medical

1. A 25 y.o. patient is treated with parenteral Aminoglycoside for a Pseudomonas aeruginosa infection. They require immediate surgery. They are premedicated with Midazolam . Dithylinum ( Succinylcholine ) is administered for intubation, with skeletal muscle paralysis maintained during surgery with Pancuronium (Arduanum) . Anesthesia is maintained with N 2 O , Isoflurane . What is the most likely outcome of having the aminoglycoside in the perioperative setting along with all these other drugs? A. Acute hepatotoxicity from an Aminoglycoside-Isoflurane interaction B. Antagonism of Diazepam and sedative effects C. Increased or prolonged response to neuromuscular blockers D. Enhanced aminoglycoside toxicity to host cells E. Reduced risk of cardiac arrhythmias

2. A 37 y.o. patient, suffering an obliterating endarteritis of the legs, receives Phenylin in a dose of 60 mg/kg. Because of convulsion development (brain trauma is in anamnesis), Phenobarbital had been given, after the cancellation of which the nasal bleeding occurred at the patient. The given complication is connected with : A. Conjugation of phenylin with a glucuronic acid B. Inhibition by phenobarbital of enzymes microsomal oxidations in a liver C. Induction by phenobarbital of enzymes microsomal oxidations in a liver D. Oxidative deamination of phenylin E. Aliphatic hydroxylation of phenobarbital