Information of a drug Nishamalaki which is used as an antidiabetic.It is a herbal drug. It is a mixture of amla and haldi. People are mostly preferring herbal medicines because of their cost effectiveness, availability and less side effects, though this medicine can be used to treat high blood sugar level in body.
2. Course structure and contents for
PRACTICE SCHOOL (BP706PS)
B. Pharm Final Year (SEM VII)
DOMAIN – 14
NOVEL HERBAL DRUG DELIVERY
SYSTEM
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TO STUDY NISHAMALAKI AS AN ANTIDIABETIC
SUSTAINED RELEASE TABLET
3. A Review Article By:
Ahirrao Bhumika Eknath
Final Year B, Pharmacy
(19528118233020)
Guided By:
Prof. Vaishali Bhamare
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4. Content
• Introduction
• Approaches in novel Herbal drug delivery
system
• Herbal excipients
• Classification of herbal excipients
• Nishamalaki composition
• Marketed preparations
• Conclusion
• Reference
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5. Introduction
Many medicines which are derived from plants are
used now-a-days worldwide. From them maximum are
naturally grown in wild areas. These wild medicinal plants
plays important role in domestic purposes.
The local people from particular areas have
knowledge of these plants and their use , which travels from
generation to generation. As the demand of herbal medicines
is increasing day by day, there are various approaches for
development of novel herbal preparations.
‘Nishamalaki’ or ‘Nisha Amalaki’ is a combination of
amla (Emblica officinalis) and haldi (Curcuma Longa)
which is used in treatment of Diabetes Mellitus. It is not
only used in diabetes but also it is effective in urinary
disorders, in neuropathy occurred due to diabetes. 5
6. Synonym – Emblica, Indian goos berry,
Amalki
Biological Source – this consists of dried as
well as fresh fruits of the plant Emblica
officinalis, belonging to the family
Euphorbiaceae.
Uses– antidiabetic,
hypolipidemic,
antioxidant,
antibacterial, etc.
NISHAMALAKI – AMLA+ HALDI
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AMLA -
8. Haldi –
Synonym – Haridra, Indian saffron,
curcuma, Turmeric
Biological Source –Turmeric consists
of dried as well as fresh rhizomes of the
plant known as Curcuma Longa,
belonging to family zingiberaceae.
Use – anti-inflammatory,
lipid lowering,
wound healing, etc.
Turmeric in this formulation
improves insulin production and beta
cells function of pancreas in diabetic
patients 8
9. Chemical constituents of Haldi –
• 5% of volatile oil,
• resin,
• starch grains
• curcuminoids (curcumin is chief constituent-50-60%)
– yellow colour
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10. Diabetes mellitus –
Diabetes mellitus, often simply referred to as diabetes, is
a group of metabolic diseases in which a person has high
blood sugar, either because the body does not produce
enough insulin, or because cells do not respond to the
insulin that is produced. This high blood sugar produces
the symptoms of polyuria, polydipsia and polyphagia.
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The increased years of life spent with diabetes and their
complications indicating a need to improve quality of
life of diabetic population with simple interventions
which could be safe and cost effective and easily
supported and accepted by community.
• Need of study -
11. Sustained Release Dosage forms -
The sustained release system provides the sufficient amount of
drug to the body to produce the desired pharmacological
action. The remaining drug amount is released periodically
and maintains the maximum initial pharmacological activity
for a desirable time period in excess of time expected from
usual single dose.
Sustained release system include any drug delivery system
that achieves slow release of drug over an extended period
of time. The system is successful at maintaining constant
drug levels in the target tissue or cells , it is considered as
sustained release system.
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12. Merits–
• Decrease in frequency of intakes.
• Reduce side effects.
• Uniform release of drug over time.
• Better patient compliance.
Objectives -
• To maintain the concentration of drug at constant level for
a preferred period of time.
• To reduce the frequency of doses administered as
compared to conservative dosage form.
• It should deliver active entity directly to site of action ,
minimizing or eliminating side effects.
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13. Demerits -
• Increased cost.
• Toxicity chances due to dose dumping.
• Increased potential for first- pass clearance.
• Reduced potential for accurate dose adjustment.
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14. Approaches in novel herbal drug delivery system –
• Types of novel formulations include –
o Phytosomes,
o Liposomes,
o niosomes,
o transferosomes.
• Phytosomes -
Phytosome is a technology used as sustained release
delivery system that consists of phospholipid complex
system of herbal extract or phytoconstituents in nano size
range(<100nm) of particles.
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15. Merits–
• They increase bioavailability due to phospholipid
complex, thus improves therapeutic effect.
• They are required in fewer doses due to high
bioavailability.
• They improve gastrointestinal absorption.
• They show high stability.
Properties –
• They are lipophilic substances with a definite
melting point, free solubility in non‐polar solvents,
and moderate solubility in fats.
• They are better absorbed in body.
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16. Herbal Excipients –
Pharmaceutical excipients can be defined as non-active
ingredients that are mixed with API to form a suitable
dosage form.
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17. Merits -
• They are biodegradable.
• Economic
• Non- toxic
• Easily available
Demerits -
• Microbial contamination.
• Slow process of production.
• Heavy metal contamination.
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18. Marketed Preparations –
There are various tablets and churnas of nishamalaki
are available in market.
• How to make Nishamlaki Churna?
Fine powder of amla and haldi in equal amount
Mix uniformly
Have it 3-4 gm daily 18
19. • How to make nishamalaki dicoction?
10 gm nishamalaki powder
In 240 ml of water
Boil this until it remains 60ml
Decoction is ready
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20. • Nishamalaki Tablets –
Tablets contains equal amount of haldi and amla.
Potassium sorbate is used as preservative.
Dosage – 1-2 tablets 2-3 times a day or as directed by
physician.
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21. Conclusion –
The sustained release tablet of Nishamalaki can be effective
to provide prolonged release of drug in control of diabetes
mellitus.
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22. Reference -
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1. Dr. Charu Bansal, Dr. Rachna Jain A review on Preventive scope of Nishamalaki
Churna (combination of turmeric and Indian gooseberry powder) in type 2 DM.
International Journal of Pharmacognosy and Life Science 2020, page no 1-2.
2. Kishore KR, Raghavendra HL, A review on Comparative Physicochemical and
Pharmacognostical Evaluation of Nishamalaki - An Ayurvedic Antidiabetic
Formulation, Page no 69.
3. Sarika S. Lokhande, phalke N. N. And badadare S. S. A review on: sustained
release technology. World journal of pharmaceutical and medical research. Page
no.60-61.
4. Prashant B. Bedarkar, nidhi ranpara, Pradeep Kumar Prajapati, A research article
on antihyperglycemic activity of nishamalaki-an ayurvedic formulation of turmeric
and emblica officinalis, European journal of biomedical and pharmaceutical
sciences,
