Pharmacology bao jiaolin

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Jiaolin Bao

My presentation in the course of Pharmacology.

Saúde e medicina

Recent Research and Progress of Juglone in Anti-cancer Reporter: Jiao-lin Bao Advisor: Maggie Pui Man, Hoi (Ph.D) (Cantab) Pharmacology & Safety Evaluation

Content Background Objective Results Discussion Methods

What is Juglone ( 胡桃醌 ) ? ,[object Object],Fig.1 The chemical structure of Juglone Fig.2 Juglans mandshurica Maxim ( 核桃楸 )

Objective ,[object Object],[object Object]

Search Strategy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Methods & Results ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

cancer cell lines ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Coomassie brilliant blue staining ( 考马斯亮蓝染色 ) ,[object Object],[object Object],Incubation with juglone resulted in obvious changes in the cell morphology. The formation of apoptotic bodies was observed

scanning electron microscopy ( 扫描电镜观察 ) ,[object Object],[object Object],Incubation with juglone resulted in obvious changes in the cell morphology and cytoskeletal alterations of the cells.

Transmission electron microscopy,TEM ( 透射电镜 ) ,[object Object],[object Object],Scanning electron microscopy revealed reduced volume of the cell bodies, dissociation of the cells, curling and malformation of the microvilli on the cell surface with rupture of the intercellular junction and enlargement of the intercellular space.TEM showed nucleolar fragmentation and formation of the apoptotic bodies after the exposure to juglone for 24 h.

Flow cytometry ( 流式细胞仪 ) ,[object Object],Cell cycle changes are analyzed by flow cytometry with cells at G1 phase significantly less than those of control and cells at G2 phase significantly more than those of control.

Western Blotting ,[object Object],[object Object],[object Object]

Rao RV ， Ellerby HM ， Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program Cell Death Differ. 2004; 11(4):372-80

Wang X. The expanding role of mitochondria in apoptosis. Genes Dev. 2001;15(22):2922-33

Discussion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Contradiction ,[object Object],[object Object],[object Object]

Molecular mechanism of Cancer Target Juglone

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