Genome Mapping

1. GENETIC MAPPING
CAROLINA CARDONA TOBÓN
Medicine Student

4. INTRODUCTION
Genetic mapping
locates a gene on
a chromosome
Allows you to find
hereditary
diseases related
to an alteration.

5. New technique maps elusive
chemical markers on proteins.
Salk Institute for Biological
Studies (2015, July 2).

6. New technique maps elusive chemical
markers on proteins
Phosphates bond to
aminoacids in the final
stages of creating a protein.
It is hard to visualize
phosphates on histidine
aminoacid.

7. New technique maps elusive
chemical markers on proteins
Researchers used
phosphonate, which
binds more tightly to
the histidine aminoacid.

8. New technique maps elusive
chemical markers on proteins
They developed
antibodies that
recognized
phosphohistidine in
proteins and added
them to mammalian
cells.

9. New technique maps elusive
chemical markers on proteins
STUDENT´S OBSERVATION
I think this investigation is
important because they found
a way of visualizing a bond
hard to see because of the
histidine aminoacid instability,
now they can analyze more
aminoacids and study its
process related with diseases.

10. The Regenerators. Stanford
University.(2015, September 1).

11. THE REGENERATORS
In mammals hair cells of
the utricle can regenerate
after damage.

12. THE REGENERATORS
They developed a genetic
marker based in a gene Lgr5, its
expression increased in
supporting cells after chemical
damage.

13. THE REGENERATORS
Lgr5 expressing cells
proliferated in vivo
after chemical
damage and
supporting cells
became hair cells.

14. THE REGENERATORS
STUDENT´S OBSERVATION
I think it is an amazing
discovery, because its
application can be really
useful for people with
hearing loss, it can
actually be a solution
for deaf people.

15. MEDICAL UTILITY

16. MEDICAL UTILITY
These investigations are medically useful
because they both analize the illness
process based on genome and also based
on an alteration of the normal function of
cells they evaluated.

17. MEDICAL UTILITY
Genome mapping is
important for medical utility
because once you are
aware of the location of the
gene in the genome you can
use some technique to
improve investigation, and
to treat some diseases.

18. MEDICAL UTILITY
Genome mapping allows
researchers to find te cure for a
disease, an specific diagnosis and
the right treatment improving
cuality of life.

19. BIBLIOGRAPHY
 Salk Institute for Biological Studies. (2015, July 2). “New
technique maps elusive chemical markers on proteins”.
Retrieved from
www.sciencedaily.com/releases/2015/07/150702131801-htm.
 Stanford University, Amanda B. Keener. (2015, September 1).
“The regenerators, a molecular signature makes it posible to
trace the details of hair cell replacement in the mammalian inner
ear”. Retrieved from
www.thescientist.com/?articles.view/articleNo/43825/title/The-
Regenerators/.