GKA deel 1 college 6

Genetische therapiën ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Targeted gene correction Ye et al., Mol. Med. Today, 1998 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Gene repair Ye et al., Mol. Med. Today, 1998 ,[object Object]

DNA repair pathways Ye et al., Mol. Med. Today, 1998 ,[object Object],[object Object]

Structure of synthetic repair molecule Ye et al., Mol. Med. Today, 1998 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Relationship between gene repair and gene therapy ,[object Object]

Biochemical approach Ye et al., Mol. Med. Today, 1998 ,[object Object],[object Object],[object Object]

Result of mutation-correction Ye et al., Mol. Med. Today, 1998 ,[object Object]

Some examples of gene repair Ye et al., Mol. Med. Today, 1998

2nd example of gene repair: Zinc-finger nuclease Urnov et al., Nature 435, 2005, 646-651 ,[object Object],[object Object],From: K.A. High Nature 435, 2005, 577-578

Gene repair by homologous recombination Nature 2005, Urnov et al.

Gene repair by homologous recombination Nature 2005, Urnov et al. Homology-directed repair X-ray induced DSB Sister chromatid Donor DNA (plasmid) ZFN-induced DSB ZFN-driven homology- directed repair:

Gene repair by homologous recombination Nature 2005, Urnov et al. ,[object Object],[object Object],Homology-directed repair X-ray induced DSB Sister chromatid Donor DNA (plasmid) ZFN-induced DSB ZFN-driven homology- directed repair:

Genetic therapies for Duchenne patients? Tidball and Spencer, Nature Med 9, 2003, 997-998 ,[object Object],[object Object],[object Object]

Einde genetische therapieën ============

GKA deel 1 college 6

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