Synthesis & Evaluation of novel Phenazine dyes for use in PDT
Amina Tariq - Supervisor Dr. Natalia Sergeeva
MSc Polymers, Colourants and Fine Chemicals
1. Introduction
Dyes as photosensitizors are in use in a myriad of applications
across all disciplines. Currently; one of the most investigated
applications of dyes is in PDT. Photodynamic therapy is a
sophisticated light driven oncological treatment.
2. Synthetic Route
6. References
Allison, R.R. and Moghissi, K. Photodynamic Therapy (PDT): PDT
Mechanisms. Clinical Endoscopy. 2013, 46(1), pp.24-29.
Robertson, C.A., Evans, D.H. and Abrahamse, H. Photodynamic therapy
(PDT): A short review on cellular mechanisms and cancer research
applications for PDT. Journal of Photochemistry and Photobiology B:
Biology. 2009, 96(1), pp.1-8.
Sharman, W.M., Allen, C.M. and van Lier, J.E. Photodynamic
therapeutics: basic principles and clinical applications. Drug Discovery
Today. 1999, 4(11), pp.507-517.
3. Mechanism of dye excitation by Jablonski Diagram
4. Photochemical and photophysical principles of PDT
Sensitizer hᶹ 1Sensitizer*
1Sensitizer* 3Sensitizer*
Type I Mechanism
3Sensitizer* + 3Sensitizer* Sensitizer+. +Sensitizer-.
3Sensitizer* + Substrate Substrate+. + Sensitizer-.
Sensitizer-. + O2 (3Σg
-) Sensitizer + O2
-.
Substrate+. + O2 (3Σg
-) Oxidative damage
Substrate + O2
-. Oxidative damage
Type II Mechanism
3Sensitizer* + O2 (3Σg
-) Sensitizer + O2 (1∆g)
O2 (1∆g) +Substrate Oxidative damage
5
Analytical Testing
1. UV-Vis
2. LC-MS
3. NMR
4. Spectroscopy