This document provides an overview of using Amazon EC2 Spot Instances for compute workloads. It discusses EC2 Spot pricing and purchase options, features like interruptions and orchestration with Auto Scaling Groups and Spot Fleet. Use cases where Spot is well-suited include stateless, fault-tolerant workloads. Integrations with container and big data services like ECS, EKS and EMR are also covered. The presentation emphasizes flexibility, automation and diversification to maximize cost savings from Spot while minimizing risks of interruptions.