Science diplomacy is having a resurgence due to global challenges like resource scarcity, climate change, and infectious diseases that cross borders. Historically, science diplomacy helped relations between countries like the US and Soviet Union and is currently practiced through collaborations between scientists in countries like China, India, and the Middle East. Science diplomacy occurs through place-based scientific collaborations on issues like energy efficiency and malaria. It involves local scientists and academies and uses frameworks like capacity development, joint infrastructure projects, and public engagement. While politics cannot be replaced, integrating science and politics through iterative programming can help advance science diplomacy.