This document contains two news articles from ScienceDaily discussing recent scientific findings. The first article describes research from UTMB that identified an enzyme called NEIL1 that fixes single-stranded DNA during cell replication. The second article discusses a study finding that biomolecules like DNA and proteins can spontaneously cluster together to form protocells in salty solutions, providing insight into how early cells may have originated. The student provides observations on the potential medical applications of this research, such as using synthetic cells for tissue regeneration and treating diseases through improved gene editing.

1. “COWCATCHER” ENZYME
FIXES SINGLE-STRAND DNA
AND PROTOCELLS MAY HAVE
FORMED IN SALTY SOUP.
VANESSA MORALES OSPINA
MEDICINE STUDENT
3RD SEMESTER

2. FOLDING

3. FOLDING

4. INTRODUCTION
• For years the DNA molecule has
been the focus of genetic and
molecular studies
• This molecular structure when
performing its functions is regulated
by highly organized processes to
ensure their proper development and
function

5. “ COWCATCHER” ENZYME FIXES SINGLE-
STRAND DNA
AUGUST 2, 2013

6. “ COWCATCHER” ENZYME FIXES
SINGLE- STRAND DNA
“Zipper” DNA
• To understand the UTMB
researchers' work, it helps to
picture DNA strand separation
during replication as analogous
to the opening of a zipper. As
the "zipper" opens, it exposes
strings of four uniformly spaced
bases attached to each single
strand of DNA.

7. “ COWCATCHER” ENZYME FIXES
SINGLE- STRAND DNA
Nei endonuclease VIII-like
1 ( NEIL 1).
• The group of scientists
from UTBM focused
their study on the
mechanisms of the
enzyme NEIL 1 found
in the single-stranded
DNA and the
replication complex.

8. “ COWCATCHER” ENZYME FIXES
SINGLE- STRAND DNA
Genome
• This enzyme is
very important
because in the cell
division, controls
and regulates
many processes,
also maintains the
integrity of the
genome.

9. OBSERVATION
This news seems to me very
useful and significant as
showing a responsible for
repairs in our genetics also
seems very important for the
medical use because with the
help of this enzyme and
biotechnology can be
implemented the elimination
of genetic mutations that
affect our patients

10. PROTOCELLS MAY HAVE FORMED IN A
SALTY SOUP
AUGUST 2, 2013

11. PROTOCELLS MAY HAVE FORMED
IN A SALTY SOUP
Cell
• This news question on a
evolutionary enigma : a cell
doesn't function without a cell
wall, but how does the cell wall
form if there is no cell?

12. PROTOCELLS MAY HAVE FORMED IN A
SALTY SOUP
Protein synthesis
• In a solution containing the
biomolecules that are normally
locked in a cell (like DNA, RNA,
enzymes, proteins) these large
biomolecules clustered together
spontaneously when the salt
concentration was increased.

13. PROTOCELLS MAY HAVE FORMED IN A
SALTY SOUP
• "When biomolecules are packed together, we expect
reactions to proceed much faster.
• A functioning cell must be entirely correct at once, in all its
complexity,“
• “ We are now closer to
Building a synthetic cell
Than anyone ever before us”
said the professor Huck.

14. OBSERVATION
This news seems very interesting
because it answers questions that
has many people we have come
and to seek an explanation, I
think the Professor Wilhelm Huck
essentially sought to show the
cell, in medicine this is very
valuable for the development of
these investigations can help
prevent and improve many
diseases using synthetic cells to
regenerate tissues, organs etc.

15. MEDICAL UTILITY

16. MEDICAL UTILITY
PROTOCELLS MAY HAVE FORMED IN A
SALTY SOUP
• Treatments such as synthetic cell development if
it can implement this, it would mean the
disappearance of malignant cell regeneration
that can invade the proliferative disease patients.

17. MEDICAL UTILITY
“ COWCATCHER” ENZYME FIXES SINGLE-
STRAND DNA
Is very important the concept of enzyme
NEIL 1 level riders because of genetic
diseases could invent and develop
processes either from the womb to born
persons, improving gene disorders can
show serious affecting the morphology
and neurological capacity

18. MEDICAL UTILITY
• These findings actually are significant in the race
that is always in favor of the health and welfare
of people.

19. BIBLIOGRAPHY
• Martínez S, lina maría. Biología molecular. 7 ed. Medellín: UPB.
Fac medicina, 2012. 74-84 p.
• Radboud University Nijmegen (2013, July 2). Protocells may have
formed in a salty soup.[On Line] ScienceDaily. Retrieved August 2,
2013, from
http://www.sciencedaily.com-/releases/2013/07/130702100115.htm.
• University of Texas Medical Branch at Galveston (2013, July 29).
'Cowcatcher' enzyme fixes single-strand DNA. [On
Line]ScienceDaily. Retrieved August 2, 2013, avalaible online: from
http://www.sciencedaily.com-/releases/2013/07/130729161751.htm.

20. THANKS.