Intestinal Permeability Determination and Absorption of Soluble Drugs, as Presented by Dr. Gordon Amidon
•Transferir como PPT, PDF•
2 gostaram•1,578 visualizações
Lecture #5 from the Drug Delivery Foundation's 2009 Oral Drug Delivery Conference: http://www.ddfint.org/previous-events/2017/5/22/odd2009-strategies-for-oral-drug-delivery
Recomendados
Recomendados
Mais conteúdo relacionado
Mais procurados
Mais procurados (20)
Semelhante a Intestinal Permeability Determination and Absorption of Soluble Drugs, as Presented by Dr. Gordon Amidon
Semelhante a Intestinal Permeability Determination and Absorption of Soluble Drugs, as Presented by Dr. Gordon Amidon (20)
Mais de Drew Hertig, MBA, CLP
Mais de Drew Hertig, MBA, CLP (7)
Último
Último (20)
Intestinal Permeability Determination and Absorption of Soluble Drugs, as Presented by Dr. Gordon Amidon
- 1. Intestinal Permeability Determination and Absorption of soluble drugs Lecture 5
- 2. Intestinal Permeability • Human Jejunum (In Vivo) – Most Reliable • Rat In Situ – Next Most Reliable • Tissue Culture – Most Common • Caco2, MDCK (Epithelial) Cell Lines
- 8. Gastrointestinal Transit • Fasted vs. Fed States • Gastrointestinal Transit Times – Rule of ‘3’ • Controlled Release Dosage Forms
- 9. Transit Rule of ‘3’
- 19. Examples • Propranolol – Peff(Human) = 2.91 x 10-4 cm/sec – Fabs = 99% – Bioavailability ~20%. • Atenolol – Peff(Human) = 0.3 x 10-4 cm/sec – Fabs = 42% – Bioavailability = ~50 % • Cephalexin – Peff (Human)= 1.56 x 10-4 cm/sec – Fabs = 94% – Bioavailability = ~40%
- 21. Water Insoluble Drugs • Metamorphic limestone • CaCO3 • Ksp= 9x10-9 = [Ca++ ] [CO3] = x2 • x = solubility = 9.4 x 10 -5 M • x = 10 µg/ml
- 30. Predicting Absorption • Solubility/Dissolution • Permeability • Dose • Transit