d.pharmacy MSBTE PCI syllabus antihypertensive are the drugs which are used in the treatment of hypertension.

1. ANTIHYPERTENSIVE
ARCHANA B CHAVHAN
M.PHARM (QA)
KYDSCT’S COLLEGE OF
PHARMACY, SAKEGAON

2. HYPERTENSION
• High blood pressure is when your
blood pressure, the force of blood
flowing through your blood vessels,
is consistently too high.

3. Blood pressure is written as two numbers.
The first (systolic)
number represents how
much pressure your blood
is exerting against your
artery walls when the
heart beats.
The second (diastolic)
number represents how
much pressure your blood
is exerting against your
artery walls while the
heart is resting between
beats.
If the measurement reads 120 systolic and 80 diastolic, you would
say, “120 over 80,” or write, “120/80 mmHg.”

4. ideal blood pressure is considered
to be between 90/60mmHg and
120/80mmHg

5. Blood pressure categories
Normal
Blood pressure numbers of less than
120/80 mm Hg are considered within
the normal range.
Elevated
Elevated blood pressure is when readings
consistently range from 120-129 systolic and
less than 80 mm Hg diastolic.
Hypertension Stage 1
Hypertension Stage 1 is when blood
pressure consistently ranges from 130-
139 systolic or 80-89 mm Hg diastolic.
Hypertension Stage 2
Hypertension Stage 2 is when blood
pressure consistently ranges at 140/90 mm
Hg or higher.
Hypertensive crisis
This stage of high blood pressure requires medical attention. If your blood pressure
readings suddenly exceed 180/120 mm Hg, wait five minutes and then test your
blood pressure again.

6. ANTIHYPERTENSIVE DRUGS
The drugs which are used to
treat of high blood pressure
are called Antihypertensive.

7. Rouwolfia
Synonyms:- Rouwolfia root, snake-root, chhotachand or
sarpgandha
Biological source:- It consists of dried roots of the
plant known as Rouwolfia serpentine
Family:- Apocynaceae
Morphology:
Color: the outer surface is greyish-yellow, light-brown
Odor: odorless
Taste: bitter
Size & shape: cylindrical or slightly tapering, tortuous
pieces, 2–10 cm long, 5–22 mm in diameter.

8. Chemical Constituents
Rauwolfia contains about 0.7–2.4% total alkaloidal bases
The prominent alkaloids isolated from the drug are
• Reserpine,
• serpentine,
• Rescidine,
• Raubescine
• Deserpidine
• yohimbinine.
Serpentine
rescidine

9. 1. Rauwolfia in used as hypnotic, sedative and
antihypertensive.
2. It is given in labours to increase uterine contractions
3. Also used to treat bronchial asthama, myocardial
infarction & gastric ulcers
4. Reserpine is used to treat certain neuropsychiatric
disorders.
5. Ajmaline for the treatment of cardiac arrhythmias.