2007;2:7.
347. Boccia S, Lauretis A de, Gianfagna F, Duijn CM van, Ricciardi G. CYP2E1PstI/Rsal
polymorphism and interaction with tobacco, alcohol and GSTs in gastric cancer
susceptibility: a meta-analysis of the literature. Carcinogenesis 2007;28:101-6.

31. 348. Boccia S, Gianfagna F, Persiani R, La Greca A, Arzani D, RauseiS, D’Ugo D, Magistrelli P,
Villari P,Duijn CM van, Ricciardi G. Methylenetetrahydrofolate reductase C677T and
A1298 C polymorphisms and susceptibility to gastric adenocarcinoma in an Italian
population. Biomarkers 2007;12:635-44.
349. Boekhoorn SS, Vingerling JR, Uitterlinden AG, Meurs JB van, Duijn CM van, Pols HAP,
Hofman A, Jong PT de. Estrogen receptor alpha gene polymorphisms associated with
incident aging macula disorder. Invest Ophthalmol Vis Sci 2007;48:1012-7.
350. Coppus AMW,Fekkes D, Verhoeven WMA,Tuinier S, Egger JIM, Duijn CM van. Plasma
amino acids and neopterin in healthy persons with Down’s syndrome. J Neural Transm
2007:11:1041-5.
351. Despriet DD, Klaver CC,Duijn CM van, Janssens AC. Predictive value of multiple genetic
testing for age-related macular degeneration (Editorial). Arch Ophthalmol 2007;125:1270-1.
352. Dijk EJ van, Prins ND, Hofman A, Duijn CM van, Koudstaal PJ,Breteler MMB. Plasma beta
amyloid and impaired CO(2)-induced cerebralvasomotor reactivity. Neurolbiol Aging
2007;28:707-12.
353. Gonzalez-Zuloeta Ladd AM, Liu F, Houben MP, Arias Vasquez A, Siemes C, Janssens AC,
Coebergh JW, Hofman A, Janssen JA,Stricker BH,Duijn CM van. IGF-1 CA repeat variant
and breast cancer risk in postmenopausal women. Eur J Cancer 2007;43:1718-22.
354. Gonzalez-Zuloeta Ladd AM, Arias Vasquez AA, Siemes C, Yazdanpanah M, Coebergh JW,
Hofman A, Stricker BH, Duijn CM van. Differential Roles of Angiotensionogen and
Angiotensin Receptor type 1 Polymorphisms in Breast Cancer Risk. Breast Cancer Res Treat
2007;101:299-304.
355. Gonzalez-Zuloeta Ladd AM, Arias Vasquez AA, Siemes C, Coebergh JW, Hofman A,
Witteman J, Uitterlinden A, Stricker BH, Duijn CM van. Transforming-growth factor beta (1)
Leu10Pro polymorphism and breast cancer morbidity. Eur J Cancer 2007;43:371-4.
356. Green A,Sanchez-Juan P,Ladogana A, Cuadrado-Corrales N, Sanchez-Valle R, Mitrova E,
Stoeck K, Sklaviadis T, Kulczycki J, Heinemann U, Hess K,Slivarichova D, Saiz A, Calero
M, Mellina V, Knight R, Duijn CM van, Zerr I. CSF analysis in patients with sporadic CJD
and other transmissible spongiform encephalopathies. Eur J Neurol 2007;14:121-4.
357. Hofman A, Breteler MM, Duijn CM van, Krestin GP, Pols HA, Stricker BH,Tiemeier H,
Uitterlinden AG, Vingerling JR, Witteman JC. The Rotterdam Study: objectives and design
update. Eur J Epidemiol 2007;22:819-29.
358. Hoppenbrouwers IA, Cortes LM, Aulchenko YS, Sintnicolaas K, Njajou O, Snijders PJ,
Oostra BA, Duijn CM van, Hintzen RQ. Familial clustering of multiple sclerosis in a Dutch
genetic isolate. Mult Scler 2007;13:17-24.
359. Isaacs A,Sayed-TabatabaeiFA,Aulchenko YS, Zillikens MC, Sijbrands EJ, Schut AF,
Rutten WP,Pols HA, Witteman JC, Oostra BA,Duijn CM van. Heritabilities, apolipoprotein
E, and effects of inbreeding on plasma lipids in a genetically isolated population: The
Erasmus Ruchpen Family Study. Eur J Epidemiol 2007;22:99-105.

32. 360. Isaacs A,Sayed-TabatabaeiFA,Hofman A, Oostra BA, Klungel OH, Maitland-van der Zee
AH, Stricker BHCh,Witteman JCM, Duijn CM van. The cholesteryl ester transfer protein
I405V polymorphism is associated with increased high-density lipoprotein levels and
decreased risk of myocardial infarction: the Rotterdam Study. Eur J Cardiovasc Prev Rehabil
2007;14:419-21.
361. Isaacs A,Aulchenko YS, Hofman A, Sijbrands EJ, Sayed-TabatabaeiFA, Klungel OH,
Maitland-van der Zee AH,Stricker BH, Oostra BA, Witteman JC, Duijn CM van. Epistatic
effect of cholesteryl ester transfer protein and hepatic lipase on serum high-density
lipoprotein cholesterol levels. J Clin Endocrinol Metab 2007;92:2680-7.
362. Jaddoe VW, Bakker R, Duijn CM van, Heijden AJ van der, Lindemans J, Mackenbach JP,
Moll HA, Steegers EA,Tiemeier H, Uitterlinden AG, Verhulst FC, Hofman A. The
Generation R Study Biobank: a resource for epidemiological studies in children and their
parents. Eur J Epidemiol 2007;22:917-23.
363. Janssens AC,Moonesinghe R, Yang Q, Steyerberg EW, Duijn CM van, Khoury MJ. The
impact of genotype frequencies on the clinical validity of genomic profiling for predicting
common chronic diseases. Genet Med 2007;9:528-35.
364. van Koolwijk LM, Despriet DD,Duijn CM van, Pardo Cortes LM, Vingerling JR, Aulchenko
YS, Oostra BA, Klaver CC, Lemij HG. Genetic contributions to glaucoma: heritability of
intraocular pressure,retinal nerve fiber layer thickness, and optic disc morphology. Invest
Ophthalmol Vis Sci 2007;48:3669-76.
365. Liu F, Arias-Vasquez A,Sleegers K, Aulchenko YS, Kayser M,Sanchez-Juan P,Feng BJ,
Bertoli-Avella AM, Swieten J van, Axenovich TI, Heutink P, Broeckhoven C van, Oostra
BA, Duijn CM van. A genomewide screen for late-onset Alzheimer disease in a genetically
isolated Dutch population. Am J Hum Genet 2007;81:17-31.
366. Mattace-Raso FU,Sie MP,Cammen TJ van der, Safar ME, Hofman A, Duijn CM van,
Witteman JC. Insertion/deletion gene polymorphism of the angiotensin-converting enzyme
and blood pressure changes in older adults. The Rotterdam study. J Hum Hypertens
2007;21:736-40.
367. Min JL, Meulenbelt I, Kloppenburg M, Duijn CM van, Slagboom PE. Mutation analysis of
candidate genes within the 2q33.3 linkage area for familial early-onset generalised
osteoarthritis. Eur J Hum Genet 2007;15:791-9.
368. Reitz C, den Heijer T, Duijn CM van, Hofman A, Breteler MM. Relation between smoking
and risk of dementia and Alzheimer disease: the Rotterdam Study. Neurology 2007;69:998-
1005.
369. Rijn MJE van, Schut AF, Aulchenko YS, Deinum J, Sayed-TabatabaeiFA, Yazdanpanah M,
Isaacs A,Axenovich TI, Zorkoltseva IV, Zillikens MC, Pols HAP,Witteman JC, Oostra BA,
Duijn CM van. Heritability of blood pressure traits and the genetic contribution to blood
pressure variance explained by four blood-pressure related genes. J Hypertens 2007;25:565-
70.
370. Rijn MJE, Bos MJ, Isaacs A,Yazdanpanah M, Arias-Vasquez A, Stricker BH, Klungel OH,
Oostra BA, Koudstaal PJ,Witteman JC, Hofman A, Breteler MMB, Duijn CM van.

33. Polymorphisms of the renin-angiotensin system are associated with blood pressure,
atherosclerosis and cerebralwhite matter pathology. J Neurol Neurosurg Psychiatry
2007;78:1083-7.
371. Sanchez-Juan P, Sanchez Valle R, Green A, Ladogana A, Cuadrado-Corrales N, Mitrova E,
Stoeck K, Sklaviadis T, Kulczycki J, Hess K,Krasnianski A,Equestre M, Slivarichova D,
Saiz A, Calero M, Pocchiari M, Knight R, Duijn CM van, Zerr I. Influence of timing on CSF
tests value for Creutzfeldt-Jakob disease diagnosis. J Neurol 2007;25:901-6.
372. Sanchez-Juan P, Cousens SN, Will RG, Duijn CM van. Source of variant Creutzfeldt-Jakob
disease outside United Kingdom. Emerg Infect Dis 2007;13:1166-9.
373. Sanchez-Juan P, Houben MPWA,Hoff JI, Jansen C, Sie MPS,Rijn MJE van, Ironside JW,
Will RG, Duijn CM van, Rozemuller A. The first case of variant Creutzfeldt-Jakob disease in
the Netherlands. J Neurol 2007;254:958-60.
374. Sánchez-Juan P, Bishop MT, Green A, Giannattasio C, Arias-Vasquez A, Poleggi A, Knight
RS, Duijn CM van. No evidence for association between tau gene haplotypic variants and
susceptibility to Creutzfeldt-Jakob disease. BMC Med Genet 2007;8:77.
375. Schelleman H, Klungel OH, Witteman JC, Breteler MM, Hofman A, Duijn CM van, Boer A
de, Stricker BH. Diuretic-gene interaction and the risk of myocardial infarction and stroke.
Pharmacogenomics J 2007;7:346-52.
376. Schelleman H, Klungel OH, Witteman JC, Breteler MMB, Yazdanpanah M, Danser AH,
Hofman A, Duijn CM van, Boer A de, Stricker BH. Angiotensinogen M235T polymorphism
and the risk of myocardial infarction and stroke among hypertensive patients on ACE-
inhibitors or beta-blockers. Eur J Hum Genet 2007;15:478-84.
377. Schelleman H, Klungel OH, Witteman JC, Hofman A, Duijn CM van, Boer A de, Stricker
BH. Pharmacogenetic interactions of three candidate gene polymorphisms with ACE-
inhibitors or beta-blockers and the risk of atherosclerosis. Br J Clin Pharmacol2007;64:57-
66.
378. Sie MP, Mattace-Raso FU,Uitterlinden AG, Arp PP,Hofman A, Hoeks AP,Reneman RS,
Asmar R, Duijn CM van, Witteman JC. TGF-beta1 polymorphisms and arterial stiffness; the
Rotterdam Study. J Hum Hypertens 2007;21:413-7.
379. Silva MC, Janssens ACJW,Hofman A, Witteman JC, Duijn CM van. Cholesteryl ester
transfer protein gene and coronary heart disease mortality: the Rotterdam study. J Am Geriatr
Soc 2007;55:1483-4.
380. Sleegers K, Koning I de, Aulchenko YS, Rijn MJ van, Houben MP,Croes EA, Swieten JC
van Oostra BA,Duijn CM van. Cerebrovascular risk factors do not contribute to genetic
variance of cognitive function The ERF study. Neurobiol Aging 2007;28:735-41.
381. Sutedja NA,Sinke RJ, Vught PW van, Linden MW van der, Wokke JH, Duijn CM van,
Njajou OT, Schouw YT van der, Veldink JH,Berg LH van den. The association between
H63D mutations in HFE and amyotrophic lateral sclerosis in a Dutch population. Arch
Neurol 2007;64:63-7.

34. 382. Vleuten GM, Isaacs A,Hijmans A, Duijn CM van, Stalenhoef AF, Graaf J de. The
involvement of upstream stimulatory factor 1 (USF1) in Dutch patients with familial
combined hyperlipidemia. J Lipid Res 2007;48:193-200.
383. Vleuten GM, Isaacs A,Zeng WW, ter Avest E, Talmud PJ,Dallinga-Thie GM, Duijn CM
van, Stalenhoef AF, Graaf J de. Haplotype analyses of the APOA5 gene in patients with
familial combined hyperlipidemia. Biochim Biophys Acta 2007;1772:81-8.
384. Visser LE, Schaik RH van, Jan Danser AH,Hofman A, Witteman JC, Duijn CM van,
Uitterlinden AG, Pols HA, Stricker BH. The risk of myocardial infarction in patients with
reduced activity of cytochrome P450 2C9. Pharmacogenet Genomics 2007;17:473-9.
385. Yazdanpanah N,Rivadeneira F, Meurs JB van, Zillikens MC, Arp P,Hofman A, Duijn CM
van, Pols HA, Uitterlinden AG. The -1997 G/T and Sp1 Polymorphisms in the Collagen Type
I alpha1 (COLIA1) Gene in Relation to Changes in Femoral Neck Bone Mineral Density and
the Risk of Fracture in the Elderly: The Rotterdam Study. Calcif Tissue Int 2007;81:18-25.
386. Yazdanpanah M, Aulchenko YS, Hofman A, Janssen JA,Sayed-TabatabaeiFA, Schaik RH
van, Klungel OH, Stricker BH, Pols HA,Witteman JC, Lamberts SW, Oostra BA, Duijn CM
van. Effects of the renin-angiotensin system genes and salt sensitivity genes on blood
pressure and atherosclerosis in the total population and patients with type 2 diabetes. Diabetes
2007;56:1905-12.
2008
387. Arias-Vásquez A, Aulchenko YS, Isaacs A,Oosterhout A van, Sleegers K, Hofman A,
Broeckhoven C van, Oostra BA,Breteler MMB, Duijn CM van. Cyclin-dependent kinase 5 is
associated with risk for Alzheimer’s disease in a Dutch population-based study. J Neurol
2008;255:655-62.
388. Aulchenko YS, Hoppenbrouwers IA, Ramagopalan SV, Broer L, Jafar N,Hillert J, Link J,
Lundström W, Greiner E, Sadovnick ED, Goossens D, Broeckhoven C van, Del-Favero J,
Ebers GC, Oostra BA,Duijn CM van, Hintzen RQ. Genetic variation in the KIF1B locus
determines susceptibility to multiple sclerosis. Nat Genet 2008; 40: 1402-3.
389. Berends AL, Groot CJ de, Sijbrands EJ, Sie MP, Benneheij SH, Pal R, Heydanus R, Oostra
BA, Duijn CM van, Steegers EA. Shared constitutional risks for maternal vascular-related
pregnancy complications and future cardiovascular disease. Hypertension 2008;51:1034-41.
390. Berends AL, Steegers EA,Isaacs A,Aulchenko YS, Liu F, Groot CJ de, Oostra BA, Duijn
CM van. Familial aggregation of preeclampsia and intrauterine growth restriction in a
genetically isolated population in The Netherlands. Eur J Hum Genet 2008; 16:1437-42.
391. Bilguvar K, Yasuno K, Niemelä M, Ruigrok YM, von Und Zu Fraunberg M, Duijn CM van,
van den Berg LH, Mane S, Mason CE, Choi M, Gaál E, Bayri Y, Kolb L, Arlier Z, Ravuri S,
Ronkainen A, Tajima A, Laakso A, Hata A, Kasuya H,Koivisto T, Rinne J, Ohman J,
Breteler MM, Wijmenga C, State MW, Rinkel GJ, Hernesniemi J, Jääskeläinen JE, Palotie A,
Inoue I, Lifton RP,Günel M. Susceptibility loci for intracranial aneurysm in European and
Japanese populations. Nat Genet 2008; 40:1472-7.

35. 392. Boccia S, Cadoni G, Sayed-TabatabaeiFA, Volante M, Arzani D, Lauretis A de, Cattel C,
Almadori G, Duijn CM van, Paludetti G, Ricciardi G. CYP1A1,CYP2E1, GSTM1, GSTT1,
EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit
and vegetables and risk of head and neck cancer. J Cancer Res Clin Oncol 2008;134:93-100.
393. Boccia S, Hung R, Ricciardi G, Gianfagna F, Ebert MP, Fang JY, Gao CM, Götze T,
Graziano F, Lacasaña-Navarro M,Lin D, López-Carrillo L, Qiao YL, Shen H, Stolzenberg-
Solomon R, Takezaki T, Weng YR, Zhang FF, Duijn CM van, Boffetta P,Taioli E. Meta-
and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C
polymorphisms and gastric cancer risk: a huge-GSEC review. Am J Epidemiol 2008;167:505-
16.
394. Boekhoorn SS, Isaacs A,Uitterlinden AG, Duijn CM van, Hofman A, Jong PT de, Vingerling
JR. Polymorphisms in the vascular endothelial growth factor gene and risk of age-related
macula degeneration: The Rotterdam Study. Ophthalmology 2008; 115: 1899-903.
395. Boogaard MJ van den, Costa D de, Krapels IP, Liu F, Duijn CM van, Sinke RJ,Lindhout D,
Steegers-Theunissen RP. The MSX1 allele 4 homozygous child exposed to smoking at
periconception is most sensitive in developing nonsyndromic orofacial clefts. Hum Genet
2008;124:525-34
396. Coppus AM,Evenhuis HM, Verberne GJ, Visser FE, Arias-Vasques A,Sayes-Tabatabaei
FA, Vergeer-Drop J,Eikelenboom P, Gool WA van, Duijn CM van. The impact of
apolipoprotein E on dementia in persons with Down’s syndrome. Neurobiol Aging
2008;29:825-35.
397. Coppus AW,Evenhuis HM, Verberne GJ,Visser FE, Oostra BA, Eikelenboom P, Gool PWA
van, Janssens ACJW,Duijn CM van. Survival in elderly persons with Down’s syndrome. J
Am Geriatr Soc 2008; 56:2311-6
398. Dehghan A, Hoek M van, Sijbrands EJ, Oostra BA, Hofman A, Duijn CM van, Witteman
JCM. Lack of association of two common polymorphisms on 9p21 with risk of coronary
heart disease and myocardial infarction; results from a prospective cohort study. BMC Med
2008;6:30.
399. Dehghan A, Köttgen A,Yang Q, Hwang SJ, Kao LWH, Rivadeneira F, Boerwinkle E, Levy
D, Hofman A, Astor BC, Benjamin EJ, Duijn CM van, Witteman JC, Coresh J, Fox CS.
Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide
association study. Lancet 2008; 372:1953-61.
400. Driel LM van, Smedts HP,Helbing WA, Isaacs A,Lindemans J, Uitterlinden AG, Duijn CM
van, Vries JH de, Steegers EA,Steegers-Theunissen RP. Eight-fold increased risk for
congenital heart defects in children carrying the nicotinamide N-methyltransferase
polymorphism and exposed to medicines and low nicotinamide. Eur Heart J 2008;29:1424-
31.
401. Driel LM van, Verkleij-Hagoort AC,Jonge R de, Uitterlinden AG, Steegers EA,Duijn CM
van, Steegers-Theunissen RP. Two MTHFR polymorphisms, maternal B-vitamin intake, and
CHDs. Birth Defects Res A Clin Mol Teratol 2008;82:474-81.