The Market for CRISPR/Cas9 2016

©2016 BioInformatics LLC www.gene2drug.com
REPORT OVERVIEW
Interactive Market Intelligence:
The Market for CRISPR/Cas9
Genome Editing Products
MAY 2016
Report #16-008
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@2013 BioInformatics, LLC n www.gene2drug.com n Report #13-005
©2016 BioInformatics LLC www.gene2drug.com 2
Interactive Market Intelligence: The Market for CRISPR/Cas9
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n TABLE OF CONTENTS
n STUDY SCOPE...........................................................................................................................................................................3
n REPORT HIGHLIGHTS........................................................................................................................................................4
n OVERVIEW..................................................................................................................................................................................6
n INTERACTIVE MARKET INTELLIGENCE...........................................................................................................8
n SELECTED DATA..................................................................................................................................................................10
n METHODOLOGY...................................................................................................................................................................12
n PRICING.......................................................................................................................................................................................13
n CURRENT 2016 REPORT TITLES...........................................................................................................................16
n ABOUT BIOINFORMATICS LLC...............................................................................................................................17
Report #16-008

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STUDY SCOPE
n STUDY SCOPE
This Interactive Market Intelligence report will help you to
compete in The Market for CRISPR/Cas9 Genome Editing
Products:
n Estimate market size, share and growth by region, industry segment and product category
n Understand the drivers of brand loyalty and compare brand performance
n Measure customer satisfaction with CRISPR/Cas9 products
n Highlight the strengths and weaknesses of competitors and their customers’ likelihood-to-switch
n Compare to 2015 data to monitor trends and identify changes

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REPORT HIGHLIGHTS
n REPORT HIGHLIGHTS
Market Analytics
n Current and planned use of genome editing tools
n Length of time utilizing genome editing tools
n Importance of CRISPR/Cas9 in achieving experimental objectives
n Lab annual budget for CRISPR/Cas9 products and service
n Spending projections for next 12 months
n Number of CRISPR experiments per month
n Number of guide RNA’s designed per CRISPR target experiment
n Number of targets edited or controlled per experiment
n Expected growth in use of CRISPR
Brand Analytics
n ●Primary supplier of CRISPR/Cas9 products/services
n ●Overall satisfaction with suppliers of CRISPR/Cas9 products/services
n ●Current and future use of CRISPR-related services
Customer Analytics
n ●Use of consumables
n ●Overall satisfaction with CRISPR/Cas9 products/services
n ●Likelihood-to-repurchase CRISPR/Cas9 products/services from current supplier

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REPORT HIGHLIGHTS
n Report highlights (continued)
n ●Likelihood-to-recommend current supplier of CRISPR/Cas9 products/services
n ●Likelihood-to-switch current supplier of CRISPR/Cas9 products/services
n ●Factors influencing decision to switch suppliers
n ●Supplier to who the customer will switch
Workflow Analytics
n ●Primary research objectives
n ●CRISPR/Cas9 experimental design
n ●Model systems used
n ●Design tools used to generate guide RNAs
n ●Satisfaction with design tools used
n ●Formats used when generating Cas9 proteins and guide RNAs
n ●Sources of vectors
n ●Delivery methods for CAS9 protein and guide RNA formats
n ●Cas9 protein or Cas9 variants currently used and plan to use
n ●Use of library-based approach for delivering multiple guide RNAs
n ●Sources of guide RNA libraries
n ●Guide RNA library formats
n ●Use of DNA for homologous recombination
n ●Techniques used to assure specificity of CRISPR/Cas9 genome editing
n ●Future product needs for CRISPR/Cas9 experiments

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OVERVIEW
n OVERVIEW
Since BioInformatics LLC last published on the CRISPR/Cas9 genome-editing system,
the scientific community has witnessed a torrent of new publications while institutions,
both private and public alike, have poured over a billion dollars into R&D for the emerging
technique. Their investment was well founded. In 2015, CRISPR/Cas9 was seen as the key
to unlocking the elusive genome, a predication that 2016 has begun to see fulfilled. With
CRISPR/Cas9, researchers have found at their disposal a novel nuclease directing system
where the ease of use, rate of performance, and versatility are unparalleled by alternative
techniques. CRISPR/Cas9 has not only revitalized genome engineering, it has revolutionized
the field.
Since its advent, the CRISPR/Cas9 system has seen exponential increase in applications,
each of which constituted novel market trends. Some recent developments include:
n Introduction of synthetic crRNA and tracrRNA that bypass the endogenous steps needed to
create sgRNA, effectively eliminating the need for additional cloning and purification steps.
n Cataloging of sgRNAs into libraries that can be screened for novelties, such as the up-regulation
of oncogenes in cancer cells.
n Modified Cas9 endonucleases that nick DNA to create single-stranded breaks rather than full,
double-stranded cleavage. This method promotes homology-directed repair (HDR), limits off-
target effects, and increases the number of sequences that can be used for site-dependent gene
modifications.

Request a Live Demo
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n Identification and analysis of protein binding domains to direct drug development.
n Directing of chromosomal recombination for high-fidelity mapping of traits of interest,
which have in turn lead to the discovery of novel genes.
n Generation of ribonucleoprotein complexes from Cas9 and gDNA. These non-viral
nucleases cleave DNA immediately upon invasion, degrade quickly and skip native, time-
consuming Cas9 activation pathways.
n Combination of CRISPR/Cas9 with lambda red for recombineering. This allows for the
knockout of disparate gene combinations, such as those pivotal in metabolic pathways.
The sheer volume of applications is staggering and, as with any breakthrough,
corporate giants have reoriented their priorities while emerging biotechs have sprung
up around the world, all in hopes to claim market share. In this rapidly evolving
environment, companies are faced with the challenge of leveraging their current
strengths to break into a field that is flush with new competition. In the same way that
CRISPR/Cas9 afforded scientists the opportunity to expand their reach, so to does
our 2016 Market for CRISPR/Cas9 Report equip suppliers with the tools they need to
capitalize on this emergent technology.

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n INTERACTIVE MARKET INTELLIGENCE
The Market for CRISPR/Cas9 Genome Editing Products utilizes our ground
breaking Interactive Market Intelligence solution that is changing the way market
research is reported and used. Traditional market research reports delivered in print
or PDF depict data in standard charts and graphs. In contrast, Interactive Market
Intelligence incorporates dynamic data visualization that adds a new dimension to
market analytics. From corporate boardrooms to reps in the field, Interactive Market
Intelligence delivers market data through visually engaging and customizable
dashboards. Customized view of the data can be easily exported into offline
presentations as needed.
INTERACTIVE MARKET
INTELLIGENCE

Request a Live Demo
or Purchase Today n INTERACTIVE MARKET INTELLIGENCE (continued)
Interactive Market Intelligence is a web-based market research delivery platform
that provides data reporting superior to PDF reports, PowerPoint and other business
intelligence tools. Unlike a PowerPoint presentation which is linear and static, one of
the core features of Interactive Market Intelligence is the ability of users to filter
and create literally hundreds of views of data—all easily obtainable from a small set
of core “key metrics” slides that include Market, Brand and Customer analytics in
well-defined segments of the life science market.
With your purchase of this report, we invite you to set up a meeting with our report
team of scientific and business analysts. We can answer any questions you may
have about the study results and we can share with you what we believe to be the
significant trends affecting your market.
INTERACTIVE MARKET
INTELLIGENCE

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SELECTED DATA
MARKET ANALYTICS SNAPSHOT: INCIDENCE OF LABS USING CRISPR/Cas9
n SELECTED DATA

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SELECTED DATA
BRAND ANALYTICS: BRAND REPUTATION COMPARISON
n SELECTED DATA

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METHODOLOGY
n METHODOLOGY
This Interactive Market Intelligence report will be based on the responses of approximately
300 current end-users of CRISPR/Cas9 technology and several hundred users of competing
techniques and planned adopters. The results are presented online using our innovative
Interactive Market Intelligence online dashboard and refreshed with biannual updates.
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PRICING
n PRICING
Why Buy Our Reports
Source of Independent, Unbiased Research
Unlike reports from other firms that are based on analyst’s subjective summary of
information from publicly available sources, our reports are based on the results of
detailed surveys of hundreds—even thousands—of scientific and medical professionals
who buy your products.
Developed by a Team of Experts
Our questionnaires are developed by a multidisciplinary team of scientists, industry
veterans and market research experts with years of experience. These professionals
understand that survey questions need to be asked in a way that ensures the answers
will directly address the business challenges you face. Once the survey data is collected,
this same team creates a unique report the presents the reader with a thorough
understanding of the topic, and the scientific and business implications of the results
based on sophisticated statistical analytics.

Request a Live Demo
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When others promote results from their online surveys, they fail to mention the
uncontrolled nature of their broadcast email invitations. To provide you with the most
valid and accurate results possible, the respondents to our surveys are members of
our unique online panel—The Science Advisory Board®
—which consists of thousands
verified life science and biomedical professionals who have agreed to take part in our
surveys, focus groups and other market research activities. These respondents are
carefully selected based on their professional qualifications, market segments and
geographic regions. We can even select them based on the products they use and
their preferred suppliers.
Complimentary Consulting Provided
With your purchase, we offer one free hour of consultation with our talented team
of scientific and business analysts who created the reports. During this consultation,
we can answer any questions you may have about the survey results and what we
believe to be the significant trends affecting the market.
PRICING

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If you’d like to delve deeper into the data from a study, we can always perform
custom cross-tabulations or other analysis on your behalf. We can even pose follow-
up questions to respondents who answered in a particular way or conduct a custom
study to extend your knowledge.
Take advantage of the unique capabilities of this Interactive Market Intelligence
analytics model from BioInformatics LLC accessible from anywhere at anytime on
your laptop or tablet.
All licenses are active for a 12-Month term.
Single User Log-In: $3,500
Up to 5 User Log-Ins: $5,500
Company-Wide License (for up to 25 User Log-Ins): $7,500
Includes access to the 2015 report to monitor trends and changes in the market.
With your purchase of this report, we also invite you to set up a meeting with our
report team of scientific and business analysts. We can answer any questions you
may have about the survey results, and we can also share what we believe to be the
significant trends affecting your market.
PRICING

Request a Live Demo
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n CURRENT 2016 REPORT TITLES:
Digital Marketing to Life Scientists: Building Digital Loyalty Now Available
The Market for Real-Time PCR Now Available
The Market for Cell-Based Assays Now Available
The Market for CRISPR/Cas9 Genome Editing Products Now Available
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A COMPLETE LIST
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n ABOUT BIOINFORMATICS LLC
BioInformatics LLC, along with our SDi division, is the premier research and advisory
firm serving the life science and analytical instrument industry. Since 1994, we have
been providing off-the-shelf reports, custom-designed studies and market analysis that
enable companies to understand their market and competitors through the eyes of the
most important information source of all — the people who buy their products.
By leveraging our online professional network of tens of thousands of biomedical
researchers, we have supported more than 500 companies and provided insights
that lead to better business decisions. Our expertise includes assessing the size and
attractiveness of markets, optimizing product configurations and pricing, validating
corporate acquisitions, measuring customers’ brand loyalty, and evaluating brand
strength and positioning.
For more information about BioInformatics’ product and service offerings,
please visit our website at www.gene2drug.com, call 703.778.3080 x15,
or email reports@gene2drug.com
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The Market for CRISPR/Cas9 2016

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The Market for CRISPR/Cas9 2016