2. Vaccines
Purpose of vaccines is to mimic immune response
Generally two types of vaccine
Modified Live Vaccine
Attenuated pathogens, able to replicate
Killed Vaccine
Safer than MLV, don’t replicate
3. Vaccines – pros & cons
Protects animal from
infection
Helps prevent spread of
disease in face of outbreak
Decreases severity of clinical
disease
• Can’t ensure 100% protection
• Vaccine can produce side effects and
rarely anaphylaxis
• Clinical disease can be caused by
vaccination
• Some vaccinations can interfere with
diagnostic tests
4. Marsupials
Swamp Wallaby: susceptible to clostridium tetani
Protected by mother’s colostrum
Vaccinate once out of the pouch - ~8months
Annual boosters
Lumpy jaw: fusobacterium necrophorous, actinobacillus bacteria
Koala:
Chlamydia spp
Koala retrovirus
5. Primates
Clostridium tetani, poliomyelitis virus, measles
Two options:
Oral trivalent MLV containing Tetanus, Polio and Diphtheria (3 doses,
2-3 months apart, boost in 3-5yrs) and MLV MMR (12-15 months, boost
4-6yrs) or
Monovalent vaccines:
Tetanus – IM 2, 4, 6, 15-18 months, 4-6 years, then every 5 years
Measles – SC 12-15 months, repeat again between 28 days and 4 years after
Polio – PO 2, 4, 15-18 months then at 4-6 years
Rabies – in the face of an outbreak
6. Lagomorpha
Two diseases to vaccinate against
Combined vaccine of:
Killed Viral Haemorrhagic Disease and MLV Myxomatosis
Can be given from 5 weeks, boosted annually
7. Carnivora
Felines – Feline herpes virus, feline leukaemia virus, feline
parvovirus
Same as in cats: 8 weeks, 12 weeks, annual booster
All MLV
Others – Canine Adenovirus 2, Canine Distemper, Canine
Parvovirus, Canine Parainfluenza, L. interrogans serovar
canicola, icterohaemorrhagiae, Pomona, grippotyphosa
Same as in dogs: 8 weeks, 10 weeks, then annual booster
All MLV
8. Perissodactyla
Grevy’s Zebra and Kiang
Clostridium tetani – first at 3-4 months, second a month
later, annual booster
Equine Herpes virus
foals to be vaccinated at 3-4 months, then every 4 months
until 1 year old, annual booster
MLV and KV available
Equine Viral Arteritis – KV, >9 months, repeat in 3-6
weeks, boost 6-12 months
9. Artiodactyla
As with cattle, want to vaccinate these animals against the clostridial
spp:
Perfringens, novyi, septicum, tetani, sordellii, chauvoie
First at 3-4 months, second 1 month later, annual booster
Leptospirosis in Vicuna and Suids – in endemic areas
Cattle vaccine so L. interrogans serovar hardjo
If high prevalence may require semiannual revaccination
BVD – in case of outbreak
Blue tongue – in case of outbreak
10. Aves
Avian polyomavirus:
Breeding psittacine birds should get 2 doses 2 weeks apart
Neonates should receive a dose when >35 days old, boosted in 2-3
weeks
Canary pox virus:
For susceptible passerine birds once >4 weeks old, boosted at 6-12
months
Duck Viral Enteritis:
Can be administered to waterfowl >2 weeks of age or in face of
outbreak
11. References
The Merck Veterinary Manual
European Association of Zoo and Wildlife Veterinarians – Transmissible Diseases Handbook
http://www.oie.int/en/international-standard-setting/terrestrial-manual/access-online/
www.hpa.org.uk Public Health England
http://wildpro.twycrosszoo.org/000ADOBES/Bonobos/D425_PASA_PrimateVetManualSecondEd/3.
12_Vaccination_programmes.pdf
http://www.msd-animal-health.co.nz/binaries/21471_ISPAH_Covexin10_DL_Farmer_v5_tcm51-
36969.pdf
http://www.vetmed.wsu.edu/depts-vth/camelids/vax.aspx