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Christine Khosropour, MPH
     Rollins School of Public Health
            Emory University

            August 15, 2011
2011 National HIV Prevention Conference
              Atlanta, GA
   Underrepresentation of black and Hispanic
    study participants

   Lack of biological outcomes on study
    participants

   Inability to retain participants for a period
    sufficient to assess outcome measures
     High attrition of black and Hispanic MSM
   Underrepresentation of black and Hispanic
    study participants

   Lack of biological outcomes on study
    participants

   Inability to retain participants for a period
    sufficient to assess outcome measures
     High attrition of black and Hispanic MSM
Sharma et al, JIAPAC, 2011
   Enrolled white, black, and Hispanic MSM in an
    online 12-month longitudinal study
     > 18 years old
     Had a male sex partner in past 12 months
     Willing to complete an at-home HIV test
     Had an SMS-enabled mobile phone
   Enrolled white, black, and Hispanic MSM in an
    online 12-month longitudinal study
     > 18 years old
     Had a male sex partner in past 12 months
     Willing to complete an at-home HIV test
     Had an SMS-enabled mobile phone
Bi-monthly FU
                                                    Online FU
                                         Baseline                               Month 12
                                 Black    Online                                 Online
                                          Survey                                 Survey
                                                                Bi-monthly FU
                                         Baseline    SMS FU                     Month 12
                                         HIV Test                               HIV Test
Click-through
  banner ad



                                                                Bi-monthly FU
                                                    Online FU
                                         Baseline                               Month 12
        Screening   Consent     White     Online                                 Online
        Questions                         Survey                                 Survey
                                                                Bi-monthly FU
                                         Baseline    SMS FU                     Month 12
                                         HIV Test                               HIV Test




                                                                Bi-monthly FU
                                                    Online FU
                                         Baseline                               Month 12
                              Hispanic    Online                                 Online
                                          Survey                                 Survey
                                                                Bi-monthly FU
                                         Baseline    SMS FU                     Month 12
                                         HIV Test                               HIV Test
Bi-monthly FU
                                                    Online FU
                                         Baseline                               Month 12
                                 Black    Online                                 Online
                                          Survey                                 Survey
                                                                Bi-monthly FU
                                         Baseline    SMS FU                     Month 12
                                         HIV Test                               HIV Test
Click-through
  banner ad



                                                                Bi-monthly FU
                                                    Online FU
                                         Baseline                               Month 12
        Screening   Consent     White     Online                                 Online
        Questions                         Survey                                 Survey
                                                                Bi-monthly FU
                                         Baseline    SMS FU                     Month 12
                                         HIV Test                               HIV Test




                                                                Bi-monthly FU
                                                    Online FU
                                         Baseline                               Month 12
                              Hispanic    Online                                 Online
                                          Survey                                 Survey
                                                                Bi-monthly FU
                                         Baseline    SMS FU                     Month 12
                                         HIV Test                               HIV Test
Willing to take   Not willing to take
                         home HIV test      home HIV test
                                                                 Crude Odds Ratio
                             n (%)               n (%)
Race/Ethnicity                                                       (95% CI)
White, non-Hispanic        3,126 (48)          3,442 (52)            Referent

Black, non-Hispanic        2,977 (60)          1,963 (40)        1.67 (1.55 – 1.80)

Hispanic                   1,445 (59)          1,023 (41)        1.56 (1.42 – 1.71)
                 Total     7,548 (54)          6,428 (46)
Bi-monthly FU
                                                    Online FU
                                         Baseline                               Month 12
                                 Black    Online                                 Online
                                          Survey                                 Survey
                                                                Bi-monthly FU
                                         Baseline    SMS FU                     Month 12
                                         HIV Test                               HIV Test
Click-through
  banner ad



                                                                Bi-monthly FU
                                                    Online FU
                                         Baseline                               Month 12
        Screening   Consent     White     Online                                 Online
        Questions                         Survey                                 Survey
                                                                Bi-monthly FU
                                         Baseline    SMS FU                     Month 12
                                         HIV Test                               HIV Test




Self-report:
  • HIV negative                                    Online FU
                                                                Bi-monthly FU
  • Unknown                   Hispanic
                                         Baseline                               Month 12
                                          Online                                 Online
  • Never tested                          Survey                                 Survey
                                                                Bi-monthly FU
                                         Baseline    SMS FU                     Month 12
                                         HIV Test                               HIV Test
   Secure data transfer
   Results over the phone
     HIV+ automatically linked to a
     counselor

   FDA approved call center
     Access to local resources
     Only FDA-approved
     telemedicine HIV counseling and
     testing service in US
896
                  HIV test kits sent




17.5%
        157     62.9%   564       19.5%
                                           175
        Black           White             Hispanic
   Choice of reminder modality
     Phone call
     Text message
     Email


   Personal outreach
     Phone call to participant
896          82%         735
Test kits sent         Test kits returned


    564          85%          481
    White                    White

    157          73%          115
    Black                    Black

    175          79%          139
   Hispanic                 Hispanic
735            3.4%     25
Test kits returned           HIV +


       481           2.3%     11
      White                  White

       115           7.8%      9
      Black                  Black

       139           3.6%      5
     Hispanic               Hispanic
25 HIV+
                     • 11 White
                     • 9 Black
                     • 5 Hispanic
                                             11
                                    Did not continue study
                 14 Active FU
                  • 7 White
                  • 5 Black
                  • 2 Hispanic

2 Not Linked
               12 Linked to Care      12 Received
                    • 7 White
                    • 3 Black         Counseling
                    • 2 Hispanic
   Willingness to take home HIV test
   82% HIV at-home test kit return
     Biological outcome = estimated HIV incidence
     Difference in kit return by race/ethnicity
     Personal outreach to increase kit return

   3.4% HIV+ among self-reported non-positive
     Known linkage to care = 86% among respondents
   Research participants
   Patrick Sullivan, DVM, PhD
   Alexandra Ricca, MPH
   Sullivan Research Team
   Cyclogram
   Emory Center for AIDS Research (CFAR)
     P30 AI050409
   NIH, National Center on Minority Health and
    Health Disparities
     Grant # RC1MD004370
Online Longitudinal Study Assesses HIV Testing and Linkage to Care Among MSM

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Online Longitudinal Study Assesses HIV Testing and Linkage to Care Among MSM

  • 1. Christine Khosropour, MPH Rollins School of Public Health Emory University August 15, 2011 2011 National HIV Prevention Conference Atlanta, GA
  • 2.
  • 3. Underrepresentation of black and Hispanic study participants  Lack of biological outcomes on study participants  Inability to retain participants for a period sufficient to assess outcome measures  High attrition of black and Hispanic MSM
  • 4. Underrepresentation of black and Hispanic study participants  Lack of biological outcomes on study participants  Inability to retain participants for a period sufficient to assess outcome measures  High attrition of black and Hispanic MSM
  • 5.
  • 6.
  • 7. Sharma et al, JIAPAC, 2011
  • 8.
  • 9. Enrolled white, black, and Hispanic MSM in an online 12-month longitudinal study  > 18 years old  Had a male sex partner in past 12 months  Willing to complete an at-home HIV test  Had an SMS-enabled mobile phone
  • 10. Enrolled white, black, and Hispanic MSM in an online 12-month longitudinal study  > 18 years old  Had a male sex partner in past 12 months  Willing to complete an at-home HIV test  Had an SMS-enabled mobile phone
  • 11. Bi-monthly FU Online FU Baseline Month 12 Black Online Online Survey Survey Bi-monthly FU Baseline SMS FU Month 12 HIV Test HIV Test Click-through banner ad Bi-monthly FU Online FU Baseline Month 12 Screening Consent White Online Online Questions Survey Survey Bi-monthly FU Baseline SMS FU Month 12 HIV Test HIV Test Bi-monthly FU Online FU Baseline Month 12 Hispanic Online Online Survey Survey Bi-monthly FU Baseline SMS FU Month 12 HIV Test HIV Test
  • 12.
  • 13. Bi-monthly FU Online FU Baseline Month 12 Black Online Online Survey Survey Bi-monthly FU Baseline SMS FU Month 12 HIV Test HIV Test Click-through banner ad Bi-monthly FU Online FU Baseline Month 12 Screening Consent White Online Online Questions Survey Survey Bi-monthly FU Baseline SMS FU Month 12 HIV Test HIV Test Bi-monthly FU Online FU Baseline Month 12 Hispanic Online Online Survey Survey Bi-monthly FU Baseline SMS FU Month 12 HIV Test HIV Test
  • 14.
  • 15. Willing to take Not willing to take home HIV test home HIV test Crude Odds Ratio n (%) n (%) Race/Ethnicity (95% CI) White, non-Hispanic 3,126 (48) 3,442 (52) Referent Black, non-Hispanic 2,977 (60) 1,963 (40) 1.67 (1.55 – 1.80) Hispanic 1,445 (59) 1,023 (41) 1.56 (1.42 – 1.71) Total 7,548 (54) 6,428 (46)
  • 16.
  • 17. Bi-monthly FU Online FU Baseline Month 12 Black Online Online Survey Survey Bi-monthly FU Baseline SMS FU Month 12 HIV Test HIV Test Click-through banner ad Bi-monthly FU Online FU Baseline Month 12 Screening Consent White Online Online Questions Survey Survey Bi-monthly FU Baseline SMS FU Month 12 HIV Test HIV Test Self-report: • HIV negative Online FU Bi-monthly FU • Unknown Hispanic Baseline Month 12 Online Online • Never tested Survey Survey Bi-monthly FU Baseline SMS FU Month 12 HIV Test HIV Test
  • 18. Secure data transfer  Results over the phone  HIV+ automatically linked to a counselor  FDA approved call center  Access to local resources  Only FDA-approved telemedicine HIV counseling and testing service in US
  • 19. 896 HIV test kits sent 17.5% 157 62.9% 564 19.5% 175 Black White Hispanic
  • 20. Choice of reminder modality  Phone call  Text message  Email  Personal outreach  Phone call to participant
  • 21. 896 82% 735 Test kits sent Test kits returned 564 85% 481 White White 157 73% 115 Black Black 175 79% 139 Hispanic Hispanic
  • 22. 735 3.4% 25 Test kits returned HIV + 481 2.3% 11 White White 115 7.8% 9 Black Black 139 3.6% 5 Hispanic Hispanic
  • 23. 25 HIV+ • 11 White • 9 Black • 5 Hispanic 11 Did not continue study 14 Active FU • 7 White • 5 Black • 2 Hispanic 2 Not Linked 12 Linked to Care 12 Received • 7 White • 3 Black Counseling • 2 Hispanic
  • 24. Willingness to take home HIV test  82% HIV at-home test kit return  Biological outcome = estimated HIV incidence  Difference in kit return by race/ethnicity  Personal outreach to increase kit return  3.4% HIV+ among self-reported non-positive  Known linkage to care = 86% among respondents
  • 25. Research participants  Patrick Sullivan, DVM, PhD  Alexandra Ricca, MPH  Sullivan Research Team  Cyclogram  Emory Center for AIDS Research (CFAR)  P30 AI050409  NIH, National Center on Minority Health and Health Disparities  Grant # RC1MD004370