Using dual pressure telemetry, systemic blood pressure AND either pulmonary artery pressure or left ventricular pressure can be measured in small species—simultaneously. Dual pressure telemetry also generates ECGs.

1. Rat Dual Pressure Telemetry
Double the Data
1

2. CorDynamics introduces telemetry that records two pressure
channels along with ECG in the rat – simultaneously!
Many options
1) systemic blood pressure and pulmonary artery pressure
- for differential effects on both arterial beds
- to study PAH (pulmonary arterial hypertension)
2) systemic blood pressure and left ventricular pressure
- test article effects on cardiac function and systemic BP
Pharmacological validation
- isoproterenol (β-adrenergic agonist)
- hydralazine (direct vasodilator)

3. Effects of hydralazine or isoproterenol on heart rate
Effect of Isoproterenol (SQ) or Hydralazine (IV) on Heart Rate in
the Conscious, Telemetrized Male Rat
600
500
400
HR (bpm)
300
200
VEHICLE (n=4)
100 ISOPROTERENOL 25 mg/kg (n=4)
HYDRALAZINE 1 mg/kg (n=4)
0
-70 -60 -50 -40 -30 -20 -10 0 10 20 30 40 50 60 70 80 90 100 110 120 130
Time (minutes)

4. Effects of hydralazine or isoproterenol on blood pressure
Effect of Isoproterenol (SQ) or Hydralazine (IV) on Mean Arterial
Pressure in the Conscious, Telemetrized Male Rat
140
120
100
MAP (mm Hg)
80
60
40
VEHICLE (n=4)
ISOPROTERENOL 25 mg/kg (n=4)
20
HYDRALAZINE 1 mg/kg (n=4)
0
-70 -60 -50 -40 -30 -20 -10 0 10 20 30 40 50 60 70 80 90 100 110 120 130
Time (minutes)

5. Effectsof hydralazine or isoproterenol on LV contractility
Effect of Isoproterenol (SQ) or Hydralazine (IV) on Maximum
Left Ventricular dP/dt in the Conscious, Telemetrized Male Rat
18000
16000
14000
dP/dt (mm Hg/sec)
12000
10000
8000
6000
VEHICLE (n=4)
4000
ISOPROTERENOL 25 mg/kg (n=4)
2000
HYDRALAZINE 1 mg/kg (n=4)
0
-70 -60 -50 -40 -30 -20 -10 0 10 20 30 40 50 60 70 80 90 100 110 120 130
Time (minutes)