This document discusses how SAP's HANA in-memory database platform can be applied to advance personalized medicine by enabling real-time analysis of large datasets from various sources, including biological, clinical, and lifestyle data. Key points: - SAP HANA allows fast loading and analysis of large genomic and other biomedical datasets in real-time to accelerate healthcare research - SAP is collaborating with Stanford University to apply HANA to genome-wide analysis from human population studies to further global health - A genome analysis application built on HANA could support computational pipelines from sequencing to variant calling to annotation and integration of various data types

1. Applying
innova,ve
commercial
technology
to
deliver
on
the
promise
of
personalized
medicine
Enakshi
Singh,
M.Sc.
SAP
Product
Management
SAP
HANA
Pla6orm
for
Healthcare
Public

2. SAP powers analytics that
SAP customers represent
86% of Global Fortune
500 companies.
74% of the world’s
transaction revenue
touches an SAP system.
Our customers
produce more than
82% of the world’s
medical devices.
track more than 6 billion
U.S. stock trades per day to
identify fraud and protect
investors.
Our customers
distribute more than
76% of the world’s
healthcare products.
Our customers
produce more than
77% of the world’s
beer.
Public

3.
But
can
you
apply
the
latest
technology
developments
and
capabili>es
to
further
healthcare
research?
Dr. Hasso Plattner,
Founder and Chairman of SAP
Supervisory Board
Public

4. Our
Vision:
Enable
Personalized
Medicine
Lifestyle
Data
SAP
HANA
Pla@orm
For
Healthcare
Clinical
Data
(EMRs)
Biological
Data
(-­‐Omics
Data
+
Annota>ons)
Can
we
interpret
all
pa>ent
data
during
a
pa>ent’s
visit?
Real-­‐>me
Data
Capture
&
Analysis
All
Relevant
Medical
Informa>on
Public

5. Vision:
SAP
HANA
Healthcare
Pla6orm
Informa>on
and
Feedback
within
the
Window
of
Opportunity
Pa>ents
Doctors
Insurers
Researchers
Real-­‐Time
Data
Capture
and
Analysis
SAP
HANA
Healthcare
Pla6orm
Biological
Data
(e.g.
genomics)
Clinical
Data
(e.g.
EMRs)
Lifestyle
Data
(Care
Circles)
Lifestyle
Data
...
All
Relevant
Medical
Informa>on
Public

6. In-­‐Memory
Technology
Building
Blocks
●
●
●
●
Read Event
Read Event
Repositories
Repositories
Combined
column
and
row
store
+
up to 2.000
up to 2.000
requests
requests
per second
per second
Minimal
projec>ons
Any
aVribute
as
index
Bulk
load
Discovery Service
Discovery Service
Mul>-­‐core/
paralleliza>on
SAP HANA
SAP HANA
No
aggregate
tables
On-­‐the-­‐fly
extensibility
Map
reduce
P
P
t
A
A
Lightweight
Compression
Par>>oning
SQL
Analy>cs
on
historical
data
Single
and
mul>-­‐tenancy
Object
to
rela>onal
mapping
Group
Key
SQL
interface
on
columns
&
rows
Reduc>on
of
layers
x
x
P
Ac>ve/passive
data
store
Dynamic
mul>-­‐
threading
within
nodes
+
+
+
up to 8.000 read
up to 8.000 read
event notifications
event notifications
per second
per second
Insert
only
for
>me
travel
+
+
+
+
A
Verification
Verification
Services
Services
T
Text
Retrieval
and
Extrac>on
No
disk
Public

7. ●
●
●
●
Read Event
Read Event
Repositories
Repositories
Verification
Verification
Services
Services
SAP
HANA
Database
Technology
up to 8.000 read
up to 8.000 read
event notifications
event notifications
per second
per second
up to 2.000
up to 2.000
requests
requests
per second
per second
Discovery Service
Discovery Service
T
SAP HANA
SAP HANA
Bulk
load
P A
A
P
Fast
inser,on
of
large
genomic
datasets
or
other
relevant
datasets
Text
Retrieval
and
Extrac>on
Search
doctor’s
notes,
diagnoses,
etc.
(unstructured
data)
Lightweight
Compression
Fit
big
data
in
main
memory
while
allowing
fast
retrieval
SQL
+
+
+
Mul>-­‐core/
paralleliza>on
Speedup
of
relevant
queries
across
many
nodes
SQL
interface
on
columns
&
rows
Easily
connect
with
other
tools
(e.g.
Rstudio)
On-­‐the-­‐fly
extensibility
Adap,ng
to
new
format
requirements
without
going
offline
(e.g.
changing
VCF
files)
Public

8. Genomics
&
Big
Data
Public

9. SAP
and
Stanford
Human
Popula>on
Genomics
and
Global
Health
“
”
"We
have
been
thrilled
to
work
with
SAP
and
HPI
on
a
collabora,on
to
accelerate
DNA
sequence
analysis.
In
our
pilot
projects,
we
are
seeing
drama,c
speedups
in
compu,ng
on
human
genome
varia,on
data
from
many
samples.
We
are
dreaming
of
what
will
soon
be
possible
as
we
integrate
phenotype,
genomics,
proteomics,
and
expose
data
to
empower
complex
trait
mapping
using
millions
of
health
records.”
-­‐
Professor
Carlos
D.
Bustamante
at
the
Stanford
University
School
of
Medicine
Dr. Carlos D.
Bustamante
 Analyze
genome
wide
paVerns
of
varia>on
within
and
between
species
to
address
fundamental
ques>ons
in
biology,
anthropology,
and
medicine:
implica,ons
for
global
health
and
disease
SAP
HANA
to
contribute
to
all
parts
of
computa>onal
pipeline
Sequencing
Pa>ent
Samples
Alignment
Raw
DNA
Reads
Mapped
Genome
Variant
Calling
Annota,on
and
Analysis
Discovered
Variants
Follow-­‐up
and
Valida>on
Public

10. SAP
HANA
for
Healthcare:
Genome
Analysis
Applica>on
Computa>onal
Pipeline
e.g.
Bioinforma>cian
Sequencing
Service/Lab
e.g.
Biologist
Sequencing
Pa>ent
Samples
•
Alignment
Raw
DNA
Reads
Computa>onal
Analysis
e.g.
Clinicians
AND
Researchers
Variant
Calling
Mapped
Genome
Annota,on
and
Analysis
Discovered
Variants
Follow-­‐up
and
Valida>on
All
steps
a`er
sequencing
will
be
supported
within
the
genome
analysis
applica>on
(from
raw
DNA
reads
to
annota>on
&
analysis)
-
Real-­‐>me
analyses
of
large-­‐scale
genome
variant
datasets
-
Implement
read
alignment,
variant
calling
&
all
other
relevant
“-­‐omic”
algorithms
in
HANA
database
-
Create
data
models
to
have
readily
available
latest
annota>ons
(literature/metadata)
from
open-­‐source
(and
poten>ally
commercial)
biological
databases
Public

11.
SAP
and
NCT
•
Medical
Explorer
For
ALL
Pa>ent
Data
The National Center for Tumor Diseases (NCT) Heidelberg provides patient
care, cancer research and cancer prevention united under one roof.
• Integrated content from various
sources of structured (tumor
documentation, medical
records, clinical trials) and
unstructured (doctor letters,
treatment guidelines, trial
reports, publications) nature.
• Medical records from 150,000
patients and 3,600,000
interactions, and a selection of
doctor letters from 120 doctors
A
search
for
lung
carcinoma
pa>ents
(only
NSCLC)
with
an
overexpressed
Epidermal
Growth
Factor
Receptor
(EGFR)
known
to
be
a
target
for
Tyrosine
Kinase
Inhibitors
(TKIs)
which
inhibit
the
EGFR
pathway.
In
this
example,
the
informa>on
on
EGFR
is
gathered
by
a
seman>c
text
analysis
of
the
pa>ents’
doctor
leVers.
Public

12. Co-­‐Innova>on:
SAP
&
PHEMI
Health
Systems
The
speed
of
SAP
HANA
and
the
Privacy
by
Design
infrastructure
of
PHEMI
Health
Systems
will
allow
healthcare
professionals
to
analyze
vast
amounts
of
data
thereby
enabling:
• Lower
costs
by
quickly
discovering
what
works
and
what
doesn’t.
• Improve
pa,ent
care
by
analyzing
a
pa>ent’s
DNA
sequence
and
using
that
informa>on
to
decide
on
the
op>mal
drug,
thereby
personalizing
the
pa>ent’s
treatment.
• Reduce
wait
,mes
by
improving
hospital
clinic
efficiency
and
forecas>ng
popula>on
health
to
determine
where
and
when
to
increase
health
care
capacity
• Provide
privacy
of
sensi>ve
pa>ent
informa>on,
an
impera>ve
in
healthcare.
Public

13. New
Ways
of
Real-­‐Time
Collabora>ve
Personalized
Medicine
Public

14. Thank
you
Contact
informa>on:
hana-­‐healthcare-­‐pla6orm@sap.com
Enakshi
Singh
Enakshi.Singh@sap.com

15. ©
2012
SAP
AG.
All
rights
reserved.
No
part
of
this
publica>on
may
be
reproduced
or
transmiVed
in
any
form
or
for
any
purpose
without
the
express
permission
of
SAP
AG.
The
informa>on
contained
herein
may
be
changed
without
prior
no>ce.
Some
so`ware
products
marketed
by
SAP
AG
and
its
distributors
contain
proprietary
so`ware
components
of
other
so`ware
vendors.
Microso`,
Windows,
Excel,
Outlook,
PowerPoint,
Silverlight,
and
Visual
Studio
are
registered
trademarks
of
Microso`
Corpora>on.
IBM,
DB2,
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Universal
Database,
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i,
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i5,
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p,
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x,
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z,
System
z10,
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Storage,
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in
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the
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Reader
are
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or
registered
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Incorporated
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United
States
and
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are
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and
its
affiliates.
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Group.
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Inc.
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XHTML,
and
W3C
are
trademarks
or
registered
trademarks
of
W3C®,
World
Wide
Web
Consor>um,
MassachuseVs
Ins>tute
of
Technology.
Apple,
App
Store,
iBooks,
iPad,
iPhone,
iPhoto,
iPod,
iTunes,
Mul>-­‐Touch,
Objec>ve-­‐C,
Re>na,
Safari,
Siri,
and
Xcode
are
trademarks
or
registered
trademarks
of
Apple
Inc.
IOS
is
a
registered
trademark
of
Cisco
Systems
Inc.
RIM,
BlackBerry,
BBM,
BlackBerry
Curve,
BlackBerry
Bold,
BlackBerry
Pearl,
BlackBerry
Torch,
BlackBerry
Storm,
BlackBerry
Storm2,
BlackBerry
PlayBook,
and
BlackBerry
App
World
are
trademarks
or
registered
trademarks
of
Research
in
Mo>on
Limited.
Google
App
Engine,
Google
Apps,
Google
Checkout,
Google
Data
API,
Google
Maps,
Google
Mobile
Ads,
Google
Mobile
Updater,
Google
Mobile,
Google
Store,
Google
Sync,
Google
Updater,
Google
Voice,
Google
Mail,
Gmail,
YouTube,
Dalvik
and
Android
are
trademarks
or
registered
trademarks
of
Google
Inc.
INTERMEC
is
a
registered
trademark
of
Intermec
Technologies
Corpora>on.
Wi-­‐Fi
is
a
registered
trademark
of
Wi-­‐Fi
Alliance.
Bluetooth
is
a
registered
trademark
of
Bluetooth
SIG
Inc.
Motorola
is
a
registered
trademark
of
Motorola
Trademark
Holdings
LLC.
Computop
is
a
registered
trademark
of
Computop
Wirtscha`sinforma>k
GmbH.
SAP,
R/3,
SAP
NetWeaver,
Duet,
PartnerEdge,
ByDesign,
SAP
BusinessObjects
Explorer,
StreamWork,
SAP
HANA,
and
other
SAP
products
and
services
men>oned
herein
as
well
as
their
respec>ve
logos
are
trademarks
or
registered
trademarks
of
SAP
AG
in
Germany
and
other
countries.
Business
Objects
and
the
Business
Objects
logo,
BusinessObjects,
Crystal
Reports,
Crystal
Decisions,
Web
Intelligence,
Xcelsius,
and
other
Business
Objects
products
and
services
men>oned
herein
as
well
as
their
respec>ve
logos
are
trademarks
or
registered
trademarks
of
Business
Objects
So`ware
Ltd.
Business
Objects
is
an
SAP
company.
Sybase
and
Adap>ve
Server,
iAnywhere,
Sybase
365,
SQL
Anywhere,
and
other
Sybase
products
and
services
men>oned
herein
as
well
as
their
respec>ve
logos
are
trademarks
or
registered
trademarks
of
Sybase
Inc.
Sybase
is
an
SAP
company.
Crossgate,
m@gic
EDDY,
B2B
360°,
and
B2B
360°
Services
are
registered
trademarks
of
Crossgate
AG
in
Germany
and
other
countries.
Crossgate
is
an
SAP
company.
All
other
product
and
service
names
men>oned
are
the
trademarks
of
their
respec>ve
companies.
Data
contained
in
this
document
serves
informa>onal
purposes
only.
Na>onal
product
specifica>ons
may
vary.
The
informa>on
in
this
document
is
proprietary
to
SAP.
No
part
of
this
document
may
be
reproduced,
copied,
or
transmiVed
in
any
form
or
for
any
purpose
without
the
express
prior
wriVen
permission
of
SAP
AG.
Public

16. ©
2012
SAP
AG.
Alle
Rechte
vorbehalten.
Weitergabe
und
Vervielfäl>gung
dieser
Publika>on
oder
von
Teilen
daraus
sind,
zu
welchem
Zweck
und
in
welcher
Form
auch
immer,
ohne
die
ausdrückliche
schri`liche
Genehmigung
durch
SAP
AG
nicht
gestaVet.
In
dieser
Publika>on
enthaltene
Informa>onen
können
ohne
vorherige
Ankündigung
geändert
werden.
Google
App
Engine,
Google
Apps,
Google
Checkout,
Google
Data
API,
Google
Maps,
Google
Mobile
Ads,
Google
Mobile
Updater,
Google
Mobile,
Google
Store,
Google
Sync,
Google
Updater,
Google
Voice,
Google
Mail,
Gmail,
YouTube,
Dalvik
und
Android
sind
Marken
oder
eingetragene
Marken
von
Google
Inc.
Die
von
SAP
AG
oder
deren
Vertriebsfirmen
angebotenen
So`wareprodukte
können
So`warekomponenten
auch
anderer
So`warehersteller
enthalten.
INTERMEC
ist
eine
eingetragene
Marke
der
Intermec
Technologies
Corpora>on.
Microso`,
Windows,
Excel,
Outlook,
PowerPoint,
Silverlight
und
Visual
Studio
sind
eingetragene
Marken
der
Microso`
Corpora>on.
IBM,
DB2,
DB2
Universal
Database,
System
i,
System
i5,
System
p,
System
p5,
System
x,
System
z,
System
z10,
z10,
z/VM,
z/OS,
OS/390,
zEnterprise,
PowerVM,
Power
Architecture,
Power
Systems,
POWER7,
POWER6+,
POWER6,
POWER,
PowerHA,
pureScale,
PowerPC,
BladeCenter,
System
Storage,
Storwize,
XIV,
GPFS,
HACMP,
RETAIN,
DB2
Connect,
RACF,
Redbooks,
OS/2,
AIX,
Intelligent
Miner,
WebSphere,
Tivoli,
Informix
und
Smarter
Planet
sind
Marken
oder
eingetragene
Marken
der
IBM
Corpora>on.
Linux
ist
eine
eingetragene
Marke
von
Linus
Torvalds
in
den
USA
und
anderen
Ländern.
Adobe,
das
Adobe-­‐Logo,
Acrobat,
PostScript
und
Reader
sind
Marken
oder
eingetragene
Marken
von
Adobe
Systems
Incorporated
in
den
USA
und/oder
anderen
Ländern.
Oracle
und
Java
sind
eingetragene
Marken
von
Oracle
und/oder
ihrer
Tochtergesellscha`en.
UNIX,
X/Open,
OSF/1
und
Mo>f
sind
eingetragene
Marken
der
Open
Group.
Citrix,
ICA,
Program
Neighborhood,
MetaFrame,
WinFrame,
VideoFrame
und
Mul>Win
sind
Marken
oder
eingetragene
Marken
von
Citrix
Systems,
Inc.
HTML,
XML,
XHTML
und
W3C
sind
Marken
oder
eingetragene
Marken
des
W3C®,
World
Wide
Web
Consor>um,
MassachuseVs
Ins>tute
of
Technology.
Apple,
App
Store,
iBooks,
iPad,
iPhone,
iPhoto,
iPod,
iTunes,
Mul>-­‐Touch,
Objec>ve-­‐C,
Re>na,
Safari,
Siri
und
Xcode
sind
Marken
oder
eingetragene
Marken
der
Apple
Inc.
IOS
ist
eine
eingetragene
Marke
von
Cisco
Systems
Inc.
RIM,
BlackBerry,
BBM,
BlackBerry
Curve,
BlackBerry
Bold,
BlackBerry
Pearl,
BlackBerry
Torch,
BlackBerry
Storm,
BlackBerry
Storm2,
BlackBerry
PlayBook
und
BlackBerry
App
World
sind
Marken
oder
eingetragene
Marken
von
Research
in
Mo>on
Limited.
Wi-­‐Fi
ist
eine
eingetragene
Marke
der
Wi-­‐Fi
Alliance.
Bluetooth
ist
eine
eingetragene
Marke
von
Bluetooth
SIG
Inc.
Motorola
ist
eine
eingetragene
Marke
von
Motorola
Trademark
Holdings,
LLC.
Computop
ist
eine
eingetragene
Marke
der
Computop
Wirtscha`sinforma>k
GmbH.
SAP,
R/3,
SAP
NetWeaver,
Duet,
PartnerEdge,
ByDesign,
SAP
BusinessObjects
Explorer,
StreamWork,
SAP
HANA
und
weitere
im
Text
erwähnte
SAP-­‐Produkte
und
-­‐Dienst-­‐leistungen
sowie
die
entsprechenden
Logos
sind
Marken
oder
eingetragene
Marken
der
SAP
AG
in
Deutschland
und
anderen
Ländern.
Business
Objects
und
das
Business-­‐Objects-­‐Logo,
BusinessObjects,
Crystal
Reports,
Crystal
Decisions,
Web
Intelligence,
Xcelsius
und
andere
im
Text
erwähnte
Business-­‐Objects-­‐Produkte
und
-­‐
Dienstleistungen
sowie
die
entsprechenden
Logos
sind
Marken
oder
eingetragene
Marken
der
Business
Objects
So`ware
Ltd.
Business
Objects
ist
ein
Unternehmen
der
SAP
AG.
Sybase
und
Adap>ve
Server,
iAnywhere,
Sybase
365,
SQL
Anywhere
und
weitere
im
Text
erwähnte
Sybase-­‐Produkte
und
-­‐Dienstleistungen
sowie
die
entsprechenden
Logos
sind
Marken
oder
eingetragene
Marken
der
Sybase
Inc.
Sybase
ist
ein
Unternehmen
der
SAP
AG.
Crossgate,
m@gic
EDDY,
B2B
360°,
B2B
360°
Services
sind
eingetragene
Marken
der
Crossgate
AG
in
Deutschland
und
anderen
Ländern.
Crossgate
ist
ein
Unternehmen
der
SAP
AG.
Alle
anderen
Namen
von
Produkten
und
Dienstleistungen
sind
Marken
der
jeweiligen
Firmen.
Die
Angaben
im
Text
sind
unverbindlich
und
dienen
lediglich
zu
Informa>ons-­‐zwecken.
Produkte
können
länderspezifische
Unterschiede
aufweisen.
Die
in
dieser
Publika>on
enthaltene
Informa>on
ist
Eigentum
der
SAP.
Weitergabe
und
Vervielfäl>gung
dieser
Publika>on
oder
von
Teilen
daraus
sind,
zu
welchem
Zweck
und
in
welcher
Form
auch
immer,
nur
mit
ausdrücklicher
schri`licher
Genehmigung
durch
SAP
AG
gestaVet.
Public