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CURRICULUM VITAE ANDREW J. GHIO, MD
Andrew Jonathan Ghio, M.D.
Curriculum vitae
Date prepared: March 23, 2016
Current position: Medical Officer
Clinical Research Branch, Environmental Public Health Division
National Health and Environmental Effects Research Laboratory
Office of Research and Development
United States Environmental Protection Agency
Professional address: Human Studies Facility Business phone: (919) 966-0670
Environmental Protection Agency
Campus Box 7315
104 Mason Farm Road
Chapel Hill NC 27599-7315
Electronic mail (work):ghio.andy@epa.gov; FAX: (919) 966-6271
Home address: 401 Perry Creek Drive Home phone: (919) 408-0018
Chapel Hill, NC 27514
Electronic mail (other): aghio@mail.unc.edu, aghio@nc.rr.com, andrew.ghio@gmail.com
Marital Status: Married Spouse’s name: Beth Ann Ghio
Children (Year born): Christine (1987), Kathleen (1989), Michael (1991), Caroline (1998)
Education: Boston College (Chem/Biology) Chestnut Hill, MA 1973-77 B.S.
Boston Univ. School of Medicine Boston, MA 1977-81 M.D.
University of Utah (Public Health) Salt Lake City, UT 1986-88
Duke University (Statistics) Durham, NC 1988-90
Duke University (Chemistry) Durham, NC 1991-93
Univ. North Carolina (Mol. Biol.) Chapel Hill, NC 1995-97
Univ. North Carolina (Mol. Biol.) Chapel Hill, NC 2000-01
Military: Lieutenant, Public Health Service, United States Navy, 1984-1985.
Centers for Disease Control. Atlanta, GA.
Lieutenant-Commander, Public Health Service, United States Navy, 1985-1986.
Centers for Disease Control. Atlanta, GA.
Honorable discharge, 1986.
Captain, United States Army National Guard, 1987-1988.
144th
Evacuation Hospital, Salt Lake City, UT.
Transferred to North Carolina National Guard, 1988.
Captain, United States Army National Guard, 1988-1992.
823th
Dispensary, Durham, NC
Officer in charge: Nuclear, biological, and chemical warfare
Honorable discharge, 1992.
Professional training and career:
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July 1981 - June 1982 St. Luke's-Roosevelt Medical Center, Columbia University, New York City, NY.
Internship in internal medicine. Dr. Edward Dwyer, Program Director
July 1982 - June 1984 Mercy Hospital, Pittsburgh, PA.
Residency in internal medicine. Dr. Frances Luparello, Program Director
July 1984 - June 1986 Division of Respiratory Disease Studies,
National Institute for Occupational Safety and Health, Centers for Disease Control,
Morgantown, WV.
Officer, Epidemiology Intelligence Service, Centers for Disease Control.
Dr. John Hankinson, Branch Director
Jan. 1985 - Dec. 1985 National Institute for Occupational Safety and Health, Cincinnati, OH.
Residency in occupational medicine. Dr. Shiro Tanaka, Program Director
July 1984 - June 1986 West Virginia University School of Medicine, Department of Internal Medicine,
Pulmonary Division, Morgantown, WV. Adjunct Instructor of Internal Medicine.
Dr. LeRoy Lapp, Division Director
July 1986 - June 1988 University of Utah, Department of Medicine,
Division of Occupational, Pulmonary, and Critical Care Medicine,
Salt Lake City, UT. Fellowship in pulmonary and critical care medicine.
Dr. Atillio Renzetti and Dr. John R. Hoidal, Division Directors
July 1988 - June 1990 Duke University, Department of Medicine,
Division of Pulmonary and Critical Care Medicine, Durham, NC.
Associate in Medicine. Dr. James D. Crapo, Division Director.
July 1990 - Jan. 1995 Duke University, Department of Medicine,
Assistant Professor of Medicine. Quality Assurance Representative
Dr. James D. Crapo, Division Director.
July 1992 - June 1998 Duke University, Integrated Toxicology Program, Durham, NC. Faculty
July 1990 - 1995 Duke University, Marine Biomedical Center, Beaufort, NC. Scholar
Dr. Celia Bonaventura, Center Director
Jan. 1995 - Jan 2001 Duke University, Department of Medicine,
Assistant Consulting Professor of Medicine
Dr. James D. Crapo, Division Director to 1997
Dr. William Fulkerson, Division Director to 1999
Dr. Neil MacIntyre, Division Director to 2000
April 2002 - Present Duke University, Department of Medicine,
Associate Consulting Professor of Medicine
Dr. David Schwartz, Division Director to 2004
Dr. Neil MacIntyre, Division Director to 2006
Dr. Paul Noble, Division Director to 2011
Dr. Monica Kraft, Division Director to 2014
Dr. Claude Piantadosi, Division Director to present
July 1988 - Jan. 1995 Durham VA Medical Center, Durham, NC. Staff Physician.
Director, Pulmonary Function Laboratory
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Director, Bronchoscopy Services
Chairman, Research Biosafety Committee
Member, Professional Standards Committee
Dr. Steve L. Young, Section Chief to 1992
Dr. Philip Fracica, Section Chief to 1994
Dr. Michael Russell, Section Chief to 1995
Jan. 1995 - 2012 Durham VA Medical Center, Durham, NC. Staff Physician.
Dr. Gilbert Schreiber, Section Chief to 2002
Dr. Karen Welty-Wolf, Section Chief to 2012
Jan. 1995 - Present Clinical Research Branch, Human Studies Division,
National Health and Environmental Effects Research Laboratory,
Environmental Protection Agency, Chapel Hill NC.
Research Medical Officer
Dr. Robert B. Devlin, Branch Director to 2007
Dr. David Diaz-Sanchez, Branch Director 2007 to present
Bronchoscopy Coordinator
NHEERL Technical Qualifications Board (TQB)
Acting Branch Director (December, 2006 to February, 2007)
Response Capability Enhancement Team, US EPA
Oct. 1997 - June, 2000 Center for the Study of Respirable Particles,
Carolina Environmental Program, University of North Carolina,
Chapel Hill, North Carolina. Dr. Scott Martin, Center Director
July 1999- June 2001 University of North Carolina, Department of Medicine
Division of Pulmonary and Critical Care Medicine, Chapel Hill, North Carolina
Clinical Assistant Professor (Code Number 209262; PID Number 710817244)
Dr. Richard Boucher, Division Director
June 2001- Present University of North Carolina, Department of Medicine
Division of Pulmonary and Critical Care Medicine, Chapel Hill, North Carolina
Clinical Associate Professor (Code Number 20926)
Dr. Richard Boucher, Division Director to 2002
Dr. Jim Donohue, Division Director 2002 to 2011
Dr. Shannon Carson, Division Director 2011 to present
Feb. 2000 - June 2002 Chairman and Chest Consultant, Advisory Medical Committee
Dusty Trades Program, State Department of Health and Human Services
Raleigh, North Carolina
January 2005 - Present Faculty member (Fixed Term), Toxicology curriculum
University of North Carolina, Chapel Hill, NC
July 2008 – Present Faculty member, North Carolina Translational and Clinical Sciences Institute
(TraCS), University of North, Chapel Hill, NC
August 2012 - Present Faculty member (Fixed Term), The Department of Pharmacology, School of
Medicine, University of North Carolina, Chapel Hill, NC
2013 – 2016 Member, North Carolina State Bar, North Carolina Board of Legal Specialization
Medical licensure (National Boards, State):
1982 National Board of Medical Examiners 249421 Active
1982 Pennsylvania 028468 Inactive
1984 West Virginia 14089 Inactive
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1986 Utah 003063 Inactive
1988 North Carolina 33046 Active
1988 Medicaid Provider Number 9835242 Active
1988 Drug Enforcement Agency BG1629267 Active
Specialty certification and dates:
American Board of Internal Medicine. Certified, 1984. Candidate No. 098455.
American Board of Internal Medicine, Subspecialty-Pulmonary Medicine. Certified, 1990.
Candidate No. 098455.
American Board of Internal Medicine, Subspecialty-Pulmonary Medicine. Recertified, 2000.
Recertified 2012. Candidate No. 098455.
American Board of Preventative Medicine, Subspecialty-Occupational Medicine, Eligible, 1988.
American Association for Laboratory Animal Sciences, Assistant Laboratory Animal Technician,
Certified, 1990.
B Reader Certification, National Institute for Occupational Safety and Health.
Certified: 1986 and recertified: 1990, 1996, 2000, 2004, 2008, 2012, and 2016
B Reader, Division of Coal Mine Workers’ Compensation, US Department of Labor.
B Reader, US Department of Defense, Department of Navy (Reader #400): 1999, 2004
B Reader, North Carolina Advisory Medical Committee, State Public Health, Dusty Trades
Act, 2000
B Reader, National Institute for Occupational Safety and Health, Coal Workers’ Health
Surveillance Program (CWHSP), 2005
National Plan & Provider Enumeration System; NPI #1609949387
Pulmonary Function Testing, National Institute for Occupational Safety and Health, Certified, 1986
Organizations and Participation:
1979 - 1989 Physicians for Social Responsibility
1979 - 1989 Union of Concerned Scientists
1984 - 1991 American College of Chest Physicians
Southern Chapter
1984 - 1991 American College of Physicians (#091463)
Western Pennsylvania/West Virginia Chapter
Utah Chapter
North Carolina Chapter
1986 - Present American Thoracic Society (#00009718)
Scientific Assembly on Environmental and
Occupational Health Program Committee
West Virginia Thoracic Society
Intermountain Thoracic Society
North Carolina Thoracic Society
1988 - 1990 American College of Occupational Medicine
1988 - 1990 Carolina Occupational Medical Association
1989 - Present American Physiological Society (#00007651)
Respiration Section
1990 - Present American Heart Association
Cardio-Pulmonary Council
1990 - Present The Oxygen Society
1990 - 1993 American Society of Internal Medicine
2004 - Present Society of Toxicology (#2897546)
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2004 – 2008 Society of Toxicologic Pathology
2004 - 2007 American Public Health Association (#9810961)
2006 - Present Genetics and Environmental Mutagenesis Society (GEMS)
2006 - Present International BioIron Society (#50301)
2006 - 2008 American Chemical Society
2013 – 2014 International Association of Wildland Fire
Editorial Board Membership:
Biochimica et Biophysica Acta (2006- present)
BMC Particle and Fibre Toxicology (2003- 2013)
Inhalation Toxicology (2001- 2013)
The Open Cardiovascular & Thoracic Surgery Journal (2008-2011)
Inhalation Toxicology, Associate Editor (2016- present)
Journal Review (Ad hoc):
Aerosol Science and Technology; American Journal of Respiratory and Critical Care Medicine;
American Journal of Respiratory Cell and Molecular Biology; American Journal of Physiology, Cell
Physiology; American Journal of Physiology, Lung Cellular and Molecular Physiology; Annals of
Occupational Hygiene; Annals of Respiratory Medicine; Arthritis and Rheumatism; Atmospheric
Environment; Applied Occupational and Environmental Hygiene; Archives of Biochemistry and
Biophysics; Biochimica et Biophysica Acta; Biochimie; Biological Trace Element Research;
Biomaterials; Biomarkers and Prevention; Brain Research Bulletin; British Journal of Medicine and
Medical Research; Cancer Epidemiology; Cell Biology and Toxicology; Chemical Research in
Toxicology; Chemico Biological Interactions; Chest; Clinical Medicine: Circulatory, Respiratory and
Pulmonary Medicine; COPD: Journal of Chronic Obstructive Pulmonary Disease; Critical Care
Medicine; Croatian Medical Journal; eBiomedicine; Environmental Health Insights; Environmental
Health Perspectives; Environmental Pollution; Environmental Research; Environmental Science and
Pollution Research; Environmental Science & Technology; Environmental Toxicology; Environmental
Toxicology and Pharmacology; European Journal of Applied Physiology; European Journal of
Pharmacology; European Respiratory Journal; Experimental Lung Research; Food and Chemical
Toxicology; Free Radical Biology & Medicine; Fuel; Fundamental and Applied Toxicology; Future
Cardiology; International Blood Research & Reviews; International Immunopharmacology;
International Journal of Biological Sciences; International Journal of Chronic Obstructive Pulmonary
Disease; International Journal of Environmental Research and Public Health; International Journal of
Hygiene and Environmental Health; International Research Journal of Microbiology; International
Journal of Nanomedicine.; Journal of the Air & Waste Management Association; Journal of Applied
Physiology; Journal of Applied Toxicology; Journal of Biological Regulators and Homeostatic
Agents; Journal of Biomedicine and Biotechnology; Journal of Breath Research; Journal of Clinical
Investigation; Journal of Diabetes and Its Complications; Journal of Environmental Research and
Public Health; Journal of Investigative Medicine; Journal of Laboratory and Clinical Medicine;
Journal of Respiratory Medicine; Journal of Leukocyte Biology; Journal of Nutritional &
Environmental Medicine; Journal of Physiology; Journal of Respiratory Medicine; Journal of
Toxicology and Environmental Health; Medical Science Monitor; Metabolism; Microbeam Analysis;
Microscopy Regulatory Toxicology and Pharmacology; Research and Technique; Molecular and
Cellular Biochemistry; Mutation Research; Naunyn-Schmiedeberg's Archives of Pharmacology; The
Open Cardiovascular And Thoracic Surgery Journal; Pediatric Pulmonology; Pharmacological
Research; Planta Medica; PLoS One; Respiratory Medicine; Respiratory Research; Scientific
Reports; Science of the Total Environment; Swiss Medical Weekly; Toxicologic and Environmental
Chemistry; Toxicological Sciences; Toxicology and Applied Pharmacology; Toxicology Letters;
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Translational Research; Turkish Thoracic Journal
Grant Review
Section committees:
American Heart Association (2004)
Defense and Health Research Program, United States Department of Defense (2000)
Flight Attendant Medical Research Institute/Molecular Biology Section (2001-2005)
National Institutes of Health, National Institute of General Medical Sciences/Minority Biomedical
Research Support- SCORE research projects (2007)
Veterans Administration Merit Review of Gulf War and Deployment Health Meeting (2004)
Veterans Administration Merit Review of Gulf War Health Meeting (2005)
Ad hoc:
Defense and Health Research Program (United States Department of Defense)
Environmental Protection Agency Grant Program (STAR)
Environmental Protection Agency, Office of Research and Development, National Center for
Environmental Research (National Research Center)
Flight Attendant Medical Research Institute/Molecular Biology Section and Centers of Excellence
Section
Health Effects Institute Grant Program
Italian Cystic Fibrosis Research Foundation
National Sciences and Engineering Research Council of Canada
Philip Morris External Research Program
South African National Research Foundation
Thrasher Research Fund
Veterans Administration Merit Review Grant Program
The Wellcome Trust
Professional Awards and Special Recognitions:
1977 Summa Cum Laude, Boston College
1977 Phi Beta Kappa, Boston College chapter
1977 Alvan T. and Viola D. Fuller American Cancer Society Junior Research Fellowship
Award. Investigation mentored by Dr. Jerry Williams, D.Sc.
Harvard Medical School. Boston, MA.
1987 First Prize, Scientific Presentation to American College of Physicians, Utah Annual
Meeting.
1988 DuPont Critical Care/American College of Chest Physicians Young Investigator
Award
1990 Fellow, American College of Physicians
1991 Physician Scientist Award, National Heart, Lung, and Blood Institute,
National Institutes of Health.
1997 Scientific and Technological Achievement Award (Level II), Environmental
Protection Agency. The role of metal-catalyzed oxidants in particle toxicity.
Protection Agency. The role of lactoferrin and ferritin in injury after particle
exposure.
Protection Agency. Concentrated ambient particles induce a neutrophilic lung
inflammation in healthy volunteers.
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2000 Scientific and Technological Achievement Award (Level III), Environmental
Protection Agency. Soluble transition metals mediate residual oil fly ash induced
acute lung injury.
2001 Scientific and Technological Achievement Award (Level I), Environmental Protection
Agency. Air Pollution Particles from the Utah Valley Cause Lung Injury and
Inflammation in Humans and Animals
2002-present Listed in Marquis’ Who's Who in Medicine and Healthcare
2003-present Listed in Marquis’ Who's Who in Science and Engineering
2004-present Listed in Marquis’ Who's Who in Executives and Professionals
2005-present Listed in Marquis’ Who's Who in the World
2005-present Listed in Strathmore’s Who’s Who
2003 Gold Medal for involvement in the National Health and Environmental Effects
Research Laboratory Particulate Matter Health Research Team, Environmental
Protection Agency
2004 Exceptional/outstanding ORD technical assistance to the regions or program offices,
Environmental Protection Agency
2005 Listed in Guide to America’s Top Physicians
Protection Agency. Formation of 8-oxo-dG in Rat Lung DNA Following Subchronic
Inhalation of Carbon Black and Air Pollution Mediated Oxidative DNA Damage in
Cell Free Systems and Human Airway Epithelial Cells in Relation to Particle Metal
Contents and Bioreactivity.
Protection Agency. Disruption of iron homeostasis as a mechanism of biologic effect
by ambient air pollution particles, DMT1 decreases metal-related injury in the lung,
and TNF, IFN-gamma, and endotoxin increase expression of DMT1 in bronchial
epithelial cells.
2008 Top 100 Scientists, 2008. Sponsored & administered by the International
Biographical Centre, Cambridge, England.
2011-present Listed in Marquis’ Who's Who in the America
2011 Scientific and Technological Achievement Award (Honorable mention),
Environmental Protection Agency. Complex Issues with Examining Diesel Exhaust
Toxicity: is the Task Getting Easier or Harder in Experimental and Toxicological
Pathology, 60:135-140 (2008) and Biodiesel Exhaust: The Need for Health Effects
Research in Environmental Health. Perspectives, 115:496-499 (2007).
2011 Alice Hamilton Award for excellence in occupational safety and health. Presented by
the National Institute for Occupational Safety and Health for leadership through
science by publishing: Sriram K, Lin GX, Jefferson AM, Roberts JR, Wirth O,
Hayashi Y, Krajnak KM, Soukup JM, Ghio AJ, Reynolds SH, Castranova V,
Munson AE, Antonini JM. Mitochondrial dysfunction and loss of Parkinson's
disease-linked proteins contribute to neurotoxicity of manganese-containing welding
fumes. FASEB J 2010; 24: 4989-5002.
2011 Charles C. Shepard Science Award. Laboratory and Methods: Sriram K, Lin GX,
Jefferson AM, Roberts JR, Wirth O, Hayashi Y, Krajnak KM, Soukup JM, Ghio AJ,
Reynolds SH, Castranova V, Munson AE, Antonini JM. Mitochondrial dysfunction
and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of
manganese-containing welding fumes. FASEB J 2010; 24: 4989-5002.
Protection Agency. Effect of Size-Fractional on the Toxicity of Amosite and Libby
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Amphibole Asbestos.
2012 Scientific and Technological Achievement Award (Honorable mention),
Environmental Protection Agency. Cumulative Exposure Assessment for Trace-
Level Polycyclic Aromatic Hydrocarbons (PAHs) Using Human Blood and Plasma
Analysis.
Protection Agency. (1) Subchronic Pulmonary Pathology, Iron Overload, and
Transcriptional Activity after Libby Amphibole Exposure in Rat Models of
Cardiovascular Disease Environmental Health Perspectives, 120(1):85-91 (2012);
(2) The role of iron Libby amphibole-induced acute lung injury and inflammation
Inhalation Toxicology, 23(6):313-323 (2011); (3) Transcriptional activation of
inflammasome components by Libby amphibole and the role of iron Inhalation
Toxicology, 24(1):60-69 (2012).
2014 Bronze Medal for involvement in the Human Research Medical and Ethics Team,
Environmental Protection Agency.
Clinical and teaching activities:
West Virginia University School of Medicine and Medical Center (1984 to 1986)
Attending Physician, West Virginia University Hospital, Pulmonary Outpatient Clinic.
Occupational Medicine Lectures- Industrial Hygiene students.
Duke University School of Medicine and Medical Center (1988 to present)
Attending Physician, Duke University General Medical Service.
Attending Physician, Durham VA General Medical Service.
Attending Physician, Durham VA Pulmonary Outpatient Clinic.
Attending Physician, Durham VA Pulmonary Consult Service.
Attending Physician, Durham VA Medical Intensive Care Unit.
Pulmonary and Critical Care Medicine Lectures- Fellows’ conference
Pulmonary and Critical Care Medicine Lectures- Second year medical students
Pulmonary and Critical Care Medicine Lectures- Physician assistants.
Physical Examination Lectures- First year medical students.
Epidemiology Course mentorship- Physician assistants.
Pulmonary Medicine Lectures- Physician assistants
University of North Carolina School of Medicine and Medical Center (1998 to present)
Attending Physician, Fellows Clinic, University of North Carolina, Ambulatory Care Center.
Pulmonary Medicine Lectures- Pulmonary fellows.
Pulmonary and Critical Care- Research conference
Air Pollution Epidemiology Lectures, Epidemiology- Pre-doctoral and post-doctoral students.
Toxicology core courses- Pre-doctoral students.
School of Public Health- Masters students.
Areas of research interest: Environmental and occupational pulmonary medicine
Role of iron in lung injury
Role of oxidants in lung injury
Research training:
Pulmonary and Critical Care Fellows (Duke University):
Robert J. Pritchard, MD (1992-1994)
Rajesh Bhagat, MD (Advisory Committee; 2001-2002)
Armin Meyer, MD (2002-2003)
8

Pediatric Intensive Care Fellow (Duke University):
Jennifer Turi, MD (1999-2001)
Pulmonary and Critical Care Fellows (University of North Carolina):
Chris Pugh, MD (2002-2003)
Thaw Sint (2005-2006)
Physicians:
Rahul Sangani (2008-2010)
Post-doctoral Students (University of North Carolina):
Xinchao Wang, MD, MPH (2000-2003)
Zhongping Deng, Ph.D, MD (2005-2007)
Pre-doctoral Students (University of North Carolina):
Alejandro R. Molinelli UNC Toxicology (2000-2001)
Jonathan Shannahan UNC Toxicology (2008- 2011)
Shalini Minocha, UNC Eshelman School of Pharmacy (2010- 2012)
Andres Henriquez, UNC Toxicology (2012-)
Desinia Johnson, UNC Toxicology (2013-)
Pre-doctoral Students (Harvard University):
Elizabeth Heilig Thesis Defense Committee (November 9, 2005)
Pre-doctoral Students (Northwestern University):
Alejandro P. Comellas, MD, (Advisory Committee; 2007)
Masters Students (University of North Carolina):
Kimberly Swanson (2005-2006)
Undergraduate Students (University of North Carolina)
Richard Grant Muller (2011)
Summer Students:
Aaron Hall, University of North Carolina (2002)
Amruta Sarma, Princeton University (2005)
Jennifer Huang, East Chapel Hill High School, Chapel Hill, NC (2008)
Suryanaren Kummarapurugu, Chapel Hill High School, Chapel Hill, NC (2012)
Patents:
1. Ghio AJ, Piantadosi CA, and Kennedy TP. Method of inhibiting oxidants using alkylaryl
polyether alcohol polymers. Filed 3/29/94. Issued 12/12/95 as U.S. Patent No. 5,474,760.
2. Ghio AJ, Piantadosi CA, and Kennedy TP. Method of inhibiting oxidants using alkylaryl
polyether alcohol polymers. U. S. Serial No. 08/299,316. Filed 8/31/94. Issued 4/30/96 as U.S.
Patent No. 5,512,270.
Ghio AJ, Piantadosi CA, and Kennedy TP. Method of inhibiting oxidants using alkylaryl
polyether alcohol polymers. Foreign patent applications PCT/US94/03460. Filed 3/30/94.
Canada Patent File No. 2,102,142. March 30, 1994.
Patent File No. 2,159,485. March 30, 1994.
Australia Application No. 65273/94. March 30, 1994.
Europe Application No. 94912904.3. March 30, 1994. Designates Austria,
Belgium, Denmark, France, Germany, Greece, Ireland, Italy, Portugal,
Netherlands, Spain, Sweden, Switzerland, Great Britain.
Japan Application No. 522323/1994. March 30, 1994.
Korea Application No. 95-704225. March 30, 1994.
New Zealand Application No. 263986. March 30, 1994.
New Zealand Application No. 328206. March 30, 1994.
Russia Application No. 95118289; Patent Application No. 95 118 289. March 30,
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1994. Issued on October 25, 1999 as Russian Letters Patent No. 2147235.
3. Ghio AJ, Piantadosi CA, and Kennedy TP. Method of mucociliary clearance in cystic fibrosis
patients using alkylaryl polyether alcohol polymers. U. S. Serial No. 08/413,699. Filed 3/30/95.
Issued 11/03/98 as U.S. Patent No. 5,830,436.
Ghio AJ, Piantadosi CA, and Kennedy TP. Method of mucociliary clearance in cystic
fibrosis patients using alkylaryl polyether alcohol polymers. Foreign patent
applications.
Canada Patent File No. 2216789. March 29, 1996.
Australia Application No. 5435896. March 29, 1996.
Europe Application No. 96911482.6. March 29, 1996. Designates Austria,
Belgium, Denmark, France, Germany, Greece, Ireland, Italy, Portugal,
Netherlands, Spain, Sweden, Switzerland, Great Britain.
Japan Application No. 8-529663. March 29, 1996.
4. Ghio AJ, and Kennedy TP. Pharmaceutical compositions containing alkylaryl polymer alcohol
polymer. U.S. Application Serial No. 08/638,893. Filed 4/25/96. Issued 11/24/98 as U.S. Patent No.
5,840,277
Ghio AJ, and Kennedy TP. Pharmaceutical compositions containing alkylaryl polyether
alcohol polymer. Foreign patent applications PCT/US97/06862. Filed 4/25/96.
Australia Application No. 6527394. Granted. 6/26/97.
New Zealand Filed 7/19/97.
5. Ghio AJ, and Kennedy TP. Treatment of chronic pulmonary inflammation. U. S. Serial No.
08/632,275. U. S. Application Serial No. 09/097,929. Filed 6/16/98. Issued 02/15/00 as U.S. Patent
No. 6,024,940
Ghio AJ, and Kennedy TP. Treatment of chronic pulmonary inflammation.
Foreign patent applications.
Europe Application No. PCT/US97/06150. Designates Austria, Belgium,
Denmark, France, Germany, Greece, Ireland, Italy, Portugal, Netherlands,
Spain, Sweden, Switzerland, Great Britain.
6. Schmechel D, Ghio A, Piantadosi C. Biomarkers of oxidative stress in acute and chronic
neuropsychiatric illness.
Manuscripts: Published in Refereed Journals
1. Ghio AJ, Crapo RO. Midcycle pneumothorax in a patient with catamenial pneumothoraces. Western
Journal of Medicine 1988; 149 (4): 462-463.
2. Ghio AJ, Elliott CG, Crapo RO, Jensen RI, Berlin SL. Impairment following Adult Respiratory
Distress Syndrome: An evaluation based on American Thoracic Society's recommendations.
American Review of Respiratory Disease 1989; 139 (5): 1158-1162.
3. Ghio AJ, Elliott CG, Crapo RO, Collins MP, Tocino I. Migratory infiltrates in a patient with
hemoptysis. Chest 1989; 96 (1): 95-196.
4. Ghio AJ, Crapo RO, Elliott CG, Adams TD, Hunt SC, Jensen RI, Fisher AG, Afman GR.
Heritability estimates of pulmonary function. Chest 1989; 96 (4): 743-746.
5. Ghio AJ, Crapo RO, Elliott CG. Survey of the use of reference equations to predict pulmonary
function at North American training programs in respiratory disease. Chest 1990; 97 (2): 400-403.
6. Ghio AJ, Crapo RO, Elliott CG. Letter to the Editor: Survey of reference equations used to predict
pulmonary function in children. Pediatric Pulmonology 1990; 8 (2): 126-127.
7. Ghio AJ, Kennedy TP, Schapira RM, Crumbliss AL, Hoidal JR. Hypothesis: Lung disease
following silicate exposure results from oxidants generated via the Fenton reaction. Lancet 1990;
336: 967-969.
8. Ghio AJ, Worley RJ, McCusker K. Letter to the Editor: Hydropneumothorax complicating
10

recruitment of oocytes for in vitro fertilization. Southern Medical Journal 1990; (6): 726-727.
9. Guo Y-L, Kennedy TP, Michael JR, Sciuto AM, Ghio AJ, Adkinson NF Jr, Gurtner GH.
Mechanism of phosgene-induced lung toxicity: Role of arachidonate mediators. Journal of Applied
Physiology 69 (5): 1615-1622, 1990.
10. Ghio AJ, Kennedy TP. Kaolin pneumoconiosis. East Texas Medicine Journal 1990; 2 (1): 32-36.
11. Ghio AJ, Castellon RI, Kinsley KB, Hankinson JL. Changes in forced expiratory volume in one
second and peak expiratory flow rate across a workshift among unexposed blue collar workers.
American Review of Respiratory Disease 1991; 143: 1231-1234.
12. Ghio AJ, Kennedy TP, Hatch GE, Tepper JS. Reduction of PMN influx diminishes lung injury and
mortality following phosgene inhalation. Journal of Applied Physiology 71 (2): 657-665, 1991.
13. Ghio AJ, Peterseim DL, Roggli VL, Piantadosi CA. Pulmonary oxalate deposition associated with
Aspergillus niger infection: An oxidant hypothesis of toxicity. American Review of Respiratory
Disease 1992; 145: 1499-1502.
14. Ghio AJ, Hatch GE. Colchicine inhibits elevations in both alveolar-capillary membrane permeability
and lavage surfactant after exposure of the rat to phosgene. Inhalation Toxicology 1992; 4: 383-392.
15. Ghio AJ, Kennedy TP, Whorton AR, Crumbliss AL, Hatch GE, Hoidal JR. The role of surface
complexed iron in oxidant generation and lung inflammation induced by silicates. American Journal of
Physiology, Lung Cellular and Molecular Physiology 1992; 263: L511-L518.
16. Ghio AJ, Zhang J, Piantadosi CA. Generation of hydroxyl radical by crocidolite increases with
surface [Fe3+
]. Archives of Biochemistry and Biophysics 1992; 298: 646-650.
17. Ghio AJ, Hatch GE. Lavage phospholipid concentration after silica instillation in the rat is associated
with complexed [Fe3+
] on the dust surface. American Journal of Respiratory Cell and Molecular
Biology 1993; 8: 403-407.
18. Ghio AJ, Kennedy TP, Stonehuerner JG, Crumbliss AL, Hoidal JR. DNA strand breaks following in
vitro exposure to asbestos increase with surface-complexed [Fe3+
]. Archives of Biochemistry and
Biophysics 1994; 311:13-18 .
19. Ghio AJ, Kennedy TP, Cooke CL, Miller MJ, Rao G, Hoidal JR. Surface complexation of iron
cations by sodium urate crystals and gouty inflammation. Archives of Biochemistry and Biophysics
313:215-221, 1994.
20. Ghio AJ, Stonehuerner J, Quigley DR. Humic-like substances in cigarette condensate and lung tissue
of smokers. American Journal of Physiology, Lung Cellular and Molecular Physiology 1994;
266:L382-L388.
21. Ghio AJ, Quigley DR. Complexation of iron by humic-like substances in lung tissue: role in Coal
Worker's Pneumoconiosis. American Journal of Physiology, Lung Cellular and Molecular Physiology
267:L173-L179, 1994.
22. Ghio AJ, Jaskot RH, and Hatch GE. Collagen deposition after intratracheal instillation of silica is
associated with an accumulation of non-heme iron in the rat lung. American Journal of Physiology,
Lung Cellular and Molecular Physiology 1994; 267:L686-L692.
23. Schapira RM, Ghio AJ, Effros RM, Morrisey J, Dawson CA, and Hacker AD. Hydroxyl radicals are
formed in the rat lung following asbestos instillation in vivo. American Journal of Respiratory Cell
and Molecular Biology 1994; 10:573-579.
24. Ghio AJ, Stonehuerner J, Steele MP, and Crumbliss AL. Phagocyte generated superoxide displaces
Fe3+
from surface of asbestos. Archives of Biochemistry and Biophysics 1994; 315:219-225.
25. Ghio AJ, Fracica PJ, Young SL, and Piantadosi CA. Synthetic surfactants scavenges oxidants and
protects against hyperoxic lung injury. Journal of Applied Physiology 77 (3):1217-1223, 1994.
26. Taylor DE, Ghio AJ, and Piantadosi CA. Reactive oxygen species produced by liver mitochondria of
septic rats. Archives of Biochemistry and Biophysics 316:70-76, 1995.
27. Ghio AJ, Crumbliss AL. Book Review: The Development of Iron Chelators for Clinical Use. Free
Radical Biology & Medicine 1995; 19 (1):129-130.
11

28. Schapira RM, Ghio AJ, Effros RM, Morrisey J, Almagro UA, Dawson CA, and Hacker AD.
Hydroxyl radical production and injury in the rat lung following silica or titanium dioxide instillation.
American Journal of Respiratory Cell and Molecular Biology 12:220-226, 1995.
29. Oury TD, Tatro L, Ghio AJ, Piantadosi CA. Nitration of tyrosine by hydrogen peroxide and nitrite.
Free Radical Research 23 (6):537-547, 1995.
30. Ghio AJ, Roggli VL. Mycotoxins and interstitial lung disease. Chest 108 (5): 1185-86, 1995.
31. Ghio AJ, Meyer GA, and Crapo RO. The association of pulmonary artery size on chest radiograph
with residence at altitude. Journal of Thoracic Imaging 11:53-57, 1996.
32. McDonald JW, Ghio AJ, Bernhardt PF, Roggli VL. Rare Earth (cerium oxide) Pneumoconiosis:
analytical scanning electron microscopy, in vitro and animal studies, and literature review. Modern
Pathology 8 (8): 859-865, 1995.
33. Ghio AJ, Hatch GE. Tolerance to phosgene is associated with a neutrophilic influx into the rat lung.
American Journal of Respiratory and Critical Care Medicine 153:1064-1071,1996.
34. Pritchard RJ, Ghio AJ, Lehmann JR, Winsett DW, Tepper JS, Park P, Gilmour MI, Dreher KL,
Costa DL. Oxidant generation and lung injury after particulate air pollution exposure increase with
the concentrations of associated metals. Inhalation Toxicology 8:457-477, 1996.
35. Ghio AJ, Pritchard RJ, Lehman JR, Winsett DW, Hatch GE. Lung inflammation after exposure to
non-fibrous silicates increases with chelatable [Fe3+
]. Journal of Toxicology and Environmental
Health 49 (1):11-28, 1996.
36. Ghio AJ, Stonehuerner J, Pritchard RJ, Piantadosi CA, Quigley DR Dreher KL, Costa DL. Humic-
like substances in air pollution particulates correlate with concentrations of transition metals and
oxidant generation. Inhalation Toxicology 8:479-494, 1996.
37. Pracyk JB, Simonson SG, Young SL, Ghio AJ, Roggli VL, Piantadosi CA. Composition of lung
lavage in pulmonary alveolar microlithiasis. Respiration 1996; 63:254-260.
38. Ghio AJ, Roggli VL. The accumulation of iron in the rat lung after intratracheal instillation of coal
dust. Applied Occupational and Environmental Hygiene 11 (7):980-985, 1996.
39. Ghio AJ, Marshall B, Diaz JL, Povia D, Kennedy TP, Piantadosi CA. Tyloxapol inhibits cytokine
release, scavenges HOCl, and is mucolytic for CF sputum. American Journal of Respiratory and
Critical Care Medicine 154 (3):783-788, 1996.45
40. Samet JM, Madden MC, Ghio AJ, Devlin RB, Carter J, Reed W. Induction of prostaglandin H
synthase 2 in cultured airway epithelial cells exposed to residual oil fly ash. Toxicology and Applied
Pharmacology 1996; 141:159-168.
41. Ghio AJ, LeFurgey A, Roggli VL. The in vivo accumulation of iron on crocidolite is associated with
decrements in oxidant generation by the fiber. Journal of Toxicology and Environmental Health 1997;
50:125-142.
42. Ghio AJ, Stonehuerner J. Complement activation after in vitro asbestos exposure corresponds to
oxidant generation by the fiber. Inhalation Toxicology 1997; 9:31-41.
43. Ghio AJ, Pritchard RJ, Dittrich K, Samet JM. Non-heme [Fe3+
] in the lung increases with age in both
the rat and man. Journal Laboratory Clinical Medicine 1997; 129:53-61.
44. Ghio AJ, Meng ZH, Hatch GE, Costa DL. Luminol-enhanced chemiluminescence after in vitro
exposure of rat alveolar macrophages to oil fly ash is metal dependent. Inhalation Toxicology 1997;
9:255
45. Dreher KL, Jaskot RH, Lehmann JR, Richards JH, McGee JK, Ghio AJ, Costa DL. Soluble
transition metals mediate residual oil fly ash induced acute lung injury. Journal of Toxicology and
Environmental Health 1997; 50:285-305.
46. Samet JM, Stonehuerner J, Reed W, Devlin RB, Dailey LA, Kennedy TP, Ghio AJ. Disruption of
protein tyrosine phosphate homeostasis in bronchial epithelial cells exposed to oil fly ash. American
Journal of Physiology, Lung Cellular and Molecular Physiology 1997; 272:L426-L432.
47. Kodavanti UP, Jaskot RH, Su WY, Costa DL, Ghio AJ, Dreher KL. Genetic variability in
12

combustion particle-induced chronic lung injury. American Journal of Physiology, Lung Cellular and
Molecular Physiology 1997; 272:L521-L532.
48. Ghio AJ, Piantadosi CA, and Crumbliss AL. The role of iron in neutrophilic inflammation.
Biometals 1997; 10:135-142.
49. Baz MA, Ghio AJ, Roggli VL, Tapson VF, Piantadosi CA. Iron accumulation in lung allografts after
transplantation. Chest 1997; 112:435-439.
50. Kadiiska MB, Mason RP, Dreher KL, Costa DL, Ghio AJ. In vivo evidence of free radical formation
in the rat lung after exposure to an emission source air pollution particle. Chemical Research in
Toxicology 1997; 10:1104-1108.
51. Carter JD, Ghio AJ, Samet JM, Devlin RB. Cytokine production by human airway epithelial cells
after exposure to an air pollution particle is metal-dependent. Toxicology and Applied Pharmacology
1997; 146:180-188.
52. Ghio AJ, Carter JD, Samet JM, Quay J, Wortman IA, Richards JH, Kennedy TP, Devlin RB. Post-
transcriptional regulation of ferritin expression after in vitro exposures of human alveolar
macrophages to silica is iron-dependent. American Journal of Respiratory Cell and Molecular
Biology 1997; 17:533-540. Cover picture.
53. Ghio AJ, Kadiiska MB, Xiang Q, Mason RP. In vivo evidence of free radical formation after
asbestos instillation: an ESR spin trapping investigation. Free Radicals Biology & Medicine 1998;
24:11-17.
54. Ghio AJ, Taylor DE, Stonehuerner JS, Crumbliss AL, Piantadosi CA. The release of iron from
different asbestos structures by hydrogen with concomitant O2 generation. Biometals 1998; 11:41-47.
55. Ghio AJ, Carter JD, Richards JH, Brighton LE, Lay JC, Devlin RB. Disruption of normal iron
homeostasis after bronchial instillation of an iron-containing particle. American Journal of
Physiology, Lung Cellular and Molecular Physiology 1998; 274:L396-L403.
56. Ghio AJ, Carter JD, Samet JM, Reed W, Quay J, Dailey LA, Richards JH, Devlin RB. Metal-
dependent expression of ferritin and lactoferrin by respiratory epithelial cells. American Journal of
57. Ghio AJ, Kennedy TP, Crissman KM, Richards JH, Hatch GE. Depletion of iron and ascorbate in
rodents diminishes lung injury after silica. Experimental Lung Research 1998; 24:219-232.
58. Ghio AJ, Richards JH, Dittrich KL, Samet JM. Metal storage and transport proteins increase after
exposure of the rat lung to an air pollution particle. Toxicologic Pathology 1998;26:388-394.
59. Ghio AJ, Bassett M, Chall AN, Levin DG, Bromberg PA. Bronchoscopy in healthy volunteers.
Journal of Bronchology 1998; 5:185-194.
60. Kennedy TP, Ghio AJ, Reed W, Samet J, Zagorski J, Quay J, Carter JD, Dailey LA, Hoidal JR,
Devlin RB. Copper-dependent inflammation and NF-κB activation by particulate air pollution.
American Journal of Respiratory Cell and Molecular Biology 1998; 19:366-378.
61. Carraway MS, Ghio AJ, Taylor JL, Piantadosi CA. Induction of ferritin and heme oxygenase-1 by
endotoxin in the lung. American Journal of Physiology, Lung Cellular and Molecular Physiology
1998; 275:L583-L592.
62. Samet JM, Graves LM, Quay J, Dailey LA, Devlin RB, Ghio AJ, Bromberg PA, Reed W.
Activation of MAP kinases in human bronchial epithelial cells exposed to metals. American Journal of
63. Ghio AJ, Stonehuerner J, Dailey LA, Carter JD. Metals associated with both the water-soluble and
insoluble fractions of an ambient air pollution particle catalyze an oxidative stress. Inhalation
Toxicology 1999; 11:37-49.
64. Ghio AJ, Stonehuerner J, McGee JK, Kinsey JS. Sulfate content correlates with iron concentrations
in ambient air pollution particles. Inhalation Toxicology 1999; 11:293-307.
65. Lay JC, Bennett WD, Ghio AJ, Bromberg PA, Costa DL, Kim CS, Koren HS, Devlin RB. Cellular
and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles.
13

American Journal of Respiratory Cell and Molecular Biology 1999; 20:631-642.
66. Ghio AJ, Carter JD, Dailey LA, Devlin RB, Samet JM. Respiratory epithelial cells demonstrate
lactoferrin receptors which increase after metal exposure. American Journal of Physiology, Lung
Cellular and Molecular Physiology 1999; 276:L933 -L940.
67. Madden MC, Thomas, MJ, Ghio AJ. Acetaldehyde (CH3CHO) production in rodent lung after
exposure to metal-rich particles. Free Radical in Biology & Medicine 1999; 26:1569-1577.
68. Sachs S, Ghio AJ, Young SL. Tyloxapol confers durable protection against hyperoxic lung injury in
the rat. Experimental Lung Research 1999; 25:543-559.
69. Prahalad AK, Soukup JM, Inmon J, Willis R, Ghio AJ, Becker S, Gallagher JE. Air pollution
particles: Effects on cellular oxidant radical generation in relation to particulate elemental chemistry.
Toxicology and Applied Pharmacology 1999; 158:81-91.
70. Frampton MW, Ghio AJ, Samet JM, Carson JL, Carter JD, and Devlin RB. Effects of aqueous
extracts of PM10 filters from the Utah Valley on human airway epithelial cells. American Journal of
Physiology, Lung Cellular and Molecular Physiology 1999; 277 (21):L960-L967.
71. Carraway MS, Ghio AJ, Carter JD, Piantadosi CA. Expression of HO-1 in the lung in chronic
hypoxia. American Journal of Physiology, Lung Cellular and Molecular Physiology 2000; 278:L806-
L812.
72. Yang F, Coalson JJ, Bobb HH, Banu J, Ghio AJ. Resistance of hypotransferrinemic mice to
hyperoxia-induced lung injury. American Journal of Physiology, Lung Cellular and Molecular
Physiology 1999; 277:L1214-L1223.
73. Samet JM, Ghio AJ, and Madden MC. Increased expression of cyclooxygenase 2 mediates oil fly
ash-induced lung injury. Experimental Lung Research 2000; 26:57-69.
74. Soukup JM, Ghio AJ, Becker S. Soluble components of Utah Valley particulate pollution alter
alveolar macrophage function in vivo and in vitro. Inhalation Toxicology 2000; 12:401-414.
75. Carraway MS, Ghio AJ, Carter JD, Piantadosi CA. Patients with pulmonary alveolar proteinosis are
not deficient in GM-CSF. American Journal of Respiratory and Critical Care Medicine 2000;
161:1294-1299.
76. Ghio AJ, Roggli VL, Kennedy TP, and Piantadosi CA. Calcium oxalate and iron accumulation in
sarcoidosis. Sarcoidosis, Vasculitits, and Diffuse Lung Diseases 2000; 17:140-150.
77. Silbajoris R, Ghio AJ, Samet JM, Jaskot R, Dreher KL, Brighton LE. In vivo and in vitro
correlation of pulmonary MAP kinase activation following metallic exposure. Inhalation Toxicology
2000; 12:453-468.
78. Welty-Wolf KE, Carraway MS, Ghio A, Kantrow SP, Huang Y-CT, Piantadosi CA. Pro-
inflammatory cytokines increase in sepsis after anti-adhesion molecule therapy. Shock 2000; 13:404-
409.
79. Ghio AJ, Carter JD, Richards JH, Crissman KM, Bobb HH, Yang F. Diminished injury in
hypotransferrinemic mice after exposure to a metal-rich particle. American Journal of Physiology,
80. Ghio AJ, Richards JH, Carter JD, Madden MC. Accumulation of iron in the rat lung after tracheal
instillation of diesel particles. Toxicologic Pathology 2000; 28 (4):619-627.
81. Ghio AJ, Richards JH, Carter JD. Iron disequilibrium in the rat lung after instilled blood. Chest
2000; 118:814-823.
82. Ghio AJ, Kim C, Devlin RB. Concentrated ambient particles induce a neutrophilic lung inflammation
in healthy volunteers. American Journal of Respiratory and Critical Care Medicine 2000; 162 (3):981-
998.
83. Yang F, Ghio AJ, Herbert DC, Weaker FJ, Walter CC, Coalson JJ. Pulmonary expression of the
human haptoglobin gene. American Journal of Respiratory Cell and Molecular Biology 2000; 23
(3):277-282.
84. Watford WT, Ghio AJ, Wright JR. Functional complement-mediated in human bronchoalveolar
14

lavage fluid. American Journal of Physiology, Lung Cellular and Molecular Physiology
2000;279:L790-L798.
85. Prahalad AK, Inmon J, Ghio AJ, Gallagher JE. Enhancement of 2'-deoxyguanosine hydroxylation
and DNA damage by coal and oil fly ash in relation to particulate metal content and availability.
Chemical Research in Toxicology 2000; 13 (10):1011-1019.
86. Madden MC, Richards J, Dailey LA, Hatch G, Ghio AJ. Effect of ozone on diesel exhaust particle
toxicity in rat lung . Toxicology and Applied Pharmacology 2000; 168:140-148.
87. Huang Y.-T., Ghio AJ, Nozik-Grayck E, Piantadosi CA. Vascular release of nonheme iron in
perfused rabbit lungs. American Journal of Physiology, Lung Cellular and Molecular Physiology
2001; 280 (3):L474-L481.
88. Brar SS, Kennedy TP, Whorton AR, Sturrock AB, Huecksteadt TP, Ghio AJ, Hoidal JR. Reactive
oxygen species from NAD(P)H:quinone oxidoreductase constitutively activate NF-kappaB in
malignanat melanoma cells. American Journal of Physiology, Cell Physiology 2001; 280 (3):C659-
C676.
89. Alexis N, Soukup J, Ghio A, Becker S. Sputum phagocytes from healthy individuals are functional
and activated: A flow cytometric comparison with cells in bronchoalveolar lavage and peripheral
blood. Clinical Immunology 2000; 97 (1): 21-32.
90. Wu W, Samet JM, Ghio AJ, Devlin RB. Activation of the EGF receptor signaling pathway in human
airway epithelial cells exposed to Utah Valley particulate matter. American Journal of Physiology,
91. Harder S, Soukup JM, Ghio AJ, Devlin RB, Becker S. Inhalation of PM2.5 does not modulate host
defense or immune parameters in blood or lung of normal human subjects. Environmental Health
Perspectives 2001; 109 (Supplement 4):599-604.
92. Ghio AJ, Roggli V, Light R. Letter to the editor: Talc should not be used for pleurodesis in patients
with nonmalignant pleural effusions. American Journal of Respiratory and Critical Care Medicine
2001 Nov 1;164(9):1741.
93. Ghio AJ, Devlin RB. Inflammatory lung injury after instillation of humans with air pollution
particles. American Journal of Respiratory and Critical Care Medicine 2001; Aug 15;164(4):704-8.
Subject of editorial. Also, subject to additional commentary in; Zucker M. Steel mill particulates
induce lung inflammation. Pulmonary Reviews 2001; 6 (11): 1.
94. Prahalad A, Inmon J, Dailey LA, Madden MC, Ghio AJ, Gallagher JE. Air Pollution Particles
Mediated Oxidative DNA Base Damage in a Cell Free System and in Human Airway Epithelial Cells
in Relation to Particulate Metal Content and Bioreactivity. Chemical Research in Toxicology 2001;
14(7):879-887.
95. Dye JA, Lehmann JR, McGee JK, Winsett DW, Ledbetter AD, Everitt JI, Ghio AJ, Costa DL. Acute
pulmonary toxicity of particulate matter filter extracts in rats: coherence with epidemiologic studies in
utah valley residents. Environmental Health Perspectives 2001; 109 (Supplement 3):395-403.
96. Ghio AJ, Gilbey JG, Roggli VL, Richards JH, McGee JK, Carson JL, Devlin DB, Cascio WE.
Diffuse alveolar damage after exposure to an oil fly ash. American Journal of Respiratory and Critical
Care Medicine 2001; Oct 15;164(8):1514-1518.
97. Welty-Wolf KE, Carraway MS, Miller DL, Ortel TL, Ezban M, Ghio AJ, Idell S, Piantadosi CA.
Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons. American
Journal of Respiratory and Critical Care Medicine 2001 Nov 15; 164(10):1988-1996.
98. Lay JC, Zeman KL, Ghio AJ, Bennett WD. Effects of inhaled iron oxide particles on alveolar
epithelial permeability in normal subjects. Inhalation Toxicology 2001; Dec 13 (12):1065-1078.
99. Yang F, Haile DJ, Coalson JJ, Ghio AJ. Haptoglobin in lung defence. Redox Reports 2001;
6(6):372-4.
100.Huang YC, Wu W, Ghio AJ, Carter JD, Silbajoris R, Devlin RB, Samet JM. Activation of EGF
receptors mediates pulmonary vasoconstriction induced by residual oil fly ash. Experimental Lung
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Research 2002 Jan-Feb; 28(1):19-38.
101.Ghio AJ, Silbajoris R, Carson JL, Samet JM. Biological effects of oil fly ash. Environmental
Health Perspectives 2002; 110 (Supplement 1): 89-94.
102.Suliman HB, Carraway MS, Velsor LW, Day BJ, Ghio AJ, Piantadosi CA. Rapid mtDNA deletion
by oxidants in rat liver mitochondria after hemin exposure. Free Radical Biology & Medicine 2002;
32 (3):246-256.
103.Carraway MS, Ghio AJ, Suliman HB, Carter JD, Whorton AR, Piantadosi CA. Carbon monoxide
promotes hypoxic pulmonary vascular remodeling. American Journal of Physiology, Lung Cellular
and Molecular Physiology 2002 April; 282 (4):L693-702.
104.Wang X, Ghio AJ, Yang F, Dolan KG, Garrick MD, Piantadosi CA. Iron uptake and Nramp-
2/DMT1/DCT1in human bronchial epithelial cells. American Journal of Physiology, Lung Cellular
and Molecular Physiology 2002; 282 (5): p. L987-L995.
105.Ghio AJ, Suliman HB, Carter JD, Abushamaa AM, Folz RJ. Overexpression of extracellular
superoxide dismutase decreases lung injury after exposure to oil fly ash. American Journal of
Physiology, Lung Cellular and Molecular Physiology 2002; 283 (1):L211-L218.
106.Alexis NE, Richards JH, Carter JD, Ghio AJ. Iron-binding and storage proteins in sputum.
Inhalation Toxicology 2002; 14 (4): 387-400.
107.Miller DL, Welty-Wolf K, Carraway MS, Ezban M, Ghio A, Suliman H, Piantadosi CA. Extrinsic
coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal
lipopolysaccharide. American Journal of Respiratory Cell and Molecular Biology 2002; 26 (6):650-8.
108.Ghio AJ, Kennedy TP, Stonehuerner J, Carter JD, Skinner KA, Parks DA, Hoidal JR. Iron regulates
xanthine oxidase activity in the lung. American Journal of Physiology, Lung Cellular and Molecular
Physiology 2002; 283(3):L563-72.
109.Turi JL, Jaspers I, Dailey LA, Madden MC, Brighton LE, Carter JD, Nozik-Grayck E, Piantadosi
CA, Ghio AJ. Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial
cells. American Journal of Physiology, Lung Cellular and Molecular Physiology 2002; 283
(4):L791-L798.
110.Molinelli AR, Madden MC, McGee JK, Stonehuerner JG, Ghio AJ. Effect of metal removal on the
toxicity of airborne particulate matter from the Utah Valley. Inhalation Toxicology 2002; 14
(10):1069-1086.
111.Yang F, Liu XB, Quinones M, Melby PC, Ghio A, Haile DJ. Regulation of reticuloendothelial iron
transporter MTP1 (Slc11a3) by inflammation. Journal of Biological Chemistry 2002; Oct 18; 277
(42): 39786-39791.
112.Yang F, Wang X, Haile DJ, Piantadosi CA, Ghio AJ. Iron increases expression of iron-export
protein MTP1 in lung cells. American Journal of Physiology, Lung Cellular and Molecular
Physiology 2002; Nov; 283(5): L932-939.
113.Sato K, Kadiiska MB, Ghio AJ, Corbett J, Fann YC, Holland SM, Thurman RG, Mason RP. In vivo
lipid-derived free radical formation by NADPH oxidase in acute lung injury induced by
lipopolysaccharide: a model for ARDS. FASEB J. 2002; 16 (13): 1713-1720.
114.Garrick MD, Dolan KG, Horbinski C, Ghio AJ, Higgins D, Porubcin M, Moore EG, Hainsworth LN,
Umbreit JN, Conrad ME, Feng L, Lis A, Roth JA, Singleton S, Garrick LM. DMT1: a mammalian
transporter for multiple metals. Biometals. 2003 Mar;16(1):41-54.
115.Yang F, Haile DJ, Berger FG, Herbert DC, Van Beveren E, Ghio AJ. Haptoglobin reduces lung
injury associated with exposure to blood. Am J Physiol Lung Cell Mol Physiol. 2003
Feb;284(2):L402-9.
116.Ghio AJ, Carter JD, Richards JH, Richer LD, Grissom CK, Elstad MR. Iron and iron-related
proteins in the lower respiratory tract of patients with acute respiratory distress syndrome. Crit Care
Med 2003; Feb; 31(2):395-400.
117.Huang YC, Ghio AJ, Stonehuerner J, McGee J, Carter JD, Grambow SC, Devlin RB. The role of
16

soluble components in ambient fine particles-induced changes in human lungs and blood. Inhal
Toxicol 2003; 15(4):327-42.
118.Carraway MS, Welty-Wolf KE, Miller DL, Ortel TL, Idell S, Ghio AJ, Petersen LC, Piantadosi CA.
Blockade of tissue factor: treatment for organ injury in established sepsis. American Journal of
Respiratory and Critical Care Medicine 2003 May 1;167(9):1200-9.
119.Ghio AJ, Wang X, Silbajoris R, Garrick MD, Piantadosi CA, Yang F. DMT1 expression is
increased in the lungs of hypotransferrinemic mice. American Journal of Physiology, Lung Cellular
and Molecular Physiology 2003 Jun; 284 (6):L938-L944.
120.Ghio AJ, Alexis N. Letter to the editor: Siderophages in sputum. Acta Cytologica 2003; 47 (4)
(July/August): 695-696.
121.Devlin RB, Ghio AJ, Kehrl H, Sanders G, Cascio W. Elderly humans exposed to concentrated
ambient air pollution particles have decreased heart rate variability. European Respiratory Journal
2003; 21 (Supplement 40):76s-80s.
122.Upadhyay D, Panduri V, Ghio A, Kamp DW. PM induces AEC DNA damage and apoptosis: role of
free radicals and the mitochondria. Am J Respir Cell Mol Biol 2003 Aug;29(2):180-7.
123.Ghio AJ, Roggli VL, Richards JH, Crissman KM, Stonehuerner JD, Piantadosi CA. Oxalate
deposition on asbestos bodies. Human Pathology 2003; 34:737-42. Subject of editorial. Cover
picture.
124.Wu W, Wang X, Whang YE, Zhang W, Reed W, Samet JM, Ghio AJ. Induction of PTEN
degradation in human airway epithelial cells exposed to zinc. Journal of Biological Chemistry 2003
Jul 25; 278 (30):28258-63.
125.Ghio AJ, Nozik-Grayck E, Turi J, Jaspers I, Mercatante DR, Kole R, Piantadosi CA.
Superoxide-dependent iron uptake: A new role for anion exchange protein Am J Respir Cell Mol Biol
2003; 29:653-60.
126.Ghio AJ, Hall A, Bassett MA, Cascio WE, Devlin RB. Exposure to Concentrated Ambient Air
Particles Alters Hematologic Indices in Humans. Inhal Toxicol 2003; 15:1465-1478.
127.Ghio AJ, Huang YC. Exposure to Concentrated Ambient Particles (CAPs): A Review. Inhal Toxicol
2004; 16: 53-9.
128.Ghio AJ. Biological effects of Utah Valley air pollution particles: A review. Journal of Aerosol
Medicine 2004; 17 (2):157-164.
129.Kadiiska MB, Ghio AJ, Mason RP. ESR investigation of the oxidative damage in lungs caused by
asbestos and air pollution particles. Spectrochim Acta A Mol Biomol Spectrosc. 2004; 60 (6):1371-
7.
130.Turi JL, Yang F, Garrick MD, Piantadosi CA, Ghio AJ. The iron cycle and oxidative stress in the
lung. Free Radic Biol Med 2004; 36 (7):850-7.
131.Brar SS, Grigg C, Wilson KS, Holder WD, Dreau D, Austin C, Foster M, Ghio AJ, Whorton AR,
Stowell GW, Whittall LB, Whittle DP, White D, Kennedy TP. Disulfiram inhibits ATF/CREB and
human melanoma growth in a metal-dependent manner in vitro, in mine and in a patient with
metastatic disease. Molecular Cancer Therapeutics 2004; 3 (9): 1049-1060.
132.Ghio AJ, Churg A, Roggli VL. Ferruginous bodies: Implications in the mechanism of fiber and
particle toxicity. Toxicologic Pathology 2004; 32:643-649.
133.Wang X, Wu Y, Li Z, Samet JM, Ghio AJ. Activation of ERK1/2 and Elk1 in A549 cells induced by
crocidolite. Wei Sheng Yan Jiu 2004; 33:398-9.
134.Ghio AJ, Roggli VL. Letter to the editor: Diagnosis and initial management of nonmalignant diseases
related to asbestos. American Journal of Respiratory and Critical Care Medicine 2005 Mar
1;171(5):527.
135.Ghio AJ, Ford ES, Kennedy TP, Hoidal JR. The association between serum ferritin and uric acid in
humans. Free Radical Research 2005 Mar; 39(3):337-42. Corrigendum included- Free Radical
Research 2007; 41 (12): 1385.
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136.Ghio AJ, Lehmann JR, Winsett DW, Richards JH, Costa DL. Colchicine decreases airway
hyperreactivity after phosgene exposure. Inhalation Toxicology 2005 May; 17 (6):277-285.
137.Erpenbeck VJ, Malherbe DC, Sommer S, Steinhilber W, Ghio AJ, Krug N, Wright JR, Hohlfeld JM.
Surfactant protein D increases the uptake of allergen-containing pollen starch granules by alveolar
macrophages. Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L692-8.
138.Beck-Speier I, Dayal N, Karg E, Maier KL, Schumann G, Schulz H, Semmler M, Takenaka S,
Stettmaier K, Bors W, Ghio A, Samet JM, Heyder J. Oxidative stress and lipid mediators induced in
alveolar macrophages by ultrafine particles. Free Radical Biology & Medicine 2005; 38:1080-1092.
Commentary focused on this article: Mossman BT, Shukla A, Fukagawa NK. Highlight Commentary
on "Oxidative stress and lipid mediators induced in alveolar macrophages by ultrafine particles". Free
Radic Biol Med 2005; 38:1080-92.
139.Wang X, Garrick MD, Yang F, Dailey LA, Piantadosi CA, Ghio AJ. TNF, IFN-δ, and endotoxin
increase expression of DMT1 in bronchial epithelial cells. American Journal of Physiology 2005;
289:L24-L33.
140.Yang F, Haile DJ, Wang X, Dailey LA, Ghio AJ. Apical location of ferroportin 1 in airway epithelia
and its role in iron detoxification in the lung. American Journal of Physiology 2005; 289:L14-L23.
141.Pugh C, Hathwar V, Richards JH, Stonehuerner J, Ghio AJ. Disruption of iron homeostasis in the
lungs of transplant patients. Journal of Heart and Lung Transplantation 2005; 24 (11):1821-1827.
142.Anseth JW, Goffin AJ, Fuller GG, Ghio AJ, Kao PN, Upadhyay D. Lung surfactant gelation induced
by epithelial cells exposed to air pollution or oxidative stress. American Journal of Respiratory Cell
and Molecular Biology 2005; 33 (2):161-168.
143.Ghio AJ, Cohen MD. Disruption of iron homeostasis as a mechanism of biologic effect by ambient
air pollution particles. Inhalation Toxicology 2005; 17 (13):709-716.
144.Ghio AJ, Piantadosi CA, Wang X, Dailey LA, Stonehuerner JD, Madden MC, Yang F, Dolan KG,
Garrick LM, Garrick MD. DMT1 decreases metal-related injury in the lung. American Journal of
Physiology 2005; 289:L460-467. Subject of news release by the American Physiological Society.
145.Wang XC, Xu YB, Wu YM, Li ZW, Samet JM, Ghio AJ. Study of IL-8 overexpression in A549
cells induced by crocidolite fibers. Wei Sheng Yan Jiu 2005; 34:141-143.
146.Devlin RB, Frampton ML, Ghio AJ. In vitro studies: what is their role in toxicology? Experimental
and Toxicologic Pathology 2005; 57:183-188.
147.Welty-Wolf KE, Carraway MS, Ortel TL, Ghio AJ, Idell S, Egan J, Zhu X, Jiao J, Wong HC,
Piantadosi CA. Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and
renal failure. American Journal of Physiology 2005; 290 (1):L21-L31.
148.Warheit DB, Reed KL, Stonehuerner JD, Ghio AJ, Webb TR. Biodegradability of para-aramid
respirable-sized fiber-shaped particulates (RFP) in human lung cells. Toxicologic Sciences 2006; 89
(1): 296-303.
149.Roggli VL, Ghio AJ, Piantadosi CA, MacIntyre NR, Young SL, Kussin PS, Steele MP, Carraway
MS, Welty-Wolf KE, Govert JA, McMahon TJ, Palmer SM, Sporn TA. Physician subsidies for
tobacco adertising. American Journal of Respiratory and Critical Care Medicine 2006; 173 (2):246.
150.Mutlu GM, Snyder C, Bellmeyer A, Wang H, Hawkins K, Soberanes S, Welch LC, Ghio AJ,
Chandel NS, Kamp D, Sznajder JI, Budinger GRS. Airborne particulate matter inhibits alveolar fluid
reabsorption in mice via oxidant generation. American Journal of Respiratory Cell and Molecular
Biology 2006; 34 (6):670-676.
151.Huang YCT, Ghio AJ. Vascular effects of ambient pollutant particles and metals. Current Vascular
Pharmacology 2006; 4:199-203.
152.Wang X, Wu Y, Stonehuerner JD, Dailey LA, Richards JD, Jaspers I, Piantadosi CA, Ghio AJ.
Oxidant generation promotes iron sequestration in BEAS-2B cells exposed to asbestos. American
Journal of Respiratory Cell and Molecular Biology 2006; 34:286-292.
153.Ghio AJ, Turi JL, Yang F, Garrick LM, Garrick MD. Iron homeostasis in the lung. Biological
18

Research 2006; 39 (1): 67-77.
154.Huang, Y-C T, Bassett MA, Levin D, Montilla T, Ghio AJ. Acute phase reaction in healthy
volunteers after bronchoscopy with lavage. Chest 2006; 129:1565-1569.
155.Turi JL, Wang X, Nozik-Grayck E, McKie AT, Piantadosi CA, Ghio AJ. The role of duodenal
cytochrome b in the iron cycle of the lung. American Journal of Physiology 2006; 291 (2):L272-80.
156.Nguyen N-B, Callaghan KD, Ghio AJ, Haile DJ, Yang F. Hepcidin expression and iron transport in
alveolar macrophages. American Journal of Physiology 2006; 291 (3):L417-L425.
157.McCaskill JG, Chason KD, Hua X, Neuringer IP, Ghio AJ, Funkhouser WK, Tilley SL. Pulmonary
immune responses to Propionibacterium acnes in C57BL/6 and BALB/c mice. American Journal of
Respiratory Cell and Molecular Biology 2006; 35(3):347-56.
158.Ghio AJ, Mazan MR, Hoffmann AM, Robinson NE. Correlates between human and equine lung
injury after particle exposure. Equine Veterinary Journal 2006; 38 (4):362-367.
159.Wang X, Samet JM, Ghio AJ. Asbestos-induced activation of cell signaling pathways in human
bronchial epithelial cells. Experimental Lung Research 2006; 32 (6):229-243.
160.Jang M, Ghio AJ, Cao G. Exposure of BEAS-2B cells to secondary organic aerosol coated on
magnetic nanoparticles. Chemical Research in Toxicology 2006; 19 (8):1044-1050.
161.Schmechel DE, Browndyke J, Ghio A. Strategies for the dissection of genetic-environmental
interactions in neurodegenerative disorders. Neurotoxicology 2006; 27 (5):637-657.
162.Ghio AJ, Funkhouser W, Pugh CB, Winters S, Stonehuerner JG, Mahar AM, Roggli VL. Pulmonary
fibrosis and ferruginous bodies in a textile worker exposed to synthetic fibers. Toxicologic Pathology
2006; 24 (6):723-729.
163.Ghio AJ, Ghio C, Bassett M. Exercise-induced pulmonary hemorrhage after running a marathon.
Lung 2006; 184 (6):331-333.
164.Soberanes S, Panduri V, Mutlu GM, Ghio A, Budinger GR, Kamp DW. P53 mediates particulate
matter-induced alveolar epithelial cell mitochondrial dysfunction and apoptosis. American Journal of
Respiratory and Critical Care Medicine 2006; 174 (11):1229-1238.
165.Carraway MS, Suliman HB, Madden MC, Piantadosi CA, Ghio AJ. Metabolic capacity regulates
iron homeostasis in endothelial cells. Free Radical Biology & Medicine 2006; 41(11):1662-9.
166.Kennedy MP, Noone PG, Carson J, Molina PL, Ghio A, Zariwala MA, Minnix SL, Knowles MR.
Calcium stone lithoptysis in primary ciliary dyskinesia. Respiratory Medicine 2007; 101 (1):76-83.
167.Wang XC, Wu YM, Samet JM, Ghio AJ. Expression of phosphorylated ERK1/2 induced by
crocidolite fibers in BEAS-2B cells. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Oct;
24(10):597-600.
168.Benedict C, Ghio AJ, Gehring H, Schultes B, Peters A, Oltmanns KM. Transient hypoxia and
downregulation of circulating prohepcidin concentrations in healthy young men. Haematologica 2007;
92:125-126.
169.Ghio AJ, Turi JL, Madden MC, Dailey LA, Richards JD, Stonehuerner JG, Morgan DL, Garrick
LM, and Garrick MD. Lung injury after ozone exposure is iron-dependent. American Journal of
Physiology 2007; 292(1):L134-43.
170.Bolger MS, Ross DS, Jiang H, Frank MM, Ghio AJ, Schwartz DA, Wright JR. Complement levels
and activity in the normal and LPS-injured lung. American Journal of Physiology 2007; 292 (3):L748-
L59.
171.Ghio AJ, Bennett WD. Metal particles are inappropriate for testing a postulate of extra-pulmonary
transport. Environmental Health Perspectives 2007; 115 (2): A70.
172.Cohen MD, Sisco M, Prophete C, Chen L-C, Zelikoff JT, Smee JJ, Holder AA, Ghio AJ,
Stonehuerner JD, Crans DC. Pulmonary immunotoxic potentials of metals are governed by select
physicochemical properties: vanadium agents. Journal of Immunotoxicology 2007; 4:49-60.
173.Ghio AJ, Bassett MA, Levin D, Montilla T. Oxygen supplementation is required in healthy
volunteers during bronchoscopy with lavage. Journal of Bronchology 2007; 14 (1):19-21.
19

174.Swanson K, Madden MC, Ghio AJ. Biodiesel exhaust: the need for human health effects research.
Environmental Health Perspectives 2007; 115 (4):496-499.
175.Zheng S, Byrd AS, Fischer BM, Grover AR, Ghio AJ, Voynow JA. Regulation of MUC5AC
expression by NAD(P)H:quinone oxidoreductase 1. Free Radical Biology & Medicine 2007; 42
(9):1398-1408.
176.Samet JM, Graff D, Berntsen J, Ghio AJ, Huang T, Devlin RB. A comparison of studies on the
effects of controlled exposure to fine, coarse and ultrafine ambient particulate matter from a single
location. Inhalation Toxicology 2007; 19 (Supple 1): 29-32.
177.Zhang J, Ghio AJ, Chang W, Kamdar O, Rosen GD, Upadhyay D. Bim mediates
mitochondria-regulated particulate matter-induced apoptosis in alveolar epithelial cells. FEBS Lett
2007; 581:4148-52.
178.Mutlu GM, Green D, Bellmeyer A, Baker CM, Burgess Z, Rajamannan N, Christman JW, Foiles N,
Kamp DW, Ghio AJ, Chandel NS, Dean DA, Sznajder JI, Budinger GRS. Ambient particulate
matter accelerates coagulation via an IL-6 dependent pathway. Journal of Clinical Investigation 2007;
117(10):2952-2961.
179.Zhang J, Ghio AJ, Gao M, Wei K, Rosen GD, Upadhyay D. Ambient particulate matter induces
alveolar epithelial cell cycle arrest: Role of G1 cyclins. FEBS Lett 2007; 581:5315-20.
180.Brown JS, Graham JA, Chen LC, Postlethwait EM, Ghio AJ, Foster WM, Gordon T. Panel
discussion review: session four--assessing biological plausibility of epidemiological findings in air
pollution research. Journal of Exposure Science and Environmental Epidemiology 2007; 17
(Supplement 2): S97-S105.
181.Ghio AJ, Stonehuerner J, Richards J, Devlin RB. Iron homeostasis in the lung following asbestos
exposure. Antioxidants & Redox Signaling 2008; 10(2): 371-378.
182.Sint T, Donohue JF, Ghio AJ. Ambient air pollution particles and the acute exacerbation of chronic
obstructive pulmonary disease. Inhalation Toxicology 2008; 20(1):25-9.
183.Ayres JG, Borm P, Cassee FR, Castranova V, Donaldson K, Ghio A, Harrison RM, Hider R, Kelly
F, Kooter IM, Marano F, Maynard RL, Mudway I, Nel A, Sioutas C, Smith S, Baeza-Squiban A,
Cho A, Duggan S, Froines J. Evaluating the toxicity of airborne particulate matter and nanoparticles
by measuring oxidative stress potential--a workshop report and consensus statement. Inhal Toxicol
2008; 20 (1):75-99.
184.Ghio AJ. Mechanism of asthmatic exacerbation by ambient air pollution particles. Expert Review of
Respiratory Medicine 2008; 2 (1):109-118.
185.Ghio AJ, Stonehuerner J, Richards JH, Crissman K, Roggli VL, Piantadosi CA, Carraway MS. Iron
homeostasis in the lungs of patients with pulmonary alveolar proteinosis: a case-control study. Respir
Res 2008 Jan 23; 9:10.
186.Ghio AJ, Stonehuerner JG, Dailey LA, Richards JH, Madden MD, Deng Z, Nguyen NB, Callaghan
KD, Yang F, Piantadosi CA. Carbon Monoxide Reversibly Alters Iron Homeostasis and Respiratory
Epithelial Cell Function. American Journal of Respiratory Cell Molecular Biology 2008; 38
(6):715-723
187.Turi JL, Piantadosi CA, Stonehuerner JD, Ghio AJ. Iron transport in bronchial epithelial cells is
dependent on concurrent sodium transport. Biometals, 2008; 21 (5):571-580.
188.Sawyer K, Samet JM, Ghio AJ, Pleil JD, Madden MC. Responses measured in the exhaled breath of
human volunteers acutely exposed to ozone and diesel exhaust. Journal of Breath Research 2008; 2:1-
9.
189.Cohen MD, Sisco M, Prophete C, Chen LC, Zelikoff JT, Ghio AJ, Stonehuerner JD, Smee JJ, Holder
AA, Crans DC. Pulmonary immunotoxic potentials of metals are governed by select physicochemical
properties: vanadium agents. J Immunotoxicol 2008; 4:49-60.
190.Kamdar O, Le W, Zhang J, Ghio AJ, Rosen GD, Upadhyay D. Air pollution induces enhanced
mitochondrial oxidative stress in cystic fibrosis airway epithelium. FEBS Letters 2008; 582(25-26):
20

3601-3606.
191.Ghio AJ, Hilborn ED, Stonehuerner JG, Dailey LA, Carter JD, Richards JH, Crissman KM, Foronjy
RF, Uyeminami DL, Pinkerton KE. Particulate matter in cigarette smoke alters iron homeostasis
producing an oxidative stress and inflammation. American Journal of Respiratory and Critical Care
Medicine 2008; 178 (11):1130-1138.
192.Ghio AJ, Jang M. Acid and organic aerosol coatings on magnetic nanoparticles increase iron
concentrations in human airway epithelial cells. Inhalation Toxicology 2009; 21 (8):659-667.
193.Li J, Ghio A, Cho S-H, Brinckerhoff C, Simon SA, Liedtke W. Diesel-exhaust particles activate the
matrix-metalloproteinase-1 gene in human bronchial epithelia in a β-arrestin-manner via activation of
RAS. Environmental Health Perspectives 2009; 117:400-409. Focus of article in International
Business Times (12/10/2008).
194.Fischer BM, Zheng S, Potts EN, Grover AR, Savov JD, Jaiswal AK, Ghio AJ, Foster WM, Voynow
JA. NADPH quinone oxidoreductase 1 (NQO1) links ozone-induced oxidative stress and acute
airway inflammation. American Journal of Respiratory Cell and Molecular Biology 2009; 41 (1):107-
113.
195.Soberanes S, Urich D, Kwon JS, Baker CM, Burgess ZO, Chiarella SE, Bell1 EL, Ghio AJ, Ridge
KM, Kamp DW, Chandel1 NS, Schumacker PT, Mutlu GM, Budinger GRS. Mitochondrial complex
III generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following
exposure to particulate matter air pollution. Journal of Biological Chemistry 2009; 284:2176-2186.
196.Connor JR, Ghio AJ. The impact of host iron homeostasis on disease. Biochimica et Biophysica
Acta General Subjects 2009; 1740: 581-582.
197.Ghio AJ. Disruption of iron homeostasis and lung disease. Biochimica et Biophysica Acta General
Subjects 2009; 1740: 731-739.
198.Kaczmarek M, CachauR, Topol IA, Kasprzak KS, Ghio A, Salnikow K. Iron oxidation in
hydroxylases accounts for activation of HIF-1 proteins by metal ions. Toxicological Sciences 2009;
107:394-403.
199.Swanson KJ,. Kado NY, Funk WE, Pleil JD, Madden MC, Ghio AJ. Release of the Pro-
Inflammatory Markers by BEAS-2B Cells Following In Vitro Exposure to Biodiesel Extracts. Open
Toxicology Journal 2009; 3: 8-15.
200.Silbajoris R, Huang JM, Cheng W-Y, Dailey L, Tal TL, Jaspers I, Ghio AJ, Bromberg PA, Samet
JM. Nanodiamond particles induce IL-8 expression through a transcript stabilization mechanism in
human airway epithelial cells. Nanotoxicology 2009; 3(2): 152-160.
201.Mazan MR, Svatek J, Maranda L, Christiani D, Ghio A, Nadeau J, Hoffman AM. Questionnaire
assessment of airway disease symptoms in equine barn personnel. Occup Med (Lond) 2009 Jun;
59(4):220-5.
202.Esther Jr CR, Boysen G, Olsen BM, Collins LB, Ghio AJ, Swenberg JW, Boucher RC. Mass
Spectrometric Analysis of Biomarkers and Dilution Markers in Exhaled Breath Condensate Reveals
Elevated Purines in Asthma and Cystic Fibrosis. Am J Physiol Lung Cell Mol Physiol 2009;
296(6):L987-93.
203.Urich D, Soberanes S, Baker CM, Burgess Z, Chiarella S, Fakhran S, Ghio AJ, Ridge KM, Green D,
Kamp DW, Sznajder JI, Chandell NS, Mutlu GM, Budinger GRS. Proapoptotic NOXA is required
for particulate matter-induced cell death and lung injury. FASEB Journal 2009; 23(7):2055-2064
204.Deng Z, Dailey LA, Soukup J, Stonehuerner J, Richards JD, Callaghan KD, Yang F, Ghio AJ. Zinc
transport by respiratory epithelial cells and interaction with iron homeostasis. Biometals 2009; 22
(5):803-15.
205.Ghio AJ, Tan RJ, Ghio K, Fattman CL, Oury TD. Iron accumulation and expression of iron-related
proteins following in vivo exposure to crocidolite. Journal of Environmental Pathology, Toxicology
and Oncology 2009; 28 (2): 153-162.
206.Sawyer K, Ghio AJ, Madden, MC. The Effect of Ambient Particulate Matter on Human Alveolar
21

Macrophage Oxidative and Inflammatory Responses. J Toxicol Environ Health A 2010; 73 (1):41-
57.
207.Huang YCT, Ghio AJ. Controlled human exposures to ambient pollutant particles in susceptible
populations. Environmental Health 2009; 8:33.
208.Baker JF, Ghio AJ. Iron homeostasis in autoimmune diseases and gout. Rheumatology 2009; 48
(11):1339-1144.
209.Cohen MD, Sisco M, Prophete C, Yoshida K, Chen LC, Zelikoff JT, Smee J, Holder AA,
Stonehuerner J, Crans DC, Ghio AJ.. Effects of metal compounds with distinct physicochemical
properties on iron homeostasis and antibacterial activity in the lungs: chromium and vanadium.
Inhalation Toxicology 2010; 22 (2):169-178.
210.Fischer BM, Lopez Domowicz DA, Zheng S, Carter JL, McElvaney NG, Taggert C, Lehmann JR,
Voynow JA, Ghio AJ. Neutrophil Elastase Increases Airway Epithelial Non-Heme Iron Levels.
Clinical and Translational Science 2009; 2 (5):333-339.
211.Ghio AJ, Sangani RG, Brighton LE, Carson JL. MRT Letter: Ambient air pollution particles and
autofluorescence by human alveolar macrophages. Microscopy Research and Technique 2010; 73
(6): 579-582.
212.D'Armiento JM, Scharf SM, Roth MD, Connett JE, Ghio A, Sternberg D, Goldin JG, Louis TA, Mao
JT, O'Connor GT, Ramsdell JW, Ries AL, Schluger NW, Sciurba FC, Skeans MA, Voelker H,
Walter RE, Wendt CH, Weinmann GG, Wise RA, Foronjy RF. Eosinophil and T cell Markers
Predict Functional Decline in COPD Patients. Respiratory Research 2009 Nov 19; 10 (1): 113.
213.Sangani RG, Soukup JM, Ghio AJ. Metals in air pollution particles decrease whole blood
coagulation time. Inhalation Toxicology 2010; 22 (8):621-626.
214.Antonini JM, Roberts JR, Chapman R, Soukup JM, Ghio AJ, Sriram K. Pulmonary Toxicity and
Extrapulmonary Tissue Distribution of Metals after Repeated Exposure to Different Welding Fumes.
Inhalation Toxicology 2010; 22 (10): 805–816.
215.McIntosh R, Lee S, Ghio AJ, Xi J, Zhu M, Shen X, Chanoit G, Zvara DA, Xu Z. Intracellular zinc
mediates adenosine A2 receptor activation induced cardioprotection against reperfusion injury.
Journal of Molecular and Cellular Cardiology 2010; 49 (1):41-47.
216.Sriram K, Lin GX, Jeffferson AM, Roberts JR, Chapman RS, Soukup JM, Ghio AJ, Antonini JM.
Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes.
Archives of Toxicology 2010; 84 (7):521-540.
217.Yang F, Stonehuerner J, Richards JH, Nguyen N-B, Callaghan KD, Haile DJ, Ghio AJ. Deficiency
in the divalent metal transporter 1 augments bleomycin-induced lung injury. Biometals 2010; 23
(4):657-667.
218.Mackenzie B, Shawki A, Ghio AJ, Stonehuerner JD, Zhao L, Ghadersohi S, Garrick LM, Garrick
MD. A role for divalent metal-ion transporter-1 is doubtful in the mechanism by which calcium-
channel blockers reverse iron overload. Blood 2010; 115(20): 4148-4149.
219. Farraj AK, Hazari MS, Haykal-Coates N, Lamb C, Winsett DW, Ge Y, Ledbetter AD, Carll AP,
Bruno M, Ghio A, Costa DL. ST depression, Arrhythmia, Vagal Dominance, and Reduced Cardiac
MicroRNA in Particulate-exposed Rats. American Journal of Respiratory Cell and Molecular
Biology 2011; 44 (2):185-96.
220.Shannahan JH, Schladweiler MC, Richards JH, Ledbetter AD, Ghio AJ, Kodavanti UP. Pulmonary
oxidative stress, inflammation, and dysregulated iron homeostasis in rat models of cardiovascular
disease. J Toxicol Environ Health A 2010; 73 (10):641-56.
221.Pleil JD, Stiegel MA, Sobus JR, Tabucchi S, Ghio AJ, Madden MC. Cumulative exposure
assessment for trace-level polycyclic aromatic hydrocarbons (PAHs) using human blood and plasma
analysis. J Chromatogr B Analyt Technol Biomed Life Sci. 2010; 878 (21):1753-1760.
222.Wang S, Prophete C, Soukup JM, Chen LC, Costa M, Ghio A, Qu Q, Cohen MD, Chen H. Roles of
MAPK Pathway Activation During Cytokine Induction in BEAS-2B Cells Exposed to Fine World
22

Trade Center (WTC) Dust. Journal of Immunotoxicology 2010; 7 (4):298-307.
223.Sriram K, Lin GX, Jefferson AM, Roberts JR, Wirth O, Hayashi Y, Krajnak KM, Soukup JM, Ghio
AJ, Reynolds SH, Castranova V, Munson AE, Antonini JM. Mitochondrial dysfunction and loss of
Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding
fumes. FASEB J 2010; 24: 4989-5002.
224.Duncan KE, Ghio AJ, Dailey LA, Bern AM, Gibbs-Flournoy EA, Padilla-Carlin DJ, Roggli VL,
Devlin RB. Effect of Size-Fractionation on the Toxicity of Amosite and Libby Asbestos.
Toxicological Science 2010; 118:420-434.
225.Sangani RG, Ghio AJ. Lung injury after cigarette smoking is particle-related. International Journal
of Chronic Obstructive Pulmonary Disease 2011; 6:191-198.
226.Shannahan JH, Schladweiler MCJ, Padilla-Carlin DJ, Nyska A, Richards JH, Ghio AJ, Gavett SH,
Kodavanti UP. Acute Pulmonary Inflammation and Injury in Rat Models of Cardiovascular Disease
after Exposure to Libby Amphibole. Inhalation Toxicology 2011; 23(3):129-141.
227.Ghio AJ, Soukup JM, Dailey LA, Richards J, Deng Z, Abraham JL. Gadolinium exposure disrupts
iron homeostasis in cultured cells. Journal of Biological Inorganic Chemistry 2011; 16 (4):567-575.
228.Li J, Kanju P, Patterson M, Chew W-L, Cho S-H, Gilmour I, Oliver T, Yasuda R, Ghio A, Simon
SA, Liedtke W. TRPV4-Mediated Calcium-influx into Human Bronchial Epithelia upon Exposure to
Diesel Exhaust Particles. Environmental Health Perspectives 2011; 119 (6):784-793.
229.Shannahan JH, Ghio AJ, Schladweiler MCJ, McGee JK, Richards JH, Gavett SH, Kodavanti UP.
The Role of Iron in Libby Amphibole-Induced Toxicity In Vitro and In Vivo. Inhalation Toxicology
2011; 23 (6): 313-323.
230.Budinger GR, McKell JL, Urich D, Foiles N, Weiss I, Chiarella SE, Gonzalez A, Soberanes S, Ghio
AJ, Nigdelioglu R, Mutlu EA, Radigan KA, Green D, Kwaan HC, Mutlu GM. Particulate Matter-
Induced Lung Inflammation Increases Systemic Levels of PAI-1 and Activates Coagulation Through
Distinct Mechanisms. PLoS One 2011; 6 (4): e18525.
231. Ghio AJ, Soukup JM, Case M, Dailey LA, Richards J, Berntsen J, Devlin RB, Stone S, Rappold A.
Exposure to wood smoke particles produces an inflammation in healthy volunteers. Occupational and
Environmental Medicine 2012;69:170-175.
232.Ghio AJ, Carraway MS, Madden MC. Composition of air pollution particles and oxidative stress in
cells, tissues, and living systems. Journal of Toxicology and Environmental Health, Part B, 15:1–21,
2012.
233. Shannahan JH, Nyska A, Cesta M, Schladwiler MCJ, Vallant BD, Ward WO, Ghio AJ, Gavett SH,
Kodavanti UP. Subchronic pulmonary pathology, iron-overload and transcriptional activity after
Libby amphibole exposure in rat models of cardiovascular disease. Environmental Health
Perspectives 2011; 120 (1):85-91.
234.Frazier MD, Mamo LB, Ghio AJ, Turi JL. IFN-γ regulates expression of hepcidin in airway
epithelial cells. Respiratory Research 2011; 12:100.
235.Ghio AJ, Soukup JM, Dailey LA, Richards JH, Turi JL, Pavlisko EN, Roggli VL. Disruption of iron
homeostasis in mesothelial cells following talc pleurodesis. American Journal of Respiratory Cell and
Molecular Biology 2012;46 80-86.
236.Ghio AJ, Bassett MA, Montilla T, Chung EH, Smith CB, Cascio WE, Carraway MS. Case report:
Supraventricular Arrhythmia Following Exposure to concentrated Ambient Air Pollution Particles.
Environmental Health Perspectives 2012; 120 (2): 275-277.
237.Ghio AJ. Letter to the editor: Anemia and global iron fortification and supplementation. Annals of
Hematology 2012; 91:957–958.
238.Bayram H, Ghio AJ. Killer jeans and silicosis. American Journal of Respiratory and Critical Care
Medicine 2011 Dec 15;184(12):1322-1324. Accompanied by an American Thoracic Society
PODCAST interview in December, 2011.
239. Ghio AJ, Weinberg ED. Complications of TNF-α antagonists and iron homeostasis. Medical
23

Hypotheses 2012; 78: 33–35.
240.Shannahan JH, Ghio AJ, Schladweiler MC, Richards JH, Knapp G, Andrews D, Gavett SH,
Kodavanti UP. Transcriptional activation of inflammasome components by Libby amphibole and the
role of iron. Inhalation Toxicology 2012; 24 (1): 60-69.
241.Ghio AJ. Letter to the editor: Effects of particulate matter from global burning of biomass. British
Medical Journal 2011; 343:d7307.
242.Ghio AJ, Smith CB, Madden MC. Diesel exhaust particles and airway inflammation. Current
Opinion in Pulmonary Medicine 2011; 18 (2): 144-150.
243.Shannahan JH, Schladweiler MC, Thomas RF, Ward WO, Ghio AJ, Gavett SH, Kodavanti UP.
Vascular and thrombogenic effects of pulmonary exposure to libby amphibole. J Toxicol Environ
Health A 2012; 75:213-31.
244.Shannahan JH, Alzate O, Winnik WM, Andrews D, Schladweiler MC, Ghio AJ, Gavett SH,
Kodavanti UP. Acute phase response, inflammation and metabolic syndrome biomarkers of Libby
asbestos exposure. Toxicology and Applied Pharmacology 2012; 260(2):105-14.
245.Piantadosi CA, Bartz RR, Carraway MS, Ghio AJ, McMahon TJ, Murdoch DM, Roggli VL, Shofer
SL, Tighe RM, Welty-Wolf KE, Young SL. Letter to the editor: The opprobrium of big tobacco.
American Journal of Respiratory Critical Care Medicine 2012; 185(9):1030.
246.Ghio AJ, Sobus JR, Pleil JD, Madden MC. Controlled human exposures to diesel exhaust. Swiss
Med Wkly. 2012; 142:w13597. doi: 10.4414/smw.2012.13597.
247.Meyer M, Potts-Kant E, Ghio A, Fischer B, Foster W, Voynow J. NAD(P)H quinone oxidoreductase
1 regulates neutrophil elastase-induced mucous cell metaplasia. American Journal of Physiology,
Lung Cellular and Molecular Physiology 2012 Aug 1;303(3):L181-188.
248. Ozment CP, Mamo LB, Campbell ML, Lokhnygina Y, Ghio AJ, Turi JL. Transfusion-related
biologic effects and free hemoglobin, heme, and iron. Transfusion 2013 Apr;53 (4):732-40. doi:
10.1111/j.1537-2995.2012.03837.x.
249. Fares WH, Ford HJ, Ghio AJ, Aris RM. Differential Distribution of Inflammatory and Cellular
Adhesion Biomarkers in Pulmonary Hypertension. Pulmonary Circulation 2012; 2 (4): 477-482.
250. Roth JA, Ganapathy B, Ghio AJ. Manganese-Induced Toxicity in Normal and Human B
Lymphocyte Cell Lines Containing a Homozygous Mutation in Parkin. Toxicol In Vitro 2012;
Oct;26(7):1143-9.
251. Huang YC, Rappold AG, Graff DW, Ghio AJ, Devlin RB. Synergistic effects of exposure to
concentrated ambient fine pollution particles and nitrogen dioxide in humans. Inhal Toxicol 2012;
24(12):790-7.
252. Funk WE, McGee JK, Olshan AF, Ghio AJ. Quantification of arsenic, lead, mercury and cadmium
in newborn dried blood spots. Biomarkers 2013; 18(2):174-177.
253. Ghio AJ, Roggli VL, Soukup JM, Richards JH, Randell SH, Muhlebach MS. Iron accumulates in
the lavage and explanted lungs of cystic fibrosis patients. J Cyst Fibros 2013; 12: 390-8. doi:
10.1016/j.jcf.2012.10.010
254. Kummarapurugu AB, Fischer BM, Zheng S, Milne GL, Ghio AJ, Potts-Kant EN, Foster WM,
Soderblom EJ, Dubois LG, Moseley MA, Thompson JW, Voynow JA. NADPH Quinone
Oxidoreductase 1 Regulates Host Susceptibility to Ozone via Isoprostane Generation. J Biol Chem.
2013; 288(7):4681-4691.
255. Fariss MW, Gilmour IM, Reilly CA, Liedtke W, Ghio AJ. Emerging Mechanistic Targets in Lung
Injury Induced by Combustion-Generated Particles. Toxicol Sci. 2013; 132 (2):253-67. Cover
picture.
256. Ghio AJ, Soukup JM, Richards JH, Fischer BM, Voynow JA, Schmechel DE. Deficiency of α -1-
antitrypsin influences systemic iron homeostasis. International Journal of COPD 2013; 8: 45–51.
257. D'Armiento JM, Goldklang MP, Hardigan AA, Geraghty P, Roth MD, Connett JE, Wise RA,
Sciurba FC, Scharf SM, Thankachen J, Islam M, Ghio AJ, Foronjy RF. Increased Matrix
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Metalloproteinase (MMPs) Levels Do Not Predict Disease Severity or Progression in Emphysema.
PLoS One 2013;8(2):e56352. doi: 10.1371/journal.pone.0056352.
258. Ghio AJ, Dailey LA, Soukup JM, Stonehuerner J, Richards JH, Devlin RB. Growth of human
bronchial epithelial cells at an air-liquid interface alters the response to particle exposure. Part Fibre
Toxicol. 2013 Jun 26; 10(1): 25. Reviewed in Pulmonary Cell News 2.26 July 4, 2013.
259. Ghio AJ. Letter to the Editor: Inhalation as a source of iron in secondary iron overload. Acta
Haematol 2014; 131(1):70. doi: 10.1159/000354822.
260. Esther CR Jr, Boucher RC, Johnson MR, Ansede JH, Donn KH, O'Riordan TG, Ghio AJ, Hirsh AJ.
Airway drug pharmacokinetics via analysis of exhaled breath condensate. Pulm Pharmacol Ther
2013; S1094-5539(13)00149-1.
261. Ghio AJ, Tong H, Soukup JM, Dailey LA, Cheng WY, Samet JM, Kesic MJ, Bromberg PA, Turi
JL, Upadhyay D, Budinger GS, Mutlu GM. Sequestration of mitochondrial iron by silica particle
initiates a biological effect. Am J Physiol Lung Cell Mol Physiol 2013; 201; 305(10):L712-24. doi:
10.1152/ajplung.00099.2013.
262. Huang JJ, Soukup JM, Ghio AJ, Huang Y-CT. Host and Environmental Factors Affect Pulmonary
Responses Measured in Bronchoalveolar Lavage. Inhalation Toxicology 2014; 26(1):30-35.
263. Sangani RG, Ghio AJ. Iron, Human Growth, and The Global Epidemic of Obesity. Nutrients 2013;
5(10):4231-4249; doi:10.3390/nu5104231.
264. Ghio AJ, Sangani RG, Roggli VL. Expanding the spectrum of particle- and fiber-associated
interstitial lung diseases. Turkish Thoracic Journal 2014; 15:1-8.
265. Vaughan JM, Garrett BJ, Prophete C, Horton L, Sisco M, Soukup JM, Zelikoff JT, Ghio A, Peltier
RE, Asgharian B, Chen LC, Cohen MD. A novel system to generate WTC dust particles for
inhalation exposures. J Expo Sci Environ Epidemiol 2014; 24(1):105-12. doi: 10.1038/jes.2013.68..
266. Duncan KE, Cook PM, Gavett SH, Dailey LA, Mahoney RK, Ghio AJ, Roggli VL, Devlin RB. In
vitro determinants of asbestos fiber toxicity: effect on the relative toxicity of Libby amphibole in
primary human airway epithelial cells. Part Fibre Toxicol 2014; 11 (1):2
267. Wolff NA, Ghio AJ, Garrick LM, Garrick MD, Zhao L, Fenton RA, Thévenod F. Evidence for
mitochondrial localization of divalent metal transporter 1 (DMT1). FASEB Journal 2014; 28:2134-
45. doi: 10.1096/fj.13-240564.
268. Ghio AJ. Particle exposures and infections. Infection 2014; 42:459–467.
269. Ghio AJ, Kummarapurugu ST, Tong H, Soukup JM, Dailey LA, Boykin E, Gilmour I, Ingram P,
Roggli VL, Goldstein HL, Reynolds RL. Biological effects of desert dust in respiratory epithelial
cells and a murine model. Inhalation Toxicology 2014; 26 (5): 299-309.
270. Meier R, Cascio WE, Ghio AJ, Wild P, Danuser B, Riediker M. Associations of Short-Term
Particle and Noise Exposures with Markers of Cardiovascular and Respiratory Health among
Highway Maintenance Workers. Environ Health Perspect 2014; 122(7):726-732.
271. Ghio AJ, Soukup JM, Dailey LA, Richards JH, Duncan KE, Lehmann J. Iron decreases biological
effects of ozone exposure. Inhalation Toxicology 2014; 26 (7): 391–399.
272. Chiarella SE, Soberanes S, Urich D, Morales-Nebreda L, Nigdelioglu R, Green D, Young JB,
Gonzalez A, Rosario C, Misharin AV, Ghio AJ, Wunderink RG, Donnelly HK, Radigan KA,
Perlman H, Chandel NS, Budinger GR, Mutlu GM. β2-Adrenergic agonists augment air pollution-
induced IL-6 release and thrombosis. J Clin Invest. 2014 May 27. pii:75157. doi:10.1172/JCI75157.
273. Hatch G, Duncan KE, Diaz-Sanchez D, Schmitt MT, Ghio AJ, Carraway MS, McKee J, Daily LA,
Berntsen J, Devlin RB. Progress in Assessing Air Pollutant Risks from In Vitro Exposures: Matching
Ozone Dose and Effect in Human Airway Cells. Toxicol Sci 2014; 141 (1):198-205. doi:
10.1093/toxsci/kfu115.
274. Fischer BM, Voynow JA, Ghio AJ. COPD: Balancing Oxidants and Antioxidants. International
Journal of COPD 2015:10 261–276. doi: 10.2147/COPD.S42414.
275. Schreinemachers DM, Ghio AJ, Sobus JR, Williams MA. Perchlorate Exposure is Associated with
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Oxidative Stress and Indicators of Serum Iron Homeostasis Among NHANES 2005–2008 Subjects.
Biomarker Insights 2015; 10: 9-19. doi: 10.4137/BMI.S20089.
276. Sangani RG, Ghio AJ, Parker J. Letter to the editor: Pleural plaques in smoking-associated fibrosis
and pulmonary asbestosis. International Journal of Chronic Obstructive Pulmonary Disease 2015:10
869–871. doi: 10.2147/COPD.S83564.
277. Miller DB, Karoly ED, Jones JC, Ward WO, Vallanat BD, Andrews DL, Schladweiler MC, Snow
SJ, Bass VL, Richards JE, Ghio AJ, Cascio WE, Ledbetter AD, Kodavanti UP. Inhaled Ozone (O3)-
Induces Changes in Serum Metabolomic and Liver Transcriptomic Profiles in Rats. Toxicol Appl
Pharmacol 2015; 286(2): 65-79. doi: 10.1016/j.taap.2015.03.025.
278. Ghio AJ. Letter to the editor: The IRONMAN trial: a protocol for a multicentre randomised
placebo-controlled trial of intravenous iron in intensive care unit patients with anaemia. Crit Care
Resusc 2015; 17 (2):144.
279. Ghio AJ, Stonehuerner J, Soukup JM, Dailey LA, Kesic MJ, Cohen MD. Iron diminishes the in
vitro biological effect of vanadium. J Inorg Biochem 2015 Jun; 147:126-33. doi:
10.1016/j.jinorgbio.2015.03.008.
280. Ghio AJ, Pavlisko EN, Roggli VL. Iron and iron-related proteins in asbestosis. Journal of
Environmental Pathology, Toxicology and Oncology 2015; 34(4): 277-285.
281. Cohen MD, Vaughan JM, Garrett B, Prophete C, Horton L, Sisco M, Ghio A, Zelikoff J, Chen L-C.
Impact of acute exposure to WTC dust on ciliated and goblet cells in lungs of rats. Inhalation
Toxicology 2015; 27 (7): 354-61. doi: 10.3109/08958378.2015.1054531.
282. Crans DC, Ghio A, Conte V. Preface: Celebrating vanadium science with leading bioinorganic
contributions from the 9th International Vanadium Symposium. J Inorg Biochem 2015 Jun; 147:1-3.
doi: 10.1016/j.jinorgbio.2015.05.006.
283. Cuevas AK, Niu J, Zhong M, Liberda EN, Ghio A, Qu Q, Chen LC. Metal rich particulate matter
impairs acetylcholine-mediated vasorelaxation of microvessels in mice. Part Fibre Toxicol 2015 Jun
4; 12(1):14. doi: 10.1186/s12989-014-0077-x.
284. Soukup JM, Dailey LA, Ghio AJ. Particle retention by respiratory epithelial cells is associated with
persistent biological effect. Inhalation Toxicology 2015; 27 (7): 335-41. doi:
10.3109/08958378.2015.1048910.
285. Yu YA, Hotten DF, Malakhau Y, Volker E, Ghio AJ, Noble PW, Kraft M, Hollingsworth JW, Gunn
MD, Tighe RM. Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar
Lavage, and Lung Tissues. Am J Respir Cell Mol Biol 2016; 54(1):13-24. doi: 10.1165/rcmb.2015-
0146OC.
286. Ghio AJ, Soukup J, Dailey L, Tong H, Kesic M, Budinger GS, Mutlu G. Wood smoke particle
sequesters cell iron to impact a biological effect. Chem Res Toxicol 2015; 28(11):2104-11. doi:
10.1021/acs.chemrestox.5b00270.
287. Miller DB, Snow SJ, Schladweiler MC, Richards JE, Ghio AJ, Ledbetter AD, Kodavanti UP. Acute
Ozone-Induced Pulmonary and Systemic Metabolic Effects are Diminished in Adrenalectomized Rats.
Toxicological Sciences 2016; doi: 10.1093/toxsci/kfv331.
288. Miller DB, Ghio AJ, Karoly ED, Bell LN, Snow SJ, Madden MC, Soukup J, Cascio WE, Gilmour
MI, Kodavanti UP. Ozone Exposure Increases Circulating Stress Hormones and Lipid Metabolites in
Humans. Am J Respir Crit Care Med 2016; .
289. Schreinemachers DM, Ghio AJ. Effects of Environmental Pollutants on Cellular Iron Homeostasis
and Ultimate Links to Human Disease. Environ Health Insights 2016 Mar 7;10:35-43. doi:
10.4137/EHI.S36225.
290. Smith GS, Ghio AJ, Stout JE, Messier KP, Hudgens EE, Murphy MS, Pfaller SL, Maillard JM,
Hilborn ED. Epidemiology of nontuberculous mycobacteria isolations among central North Carolina
residents, 2006-2010. J Infect 2016 Mar 17. pii: S0163-4453(16)30002-0. doi:
10.1016/j.jinf.2016.03.008.
26

291. Ghio AJ, Schreinemachers DM. Heme oxygenase activity correlates with serum indices of iron
homeostasis in healthy non-smokers. Biomarker Insights 2016; in press.
292.
Letters to the editor (unpublished)
1. Ghio AJ. Provision of iron to COPD patients. BMJ Open 2015.
http://bmjopen.bmj.com/content/5/7/e007911/reply#bmjopen_el_9304
Publications and Appearances in Lay Media
1. Ghio AJ. Asbestosis: overdiagnosed? Raleigh News & Observer, April 12, 2004, page 11A.
2. Ghio AJ. Assembly-line diagnoses of lung diseases. Raleigh News & Observer, March 22, 2006,
page 15A.
3. Appearance in “Air Aware” on the Weather Channel (2006). See: http://www.airnow.gov/index.cfm?
action=movie.main
Proceedings, books, and book chapters:
1. Castellan RM, Olenchock SA, Kinsley KB, Townsend MC, Keimig DG, Ghio AJ, Piacitelli GM.
Airborne endotoxin concentrations in the cotton industry; Effect of cotton growing area. In: Wakelyn
PJ, Jacobs RR (Eds), Cotton Dust: Proceedings of the twelfth Cotton Dust Research Conference.
Memphis, National Cotton Council, 1988, pp. 3-46.
2. Ghio AJ, Renzetti AD Jr., Crapo RO. ILO (1980) Classification and the association of small
opacities with aging. In: Proceedings of the VIIth
International Pneumoconioses Conference, pp. 1336-
1337, 1990.
3. Ghio AJ, Kennedy TP, Baser M, Rawlings WR, Rao NV, Hoidal JR. Kaolin generates OH and
causes hemolysis by acting as a Fenton reagent. In: Proceedings of the International Conference on
Health Related Effects of Phyllosilicates. J. Bignon, Ed. NATO ASI, Springer-Verlag, 1988, pp.
360-368.
4. Coffin DL, Ghio AJ. Relative intrinsic potency of asbestos and erionite fibers: Proposed mechanism
of action. In: Proceedings of the NATO Advanced Research Workshop on Mechanisms in Fibre
Carcinogenesis. Plenum Press, New York, 1991, pp 71-80.
5. Ghio AJ. Silicosis. In: Conn’s Current Therapy. W.B. Saunders Company, New York, 1996, pp.
231-233.
6. Ghio AJ and Samet JM. Metals and air pollution particles. In: Air Pollutants and Effects on Health.
Holgate, Koren, Samet, and Maynard, editors. Academic Press, London, 1999, pp. 635-651.
7. Ghio AJ. The role of metals in the toxicity of air pollution particles. Proceedings of the World
Equine Airways Symposium, 1999; pp. 1-13.
8. Devlin RB, Ghio AJ, Costa DL. Responses of the lung to inhaled particles. Cellular Responses. In:
Particle-Lung Interactions. P. Gehr and J. Hyder, editors. Marcel Dekker, Inc., New York, 2000,
Volume 143, pp. 437-472.
9. Ghio AJ, Vandenberg J, Soukup J, Becker S. Overview of the PM Health Effects Research Program.
In: Cotton and Other Organic Dusts. Proceedings of the Twenty-Fourth Cotton and Other Organic
Dusts Research Conference. Beltwide Cotton Conferences, January 7th
to 8th
, 2000. P.J. Wakelyn,
R.R. Jacobs, R. Rylander, editors. National Cotton Council of America, pp. 212-219.
10. Devlin RB, Ghio AJ, Samet JM, Carter JD, Frampton MW. Pulmonary Toxicity of Utah Valley
PM: Are Empirical Indices of Adverse Health Effects Coherent with the Epidemiology? In:
Relationships Between Acute and Chronic Effects of Air Pollution (U.Mohr, ed.); ILSI Press, 2001,
pages 159-168.
11. Ghio AJ. Interstitial Lung Disease. In: Respiratory Care: Principles and Practice. D. Hess, N.R.
MacIntyre, S.C. Mishoe, W.F. Galvin, A.B Adams, and A.B. Saposnick, editors. W.B. Saunders
27

Company, New York, 2002, pages 955-967.
12. Johnson TA, Devlin RB, Ghio AJ, Huang YC, Costa DL, Bromberg P, Cascio WE.
Cardiopulmonary effects of nebulized residual oil fly ash in anesthetized pigs. In: Critical Issues in
Inhalation Research. Mechanistic, Clinical and Epidemiologic. U. Heinrich and U. Mohr, Editors.
Fraunhofer IRB Verlag, Stuttgart, 2002, pages 199-212.
13. Ghio AJ. Silicosis. In: Conn’s Current Therapy. Elsevier Science, New York, 2003, pp. 271-274.
14. Ghio AJ. Aetiological agents: Outdoor environment and agents. In: Proceedings of a Workshop on
inflammatory airway disease: defining the syndrome. Havemeyer Foundation Monograph 9, R & W
Publications, 2003, pages 29 - 30.
15. Ghio AJ. The diagnostic approach to chronic cough in people. In: Proceedings of a Workshop on
inflammatory airway disease: defining the syndrome. Havemeyer Foundation Monograph 9, R & W
Publications, 2003, pages 23 – 24.
16. Ghio AJ, Huang YC, Bennett WD, Bromberg PA, Devlin RB. A similar biological response
following exposure to different types of particles suggests a common mechanism of injury. In: Effects
of Air Contaminants on the Respiratory Tract- Interpretations from Molecular to Meta Analysis. U.
Heinrich, Editor. Fraunhofer IRB Verlag Stuttgart, 2004, pages 259-268.
17. Samet JM, Ghio AJ. Particle-associated metals and oxidative stress in signaling. In: The Toxicology
of Particles (Donaldson K and Borm P, editors). CRC Press, Boca Raton, 2007, pages 161-181.
18. Ghio AJ, Samet JM. Biological effects of vanadium in the lung. Vanadium: The Versatile Metal.
Kustin K, Pessoa JC, Crans DC (editors). American Chemical Society, Washington DC, 2007; pages
240-248.
19. Ghio AJ, Bromberg PA. Environmental Lung Disease. In: Netter’s Internal Medicine, second edition
(Runge MS and Greganti A, editors), 2008, pages 150-154.
20. Short K, Ghio AJ. Interstitial Lung Disease. In: Respiratory Care: Principles and Practice, 2nd
edition. D. Hess, N.R. MacIntyre, S.C. Mishoe, W.F. Galvin, A.B Adams, and A.B. Saposnick,
editors. W.B. Saunders Company, New York, 2011, pages 765-778.
21. Ghio AJ, Huang YCT. Role of chemical composition in determining the cardiovascular effects of
particles. In: Cardiovascular Effects of Inhaled Ultrafine and Nanosized Particles (Cassee FR, Mills
NL, and Newby D, editors). Hoboken, New Jersey: John Wiley & Sons, Inc., 2011, pages 145-170.
22. Huang Y-CT, Ghio AJ, and Maier LA, editors. A Clinical Guide to Occupational and Environmental
Lung Diseases. Springer, New York City, 2012.
23. Ghio AJ. Chapter 9: Pneumoconiosis in the 21st century: practical considerations. In: A Clinical
Guide to Occupational and Environmental Lung Diseases. Huang YHC, Maier L, Ghio AJ (editors).
Springer, New York City, 2012, pages 171-188.
24. Ghio AJ. Oxidative injury caused by cigarette smoking and air pollution. In: Oxidative Stress in
Applied Basic Research and Clinical Practice – Studies on Respiratory Disorders. Jindal SK,
Ganguly NK, Barne P, Pawankar R, Biswal S (editors). Springer, New York, 2015, pages 131-150.
25. Short K, Ghio AJ. Interstitial Lung Disease. In: Respiratory Care: Principles and Practice, 3rd
edition. D. Hess, N.R. MacIntyre, S.C. Mishoe, W.F. Galvin, A.B Adams, and A.B. Saposnick,
editors. W.B. Saunders Company, New York, 2015, pages.
Invited Presentations:
1. Ghio AJ. Current guidelines and controversies in the prediction of pulmonary function. Annual
Meeting of the National Society for Cardiovascular and Pulmonary Technology, Denver, Colorado,
1988.
2. Ghio AJ, Crapo RO, Elliott CG, Berlin SL. Is pulmonary function inherited? DuPont Critical
Care/ACCP Young Investigator's Award, 1988. ACCP Annual Conference, 1988.
3. Ghio AJ. Lung injury after exposure to silica and silicates. Duke University Medical Grand Rounds,
Durham, North Carolina, November 8, 1991.
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