GKA deel 1 college 7

Overzicht deel tumoren ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Nature 442, 2006, 140

How cancer arises Weinberg, Sci Am 275-3, 1996, 32-40 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Progression to invasive tumor Weinberg, Sci Am 275-3, 1996, 32-40 ,[object Object],[object Object],[object Object]

Signal transduction: on and off Weinberg, Sci Am 275-3, 1996, 32-40 Avoid words such as ‘fires’

Some proto-oncogenes Weinberg, Sci Am 275-3, 1996, 32-40 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],======================================================

Some tumor suppressor genes Weinberg, Sci Am 275-3, 1996, 32-40 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Some tumor suppressor genes Weinberg, Sci Am 275-3, 1996, 32-40 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],DNA repair genen geen tumor suppressors noemen!

The cell cycle Weinberg, Sci Am 275-3, 1996, 32-40

The cell cycle Weinberg, Sci Am 275-3, 1996, 32-40 ,[object Object],[object Object],[object Object],Most cells are not cycling but in G 0 -stage

The pRb switch Weinberg, Sci Am 275-3, 1996, 32-40 E2F-member

Progression to cell division Weinberg, Sci Am 275-3, 1996, 32-40 mdm2 p21 p21 waf : see Vogelstein Proteins involved in DNA synthesis Liberated Transcription factors Active pRb protein complexed with inactive transcription factors (master brake) Transforming growth factor ß (an inhibitor) Cell division DNA synthesis Growth promoting signals issued vy neighboring cells

The Ink4 locus Kim & Sharpless, 2006, Cell 127, 265-275 ,[object Object],[object Object],[object Object],[object Object],[object Object],Inserted 4-12-07 http://www.mtmlabs.com/cda/science_technology/ p16supink4a/sup/content-121885.html

Effect of activating c-myc (from Alberts et al. 2002)

Aberrant chromosomes: aneuploidy Weinberg, Sci Am 275-3, 1996, 32-40 ,[object Object],[object Object],[object Object],[object Object],[object Object],Karyotype ============

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