A Call to Action: Improving brain & mental health via digital platforms, neuroplasticity research and the White House BRAIN initiative
•
9 gostaram•14,935 visualizações
(Session held at the 2014 SharpBrains Virtual Summit; October 28-30th, 2014) 8:15–9:45am. A Call to Action: Improving brain & mental health via digital platforms, neuroplasticity research and the White House BRAIN initiative - Dr. Thomas Insel, Director of the National Institute of Mental Health (NIMH) - Dr. Adam Gazzaley, Director of UCSF Neuroscience Imaging Center and Co-founder of Akili Interactive Labs - Dr. Daphne Bavelier, Head of the Brain & Learning Lab at the University of Geneva & U. of Rochester - Jack Young, Head of Qualcomm Life Fund - Chair: Alvaro Fernandez, CEO of SharpBrains Learn more here: http://sharpbrains.com/summit-2014/agenda/
Recomendados
Recomendados
Mais conteúdo relacionado
Mais procurados
Mais procurados (20)
Semelhante a A Call to Action: Improving brain & mental health via digital platforms, neuroplasticity research and the White House BRAIN initiative
Semelhante a A Call to Action: Improving brain & mental health via digital platforms, neuroplasticity research and the White House BRAIN initiative (20)
Mais de SharpBrains
Mais de SharpBrains (20)
Último
Último (20)
A Call to Action: Improving brain & mental health via digital platforms, neuroplasticity research and the White House BRAIN initiative
- 1. A Call to Action: Improving brain & mental health via digital platforms and neuroplasticity research
- 3. 215 Participants in 17 Countries
- 5. Source: The SharpBrains Guide to Brain Fitness: How to Optimize Brain Health and Performance at Any Age
- 6. A Call to Action: Improving brain & mental health via digital platforms, neuroplasticity research and the White House BRAIN initiative Chaired by: Alvaro Fernandez, CEO of SharpBrains Dr. Thomas Insel, Director of the National Institute of Mental Health Dr. Adam Gazzaley, Director of UCSF Neuroscience Imaging Center and Co-founder of Akili Interactive Labs Dr. Daphne Bavelier, Head of the Brain & Learning Lab at the University of Geneva & U. of Rochester Jack Young, Head of Qualcomm Life Fund
- 7. A Call to Action: Improving brain & mental health via digital platforms, neuroplasticity research and the White House BRAIN initiative Dr. Thomas Insel, Director of the National Institute of Mental Health
- 8. October 28, 2014 SharpBrains Summit Improving Brain Health: A Call to Action Thomas R. Insel, MD Director, NIMH Public Filer Nothing to Disclose
- 9. Brain health and Brain training – In the News Emily Underwood Oct 22, 2014
- 11. U.S. Burden of Diseases: 291 diseases and injuries 11 Leading Categories of DALYs 2010 5.1 6.5 8.0 11.8 15.1 16.8 0.0 2.0 4.0 6.0 8.0 10.0 12.0 14.0 16.0 18.0 20.0 1. Neuropsychiatric Disorders 2. Cardiovascular and Circulatory Diseases 3. Neoplasms 4. Musculoskeletal Disorders 5. Diabetes, Urogenital, Blood, and Endocrine Diseases 6. Chronic Respiratory Diseases 7. Other Non-communicable Diseases Percent of Total U.S. DALYs 18.7 Neurological Disorders 5.1 Mental and Behavioral Disorders 13.6 US Burden of Disease Collaborators, JAMA, 2013.
- 12. Neurons to Neighborhoods: Our Toolbox Molecules Cells Systems Individual Social “ New directions in science are launched by new tools much more often than by new concepts. The effect of a concept-driven revolution is to explain old things in new ways. The effect of a tool-driven revolution is to discover new things that have to be explained. ” Freeman Dyson (1997) Imagined Worlds Harvard University Press, Cambridge, MA
- 13. The Human Connectome Project Functional Connectivity Structural Connectivity Molecular Imaging Multimodal Integration New Molecular Imaging Temporal Connectivity Wash U U Minn MGH
- 14. “The Next Great American Project” “So there is this enormous mystery waiting to be unlocked, and the BRAIN Initiative will change that by giving scientists the tools they need to get a dynamic picture of the brain in action and better understand how we think and how we learn and how we remember. And that knowledge could be – will be – transformative.” ~President Obama, April 2, 2013
- 15. The NIH BRAIN Scientific Plan To map the circuits of the brain, measure the fluctuating patterns of electrical and chemical activity flowing within those circuits, and understand how their interplay creates our unique cognitive and behavioral capabilities.
- 16. Bending the curve with clinical neuroscience Transforming diagnostics From behavioral disorders to brain disorders: Diagnosis rooted in biology and behavior Transforming therapeutics From chemical imbalance to circuit dysfunction Treatments for circuit tuning Transforming the culture of science From “these data are mine” to “mine these data” Open science as a new model for discovery
- 17. Bending the curve with clinical neuroscience Transforming diagnostics From behavioral disorders to brain disorders: Diagnosis rooted in biology and behavior Transforming therapeutics From chemical imbalance to circuit dysfunction Treatments for circuit tuning Transforming the culture of science From “these data are mine” to “mine these data” Open science as a new model for discovery
- 18. Defining mental illnesses as circuit disorders OCD PTSD Depression Insel. Sci Am, 2010
- 19. RDoC: Precision Medicine for Psychiatry 19 Rare variants for etiology, common variants for risk iPSCs for pathways analysis Imaging biomarkers Cognitive testing Information Sensors Commons
- 20. Bending the curve with clinical neuroscience Transforming diagnostics From behavioral disorders to brain disorders: Diagnosis rooted in biology and behavior Transforming therapeutics From chemical imbalance to circuit dysfunction Treatments for circuit tuning Transforming the culture of science From “these data are mine” to “mine these data” Open science as a new model for discovery
- 21. Treating mental illnesses as circuit disorders Sci Transl Med 2012 Nat Rev Drug Dev, 2013
- 22. Depression as a Brain Circuit Syndrome PF9/46 PM6 Par40 oF11 pACC24 mF9/10 MCC PCC sACC25 amg mb-vta a-ins hth bstem hc na-vst thal Salience Motivation Mood state Self-awareness insight Cognition (attention-appraisal-action) Interoception (drive-autonomic-circadian) P F P MEDS Cg25 PCC BS CBT PF MF MCC DBS Br Med Bul 65:193-207, 2003 Arch Gen Psych 61:34-41-2004 Helen Mayberg Emory University
- 23. Networked Psychiatric Treatments 23 Protective LOF mutations, Pathway targets, epigenetics Cell replacement Rx, Plasticity agents Circuit based Rx, rTMS, DBS Cognitive training mHealth, Social networks Network Solutions
- 24. Bending the curve with clinical neuroscience Transforming diagnostics From behavioral disorders to brain disorders: Diagnosis rooted in biology and behavior Transforming therapeutics From chemical imbalance to circuit dysfunction Treatments for circuit tuning Transforming the culture of science From “these data are mine” to “mine these data” Open science as a new model for discovery
- 25. Transforming the Culture Academia Standardization Integration Data/Reagent/Tissue Sharing Industry Foundations Government
- 26. Summary Thoughts Hype/hope usually drive new technologies (e.g. gene therapy) including those that ultimately prove effective. For complex problems, magic bullets (e.g. drugs or cognitive training) are unlikely to be effective alone. There is no short-cut to rigorous science – unbiased RCTs looking at effect size, generalization, durability are essential to demonstrate value.
- 27. “We always overestimate the change that will occur in the next two years and underestimate the change that will occur in the next ten.” --Bill Gates Jr. Finally
- 28. Thank you ! Paving the Way for Prevention, Recovery, and Cure www.nimh.nih.gov Research = Hope
- 29. A Call to Action: Improving brain & mental health via digital platforms, neuroplasticity research and the White House BRAIN initiative Dr. Adam Gazzaley, Director of UCSF Neuroscience Imaging Center and Co-founder of Akili Interactive Labs
- 30. A Vision of the Future of Medicine Adam Gazzaley, MD PhD Professor - Neurology, Physiology and Psychiatry Director - Neuroscience Imaging Center University of California, San Francisco
- 31. Challenge Develop effective approaches to enhance cognition in both healthy and impaired individuals
- 32. Current Approach 60 year old with mild cognitive impairment • Poor characterization • Poor targeting • Non-personalized • Unimodal • Open Loop This is just not good enough
- 33. Create a New Approach closed-loop targeted personalized multimodal
- 34. Video Games
- 35. Video Game Training ★ Adaptive training of interference processing drives enhancements of cognitive control in older adults. ★ Task improvements are associated with changes in engagement of prefrontal cortex networks. Anguera et al. Nature 2013
- 36. Move to the Real World Akili Interactive Labs Co-founder and Chief Science Advisor Patent-pending: “Enhancing Cognition in the Presence of Distraction and/or Interruption”
- 37. Bridging the Gap Between Technology and Neuroscience Neuroscapelab.com
- 39. New Technology Mobile / Wireless
- 40. New Technology Virtual Reality Motion Capture
- 41. Enhance the Effects Neuromodulation Neurofeedback Video Games
- 42. Glass Brain
- 43. Thanks for your attention
- 44. Many thanks Associates Students • Omar Alhashimi • Alan Legitt • Benjamin Dorn • Cammie Rolle • Jacki Janowich • Roger Anguera • Rajat Jain Fellows • David Ziegler • Morgan Hough • WanYu Hsu • Yixuan Ku • Martine Schouwenburg Faculty • Ted Zanto • Judy Pa • Jyoti Mishra • Peter Wais • Joaquin Anguera GlassBrain • Tim Mullen • Christian Kothe • Oleg Konigs • John Fesenko Financial Support www.gazzlab.com Game Development • Matt Omernick • Dmitri Ellingson • Eric Johnson • Noah Fahlstein Hardware • Apple • NVIDIA • National Institute on Aging • National Institute of Mental Health • American Federation of Aging Research • Robert Wood Johnson Foundation • Zynga.org Foundation • Center 17 Foundation • Ellison Medical Foundation • James Gates Family Foundation • Sandler Foundation • Rose Family Foundation • Feldman Family Foundation • Grammy Foundation • Biggelsworth Foundation • UCSF CTSI • Posit Science • Pfizer / Eisai • Tim Ferriss • Tully and Elise Friedman • Sara and Evan Williams Foundation • Oculus VR • Ty Clark • Matt Whitman • Mike Gonzales • Mickey Hart • to Gazzlab alumni, collaborators, research and industry partners ... • Myers Sound
- 45. A Call to Action: Improving brain & mental health via digital platforms, neuroplasticity research and the White House BRAIN initiative Dr. Daphne Bavelier, Head of the Brain & Learning Lab at the University of Geneva & U. of Rochester
- 46. Action video games as exemplary learning tools Daphne Bavelier Disclosure • Advisory Board, Co-founder, Akili, PureTech Venture • Product Partner, E-line Media • Patent on Method and System for Treating Amblyopia (US Pat. Appln. No. 61/403,585) • Patent on Method and System for Training ‘Number Sense‘ (US Pat. Appln. No. 13/301,392)
- 47. Enhancing learning and facilitating transfer is possible In young adults, action-packed fast paced games appear to have an edge
- 48. Better vision
- 49. ACTION SOCIAL Medal of Honor UT Call of Duty Tetris the Sims Restaurant Empire
- 50. Before After
- 51. Green & Bavelier, 2007, Psych. Science Li, Polat, Makous & Bavelier, 2009, Nat. Neuro Li, Polat, Scalzo & Bavelier, 2009, J. of Vision
- 53. 1 2 3 4 Feng, Pratt, Spence, 2007, Psych Science
- 54. Action-Games: FPS Pretesting Post-testing Training 10 hours of in labs training Feng, Pratt, Spence, 2007, Psych Science
- 55. Surprisingly broad transfer Contrast sensitivity/Crowding Acuity/Backward masking: Green & Bavelier, 2007; Li et al., 2009; Li et al. 2010; Mental Rotation: Feng et al, 2007; Boot et al, 2008; Cherney, 2008; Task-switching: Colzato, et al., 2010, 2013; Boot, et al., 2008; Andrews & Murphy, 2006; Karle, Watter, & Shedden, 2010; Cain, Landau, Shimamura, 2012; Green et al., 2012; Strobach, Frensch, Schubert, 2012; Chiappe et al. 2013; Attentional Blink/Temporal masking: Green & Bavelier, 2003, 2006; Dye & Bavelier, 2010; Li et al., 2010; Cohen et al., 2009; UFOV/Goldman Perimetry: Green & Bavelier, 2003, 2006; Feng et al, 2007; Spence et al, 2009; Buckley et al, 2010 ; Visual Search: Castel et al, 2005; Hubert-Wallander et al, 2011; West et al, 2008; Bavelier et al., 2012; Clark, Fleck & Mitroff, 2011; vSTM/Object Memory: Boot et al, 2008; Sungur & Boduroglu, 2012; McDermott, Green & Bavelier, 2014; Blacker & Curby, 2013; Multiple Object Tracking: Trick et al, 2005; Green & Bavelier, 2006; Boot et al, 2008; Cohen, Green & Bavelier, 2009; Dye & Bavelier, 2010 Decision Making: Green et al., 2010; Dye et al., 2009; Time estimation: Donohue et al, 2010 Change Detection/Redirecting of attention/Distractor Suppression: Clark et al, 2011; Chisholm et al. 2010, 2011; Mishra et al., 2011; Krishman et al., 2012; Oei & Patterson, 2013; META–ANALYSIS of action games vs. other video games - MEDIUM EFFECT SIZE (0.45 - 0.6)
- 56. Not all games are created equal Action games in young adults and children have that effect Social Games, Tetris not so much
- 57. Enhancing learning and facilitating transfer to new tasks is possible with some video games: action-packed, fast paced games This holds in young adults – in older adults or patients, action games are ill-adapted Need adaptive training, video games or other experiences, that will enhance attentional control
- 58. Action video game play results in enhanced attentional control Test of Variables of Attention (T.O.V.A.®)
- 59. http://www.tovatest.com/ - Target Frequent - Target Infrequent Dye, Green and Bavelier (2009) Current Directions in Psych. Science
- 60. Sustained Impulsivity Sustained Impulsivity Gamers are faster but no less accurate No issue with impulsivity or sustained attention Dye, Green & Bavelier (2009). Current Dirs. Psych. Sci.
- 61. Enhanced Attentional Control • Test of Variables of Attention (T.O.V.A.®) • Selective Attention in Space, in Time or to Objects • More efficient suppression of distractors • Major changes in fronto-parietal attentional control network Green, C.S. and Bavelier, D. (2003) Nature Green, C.S. and Bavelier, D. (2012) Current Biology Bavelier, Achtman, Mani, Fockert (2012) Vis. Research Mishra, Zinni, Bavelier & Hillyard (2011). J. of Neuroscience C. Shawn Green Enhanced attentional control allows for faster learning of task statistics, and thus greater adaptability and broader transfer
- 62. Summary • Broad transfer to perception, attention and cognition after action game play • Not all video games are created equal – for young adults and skills studied so far action packed video games have an edge BUT action video games too challenging for older adults or low vision patients… • Evaluating key game play components and how they may be best adapted to induce learning and transfer as a function of the population studied
- 64. A Call to Action: Improving brain & mental health via digital platforms, neuroplasticity research and the White House BRAIN initiative Jack Young, Head of Qualcomm Life Fund
- 65. To learn more, visit SharpBrains.com