Rise above the risk of the helium supply shortage with innovative solutions that optimize the usage of the non-renewable gas. The new Thermo Scientific™ Instant Connect Helium Saver Module enables you to continue your analyses without helium supply concerns or extensive supply costs. Save precious non-renewable noble helium when your instrument is idle, as well as during the analytical run. Keep your methods intact, validation-effective, and regulation-compliant. Find out how to extend the lifetime of one helium cylinder to over 14 years under certain conditions and experience significant savings in both helium supply needs and financial costs throughout the lifetime of your Gas Chromatography-Mass Spectrometry instrument. · Maintain your methods · Prolong your helium supply · Save your budget

1. Maintain your Methods,
Prolong your Helium Supply,
Supply
and Save Your Budget
with an Innovative Helium Solution
The world leader in serving science
1

2. Existing Ways to Tackle the Helium Supply Shortage
• Migrate to H2 carrier gas
• Switch over to nitrogen when
the GC or GC-MS is not
running
g
• Reduce the split ratio (and
amount injected) during the
split time of the split injection
2

3. Limitations of the Existing Approaches
• Migrate to hydrogen carrier gas
•
•
•
•
Safety concerns
Method translation
Reduced sensitivity
QA/AC adjustments
• Switch over to nitrogen when
the GC or GC-MS is not running
• Reduce the split ratio (and
amount injected) during the split
time of the split injection
•
•
3
Not applicable to splitless
Accuracy may be affected with
smaller-volume injections
j

4. The Helium Saver
The
Th revolutionary Th
l i
Thermo Scientific™ I
S i ifi ™ Instant C
Connect H li
Helium S
Saver
Module for chromatographers seeking freedom from the helium supply
crisis, offers a GC & GC-MS instrument lifetime helium carrier gas
solution while keeping existing methodology. Unlike others the Helium
methodology
others,
Saver is a module that is always ready and works while your instrument
is running, as well as when it is idle, providing up to 14 years of GC & GCMS operation from a single helium cylinder
cylinder.
• Maintain your Methods
• Prolong your Supply
• Save your Budget
www.thermoscientific.com/heliumsaver
4

5. Instant Connect Modularity
• Modularity makes the Thermo Scientific™ TRACE™ 1300 GC a futureproof GC platform
• New modules are compatible with existing TRACE 1300 Series GCs
• User-installable: no service engineer, special training/tools required
• Swap modules for continuous operations
• Tailor instrument configuration to workload
• Quickly install injector/detector modules
• Every module is self-sufficient
• Reduce capital investments
• Eliminate downtime
5

6. Helium Saver Enables a Cylinder of Helium to Last…
3.5 years continuously used 24/7/365 for GC-MS analysis
5.4 years shutting Helium off or to N2 during weekends
10.5 years shutting Helium off or to N2 overnight (8 hr day)
14.6
14 6 years shutting Helium off or to N2 on weekends and overnight
For a Thermo Scientific™ TRACE 1300 Series GC,
ISQ
ISQ™ Series GC-MS and TSQ™ 8000 GC-MS/MS
TSQ
with the Helium Saver Module,
it means this could be the last and only helium cylinder that
will b needed f th lif ti
ill be
d d for the lifetime of th i t
f the instrument
t
6

7. Helium Saver Module Example
EPA 8270
EPA 8270
Standard
GC Flow Conditions
He carrier gas flow
He split flow
H
li fl
Gas saver flow
Gas saver on
Purge flow
Run time
He volume in cylinder
Runs per Day
He cylinder cost
N2 cylinder cost
mL/min
mL/min
L/ i
mL/min
min
mL/min
min
L
USD
USD
1
60
20
3
5
25
7,300
57
$300
$60
• Example: U.S. EPA Method 8270
(semi-volatiles analysis with GC-MS)
• Total Analysis Time: 25 minutes
•A
Around the Clock Analyses per Day: 57
d th Cl k A l
D
Helium cylinder life time was
extended from 5 months to 3.5 years
35
of continous uninterrupted use
Daily He Usage
Helium Savings: 7 times
g
He Cylinder Life
He Cylinder Life
(continuous uninterrupted use) Daily N2 Usage
N2 Cylinder Life
Monetary Savings: 3 times
7
Total Annual Cost
T t lA
lC t
Total Savings
Standard
He Consumption
Liters
Days
Liters
Days
Helium Saver
Consumption
46.56
157
0
0
5.76
1,267
1 267
40.8
179
$688
$205
$483

8. Helium Saver Module vs. Conventional SSL
Helium Saver Module
Contains the SSL as a subsystem
Industry standard injector
Uses exactly th same methods
U
tl the
th d
Used for
U d f > 80% methods
th d
Preserves your methods
and saves helium
8
Conventional SSL
Wastes most of the helium

9. Helium Saver vs. Conventional SSL: Rt Unchanged
C10 C11
C12
C13
C14
C10 C11
C15
C16
C12
C13
C14
C15
C16
C19
C20
C17 C18
C19
C20
C17 C18
C21 C23
C24 C25
C22
C21 C23
C25
C22 C24
Helium Saver
He column flow
N2 split and
septum purge
SSL
Only He supplied
Splitless 1 uL
30 m, 0.25 mm ,0.25 µm
Thermo Scientific™
TRACE TR5 Column
50 ˚ to 300 ˚C at 10 C/min
CF 1 mL/min
FID at 300 °C
9

10. Helium Saver: High Boiling Compounds Transfer
Complete recovery of high boiling compounds
C14
C10
C12
C16
Component
C18
C20 C22
Splitless 1 uL
7 m, 0.32 mm ID,0.25 µm TRACE TR5 Column
60  to 320 C at 10 C/min
CF 2 mL/min
Helium Saver SSL and FID at 340 C
10
C24
C26
C30
C34
C28
C32 C36 C38
C40
nC10
nC12
nC14
nC16
nC18
nC20
nC22
nC24
nC26
nC28
nC30
nC32
nC34
nC36
nC38
nC40
Absolute Peak
Recovery
Areas
(%) *
(%) *
(counts)
2498258
100.3
2457224
98.7
2550661
102.4
2504229
100.6
2484007
99.8
2489876
100.0
2482628
99.7
2455417
98.6
2409871
96.8
2438442
97.9
2469831
99.2
2412554
96.9
2472760
99.3
2422105
97.3
2394975
96.2
2349780
94.4
* nC20 internal standard reference

11. EPA Method 8270 Calibration Curves R2 Results
SSL
Helium Saver
Average: 0.998
1.000
0.995
0 995
0.990
0.985
0.980
0.975
0.970
0.965
0.960
0.955
0.950
11
Compound Name
N‐Nitrosodimethylamine
y
Pyridine
Phenol
Aniline
Phenol, 2‐chloro‐
N‐nitrosodi‐n‐propylamine
N nitrosodi n propylamine
Phenol, 2‐nitro‐
Phenol, 2,4‐dichloro‐
p‐Chloroaniline
Phenol, 4‐chloro‐3‐methyl‐
Hexachlorocyclopentadiene
Phenol, 2,4,6‐trichloro‐
Phenol, 2,4,5‐trichloro‐
2‐Nitroaniline
Dimethyl phthalate
Dimethyl phthalate
2,6‐dinitrotoluene
SSL
0.99852
0.99831
0.99843
0.99846
0.99847
0.99811
0 99811
0.99838
0.99763
0.99901
0.99561
0.99541
0.99723
0.99609
0.99774
0.99820
0 99820
0.99702
Helium Saver
0.99871
0.99855
0.99722
0.99813
0.99743
0.99808
0 99808
0.99859
0.99937
0.99875
0.99660
0.99856
0.99948
0.99893
0.99915
0.99757
0 99757
0.99920

12. Helium Saver Technology: Revolutionary Approach
Innovative and Unique Features and Benefits
• Up to 14 years of one helium cylinder life time
• Always saves – works during analytical run and idle time
• Always ready – no switch-back equilibration time
• Change septum and liner without GC or MS cooling down
• Can maintain existing methods
• Helium Saver Technology is covered by U.S. Patent 8,371,152
12

13. How Long Can One Helium Cylinder Last in YOUR Lab?
Use our calculator to find out
how much the Helium Saver
Module can help y
p your lab.
Enter your working
parameters and discover the
following:
• How long one cylinder of
helium can last in your lab
y
• How much budget you can
save on helium supplies over
the lifetime of your GC or GCy
MS instrument
www.thermoscientific.com/heliumsaver
www thermoscientific com/heliumsaver
13

14. Interested in Learning More?
Visit the website address below
for more information:
• Determine your potential
helium savings with our
online calculator
• Download a technical article
that outlines the helium
supply shortage and solution
• Vi
View a webinar that
bi
h
discusses this information in
detail
www.thermoscientific.com/heliumsaver
www thermoscientific com/heliumsaver
14

15. Thank You for Your Attention!
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St connected with us
t d ith
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